www.vet4arab.co.ccIn memory of Charles Leblois, Clinical director of the National Veterinary School, Alfort, who in the 1920s, was the first to propose a diagnostic approach in animal dermatology, that was based on history taking, clinical examination, differential diagnosis and performing suitable diagnostic tests. "Diagnosis is an art I pursue with passion Treatment is a chore" Area of initial presentation of notoedric mange: base of the anterior concha1 cartilage. It is from here that samples should be taken. Distribution m a s of notoedric mange Distribution areas of notoedric mange Documents pour servir d l~d@cation dune Dermatologie Animale. ~ d i t i o n Vigot, 1926 s
www.vet4arab.co.ccTo Didier Noel Carlotti, Pierre Fourrier. to whom French and European dermatology owes its dynamism and international recognitionTo Zeineb Alhaidari, Blaise Hubert, Dominique H&ripret, Thierry Olivry, old friends and companions in veterinary dermatologyTo Jean-Pierre Magnol, for teaching us our first steps in dermatohistopathologyTo Peter Ihrke, Danny Scott, Ton Willemse, Stephen White, for instilling in us a thorough approach, both clinical and scientificTo all the members of the Groupe d ~ t u d en Dermatologie des Animaux de Compagnie (GEDAC), e for keeping us motivated
www.vet4arab.co.ccOur thanks go particularly to :- Merial, who has enabled this ambitious project to take place- Doctors Alhaidari, Atlee, Bensignor, Bourdeau, Bourdoiseau, Burton, Carlotti, Cozette, Declercq,Degorce, Dehasse, Delabre, Delisle, Denerolle, Devauchelle, Dryden, Ferrer, Fondati, Fontaine, Fritz,Gaultier, Groux, Habran, Hkripret, Hubert, Hugnet, Ihrke, Laubis, Leclercq, Legrand, Lopez, Magnol,Mason, Mege, Mialot, Mueller, (G) Muller, (G.H.) Muller, Noli, Olivry, Paghs, Poirson, Power, Prost,Rivierre, Rzeznik, Saenz de Santa Maria, Scott, Smal, Thomas, Verde, Vroom, White, Wilkinson,Willemse, for contributing their outstanding photographs.- Doctor Mark Craig for his outstanding translation skills- Doctors Emmanuel Bensignor, William Bordeau and Cathy Curtis for checking the manuscript. % .- Professor Gilles Bourdoiseau for his generous encouragement and advice.- Gabrielle McGarvey, Mary Craig, Aiden Foster, Sarah Heath and Maggie Fisher for assisting in thetranslation of certain chapters.- Blackwell Science, PMCAC, Le Recueil de Mkdecine Vktkrinaire, Harcourt Publishers, Saunders forpermission to reprint certain illustrations.
a aGuide to k h DamatoIogy cl www.vet4arab.co.cc I Preface I have to share a little something with you.., When my friends, Eric Guagdre and Pascal Prflaud, contacted me and told me that this great work on feline dermatology was being developed... and that they wanted me to write the preface ... I chuckled to myself. You know that you are getting old when folks start asking you topresent overviews and historical perspectives, and to write prefaces ! Eric also told me that I was considered to be the "father " offeline dermatology.Now ... I must say... I never considered myselfto be father of anything but Travis (my son) and Tracy (my daughter). However, as Ipondered the invitation and the acclamation, it certainly gave me a warm,fuzzy (or is thatfurry ?/feeling inside. It is certainly true that dermatology has been my professional life, and that feline dermatology, in particular, has always been my "professional hobby", my little " subspecialty ". But I suppose it was my "fatherly " monograph and the three addendumsZ4 that followed that publicised and validated my " felinophilic " nature. I want to acknowledge the inspirational writings of three of my predecessors in thefeline dermatology arena :Kenneth P. Baker, Jean Holzworth, and Joan 0.Joshua. Feline dermatology began to " boom " in 1980, with over 3,000 publications being devoted to the subject over the course of the subsequent decade. " Feline endocrine alopecia " evolved from a common to a vanishing cause of bilaterally symetric hypotrichosis, and hypersensitivity (allergy) disorders (atopy, food hypersensitivity, flea-bite hypersensitivity) took its place. The " eosinophilic granuloma complex " vacated the veil of idiopathy and became increasingly recognised as a manifestation of hypersensitivity disorders. " Idiopathic milliary dermatitis " became an endangered species, vanishing before the onslaught of numerous spec$c diseases. " Psychogenic alopecia " retreated to the realm of the rarely diagnosed when we realised that most cats were perfectly sane, they just itched ! In this new millennium, the possibilities are enormous, with more folks interested in, working in, and contributing to the field of feline dermatology than ever before. The knowledge and discoveries in this area can only continue to skyrocket. Continued specialisation in veterinary medicine... look at all the practices andpractitioners now exclusively devoted to cats... will demand increasing expertise and sophistication, be it in the clinic, in the research laboratory, or in the continuing education arena. In this practical guide to feline dermatology, a host of international experts and " stars " have been assembled. You will find, tucked in between the covers of this guide, the absolute most current and useful information in feline dermatology... all thoughtfully, lovingly, and analytically packaged for you. This guide has been expressly designed to be practical, concise, and user-friendly. Use it frequently and use it in good health (yours and that of your feline patients !). Feline dermatology is the best ! Danny W. Scott, DVM, Dip. ACVD Ithaca, New York March 1999 REFERENCES 1 Scott, D.W. J. Amer Anim. Hosp. Assn. 16,331-459 (1980). 2 Scott, D.W. J. Amer. Anim. Hosp. Assn. 23,255-274 (1987). 3 Scott, D.W. J. Amer Anim. Hosp. Assn. 26,515-537 (1990). 4 Norman, P.S. Currenr Opinion in Immunology 5,968-973 (1993).
