Okay, here is the deal: I made a bunch of questions as I was going ...
Okay, here is the deal: I made a bunch of questions as I was going through the Pharm.
Lectures. I may have made mistakes, and I know I made a lot of typos, so please ignore
any that you see. Get out your “drugs you need to know list” for each lecture, and then
use it as you try to answer the questions (that way you have an idea about which drugs
you would be able to choose from in a multiple choice test).
I hope this helps!
Neurodegenrative Disorders (PD)
1. Stimulation of each of the following receptors will lead to what?
a. D1 receptor
b. D2 receptor
2. This is the main drug of choice in treatment for PD.
3. These drugs are MAO-B inhibitors used with levodopa and may be
neuroprotective (2 drugs)
4. These two parkinson’s drugs are not used often, are D1 and D2 agonists, and are
5. These two drugs are used in combination with levodopa to decrease peripheral
metabolism and side effects. One also increases the half life of levodopa.
6. These are D2 and D2 agonist used prior to levodopa – it is contraindicated in
patients with glaucoma (3 drugs).
7. This drug reduces free radical damage and is used as first line or adjunct in
8. Studies have shown that these two drugs act as adenosine receptor antagonists
– they may be neuroprotective, though their mechanisms are not entirely
9. This drug is injectable only and is available in an infusion pump.
10. These drugs are used in PD patients with hallucinogenic disturbances.
11. You should avoid using this drug with antihypertensives.
12. This drug is genereally well tolerated, but may cause peripheral edema, cognitive
changes, and livedo reticularis. It is an antiviral used because it blocks DA
reuptake and stimulates D2 and D3 receptors.
13. This drug is a peripheral COMT inhibitor only.
14. This drug is both a central and peripheral COMT.
15. This drug is used for Restless Leg syndrome.
a. D1 = excitatory increased cAMP increased Ca2+ activation of
protein kinase C.
b. D2 = inhibitory hyperpolarization.
3. Seligiline and Rasagilene.
4. Bromocriptine and Pergolide.
5. Carbidopa (increases ½ life, also decreases nausea) and Benserazide.
6. Trihexyphenidyl, Benztropine Mesylate, and Diphenhydramine.
8. Caffiene and Istradefylline.
Neurodegenerative disorders (AD, HD, ALS).
1. This drug is a AChE inhibitor, was the first AD drug, and is no longer used due to
2. This drug is more selective for AChE than BChE and significantly improves
performance scores; it is reversible and competitive.
3. This drug has 100% bioavailability.
4. HMG CoA Reductase inhibitors thought to have antioxidant effects, but many
5. This drug is “pseudoreversible” and inhibits central and peripheral AChE.
6. This is the main side effect that causes people to stop using the above drug.
7. This drug is used to treat both AD and PD – it is a monoamine oxidase inhibitor
and can reduce the production of free radicals.
8. Herbal thought to improve memory.
9. Doses over how much per day is not indicated for Vitamin E?
10. These two drugs are used to treat disease-associated depression in AD.
11. These two drugs are used to treat diseases-associated spasticity.
12. When using this drug, which inhibits glutamate release, you must monitor
13. This drug increases pre-synpatic inhibition and decreases spasticity.
1. Which type of MS is characterized by steady increase in disability without
2. This type of drug is used in the treatment of an exacerbation (attack) of a
3. This is one of the primary drugs for RRMS – the two types antagonize the effects
of cytokine activity.
4. This drug is an anti-seizure medication used to control neuropathic pain in MS.
5. This drug is used only in RPMS.
6. This drug blocks access of lymphocytes to CNS by blocking integrin interactions
at the BBB.
7. This drug’s side effects include flu-like symptoms, which can be controlled with
ibuprofen or acetominophen.
8. This drug is often effective in patients who do not responde well to IFN.
9. This vitamin may reduce disease progression.
10. These two drugs are antihistamines used to treat balance and coordination
difficulties in MS.
