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The MORE Than Ten Things You
Should Do to Prevent or Treat Cancer
Jerry Brunetti©
www.agri-dynamics.com
ACRES USA 2007
More People Make
Their Living From
the Cancer Industry
than Die From
Cancer
The War on Cancer
By Guy B. Faguet
Samuel Epstein, M.D.
“The Stop Cancer Before it
Starts Campaign- How to Win
the Losing War Against Cancer”
www.preventcanc...
Percentage Increase in Cancers
1973-1999 (All Races)
Breast (All ages) 41.2%
Breast (50+ years) 53.9%
Kidney 40.5%
Liver 1...
Childhood Cancers (1975-1999)
% Increase
Bone and Joint 39.8%
Brain (0-14 years) 50.2%
Leukemia (overall) 44.5%
Acute Lymp...
Disturbing Statistics
• Between 1973 and 1999 Cancer deaths increased 30% (17.7% -23% of
population)
• For the first time ...
No Refined Carbohydrates!
“Fuel for the Fire”
• 2001 US per Capita Consumption: 170 lbs/year
• 1820 US per capita Consumpt...
Sugar = Insulin
• Cancer Cells have 6-15 X Insulin Receptor
Sites
• Insulin Directs Inflammatory Eicosanoids
Pathways
“The Metabolism of Carcinoma Cells”
by Otto Warburg
The Journal of Cancer Research
Volume 9, pg 148-163 (1925)
INFLAMMATORY EICOSANOIDS & ENZYMES
Linoleic Acid (LA)
Gamma Linoleic Acid (GLA)
Di-homo Gamma Linoleic Acid (DGLA)
Good
Ei...
CANCER & CLA
•1996 Study of 4,697
Women: The More Whole
Fat Milk in the Diet (More
CLA) = Lower Risk of
Breast Cancer. Wom...
Inflammatory Lab Markers
• C-Reactive Protein < 1.0
• Homocysteine < 7.5
• Fasting Insulin < 5 uIU/ml
• Fibrinogen < 350 m...
Anti-Inflammatory
(High ORAC)• Resveratrol
• Curcumin
• Seanol
• Pynogenol
• Mangosteen/Pomegranate/Acai
• Green Tea (EGCG...
Resveratrol
“Of All the Plants We’ve Tested For Cancer Chemo- Preventive Activity, and The
Compounds We’ve Seen, This Has ...
CURCUMIN
• Increases Production TGF-beta (Transforming Growth Factor)
Producing Apoptosis
• Increases Expression of Nuclea...
Seanol
(aka Fibroboost)
2-4 caps/day
Carotenoid Study
25,802 Adults in Maryland
• High Levels of beta carotene & alpha
tocopherol = decreased cancer risk
• Per...
Vitamin D (Cholecalciferol)
• “Potential impact far greater than influenza
vaccine”- Dr. Scott Dowell (US CDC
11/26/06- Ba...
Cancer Risk Reduction & Vitamin D Status
Cancer
Risk Reduction with
Increased Vitamin D Intake
Breast 50%
Colon 50%
Prosta...
Vitamin D Cancer Mechanisms
• Affects at least 200 human genes, including those
controlling
– Proliferation
– Differentiat...
American Journal of Clinical Nutrition
2007 Jun; 85(6): 1586-91
“Vitamin D and Calcium Supplementation
Reduces Cancer Risk...
SELENIUM
• Potentiates Chemotherapy for Prostate & Colon Cancer
• Drew University of Medicine and Science
– Significant In...
IODINE
• Japanese: Lowest Level of Breast, Uterine Ovarian and Prostate Cancer
• Daily Japanese Iodine Consumption: 14-100...
I3C (INDOLE 3 CARBINOL)
• Inhibits Growth of Estrogen- Receptor Positive Breast Cancer Cells by 90% vs.
Tamoxifen @ 60%
• ...
Soil Sulfur
Glucosinolates (14 identified) e.g.
Crobene, Neoglucobrassin,
Glucoerucin, Glucobrassicin,
Glucoraphanin
Gluco...
Di Indole Methane (DIM)
300-600 mg.day
• Estrogen & Xenobiotics
– Increase aryl hydrocarbon receptors (AhR)
– Estrogen + A...
Lycopene
40-60 mg/day
• Up Regulates Gene Connexin 43
– Allows intercellular gap communication
• Synergistic with vitamin ...
Lycopene du Jour
CO-Q10 (Ubiquinol)
400-600 mg
• University of Miami
• Significantly reduces expression of bcl-2 gene
(resistance to apopto...
Vitamin E Complex
800 IU/day
• Need all tocopherols (alpha, beta,
gamma delta)
• Inhibit cycloxygenase 2 (COX)
enzyme
• Ne...
