The document discusses many associations between gastrointestinal disorders and skin manifestations. Some key points discussed include inflammatory bowel diseases like ulcerative colitis and Crohn's disease being associated with conditions like erythema nodosum and pyoderma gangrenosum. Liver diseases can cause signs like spider telangiectasias. Viral hepatitis may cause conditions like mixed cryoglobulinemia. Nutritional deficiencies from malabsorption disorders can induce nonspecific eruptions or specific deficiencies like zinc deficiency. Various cutaneous syndromes are also associated with increased cancer risks in the GI tract.
27. Inflammatory bowel diseases Inflammatory disorders of the bowel discussed here include ulcerative colitis (UC), Crohn's disease, and bowel bypass syndrome Both UC and Crohn's disease (the traditional inflammatory bowel diseases [IBD]) can present with abdominal pain, GI bleeding, or diarrhea. Bowel bypass syndrome : a bacterial overgrowth in the blind loop associated with a dermatosis-arthritis syndrome
45. Cutaneous syndromes and the GI Tract Cutaneous syndromes associated with gastrointestinal diseases and malignancy Abbreviations : AD, autosomal dominant; BCC, basal cell carcinoma; GI, gastrointestinal; MEN, multiple endocrine neoplasia; MSH. Syndrome Inheritance Cutaneous findings Internal Associations With increased DEFECT risk of malignancy Gardner’s Syndrome AD Osteoma, desmoid Intestinal polyposis, (familial Chromosome 5 tumors epidermoid colon cancer, thyroid Polyposis cysts, dental cancers, retinal Syndrome) anomalies abnormalities
46. Syndrome Inheritance Cutaneous findings Internal Associations Cronkhite Acquired Alopecia, nail GI polyps, colon Canada dystrophy; macular carcinoma, diarrhea Syndrome hyperpigmentation abdominal pain Cowden’s AD Hamartomas of Hamartomas and disease Mutation PTEN mucous membranes malignancy of colon, (multiple Gene / facial breast, thyroid, Hamatoma chromosome tricholemmonas, renal and bladder Syndrome) 10 papillomas Palmar- colon polyps plantar keratoses, scrotal tongue Muir – Torre ADMutation in Sebaceous gland tumors, Nonpolyposis colon cancer BCC with sebaceous differentiation MSH2 gene on
47. Syndrome Inheritance Cutaneous findings Internal Associations Peutz – AD Periorifical and Hamartomas polyps Jeghers mucosal lentigines, throughout GI tract Syndrome pigmented maculae increased incidence hands and feet of malignancy throughout GI tract, ovarian tumors, pancreatic carcinoma gallbladder cancer, GI bleeding, pancreatic carcinoma
48. Cutaneous syndromes associated with gastrointestinal diseases and malignancy Syndrome Inheritance Cutaneous findings Internal Associations Howell- Palmer - plantar Esophageal carcinoma Evans’ hyperkeratosis syndrome Bazex’s Acquired Acrodermatitis, Esophageal, laryngeal, syndrome nail dystrophy tongue carcinoma MEN type I AD Multiple facial Pituitary, parathyroid, (Wermer’s Mutation in angiofibromas, pancreatic endocrine syndrome) MEN I gene collagenomas, abnormalities, peptic U on chromosome lipomas, confetti-like disease,Zollinger-Ellison 11 hypopigmented syndrome, gastronoma, macules insulinoma, carcinoid.
49. Syndrome Inheritance Cutaneous findings Internal Associations MEN IIA AD Amyloidosis Medullary thyroid ( Sipple’s Mutation in RET carcinoma, syndrome) gene on pheochromocytoma, chromosome 10 hyperparathyroidism, Zollinger – Ellison syndrome, Cushing’s syndrome, malignant melanoma, pitutary ad. MEN IIB AD Multiple mucosal Hirschprung’s disease, Mutation in RET neuromas, cervical medulloblasoma gene on marfinoid body increased risk of chromosome 10 habitus, nasal malignancy neuromas