Biocatalysis - Jonathan Dordick

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Biocatalysis - Jonathan Dordick

  1. 1. Biocatalysis for Our Sustainable Futurewhattheythink.com
  2. 2. Chemical Processing: Fueling the 20th Century Straathof et al. Curr. Opin. Biotech. 13, 548-556, 2002
  3. 3. Biocatalysis: Fueling the 21st “Sustainable” Century Chemicals Fuels Drugs
  4. 4. From Nature (1.3 billion tons)…
  5. 5. …to Products Through Biorefining
  6. 6. Challenges to Overcome Ionic Liquids scidac.org Cellulase
  7. 7. Biocatalysis for Healthcare OH O O OH OH OCH3 O OH O NH2 O OH
  8. 8. Drug Discovery at a Crossroads $2 billion/approval? Source: Burrill & Co.
  9. 9. Biology’s Complexity
  10. 10. Biocatalysis- drivenDrug DiscoveryHuman Toxicity =
  11. 11. Developing Better Biocatalytic Materials
  12. 12. From Enzymology to Enzyme-Based Materials Nanoscale Materials Designed GelsEnzymes Biocatalytic Plastics Biocatalytic Coatings Up in Space
  13. 13. Exploiting Nature’s Composite Materials Biomimetic,Biocatalytic Coating CYP3A4 100 nM Ketoconazole 250 nM Sulfaphenazole CYP2C9 10 nM Quinidine 100 nM Ketoconazole Biocatalytic 250 nM Sulfaphenazole Plastics 10 nM Quinidine CYP2D6 100 nM Ketoconazole 250 nM Sulfaphenazole 10 nM Quinidine ) ) )

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