Vitamin A
100,000-300,000 IU/day
• Secretory IgA = Immunity of
Mucosal Tissue
• 14 month trial, 181 patients with
post-sur...
Green Tea
• Polyphenols (Epigallocatechin gallate EGCG)
• Elevates Caspase 3 Enzyme (Apoptosis)
• Inhibits Invasilon
• Inh...
ARTEMINISIN
Artemisia Annua or Sweet Wormwood
• University of Washington Drs. Henry Lai and Narerida Singh
• Int’l Journal...
Vitamin C Paradox
Anti-Oxidant
or
Pro-Oxidant
“Then and Now”
Proceedings of National Academy of Science USA
Volume 73, No. 10 pp 3685-3689 October 1976
by E. Cameron and L. Pauling
• ...
Average Survival Times and ratios for Ascorbate & Matched Controls
A
Type of Cancer (X)
# of ascorbate
B
Ascorbate
(Days)
...
Proceedings of National
Academy of Sciences USA
Vol. 75, No 9 pp. 4538-4542,
September 1978
Difference in Average Survival Times of Ascorbate-Treated Patients & Matched Controls
Primary
Tumor Type
Patient No.
Test ...
The Center for the Improvement of
Human Functioning
The Late Dr. Hugh Riordan (M.D.) Founder 1975
Wichita, Kansas, 67219 (...
Ascorbate Findings by RECNAC
• Animals synthesize Vitamin C from glucose
in only (4) metabolic steps
• Cancer cells readil...
• At adequate concentrations (400+ mg/dl)
Vitamin C is selectively toxic to cancer cells
• Vitamin C behaves as pro-oxidan...
IV Vitamin C Boost Immunity
Ascorbate Findings by RECNAC
• IV Vitamin C inhibits hyaluronidase
• IV Vitamin C Corrects scurvy in Cancer Patients
• IV Vitamin C induces apoptosis
•...
Tumor
GAGS
Collagen
Hyaluronidase
Collagenase
METASTASIS
Glucosaminoglycans (GAGS) + Proteins = Proteoglycans
(e.g. Glucos...
IV Vitamin C
Stimulates Collagen
Formation Via
Hydroxylation of
Proline
Ascorbate
Findings by
RECNAC
Benefits of Additional Vitamins
• Adding Vitamin B-12 create cytotoxic
cobalt ascorbate
• Adding Lipoic Acid “recycles” as...
RECNAC Vitamin C Case Histories
52 year old female- Renal Cell Carcinoma
• Diagnosed 9/95
• 9/96- (8) 1-3 cm lung metastas...
70 Year Male- Renal Carcinoma
• Diagnosed 12/85
• Radical nephrectomy; Xrays/CT: multiple
pulmonary & liver lesions. No ch...
Wayne Martin
July 17, 1911- May 23, 2006
Sleuth of Conventional Medical Research
Cimetidine
The Lancet, 1979 (pp. 822-823) USA
• University of Nebraska- Two Patients
1. Squamous cell carcinoma metastasis...
The Lancet 1982ii (p 328) Ireland
• Four Stage IV Melanoma patients (mets to
liver and lung)
– 1000 mg/day Cimetidine & Co...
New England Journal of Medicine
1983, Vol. 308, pp 591-592 Sweden
• Cimetidine
– Six Melanoma Patients (Interferon &
Cimet...
The Lancet
December 31, 1994 pp 1768-1769 Australia
• Cimetidine given (7) days only at time of
surgery
• Three year survi...
The Lancet (Colorectal Cancer)
Dec 24-31, 1994; 344 (8939-8940)
• Cimetidine given for 5 days pre & 2 days
post operative
...
British Journal of Cancer
2002 (86) 161-167
• Dukes Grade C Aggressive Colon Caner
• 10 Year Study with 15 Japanese Instit...
The Lancet
December 12, 1987 pp 1371-1374 European Stroke
Prevention- Two year study
– No benefits from Aspirin Alone
– Wi...
The Lancet
March 23, 1985 p 692
Dr. E.H. Rhodes, St. Hiler and Kingman Hospital in
Surrey, England
• 30 Melanoma Patients
...
The Lancet
October 17, 1964 Canada
pp 832-835
“Cancer Incidence and Mortality in Patients Having
Anticoagulant Therapy”
• ...
New England Journal of Medicine
February 25, 1982 p. 484 Sweden
Bjorn Stenkvist M.D., University Hospital, Uppsala, Sweden...
Medical Hypotheses 1999 53 (6)
Johan Haux M.D. Institute of Cancer Research and Molecular
Biology, Norwegian University fo...
Low Dose Naltrexone
www.lowdosenaltrexone.org
• Increases endorphins that migrate to opiate
receptor sites apoptosis
• Inc...