11. This drug is used to treat bladder specificity associated with MS.
12. I don’t think we need another question about steroids, so just be aware that you
13. This antiviral is used to treat fatigue in MS.
14. This OTC medication is used to decrease immune cell migration and chemotaxis.
15. This drug’s main side effects are pain and swelling at the injection site.
16. This drug targets CD25 antigen (part of the IL-2 receptor) and stimulates natural
1. Primary progressive MS. Other three are Progressive Relapsing (steady decline
since onset with attacks), Secondary Progressive (Initial relapsing-remitting MS
that suddently begins to have decline without periods of remission), and
relapsing-remitting (unpredictable attacks followed by periods of remission).
7. IFN- Beta.
9. Vitamin D.
10. Meclizine and Promethazine.
14. Alpha-lipoic acid.
1. No miosis, least urinary retention in this drug.
2. Less euphoric effects – used for addiction.
3. Drug of choice for opiod overdose.
4. Drugs used for neuropathic pain.
5. Used in mid/moderate pain, similar to morphine but less potent.
6. The main side effect of this drug is cardiotoxicity and pulmonary edema.
7. Rank the order of potency for Fentanyl, Alfentanil, Sufentanil, and Remifentanil.
8. This drug is used during surgeries because of its rapid onset and rapid recovery;
it can be given IV only.
9. This drug inhibits NE and serotonin reuptake and is contraindicated in patients
10. This drug is more potent than morphine, used to treat moderate to severe pain
and is a partial M agonist.
11. This drug acts at K receptors and has the side effect of dysphoria.
12. This drug acts at K receptors and mildly at the M receptor.
13. This drug is the drug of choice for treating alcoholism.
14. This drug is used for diabetic neuropathy and trigeminal neuralgia.
15. This drug has no histamine release (kinda broad, I know…but just go with it).
16. What are the meperidine derivatives used for the treatment of diarrhea that are
a. Combined with atropine?
b. Poorly absorbed due to P-protein pump?
17. This drug is in OTC cough preps because it elevates CNS cough threshold.
1. These two drugs are the first line treatment for status epilepticus.
2. The major side effect of this drug is decreased Vitamin K.
3. Drugs of choice for partial and generalized tonic – clonic seizure.
4. Drug used for partial tonic-clonic seizures, status epilepticus, but should be
avoided in absence seizures.
5. MOA that slows the rate of recovery of voltage-gated Na channels, upregulates
adenosine in the brain, and blocks NE reuptake.
6. Drug above also often used to treat what psychiatric disorder?
7. IV version of phenytoin.
8. The major side effects of this drug, which is used to treat Lennox-Gastaut
syndrome, are Stevens-Johnson rash and DIC.
9. Drug of choice for absence seizures.
10. This drug may increase the metabolism of birth control drugs.
11. This drug is used to treat tonic-clonic, myoclonic, absence seizures, and bipolar
12. This drug’s main side effects are Parkinson’s like sndrome and photophobia.
13. This barbiturate was the 1st anti-seizure medication and is sometimes still used
14. This drug for long term seizure management has the lease side effects of all anti-
15. This drug is used in Lenox-Gaustaut and for “refractory epilepsy.”
16. This drug is very well tolerated and is also used to treat diabetic neuropathy.
17. This drug works by inhibition of GAT-1.
18. The drug, with “novel pharmacological profile,” works by inhibiting the burst-fire
without inhibiting normal neuronal activity.
