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    endocrine system endocrine system Document Transcript

    • Endocrine System Endocrine System od pophysis) pophysis) retion s During Exercise ng Exercise ctrolyte Balance
    • ductless glands called endocrine glands that secrete chemical messengers called hormones into the bloodstream or in the extrac made and secreted by one cell that travels through the circulatory system or the extracellular fluid to affect the activities of cells onment in the body (the optimum biochemical environment) es wth and development. igates sexual reproduction, including gametogenesis, coitus, fertilization, fetal growth and development and nourishment of the n ural functions and rmones and ones and exocrine o produce ells of the small and heart
    • Nervous System Endocrine System Neurons release neurotransmitters Endocrine cells release hormones A neurotransmitter acts on specific cell right next to it. Hormones travel to another nearby cell or act on cell in another part of the body. Neurotransmitters have their effects within milliseconds. Hormones take minutes or days to have their effects. The effects of neurotransmitters are short-lived. The effects of hormones can last hours, days, or years. Performs short term crisis management Regulates long term ongoing metabolic function Neurotransmitter acts on specific cell right next to it. Hormone can travel to another nearby cell or it can act on another part of the body. Note, however that these two systems coordinate their activities: certain parts of the nervous system stimulate or inhibit the release of hormones (e.g. hypothalamus) and in turn, certain hormones can stimulate or inhibit the flow of nerve impulses. The nervous system modifies the stimulation of endocrine glands and their negative feedback mechanisms. The nervous system can override normal endocrine controls
    • reted by cells into the extracellular fluids tion of other cells m seconds to hours cts nly activate cells referred to as target cells fic receptors to which the hormone binds. acellular or located on the plasma membrane. tors: ormone eceptors on the target cell eptors for the hormone form more receptors in response to the hormone lls lose receptors in response to the hormone ore of the following cellular changes in target cells meability
    • me systems modified from the amino acid called tyrosine. They include the thyroid hormones and the hormones of the adrenal medulla (epi oluble. hains of amino acids that vary in size from 3 amino acids (TRH) to 191 amino acids (GH). These hormones are water soluble. t are steroids (e.g. estrogen and testosterone) and fatty acids derivatives (e.g. prostaglandins). These hormones are lipid soluble. rget cell in 1 of 2 ways: volves regulatory G proteins) ptide, and fatty acid-derived hormones work) n-linked receptor on the cell membrane; t he hormone acts as a first messenger.2. The binding of the hormone to the G protein-lin cond messenger than activates or inactivates enzymes in the cell l help you understand how hormones that bind to G protein-linked receptors on the surface of the cell activate second messenger mones work) rmones pass directly through the cell membrane of target cells. oplasm or in the nucleus. (Thyroid hormones also bind to receptors in the mitochondria.) toplasm, the hormone-receptor complex then enters the nucleus. ctly either turn genes “on” or turn genes “off.” That is they either cause the gene to start making a protein by transcription and tra tochondria increase the rate of ATP production in the cell.
    • l help you understand how hormones that bind to intracellular receptors (activate second messengers) work. od ood in two forms – free or bound ne are attached to plasma proteins d g hormone reflect: emoval from the body m the blood by: ed by negative feedback systems ithin a narrow desirable range nd released in response to humoral, neural, and hormonal stimuli
    • d in blood 2+ ates ds to yroid e and ved
    • etic s la d in response to hormones produced by other endocrine organs mones stimulate the anterior pituitary to release hormones. The pituitary hormones then stimulate other target organs to secrete s
    • in the diencephalon, inferior to the thalamus. euroglial cells. ormones: anterior pituitary gland to release a specific hormone (e.g. GRH-GH)
    • anterior pituitary gland to not release a specific hormone (e.g. GRIH-GH) also called vasopressin) e conserves body water by reducing the loss of water in urine. s the collecting ducts of the kidneys to reabsorb more water and constrict blood vessels, which leads to higher blood pressure and dration. h muscle of the uterus to contract, inducing labor. pithelial cells of the breasts to contract which releases milk from breasts when nursing. behavior. s muscle contractions in the prostate gland to release semen during sexual activity hormones made by the hypothalamus reach the anterior lobe of the pituitary gland DIRECTLY by a special set of blood vessels tidiuretic hormone (ADH) and oxytocin in the cell bodies of neurons and then the hormones are transported down the axons wh r pituitary gland The posterior pituitary gland stores and later releases the hormones as needed. elationship of the hypothalamus to the anterior and posterior pituitary glands and on the relationship of the hormones made in th hormones) to the anterior and posterior pituitary glands.