Iscador (Eurixor)
• Immune Boosting Lectins (cytokines,
phagocytosis)
• Anti-metastasis
• Improved survival with breast, c...
Endocrine (hormone) Therapy
• Bio-identical Hormones
– Thyroid, Adrenals
– Estrogens, Progesterone, Testosterone
Melatonin
• 40-50 mg/day
• Stimulates immune
system
• Anti estrogen
activity
• Powerful anti-
oxidant
• Very synergistic w...
Immune Modulators
• Thymic & Spleen Peptide
– Pro-Boost (Thymic Protein A)
– Thymostimulin
– Polyerga Plus (Spleen)
Thymus
Colostrum Derivatives
• Transfer factor
• AIE-10
• Colostrum Whey Serums
• Hyper-Immune Milk
Immune Modulators
Herbals
• Astragalus
• Echinacea
• Cordyceps
• Ligustrum
Immune Modulators
Mushrooms
– Coriolus
– Maitake
– Reishi
– Shitake
– AHCC (Immupower)
Immune Modulators
Beta 1-3,1-6 glucans
Other
– Ave (wheat germ Methoxy Benzoquinone)
– Russian Choice Immune (L. rhamnosus)
– Arabinogalactin (larch polysacchari...
Center for the Study of Natural Oncology
Vince Gammill N.D.
vgammill@adelphia.net
858-523-9144
San Diego Clinic
Filiberto ...
Resources
• Weston A. Price Foundation
www.westonaprice.org
• Life Extension Foundation www.lef.org
• People Against Cance...
The More Than Ten Things You Should Do to Prevent and Cure Cancer
The More Than Ten Things You Should Do to Prevent and Cure Cancer
The More Than Ten Things You Should Do to Prevent and Cure Cancer
The More Than Ten Things You Should Do to Prevent and Cure Cancer
The More Than Ten Things You Should Do to Prevent and Cure Cancer
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Transcript of "The More Than Ten Things You Should Do to Prevent and Cure Cancer"

  1. 1. The MORE Than Ten Things You Should Do to Prevent or Treat Cancer Jerry Brunetti© www.agri-dynamics.com ACRES USA 2007
  2. 2. More People Make Their Living From the Cancer Industry than Die From Cancer
  3. 3. The War on Cancer By Guy B. Faguet
  4. 4. Samuel Epstein, M.D. “The Stop Cancer Before it Starts Campaign- How to Win the Losing War Against Cancer” www.preventcancer.com
  5. 5. Percentage Increase in Cancers 1973-1999 (All Races) Breast (All ages) 41.2% Breast (50+ years) 53.9% Kidney 40.5% Liver 103.7% Lung 142.6% Malignant Melanoma 155.9% Non-Hodgkin’s Lymphoma 87.3% Prostate 104.9% Testes 66.7%
  6. 6. Childhood Cancers (1975-1999) % Increase Bone and Joint 39.8% Brain (0-14 years) 50.2% Leukemia (overall) 44.5% Acute Lymphocytic Leukemia 61.7%
  7. 7. Disturbing Statistics • Between 1973 and 1999 Cancer deaths increased 30% (17.7% -23% of population) • For the first time (2005), cancer has surpassed heart disease as the top killer of Americans under 85….” (Los Angeles Times, Jan. 19, 2005 • 1.3 million diagnosed and 570,000 die annually in US • In the 25-35 year old age group a recent analysis of the National Cancer Institute statistic showed that survival rates have not increased at all since 1975 “Cancer is the leading disease killer in people age 20 to 39…..more than 70,000 young adults get cancer every year……” The Wall Street Journal, July 5, 2005, page D1
  8. 8. No Refined Carbohydrates! “Fuel for the Fire” • 2001 US per Capita Consumption: 170 lbs/year • 1820 US per capita Consumption: 10-20 lbs/year
  9. 9. Sugar = Insulin • Cancer Cells have 6-15 X Insulin Receptor Sites • Insulin Directs Inflammatory Eicosanoids Pathways
  10. 10. “The Metabolism of Carcinoma Cells” by Otto Warburg The Journal of Cancer Research Volume 9, pg 148-163 (1925)
  11. 11. INFLAMMATORY EICOSANOIDS & ENZYMES Linoleic Acid (LA) Gamma Linoleic Acid (GLA) Di-homo Gamma Linoleic Acid (DGLA) Good Eicosanoids, PGA1, PGA2, 15-Hetri E Delta – 6 Desaturase Elongase Oxidized Arachidonic AcidLOX COX-1 / COX-2Leukotrines (LTB-4) Hydroxylated FACS 5-Hete Delta-5 DesaturaseHealthy A.A 5-Lipoxygenase Inflammation Tissue Destruction Thromboxane Abnormal Platelet Aggregation “Seal the Wound” Prostaglandin E-2 Inflammation & Tissue Destruction Damaged PUFA’s Insulin Infection Injury
  12. 12. CANCER & CLA •1996 Study of 4,697 Women: The More Whole Fat Milk in the Diet (More CLA) = Lower Risk of Breast Cancer. Women Drinking the Most Milk Had a 60% Lower Risk of Breast Cancer •Rats Fed 1.5% of Calories as CLA = Tumor Size Reduced 60% •Dr. Tikal Dhiman at Utah State University: One Can Lower Cancer Risk by Consuming Daily, One Ounce of Cheese, One Serving of Grassfed Meat & One Glass of Whole Milk From Pastured Cattle.
