Microsoft PowerPoint - Recurrent Astrocytoma

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Microsoft PowerPoint - Recurrent Astrocytoma

  1. 1. RecurrentAstrocytoma Prof. Nadia Mokhtar
  2. 2. Classification & GRADING (WHO, 2000) • Grade I: Pilocytic astrocytoma • Grade II: Astrocytoma * Fibrillary * Protoplasmic * Gemistocytic • Grade III: Anaplastic astrocytoma • Grade IV: Glioblastoma multiforme & gliosarcoma
  3. 3. Pilocytic astrocytoma
  4. 4. Diffuse astrocytomas Grade II High cellularity
  5. 5. Anaplastic astrocytoma, grade III
  6. 6. Glioblastoma multiforme Grade IV
  7. 7. Molecular Pathogenesis Of Astrocytomas
  8. 8. Prognostic Factors I: Tumor-related factors: • Histologic grade • Tumor size • Tumor site: pons tumors carry worse prog • Necrosis • Proliferation • Genetic alterations
  9. 9. Ki-67
  10. 10. Prognostic Factors (cont) II Host-related Factors • Age: younger age • Pre-operative status: performance status III Treatment-related Factors • Extent of resection • Adjuvant therapy

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