19. The major side effect of this drug is aplastic anemia and hepatic failure.
20. This drug blocks keinate type glutamate receptors.
21. This drug irreversibly binds GABA-T.
22. This drug’s major side effect is metabolic acidosis.
23. This drug is easily combined with other drugs because it does not induce the
1. Increased activity in this pathway may cause the positive symptoms of
2. Decrease activity in this pathway may cause the negative symptoms.
3. Inhibition of this pathway causes extrapyramidal side effects.
4. Inhibition of this pathway leads to increased serum prolactin.
5. In general, Neuroleptics (“typical” antipsychotics) have what mode of action?
6. Atypicals are active at what receptor?
7. Binding affinity to which receptor determines potency for the neuroleptics?
8. Positive symptoms are alleviated via (increase/decrease) dopamine. (Pick one).
9. Major movement disorder that is a side effect for anti-psychotics is..
10. What two antipsychotics are marketed as anti-metics only?
11. Which four antipsychotics have the least anti-adrenergic activity?
12. This antipsychotic is a partial agonist at D2 and 5HT1A and an antagonist at
5HT2A; t is primarily use in bipolar disorder and has decreased extrapyramidal
13. Which two drugs may be antidotal for neuroleptic malignant syndrome?
14. Which drug offers lowest weight gain?
15. Which drug is most likely to cause blood dyscrasias?
16. Antipsychotics may produce more severe extrapyramidal effects when combined
with which drug?
17. Nephorgenic diabetes inspidus responds to what drug?
18. Which two drugs are becoming the 1st line treatment for bipolar disorder?
19. Which antipsychotics are histamine H1 antagonists?
20. What are the four high potency antipsychotics?
21. What is the main receptor of action for clozapine?
22. This drug can cause weight gain, hyperglycemia, and type II diabetes.
23. This drug is antisopaminergic, antiserotonergic, increases glutamate uptake in
astrocytes, and increases endrogenous antioxidants in astrocytes.
24. This drug is short acting and used in anesthesia.
25. This drug is used to treat Tourette syndrome and other tic disorders.
26. These two drugs mac act at the alpha1, alpha 2, 5HT, muscarinic, and histamine
H1 receptors and may improve cognitive function in psychotic disorders.
Drugs for Affective Disorder
1. What is the mode of action for:
2. What is the treatment for cardiac overstimulation due to increased catecolamine
3. Which class of antidepressents have the longest half lives?
4. Galucoma, epilepsy, cardiac problems, and MAOI use are all contraindications for
5. Current class of antidepressents considered to be the drugs of choice for
6. The most severe side effect/ toxicity effect of SSRIs is called what?
7. This SSRI may impair blood glucose control in diabetics.
8. The major concern with using SSRIs in children and young adults is what?
9. Ingesting this compound, present in red wine and smoked meats, can be deadly
for people on MAOIs.
10. What class of drugs do Venlafaxine and Duloxetine belong to?
11. Current drugs of choice for panic disorder.
12. What is the drug of choice for generalized anxiety disorder?
13. Group of antidepressents used to treat enuresis and diabetic neuropathy.
14. The drug of choice for OCD
15. This drug is used to treat OCD, PTSD, panic disorder, and it is preferred in the
16. This drug decreases nicotine cravings.
17. When switching someone from a SSRI/SNRI to an MAOI, or vice versa, how much
time should you wait after discontinuing one class before starting the next?
18. This MAOI has no dietary restrictions and it is MAO-B selective.
19. These two MAOIs are irreversible inhibitors of MAO-A and B and have dietary
20. This atypical antidepressent is contraindicated in patients with hepatic
dysfunction or kidney disease; it equally inhibits NE and serotonin reuptake.
21. This drug may cause hypotension and priapism.
22. This SSRI has the longest half life.
23. SSRI for the treatment of PTSD and PD; has significant drug interactions due to
24. This is the active metabolite of imipramine that selectively blocks NE reuptake.
25. This is contraindicated in people with manic-depression (class of antids).
a. inhibit MAO increased monoamines increased release of NT.
b. Inhibit NE and 5HT transporter increased NE and 5HT.
c. Inhibit 5HT mediated reuptake of 5HT.
3. TCA and heterocyclic.
4. Same as ^
6. Serotonin syndrome
8. Increased suicidal ideation
11. Sertaline, paroxetine, fluvoxamine
12. Paroxetine, venlafaxine
17. 14 days
19. phenzlizine, tranylcypromine