  13. 13. Inflammatory Lab Markers • C-Reactive Protein < 1.0 • Homocysteine < 7.5 • Fasting Insulin < 5 uIU/ml • Fibrinogen < 350 mgdl • IL-6 < 9.8 pg/ml • Lipoprotein (a): < 10 mgdL • LDL < 70 mgdL • HDL > 60 mgdL • TG’s < 100 • Fasting glucose < 100
  14. 14. Anti-Inflammatory (High ORAC)• Resveratrol • Curcumin • Seanol • Pynogenol • Mangosteen/Pomegranate/Acai • Green Tea (EGCG) • R-Lipoic Acid • Tocopherol Complex (E) • Vitamin C
  15. 15. Resveratrol “Of All the Plants We’ve Tested For Cancer Chemo- Preventive Activity, and The Compounds We’ve Seen, This Has the Greatest Promise” (University of Illinois-Chicago) • Significantly Reduce Tumor Volume (42%), Tumor Weight (44%) and Metastasis (56%) in Mice w/Highly Metastasized Lung Cancer • Induced Apoptosis in Human Leukemia Cells; Stopped Growth of Lymphocytic Leukemia • Inhibits NF-kB • Anti-Cancer For Hormone Dependent and Independent Breast Cancers • Inhibits COX-2 • Restored Glutathione • Increase Levels of Phase II Detoxification (Quinone Reductase) • Dose: 20-50-mg/Day
  16. 16. CURCUMIN • Increases Production TGF-beta (Transforming Growth Factor) Producing Apoptosis • Increases Expression of Nuclear p53 Protein in Basal Cell Carcinomas, Hepatomas & Leukemia, Producing Apoptosis • Inhibits PTK (Protein Tyrosine Kinases) and PKC (Protein Kinase C), Which Relay Chemical Signals for Proliferation, Metastases, Angiogenesis, Differentiation, Avoidance of Apoptosis • Inhibits COX-2 • Inhibits Nuclear Factor-Kappa B (NF-kB) • Dose 900 mg Capsules 1-3x/Day
  17. 17. Seanol (aka Fibroboost) 2-4 caps/day
  18. 18. Carotenoid Study 25,802 Adults in Maryland • High Levels of beta carotene & alpha tocopherol = decreased cancer risk • Persons with highest tier of total carotenoids = 66% reduction in cancer risk versus lowest tier Cancer Res 1993 Feb 15; 53(4): 795-8
  19. 19. Vitamin D (Cholecalciferol) • “Potential impact far greater than influenza vaccine”- Dr. Scott Dowell (US CDC 11/26/06- Baltimore Sun) • Vitamin D produces anti-biotic peptides via white cells • 200,000 IU’s for (3) days • Ideal Blood Levels 25 hydroxy vitamin D: 70-80 ng/mL
  20. 20. Cancer Risk Reduction & Vitamin D Status Cancer Risk Reduction with Increased Vitamin D Intake Breast 50% Colon 50% Prostate 49% Ovary 36% Recent Results Cancer Res. 2007. 174:225-34; J. Steroid Biochem Mol Biol. 2007 Mar; 103 (3-5); 708-11; J Steroid Biochem Mol Biol. 2005 Oct; 97(1-2):179-94; Cancer Res. 2005 June 15; 65 (12); 5470-9; Cancer Epidemial Biomarkers Prev. 2004 Sept. 13 (9): 1502-8.
