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Biotechnology is as old as man. The old techniques involve the use of whole organisms for the benefit of man. The modern techniques are primarily concerned with modification of whole organisms, their genome or DeoxyriboNucleic Acid (DNA) for profit. Nigeria is endowed with diverse biodiversity some of which are unique to our ecosystems. While the short term economic benefits can easily be predicted, the long term health and environmental costs are largely unknown. Currently our communities are vulnerable to Genetically Modified Organisms (GMOs). They are exposed to these organisms in agro-seeds, vaccines, foods and other essentials of life. Nigeria lack the capacity to compete and make significant contributions in the already established and fast evolving market of bio-opportunities. Consequently there is urgent need to safeguard our bio-resources against predatory advances of profit seeking multinationals. These resources and the indigenous bioengineering skills for their management are in custody of diverse communities across Nigeria. Therefore it is critical to sensitize and concientize all stakeholders on the import of biosafety and the necessity of collaboration in evolving a National Strategy for development and management of local bio-resources. This paper reviewed global and local bio-safety issues and propose a local action plans for rural communities. These strategies when implemented will safeguard our bio-resources for the future.