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Okay, here is the deal: I made a bunch of questions as I was going through the Pharm. Lectures. I may have made mistakes, and I know I made a lot of typos, so please ignore any that you see. Get out your “drugs you need to know list” for each lecture, and then use it as you try to answer the questions (that way you have an idea about which drugs you would be able to choose from in a multiple choice test).<br />I hope this helps!<br />-Cara Tillotson<br />Neurodegenrative Disorders (PD)<br />
Stimulation of each of the following receptors will lead to what?
This is the main drug of choice in treatment for PD.
These drugs are MAO-B inhibitors used with levodopa and may be neuroprotective (2 drugs)
These two parkinson’s drugs are not used often, are D1 and D2 agonists, and are ergot derivatives.
These two drugs are used in combination with levodopa to decrease peripheral metabolism and side effects. One also increases the half life of levodopa.
These are D2 and D2 agonist used prior to levodopa – it is contraindicated in patients with glaucoma (3 drugs).
This drug reduces free radical damage and is used as first line or adjunct in treatment.
Studies have shown that these two drugs act as adenosine receptor antagonists – they may be neuroprotective, though their mechanisms are not entirely understood.
This drug is injectable only and is available in an infusion pump.
These drugs are used in PD patients with hallucinogenic disturbances.
You should avoid using this drug with antihypertensives.
This drug is genereally well tolerated, but may cause peripheral edema, cognitive changes, and livedo reticularis. It is an antiviral used because it blocks DA reuptake and stimulates D2 and D3 receptors.
This drug is a peripheral COMT inhibitor only.
This drug is both a central and peripheral COMT.
These two drugs are antihistamines used to treat balance and coordination difficulties in MS.
This drug is used to treat bladder specificity associated with MS.
I don’t think we need another question about steroids, so just be aware that you use them.
This antiviral is used to treat fatigue in MS.
This OTC medication is used to decrease immune cell migration and chemotaxis.
This drug’s main side effects are pain and swelling at the injection site.
This drug targets CD25 antigen (part of the IL-2 receptor) and stimulates natural killer cells.
Primary progressive MS. Other three are Progressive Relapsing (steady decline since onset with attacks), Secondary Progressive (Initial relapsing-remitting MS that suddently begins to have decline without periods of remission), and relapsing-remitting (unpredictable attacks followed by periods of remission).