  21. 21. Vitamin D Cancer Mechanisms • Affects at least 200 human genes, including those controlling – Proliferation – Differentiation – Apoptosis – Angiogenesis – Metastasis • 89 identified studies showing vitamin D intake reduces cancers of breast, prostate, colon, esophagus, pancreas, ovary, rectum, bladder, kidney, lung and uterus – Life Extension October 2007
  22. 22. American Journal of Clinical Nutrition 2007 Jun; 85(6): 1586-91 “Vitamin D and Calcium Supplementation Reduces Cancer Risks” • 1180 Post Menopausal Women • 1000 IU’s Vitamin D/day for (4) years – 60% Lower Cancer Risk – 77% Lower Cancer Incidence when excluding cancers in first year of study • Vitamin D & Calcium = best outcomes
  23. 23. SELENIUM • Potentiates Chemotherapy for Prostate & Colon Cancer • Drew University of Medicine and Science – Significant Increase in Apoptosis and Decrease in DNA Synthesis in Cancers of Breast, Lung, Small Intestines, Colon and Liver • 10 Year Study on 1312 Subjects – Prostate Cancer Reduced 63% – Colon Rectal Cancer Reduced 58% – Lung Cancer Reduced 46% • Dose: Use Se-Methylselenocysteine: and Selenium Yeast: 400-600 mcg/day. Take with Vitamin E (Tocotrienols and Gamma Tocopherol) 400-800 IU/day
  24. 24. IODINE • Japanese: Lowest Level of Breast, Uterine Ovarian and Prostate Cancer • Daily Japanese Iodine Consumption: 14-100 mg • U.S. R.D.A.: 150-200 mcg • Maintaining Iodine Sufficiency : 13 mg/Day – 6 mg Thyroid – 5 mg Breast – 2 mg Rest of Body • Displaces Bromine (Carcinogen) • Chelates Metals and Other Toxins • Destroys Parasites, Yeast, Bacteria, Virus • Promotes Stomach Acidity • Helps Hypo and Hyper Thyroidism • Prevents, Reverses Hashimoto’s and Grave’s • Reduces Lipoprotein (a) • Misc. : Headaches; Parotid Duct Stones; Keloid Formation; Peyronies Contractures; Breast, Ovarian, & Skin Cysts
  25. 25. I3C (INDOLE 3 CARBINOL) • Inhibits Growth of Estrogen- Receptor Positive Breast Cancer Cells by 90% vs. Tamoxifen @ 60% • Stops Human Cancer Cells From Growing (54-61%) and Initiated Apoptosis • Increases Conversion of Estradiol to Estriol by 50% in (1) Week (12 Subjects) • Prevented Aflatoxin Induced Liver Cancer, Leukemia, Colon Cancer & Chemically Induced Breast Cancer 70-96% (Lab Rats) • Restores p21 and Other Proteins That Correct Adducts (Tamoxifen No Effect) • Hoechst Marrion Roussel: New Generation of Indole Drugs to Replace Estrogen Drugs • Dose 200 mg 2-4x / Day As Per Body Wt.
  26. 26. Soil Sulfur Glucosinolates (14 identified) e.g. Crobene, Neoglucobrassin, Glucoerucin, Glucobrassicin, Glucoraphanin Glucobrassicin I3C (Indole 3 Carbinol) Ascorbigen Glutathione I3C I3CA, I3A, ICZ, DIM, Ltr, HI-IM Glucoraphanin Sulforaphane Vitamin C NAC HCL
  27. 27. Di Indole Methane (DIM) 300-600 mg.day • Estrogen & Xenobiotics – Increase aryl hydrocarbon receptors (AhR) – Estrogen + AhR 4-hydroxy estrogen • Decreases 4-hydroxy estrogen • Increases 2-hydroxy estrogen • Increases 2/16 hydroxy estrogen (60%) • Shuts down AhR system • 300 mg = 2 lbs broccoli Eur. J. Cancer Prev., 2004 Feb; 13 (10 83-6 Carcinogenesis, 2000 Aug, 21 (8): 1593-9
  28. 28. Lycopene 40-60 mg/day • Up Regulates Gene Connexin 43 – Allows intercellular gap communication • Synergistic with vitamin D3 (cell proliferation/differentiation) • Interferes with growth factor receptor signaling • Very potent anti-oxidant • Reduces Insulin-like growth factor- 1 (IGF-1) by 31% • Prostate, breast, lung, stomach, pancreatic cancers
  29. 29. Lycopene du Jour
  30. 30. CO-Q10 (Ubiquinol) 400-600 mg • University of Miami • Significantly reduces expression of bcl-2 gene (resistance to apoptosis) of cancer cells • Remission of metastasized breast cancer- 1994 European Study • Rats on Tamoxifen: 3 X increase in tumor weight • Rats of Tamoxifen & Co-Q10: No increase in tumor weight – Restored SOD, Catalase, Glutathione