    • cretes nine major hormones posterior lobe (neural tissue) receives, stores, and releases hormones (oxytocin and antidiuretic hormone) made in the hypothala a axons. anterior lobe, made up of glandular tissue. Synthesizes and secretes a number of hormones. easing hormones to the anterior pituitary that stimulates the synthesis and release of hormones from the anterior pituitary gland s inhibiting hormones that shut off the synthesis and release of hormones from the anterior pituitary gland nine important peptide (protein) hormones ind to membrane receptors and use cyclic AMP as a second messenger
    • ry Gland (Adenohypophysis) totropin) matotropic cells of the anterior lobe s, but target bone and skeletal muscle and other tissues to secrete insulin-like growth factor I (IGF-I or somatomedin) iferation of chondrocytes (cartilage cells), resulting in bone growth. rowth, replication, and protein synthesis through release of IGF-I. es lipolysis to encourage the use of fats for fuel and inhibits glucose uptake alamic hormones regulate GH mone–releasing hormone (GHRH) stimulates GH release mone–inhibiting hormone (GHIH or somatostatin ) inhibits GH release
    • (TSH or Thryotropin) d gland (target cells) where it stimulates the release of thyroid hormones in response to low temperatures, stress, and pregnancy g hormone (TRH) from the hypothalamus promotes the release of TSH of thyroid hormones act on the pituitary and hypothalamus to block the release of TSH (ACTH or Corticotropin) l gland (target cells) where it stimulates the release of corticosteroids (such as cortisol) in the adrenal cortex. ng hormone (CRH) from the hypothalamus promotes the release of ACTH in a daily rhythm factors such as fever, hypoglycemia, and stressors can trigger the release of CRH FSH) s (target cells) and stimulates sperm or egg cell production and maturation and estrogen secretion ing hormone (GnRH) from the hypothalamus promotes the release of FSH during and after puberty s in females (target cells) and stimulates ovulation, maturation of follicles (together with FSH) and stimulates the corpus luteum o the testes (target cells) to stimulate secretion of testosterone. o as interstitial cell-stimulating hormone (ICSH) l help you to understand how GnRH, FSH, and LH are involved in the female reproductive cycle. mary glands (target cells) and stimulates the development of mammary glands to produce milk. ink prolactin influences the sensitivity of cells in the testes (interstitial cells) to the effects of luteinizing hormone (LH) ormone (PRH) from the hypothalamus stimulates the release of prolactin hormone (PIH) from the hypothalamus inhibits the release of prolactin ward the end of pregnancy, suckling stimulates PRH release and encourages continued milk production Gland (Neurohypophysis) ns axons from neurons in the hypothalmus r vasopressin) the supraoptic nucleus in the hypothalamus g ducts of the kidneys to reabsorb more water and constrict blood vessels, which leads to higher blood pressure and thus counters reasons cribes how the hypothalamus releases antidiuretic hormone (ADH or vasopressin) which then acts on other organs to have its ef
    • mone. the paraventricular nucleus of the hypothalmus h muscle of the uterus to contract, inducing labor pithelial cells of the breasts to contract which releases milk from breasts when nursing. behavior. s muscle contractions in the prostate gland to release semen during sexual activity.
    • ecretion
    • c stimulation–from CNS ulation–from hypothalamic trophic hormones and stimulation–from pituitary trophic hormone vides an example of positive and negative feedback control of the reproductive hormones. ctice questions. Click here for even more practice questions. ntains numerous thyroid follicles that release 2 hormones: thyroxine (T4) and triiodothyronine (T3) e held in storage but eventually attach to thyroid binding globulins (TBG); some are attached to transthyretin or albumin gulate metabolism; they diffuse into target cells and bind to mitochondria, thereby increasing ATP productio; they also bind to r ation crease protein synthesis, and promote glycolysis, gluconeogenesis, and glucose uptake e necessary for normal growth as they stimulate release of GH from the anterior pituitary e very important for brain development he thyroid follicles produce calcitonin. the concentration of calcium in the blood where most of it is stored in the bones; it stimulates osteoblast activity and inhibits ost on. calcium concentration in body fluids cribes the structure of the thyroid gland, how thyroid hormones are made, the functions of calcitonin and thyroid hormones, and
    • ds are four or so masses of tissue embedded posteriorly in each lateral mass of the thyroid gland ne (PTH) is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid e effect of calcitonin.
    • oclasts which increases blood calcium levels. tion of Ca+2 from kidneys so it is not excreted in the urine hesis of calcitriol (hormone made in the kidney which the active form of Vitamin D which increases Ca+2 absorption from sma cribes the structure of the parathyroid glands, the function of parathyroid hormones, and the effects of hypo- and hyperparathyro
    • re located superior to each kidney. as a pyramid shape. as an inner medulla and outer cortex:
    • over 30 different steroid hormones (collectively called corticosteroids) as 3 regions (zones) that each make a major type of hormones: rone) e kidneys to reabsorb sodium if blood pressure drops es (eliminates) potassium nes help you to cope with stress eases the level of sugar in the blood by stimulating the production of glucose from fats and proteins (gluconeogenesis)
    • s swelling s, cortisol inhibits the immune system. gluconeogenesis, mobilization of free fatty acids, glucose sparing. Also acts as an anti-inflammatory agent one, estrogens, and progesterone ) gland also makes small amts of the sex hormones (mostly androgens (testosterone) and lesser amounts of estrogens and progester certain what role these hormones play; but know that when over secreted they can cause problems s epinephrine and norepinephrine when stimulated by sympathetic neurons of the autonomic nervous system (ANS) d norepinephrine contribute to the bodies' "fight or flight" response, just like the sympathetic nervous system. effects as direct stimulation by the sympathetic NS (increase heart rate, breathing rate, blood flow to skeletal muscles, and conce onger lasting milar to epinephrine, but it is less effective in the conversion of glycogen to glucose. ne hrine bes adrenal gland structure and hormones,
    • wer curvature of the small intestine (duodenum) ns both exocrine and endocrine cells secretes digestive enzymes into the duodenum via the pancreatic duct n has clusters of endocrine cells within the pancreas called pancreatic islets or Islets of Langerhans
    • ecrete glucagon rete insulin the levels of glucose in the blood by stimulating the liver to breakdown glycogen into glucose during fasting or starvation d glucose by increasing the rate of glucose uptake and utilization d glucose by increasing the rates of glycogen breakdown and glucose manufacture by the liver cribes pancreas structure and hormones.
    • This material is based upon work supported by the Nursing, Allied Health and Other Health-related Educational Grant Program, a grant program funded with proceeds of the State’s Tobacco Lawsuit Settlement and administered by the Texas Higher Education Coordinating Board.