Your SlideShare is downloading. ×
Quiz (retroviruses)
Upcoming SlideShare
Loading in...5
×

Thanks for flagging this SlideShare!

Oops! An error has occurred.

×
Saving this for later? Get the SlideShare app to save on your phone or tablet. Read anywhere, anytime – even offline.
Text the download link to your phone
Standard text messaging rates apply

Quiz (retroviruses)

2,105
views

Published on

Simple quiz made for tutorial session with my juniors

Simple quiz made for tutorial session with my juniors

Published in: Health & Medicine, Technology

0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total Views
2,105
On Slideshare
0
From Embeds
0
Number of Embeds
12
Actions
Shares
0
Downloads
45
Comments
0
Likes
0
Embeds 0
No embeds

Report content
Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
No notes for slide

Transcript

  • 1. YusriArif bin Sapaee
    5th Year Medical Student
    Kasr El-Ainy School of Medicine, Cairo University
    Quiz (Retroviruses)
  • 2. Classification of retroviruses that cause disease in humans
  • 3. Structure of the human immunodeficiency virus
  • 4. HIV proviral genome
  • 5. Binding of HIV to surface of lymphocyte
  • 6. Attachment and entry of HIV virus
  • 7. The HIV replication cycle
  • 8. Common modes of transmission of HIV
  • 9. Typical time course of HIV infection
  • 10. Pathogenesis of HIV
  • 11. Pattern of opportunistic infections associated with declining CD4+ cell counts
  • 12. Highly active antiretroviral therapy (HAART)
  • 13.
  • 14. Retroviruses are non enveloped positive sense ssRNA viruses
  • 15. Retroviruses contain enzyme reverse transcriptase
    Retroviruses rely on the reverse transcriptase (RT) enzyme to transcribe their genome from RNA into a DNA copy, which can then be integrated as a DNA provirus into the genomic DNA of the host cell.
  • 16. Important members of Retroviridae family that affect humans are?
    Human immunodeficiency virus (HIV) and Human T-cell lymphotropic viruses (HTLV)
    HIV  Lentivirinae subfamily
    HTLV  Oncovirinae subfamily
  • 17. Human Immunodeficiency Viruses replicate in?
    CD4+ T helper cells
  • 18. HIV-2 is the major cause of AIDS worldwide
  • 19. HIV-2 is characterized by the following EXCEPT:
    First described in 1986
    Slower in progression
    Limited mostly to West Africa and Portugal
    Much less severe
    Has 2 groups (M & O)
  • 20. Group M viruses are rare and limited to western part of Africa
  • 21. HIV-1 and HIV-2 resemble each other strikingly. However, they differ in?
    Molecular weight of their proteins and accessory genes
    The virus has spherical shape with a diameter of 100nm.
    The virus envelope is line with an HIV protein called p17 (matrix protein, MA).
    Inside, a conical-shaped capsid (CA) made of protein called p24 (core antigen)
  • 22. What is the most abundant protein in the virus particle?
    p24 (core antigen)
  • 23. Envelope antigens
    Core capsid antigens
    RT antigen
    Its absence  successful tx
    Responsible for receptor binding
    gp120
    p66/51 complex
    gp120 (SU) & gp41 (TM)
    p17 and p24
    p24
    HIV antigens
  • 24. Cells that are not infected by HIV
    Monocytes/macrophages
    Follicular dendritic cells (FDCs)
    CD4+ T helper lymphocytes
    Oligodendrocytes, astrocytes, neurones and glial cells
    Hepatocytes
  • 25. Name receptors on the cell surface required for the entry of HIV into the cell
    CD4 receptor and co-receptor CCR5 & CXCR5
  • 26. First
    Second
    Third
    Forth
    Fifth
    Assembly and budding
    Transcription
    Reverse transcription
    Integration
    Translation
    Post-fusion events
  • 27. HIV antibody positive
    Not infected
    HIV antibody negative, HIV RNA detectable
    Acute HIV infection
    HIV antibody negative, HIV RNA  viral load >5000 copies/ml
    Established HIV infection & no acute infection
    HIV antibody negative, HIV RNA  viral load 50-5000 copies/ml
    Repeat HIV RNA test in the same specimen
    HIV antibody negative, HIV RNA  viral load <50 copies/ml
    Indeterminate  repeat testing on follow up specimen
    Diagnosis of acute HIV infection(acute retroviral syndrome)
  • 28. How to diagnose HIV infection in newborns?
    PCR or viral load
  • 29. Nucleoside analogues transcriptase inhibitors
    Non-nucleoside analogues transcriptase inhibitors
    Protease inhibitors
    Protease inhibitors
    Fusion inhibitors
    Enfuvirtide (Fuzeon)
    Ritonavir
    Lamivudine
    Nevirapine
    Indinavir
    Highly active antiretroviral therapy (HAART)
  • 30. How to monitor anti-HIV therapy?
    Viral load measurement & CD4 count
  • 31. Best regimen for post-exposure chemoprophylaxis
    1reverse transcriptase inhibitor + 2 protease inhibitor
    1 reverse transcriptase inhibitor + 1 protease inhibitor
    2 fusion inhibitors + 1 protease inhibitor
    1 reverse transcriptase inhibitor + 2 fusion inhibitors
    2 reverse transcriptase inhibitors + 1 protease inhibitor