  31. 31. Vitamin E Complex 800 IU/day • Need all tocopherols (alpha, beta, gamma delta) • Inhibit cycloxygenase 2 (COX) enzyme • Neutralizes reactive nitrogen oxides • Reduces oxidation of LDL and fats • Reduces Leukotrine b4 and TNF-@ • Finnish study of 29,000 PC patients (smokers) for 5-8 years: 32% decrease; 40% decrease in mortality
  32. 32. Vitamin A 100,000-300,000 IU/day • Secretory IgA = Immunity of Mucosal Tissue • 14 month trial, 181 patients with post-surgical non-small lung cancer – 300,000 IU/day – Relapses: 18% vs 28% (controls) • After 46 months, rates of tumor reoccurrence/new tumors – 37% (treated) versus 48% controls Journal of Clinical Oncology 1993; 11(7): 1216-22
  33. 33. Green Tea • Polyphenols (Epigallocatechin gallate EGCG) • Elevates Caspase 3 Enzyme (Apoptosis) • Inhibits Invasilon • Inhibits metastasis • Stimulates Immunity • Free Radical Scavenger (greater than Vitamin E) – E.g. Mice with melanoma & lung carcinoma cells- number of tumors decreased 50% and 29% • Inhibits interaction between estrogen and estrogen receptors (prostate and breast cancer)
  34. 34. ARTEMINISIN Artemisia Annua or Sweet Wormwood • University of Washington Drs. Henry Lai and Narerida Singh • Int’l Journal of Oncology 18; 767-773, 2001 • Peroxide Linkage Attacks “Free” Iron (Cancer and Malaria) – Releases Free Radicals; Destroys Cells • All Cancers Respond- No resistance! • Active Ingredients – Artesunate: Water Soluble, Most Active, Shortest Half Life – Artemisinin: Intermediate Half Life – Artemether: Fat Soluble, Most Toxic, Longest Half Life • 500 mg Twice Daily on Empty Stomach w/ Whole Milk or Cod Liver Oil (Fat) • Take for (2) Years Nutricology 800-545-9960 www.nutri-cology.com
  35. 35. Vitamin C Paradox Anti-Oxidant or Pro-Oxidant “Then and Now”
  36. 36. Proceedings of National Academy of Science USA Volume 73, No. 10 pp 3685-3689 October 1976 by E. Cameron and L. Pauling • All Patients were determined to be terminal; ascorbate only administered to “untreatable” patients – Treated Group: 10 grams ascorbate I.V. for 10 days; orally thereafter – Matched Controls: No Treatment
  37. 37. Average Survival Times and ratios for Ascorbate & Matched Controls A Type of Cancer (X) # of ascorbate B Ascorbate (Days) C Control (Days) D Ratio B/C E Ave Day survival both goups F % Ascorbate surviving > E G % Controls Surviving > E Bronchus (15) 136 38.5 3.53 47 47 8.7 Colon (13) 282 37 7.61 59 54 20 Stomach (13) 99 38 2.61 43 46 19 Breast (11) 367 64 53-.75 91 55 22 Kidney (9) 333 64 5.21 88 67 22 Bladder (7) 196 43.6 4.49 57 57 20 Rectum (7) 226 55.5 4.10 71 86 33 Ovary (6) 148 71 2.08 78 83 30 Others (19) 172 56.8 3.03 67 53 27 All (100) 209 50.4 4.16 65 60 25.7 16% of Ascorbate patients survived in excess of (1) year, vs. 0.3% of controls (53X)
  38. 38. Proceedings of National Academy of Sciences USA Vol. 75, No 9 pp. 4538-4542, September 1978
  39. 39. Difference in Average Survival Times of Ascorbate-Treated Patients & Matched Controls Primary Tumor Type Patient No. Test Control From First Hospital Attendance A B Test Control From Date of Untreatability C D Test Control Increased Survival Times of Ascorbate Treated patients, days E F A-B C-D Colon 17 170 458(+) 316 352(+) 33 142(+) 319(+) Bronchus 17 170 219(+) 118 186(+) 31 101(+) 155(+) Stomach 13 130 286(+) 159 182(+) 32 127(+) 150(+) Breast 11 110 1369(+) 1020 487(+) 52 376(+) 435(+) Kidney 8 80 774(+) 492 38(+) 39 282(+) 342(+) Bladder 7 70 1669(+) 420 355(+) 21 1249(+) 334(+) Rectum 7 70 634 336 270 43 298 227 Ovary 6 60 884 366 183 69 518 114 Other 14 140 706(+) 279 278(+) 37 427(+) 241(+) All 100 1000 681(+) 360 293(+) 38 321(+) 255(+) Mean Survival Times, Days (+) indicates one patient in group survived after May 15, 1978
  40. 40. The Center for the Improvement of Human Functioning The Late Dr. Hugh Riordan (M.D.) Founder 1975 Wichita, Kansas, 67219 (RECNAC) www.brightspot.org (316) 682-3100 •20 Published papers on Vitamin C & Cancer •RECNAC II University of Puerto Rico “Orthomolecular Oncology Review: Ascorbic Acid & Cancer 25 Years Later”