A Practical Guide to Feline Dermatology 1 www.vet4arab.co.cc Blaise HUBERT PIN Didier Clinique VCtCrinaire Foch Cabinet de Dermatologie VCt6rinaire 38, avenue du MarCchal Foch HCliopolis B3 -Avenue de Magudas 34500 BCziers - France 33700 Bordeaux-MCrignac - France Chapter :24 Chapter :2 Ken MASON Pascal PRELAUD Albert Animal Hospital 2, me Gay Lussac 333 1 Pacific Highway 44300 Nantes - France Springwood 4127 -Australia Chapters :1 0 , 1 1 , 2 3 , 2 4 , 2 6 Chapter :12 Maite VERDE Catherine MEGE Servicio Dermatologia - Facultad de Veterinaria Clinique V6t6rinaire des Grands Cms C/Miguel Servet, 177 60, avenue du 14 juilllet Zaragosa - Espana 21300 Chenove - France Chapter :25 Chapter :17 Margreet VROOM Karen A. MORIELLO Veterinaire Specialisten Oisterwijk Department of Medical Sciences Boxtelsebaan 6 School of Veterinaxy Medicine 5061 VD - Oisterwijk - The Netherlands University of Wisconsin-Madison Chapter :9 2015 Linden Drive West Madison-Wisconsin - W 53706 - USA Ton WILLEMSE Chapter :4 Utrecht University Faculty of Veterinary Medicine Ralf S. MUELLER Department of Clinical Sciences Department of Clinical Sciences of Companion Animals Colorado State University VTH Yalelaan 8 Fort Collins - CO 80523 - USA 3584 CM - Utrecht - The Netherlands Chapter :6 Chapter :13 Chiara NOLI Via Sismondi 62, 20133 - Milano - Italy Chapter :1 Translator Mark CRAIG Re-Fur-All Referrals 3 1 Porchester Rd Newbury, Berks RG14 7QH England
- www.vet4arab.co.cc SUMMARY OP CONTENTS IStructure and functions of skin and coat 1 Chiara Noli The skin and cutaneous adnexae make up the most important anatomical and physiological barrier between the external environment and the internal organism. Knowledge of the anatomy and histology of the various cutaneous structures, some of which are specific to cats, allows better understanding of all the functions of the skin in the cat (e.g. mechanical protection against water and light, thermoregulation, biochemical homoeostasis, metabolic regulation, immunoregulation, sensory perception and social functions). Genetic determination of coat type and colour, and specific aspects of felime skin and its ecosystem are discussed in detail. 12 Diagnostic approach Didier Noel Carlotfi - Didier Pin The diagnostic approach in feline dermatology must be methodical and include the various steps of a conventional medical consultation as well as additional ones relevant to felime dermatology. Information gleaned from the history and clinical examination, both general and dermatological, allow the practitioner to construct a differential diagnosis. Appropriate diagnostic tests are then chosen to narrow down this list and produce a definitive diagnosis. 01 3 Ectoparasitic skin diseases Eric Guaguere Skin diseases caused by mites and insects are of prime importance in feline dermatology and enter into the differential diagnosis of many diierent conditions. Although some are often suspected, others are less so because the signs associated with them are non-specific. Some ectoparasitic conditions may be the source of human infestations, unrecognised by either the vet or the dermatologist. This chapter deals with notoedric mange, sarcoptic mange, otodectic mange, cheyletiellosis, trombiculiasis, dernodicosis, pediculosis and flea infestation. Methods of flea control, both mechanical and chemical, are described. 14 Dermatophytosis Karen A. Moriello - Douglas J. DeBoer Dermatophytosis is a superficial fungal infection of the skin. Microsporum canis, the most common cause of feline dermatophytosis, is not p m of the normal fungal flora of cats and its isolation warrants special attention. As dermatophytosis is an important zoonosis, it is very important for veterinary surgeons to be familiar with the condition. Dermatophytosis is transmitted by direct contact involving an infected cat or indirectly via a contaminated environment. Clinical signs are very pleomorphic and dermatophytosis should be considered in the differential diagnosis of all feline skin conditions. Fungal culture is still considered the gold standard for diagnosing felinedermatophytosis as it allows genus and species identification of the causal organism. Although the disease will resolve spontaneously, treatment is required to speed up resolution, limit the risk of spread to other animals and man, and prevent contamination of the - -. environment. Svstemic antifungal treatment is the treatment of choice. Cliooing oromotes faster .& healmg and is recommended for long-haired cats and cats with severe infections. Topical therapy limits transmission and the spread of spores in the environment. It needs to be continued until fungal cultures are negative on two or three successive occasions in all animals examined. A contaminated environment is often an important reservoir of spores. Environmental decontamination requires repeated cleaning to eliminate organic debris and frequent application of an antifungal disimfectant. Vaccination is not currently an effective means of preventing dermatophytosis.
