Sc10 vitamins in 2 pages

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Sc10 vitamins in 2 pages

  1. 1. Viatmin Source Deficiency Function Toxicity Greater need if..Thiamin B1 Whole grain, pork,poultry, fish,vegetable, dairy.Wet Beri Beri (cardiac symptoms),Dry Beri Beri (peripheralneurophathy, gait) Wernicke-Korsakoff, accumulation of lactate inmusclesCo-enzyme in metabolic pathways.(Pyruvate dehydrogenase)Raw fish, coffee, tea,alcohol (inhibitsabsorbtion & enzymeconverting thiamin intoTPP), high carb,polished riceRiboflavin B2 Milk, protein In alcoholics (because of impairedliver/storage), cataractsFAD and FMN in redox Non-toxicNiacin B3 Cereals,converted fromtryptophan inproteinPellagra, photosensitive dermatitis,diarrhoea, dementiaNAD and NADP in redoxPantothenicAcid B5Ubiquitous Rare Component of Coenzyme APyridoxine B6 Root and greenveg., supplementsgiven withIsonazidIsonazid (TB drug) Transamination, haem synthesis,treatment of seizures, PMS, Downʼs,autismPeripheralneuorpathyBiotin B7 Peanuts,chocolate, eggyolk, gut floraRare Prosthetic group for pyruvate tooxaloacetate (Krebs) and acetylCoA to malonyl CoaRaw egg whites or longterm antibiotic therapy(kills flora)Folate B9 Green veg (activeastetrahydrofolate)Results: Inadequate myelinsynthesis, neural tube defectsFrom: malabsorbtion, ethanol, drugs(anti-convulsants)Carrier of 1C units in metabolism,DNA
  2. 2. Viatmin Source Deficiency Function Toxicity Greater need if..CobalaminB12Animal tissues Results in: pernicious anemia,inadequate myelin synthesis.From: Vegan diet, absent/defectiveIF, coeliac disease, gastrectomy,Carrier of methyl groups inmetabolism, conversion ofhomocysteine to methionine, DNA,needed for conversion of MeTHFback to methotrexate (from B6),needed for myelin synthesisVitamin C(ascorbic acid)RDI: 40mgCitrus fruits,berries, tomatoesScurvy (after 3 months with no vit.C).Anti-oxidant nutrient, collagen,maintain Fe2+ stateOxalate, kidneystones,diarrhoeaSmokers need 2xVitamin A(retinol/carotene)Carrots, oils, milk,egg yolkResults: night blindness,keratinisation of retina.From: inadequate protein dietsControl of protein synthesis, in visionat low light intensity.Dermatitis, hairloss, mucousmembranedefects, liverdisfunction andthinning ofbonesVitamin E Vegetable oils,wheat germ, nuts,veg.From: Depleted in frozen foodResults: Hemolytic anaemia due tofragile RBC membranesAntioxidant, membrane integrity(against free radicals)Vitamin D UV light, milk,dairyRickets (bendy bones),Osteomalacia (adult rickets)Acts as steroid hormones, maintainlevels of calcium and phosphate inthe bones so they becomemineralisedhypercalcemia,calcification ofsoft tissues(heart, lungs)Vitamin K Green vegetables,meat, eggs,cereals, milk, gutfloraFrom: long term antibiotic therapy(destruction of gut flora).Results: increased clotting time,haemorrhagic disease of newborn

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