  41. 41. Ascorbate Findings by RECNAC • Animals synthesize Vitamin C from glucose in only (4) metabolic steps • Cancer cells readily absorb and accumulate ascorbate (similar to glucose molecule?) Vitamin CGlucose
  42. 42. • At adequate concentrations (400+ mg/dl) Vitamin C is selectively toxic to cancer cells • Vitamin C behaves as pro-oxidant – Interacts with intracellular Fe & Cu – Reaction produces H2O2 – Cancer cells are deficient in catalase Ascorbate Findings by RECNAC
  43. 43. IV Vitamin C Boost Immunity Ascorbate Findings by RECNAC
  44. 44. • IV Vitamin C inhibits hyaluronidase • IV Vitamin C Corrects scurvy in Cancer Patients • IV Vitamin C induces apoptosis • IV Vitamin C reduces pain • IV Vitamin C neutralizes chemo and radiation toxicity without neutralizing their cancer killing effects • IV Vitamin C helps cancer patients recover faster from treatments and disease Ascorbate Findings by RECNAC
  45. 45. Tumor GAGS Collagen Hyaluronidase Collagenase METASTASIS Glucosaminoglycans (GAGS) + Proteins = Proteoglycans (e.g. Glucosamine Sulfate & Other Sulfur Amino Sugars) Proteoglycans & Collagen = Intercellular Cement (“Ground Substance”)
  46. 46. IV Vitamin C Stimulates Collagen Formation Via Hydroxylation of Proline Ascorbate Findings by RECNAC
  47. 47. Benefits of Additional Vitamins • Adding Vitamin B-12 create cytotoxic cobalt ascorbate • Adding Lipoic Acid “recycles” ascorbate to maintain plasma saturations and increase sensitivity of cancer cells to ascorbate • Adding Vitamin K-3 (menadione) recycles DHA (Dihydro ascorbate)
  48. 48. RECNAC Vitamin C Case Histories 52 year old female- Renal Cell Carcinoma • Diagnosed 9/95 • 9/96- (8) 1-3 cm lung metastasis – No prior treatment – 10/96 IV Vitamin C- 65 gms bi-weekly plus NAC, beta 1,3 glucan, fish oil EPA, vitamin C (9 gms/day), beta- carotene, L-threonine, niacin, chromium, Bacillus laterospores • Treatments until June 1997. 7 masses resolved. Large reduction of 8th mass. • Four years later (2001), no evidence of progression
  49. 49. 70 Year Male- Renal Carcinoma • Diagnosed 12/85 • Radical nephrectomy; Xrays/CT: multiple pulmonary & liver lesions. No chemotherapy decided – March 1986- IAA, 30 gms 2X/week – April 1986 (6 weeks treatment): complete resolution of lung, liver and lymph node metastasis – 1986: 30 gms IAA 2X/week for 7 months; reduced to 1X/week for 8 months; reduced to 15 gm IAA 1X week for six months – Patient expired 12 years later, cancer free at age 82 RECNAC Vitamin C Case Histories
  50. 50. Wayne Martin July 17, 1911- May 23, 2006 Sleuth of Conventional Medical Research
  51. 51. Cimetidine The Lancet, 1979 (pp. 822-823) USA • University of Nebraska- Two Patients 1. Squamous cell carcinoma metastasis to lung 2. Non small cell lung cancer metastasis to brain 1. 1200 mg/day Cimetidine for stomach distress • Reduced to 600 mg/day cimetidine • One year later, no detectable tumor 2. 600 mg/day Cimetidine & steroids (brain swelling) • Brain tumor excised, one year later no long tumor
  52. 52. The Lancet 1982ii (p 328) Ireland • Four Stage IV Melanoma patients (mets to liver and lung) – 1000 mg/day Cimetidine & Coumadin – Three patients: dramatic remissions – One patient: death – All four patients had T-suppressor cells decreased by Cimetidine
  53. 53. New England Journal of Medicine 1983, Vol. 308, pp 591-592 Sweden • Cimetidine – Six Melanoma Patients (Interferon & Cimetidine) • 2 complete remissions • 1 partial remission • 1 progression arrested • 2 deaths
  54. 54. The Lancet December 31, 1994 pp 1768-1769 Australia • Cimetidine given (7) days only at time of surgery • Three year survival • Cimetidine: 93% (T-cell infiltration into tumors: 63%) • Controls: 59% (T-cell infiltration into tumors: 24%)
  55. 55. The Lancet (Colorectal Cancer) Dec 24-31, 1994; 344 (8939-8940) • Cimetidine given for 5 days pre & 2 days post operative • Decrease 3 year mortality rate from 41% to 7%