www.vet4arab.co.cc 5 ~ e mycoses e ~ Lluis Ferrer - Alessandra Fondati Deep mycoses are rare in the cat and may affect only the skin (subcutaneous mycoses) or internal organs and the skin (systemic mycoses). They are caused by saprophytic fungi that normally live in the soil, vegetation and decomposing organic matter. Most are considered opportunistic pathogens. Dermatological signs are characterised by nodules, fistulae and ulcers on the ventrum, distal limbs and/or the face. In systemic mycoses, various systemic signs (respiratory, neurological, ocular, bony) are observed. Diagnosis is based on cytology or histopathology to demonstrate fungi in affected tissues. Fungal culture is necessary to identify the causal organism. Immunological techniques can sometimes be used in the diagnosis of systemic mycoses. Treatment of deep mycoses is difficult and definitive cure is rarely possible.1 6 R. Mueller dermatoses Bacterial Bacterial dermatoses, also called pyodermas, are rare in the cat despite being so common in the dog. The main reasons for this are perhaps the small number of bacteria on the skin and coat of the cat and also the importance of grooming in this species. Bacterial skin infections are usually secondary to trauma, bites or scratches and resolve easiiy with suitable antimicrobial treatment. However, some specific bacterial infections, possibly secondary to a systemic illness (e.g. retrovirus infection), can be difficult both to diagnose and to treat. Viral dermatoses1 7 E. Guaguere Vial dermatoses are a developing field in felime dermatology. They are underdiagnosed because of difficulties in identifying the causal virus, but new investigative procedures (e.g. electron microscopy, immunohistochemistry and molecular biology) now enable these new dermatoses to - be characterised. An understanding of them is imoortant as thev enter into the differential diagnosis of many different conditions. Some of these conditions also represent a major zoonotic risk for man. Poxvirus infection, feline infectious peritonitis, papillomavirus infection, retrovirus infections and herpesvirus infection are considered in this chapter. 8 The cat flea: applied biology M . Dryden The cat flea Ctenocephalides felis felis is the cause of recurrent infestations in cats, dogs and their environment. Flea control can be difficult without a good understanding of how the flea interacts with its hosts and environment. This chapter deals with the biology, ecology and epidemiology of the cat flea. Practical, effective methods of flea control are presented. 9 Flea allergy dermatitis Margreet W. Vroom Flea allergy dermatitis (FAD) is the most common pruritic dermatosis in the cat. A diagnosis of FAD cannot be e l i i a t e d by the absence of fleas or flea faeces because allergic cats can remove fleas from their coat by grooming. FAD should be suspected when self-induced, principally dorsolumbar, alopecia, miliary dermatitis or, more rarely, eosiiophiiic plaques or limear granulomas are present. Allergy testing has little diagnostic value. Treatment initially involves rigorous flea control for the affected cat, in-contact animals and the environment. When antipruritic treatment is necessary, the use of corticosteroids produces immediate improvement. Immunotherapy is, currently, of no benefit.
