Irrational Economic Decision Making in Schizophrenia

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Kyongsik Yun, Yang Tae Kim, Jaeseung Jeong. “Irrational Economic Decision-Making in Schizophrenia: Evidence from the Ultimatum Game”, Korean Neuropsychiatric Association. Seoul, Korea, October 23 – …

Kyongsik Yun, Yang Tae Kim, Jaeseung Jeong. “Irrational Economic Decision-Making in Schizophrenia: Evidence from the Ultimatum Game”, Korean Neuropsychiatric Association. Seoul, Korea, October 23 – 24, Oral Presentation

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  • 1. Irrational Economic Decision Making in Schizophrenia: Evidence from the Ultimatum Game Korean Neuropsychiatric Association 2008.10.23, 03:25p.m. Kyongsik Yun, Ph.D. Candidate Bio and Brain Engineering KAIST yunks@kaist.edu
  • 2. Questions to be asked • Is the Ultimatum game behavior of schizophrenia different from that of normal controls? • Does time frequency analysis of EEGs show impaired decision making in schizophrenia? • Does phase synchronization of EEGs show impaired decision making in schizophrenia? 2
  • 3. 3
  • 4. What are the temporal dynamics of social interaction? proposer responder 4
  • 5. What are the temporal dynamics of social interaction? proposer responder 1. Make an offer: 9:1 (send emotional cue) Reward anticipation (NAcc) 5
  • 6. What are the temporal dynamics of social interaction? proposer responder 1. Make an offer: 9:1 2. Conflict btwn emotion & cognition (send emotional cue) ACC, Ins, dlPFC activation (interaction) Reward anticipation (NAcc) 6
  • 7. What are the temporal dynamics of social interaction? proposer responder 1. Make an offer: 9:1 2. Conflict btwn emotion & cognition (send emotional cue) ACC, Ins, dlPFC activation (interaction) Reward anticipation (NAcc) 3. Make a decision (reject: Ins) 7
  • 8. What are the temporal dynamics of social interaction? proposer responder 1. Make an offer: 9:1 2. Conflict btwn emotion & cognition (send emotional cue) ACC, Ins, dlPFC activation (interaction) Reward anticipation (NAcc) 3. Make a decision (reject: Ins) 4. Reward prediction error 8
  • 9. Previous studies: emotion vs. cognition Sanfey et al. Science, 2003 9
  • 10. What are the neural mechanisms of human decision making in the context of emotion and cognition? dlPFC Anterior insula ACC 10
  • 11. Time line for a single round of the Ultimatum Game Subject decides 6 sec 6 sec 6 sec x sec 6 sec + He gets $9 Accept Reject He gets $0 You get $1 You get $0 Reveal Reveal Reveal Reveal Reveal Fixation Partner Offer Options Outcome x: Time continues until the subject decides. 11
  • 12. Behavioral results from the Ultimatum Game 100 Schizophrenic Control 80 Acceptance rates (%) 60 40 * 20 0 5:5 7:3 8:2 9:1 Offer These are the offer acceptance rates averaged over all trials. Each of schizophrenia patients and normal controls saw three $5:$5 offers, two $7:$3 offers, two $8:$2 offers, and three $9:$1 offers from human partners (10 offers in total). 12
  • 13. No difference between schizophrenia and controls was found in total earnings and reaction times. 13
  • 14. Group average of induced spectral power for all electrodes schizo Overall power is decreased in schizo. normal Especially when accepting the offer -> fairness valuation deficiency 14
  • 15. Topography of event related spectral power for each condition Schizo accept Schizo reject Normal accept SD Normal reject -800~400ms -400~0ms 0~400ms 400~800ms 15
  • 16. Group average of time series of event related spectral power for all electrodes and each decision in gamma schizo frequency range (30~50Hz) Lower overall power in schizo. Power change is not stable -> meaning?? regional communication is impaired. normal 16
  • 17. Phase synchronization analysis Lachaux et al. 1999 17
  • 18. Group average of phase synchrony for all electrodes schizo Long range synchronization and communication is impaired in schizo normal Especially when accepting the offer -> fairness valuation deficiency 18
  • 19. Summary • Is the Ultimatum game behavior of schizophrenia different from that of normal controls? – Yes. Abnormally accept. – Fairness valuation deficiency? Or economically rational? • Does time frequency analysis of EEGs show impaired decision making in schizophrenia? – Yes. Lower overall power amplitude. – Especially when accepting the offer -> fairness valuation deficiency • Does phase synchronization of EEGs show impaired decision making in schizophrenia? – Yes. Lower phase synchrony. – Especially when accepting the offer -> fairness valuation deficiency 19
  • 20. Acknowledgments • Jaeseung Jeong, Ph.D. – Advisor, Brain Dynamics Lab, KAIST, • Dongil Chung – Ph.D. candidate, Brain Dynamics Lab, KAIST • Yang Tae Kim, M.D. – Bugok National Hospital 20