  56. 56. British Journal of Cancer 2002 (86) 161-167 • Dukes Grade C Aggressive Colon Caner • 10 Year Study with 15 Japanese Institutions – Treated patients given 800 mg Cimetidine/day for 12 months – Treated 10 year survival rate: 84.6% – Control 10 year survival rate: 23.1%
  57. 57. The Lancet December 12, 1987 pp 1371-1374 European Stroke Prevention- Two year study – No benefits from Aspirin Alone – With Dipyridamole: Stroke reduced 50%, myocardial infarction reduced 38%, cancer reduced 30% – Boehringer Ingelheim (original patent holder): no longer advise M.D.’s that dipyridamole prevents cancer cells from attaching to vascular system (metastasis) Dipyridamole
  58. 58. The Lancet March 23, 1985 p 692 Dr. E.H. Rhodes, St. Hiler and Kingman Hospital in Surrey, England • 30 Melanoma Patients – 300 mg/day Dipyridamole: 11 year study • 26 patients: Stage IV – 5 year survival = 74% – English Average = 32% • 4 patients: Stage III – 5 year survival = 100%
  59. 59. The Lancet October 17, 1964 Canada pp 832-835 “Cancer Incidence and Mortality in Patients Having Anticoagulant Therapy” • L. Michaels (student of O.Meara) studied 1500 “patient years” of patients on Coumadin – Statistical expectation of 8 deaths from cancer – Only 1 death detected (lung cancer)
  60. 60. New England Journal of Medicine February 25, 1982 p. 484 Sweden Bjorn Stenkvist M.D., University Hospital, Uppsala, Sweden Digitalis • 149 Breast Cancer Patients • 40 on Digitalis – 34 Digitoxin – 6 Digoxin • 109 Controls • 5 year outcomes – Digitalis Patients: 1 re-occurrence (2.5%) – Controls: 21 re-occurrences (19.25%) • Observation: Digitalis made breast cancer cells smaller and more uniform
  61. 61. Medical Hypotheses 1999 53 (6) Johan Haux M.D. Institute of Cancer Research and Molecular Biology, Norwegian University for Science and Technology, Trondiem, Norway • Digitalis – Anti-Cancer effect of digitalis is induction of apotosis – Digitoxin (natural) has greater anti-cancer effect than digoxin (synthetic) – Effective for Glioblastoma – Cost is < $2.00/day!
  62. 62. Low Dose Naltrexone www.lowdosenaltrexone.org • Increases endorphins that migrate to opiate receptor sites apoptosis • Increases levels of natural killer cells • Opiate receptor rich tissue: prostate, pancreas, lymph, blood, testes
  63. 63. Iscador (Eurixor) • Immune Boosting Lectins (cytokines, phagocytosis) • Anti-metastasis • Improved survival with breast, colorectal, pancreatic & lung with concurrent therapy versus controls
  64. 64. Endocrine (hormone) Therapy • Bio-identical Hormones – Thyroid, Adrenals – Estrogens, Progesterone, Testosterone
  65. 65. Melatonin • 40-50 mg/day • Stimulates immune system • Anti estrogen activity • Powerful anti- oxidant • Very synergistic with IL-2 and Tamoxifen Cancer 1994c Feb 1: 73(3): 699-701 Oncology 1992a 49(5): 336-9 Oncology 1991b 48(6): 448-50 Oncology 1994b July-Aug 51 (4): 344-7 Eur J Cancer 1993b; 29a(2); 185-9 Ann NY Acad Sci 1994a: Nov 25; 741: 191-196 Oncology 1993c; 50(6): 399-402
  66. 66. Immune Modulators • Thymic & Spleen Peptide – Pro-Boost (Thymic Protein A) – Thymostimulin – Polyerga Plus (Spleen) Thymus
  67. 67. Colostrum Derivatives • Transfer factor • AIE-10 • Colostrum Whey Serums • Hyper-Immune Milk Immune Modulators
  68. 68. Herbals • Astragalus • Echinacea • Cordyceps • Ligustrum Immune Modulators
  69. 69. Mushrooms – Coriolus – Maitake – Reishi – Shitake – AHCC (Immupower) Immune Modulators Beta 1-3,1-6 glucans
  70. 70. Other – Ave (wheat germ Methoxy Benzoquinone) – Russian Choice Immune (L. rhamnosus) – Arabinogalactin (larch polysaccharides) Immune Modulators
  71. 71. Center for the Study of Natural Oncology Vince Gammill N.D. vgammill@adelphia.net 858-523-9144 San Diego Clinic Filiberto Munoz M.D. Tijuana, Mexico 619-804-7783
  72. 72. Resources • Weston A. Price Foundation www.westonaprice.org • Life Extension Foundation www.lef.org • People Against Cancer (Ralph Moss) www.peopleagainstcancer.com • Cancer Control Society • www.preventcancer.com (Dr. Samuel Epstein)
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