www.vet4arab.co.cc 10 Atopic dermatitis Pascal Prdlaud - Sophie Gilbert Atopy is the cause of many pruritic dermatoses (e.g. miliary dermatitis, eosinophilic plaques, self- induced alopecia and cemicofacial pruritus). Lesions can sometimes even resemble those seen in human and canine atopic dermatitis. Diagnosis of atopy is complicated by the unreliability of intradermal testing, poor specificity of serological tests, many normal cats having comparable serum allergen-specific IgE levels, and relatively non-specific clinical signs. Treatment is usually based on avoidance of the allergens involved (e.g. using elimination diets and flea control), anti- inflammatory medication, either steroidal or non-steroidal, and as a last resort specific immunotherapy, although the efficacy of this is difficult to assess.I l Food intolerance l E. Guagu2re Food intolerance should be considered a possible cause of non-seasonal pmritus in the cat, especially for self-induced lesions of the face and neck, and when lesions are accompanied by gastrointestinalproblems. Diagnosis is based on response to an elimination diet fed over at least 10 weeks. The diet must contain novel sources of protein and should only be formulated after looking very carefully at the cats previous diet. Either a commercial or home-prepared diet may be given, depending on what suits the animal and its owners. Challenging the cat with its previous diet is the only way to conf~rm diagnosis and to select foods for inclusion in the maintenance the diet. 12 Eosinophilic granuloma complex K . Mason - G . Burton The eosinophilic granuloma complex is a group of diverse clinical entities. Typical forms (indolent ulcer, eosinophilic plaque and eosinophilic granuloma) and atypical forms (mosquito bite hypersensitivityand familial forms) are described. These entities are, in fact, reaction patterns with many diierent causes. A thorough diagnostic approach is, therefore, required to investigate allergic and infectious causes. For refractory or prolonged cases, an inverse allergy work-up can be implemented. This consists of eliminating all the possible causes, associated with symptomatic treatment, then challenging the cat with one thing at a time, once lesions are under control. Therapy should, primarily, be based on treating the cause. Symptomatic therapy is often required and involves mainly corticosteroids, antibiotics and cyclosporin.1 1 3 Auto-immune dermatoses Auto-immune dermatoses are rare. They are characterised immunologically by the deposition of auto-antibodies at various levels of the epidermis (pemphigus) and basement membrane (bullous pemphigoid), or immune complexes within the basement membrane (lupus erythematosus). Knowledge of these diseases is important as they enter into the differential diagnosis of many diierent conditions. The pemphigus complex consists of several forms: pemphigus vulgaris (PV), pemphigus foliaceus (PF) and pemphigus erythematosus (PE). Bullous pemphigoid (BP) has just recently been identified in the cat. Discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE) are encountered only exceptionally. Diagnosis is based on the history, clinical examination, and histopathology. For SLE, other procedures such as haematology and antinuclear antibody tesimg, must be canied out. The prognosis for auto-immune disorders is variable; relatively good for PF, PE and DLE, guarded for PV, BP and SLE. Treatment involves mainly oral corticosteroids at immunosuppressive doses and possibly certain alkylating agents (chlorambucyl) and gold salts (aurothioglucose).
www.vet4arab.co.cc 14 ~ermatolo~ical manifestations of systemic diseases D. Hkripizt Dermatological manifestations of systemic diseases are starting to be documented in the cat, although their pathogenesis is not always understood. They are very diverse, clinically, and relate to various systemic illnesses. Their diagnosis is important as these skin lesions enter into the differential diagnosis of many different conditions and may appear before the underlying illness. Unlike in the dog, endocrinopathies very rarely cause skin lesions in the cat. Spontaneous and iatrogenic Cushings syndrome are very rare, spontaneous hypothyroidism is exceptionally rare, hyperthyroidism produces a few non-specific changes in the skin, and dermatological signs associated with sex hormone imbalances are now hotly disputed. However, the cat has a whole range of systemic disease-associated dermatological lesions, of its own. 15 Skin tumours Delisle - Pahick Devauchelle Fran~oise Tumours of the skin and its adnexae are some of the most diverse and common tumours seen in the cat. Such a large variety is possible because the skin is made up of lots of different components, each of which can potentially form a tumour. We, therefore, see epithelial tumours which involve the malpighian layer, the adnexal sebaceous or sweat glands and hair follicles, tumours of the melanogenesis system, mesenchymal tumours developing in the dermis or subcutaneous connective tissue, tumours derived from lymphoid tissue and finally, nerve and vascular tumours. The majority of skin tumours in the cat are primary. Tumours secondary to, for example, a pulmonary adenocarcinoma (which is usually asymptomatic) or a mammary adenocarcinoma are much less frequent.1 1 6 Genodermatoses Eric Guagusre - Zeineb Alhaidari -Jacques Fontaine Genodermatoses are rare, although they constitute a developing field in feline dermatology. In - . recent vears. investieative orocedures such as electron microscopv and immunohistochemis@y have lei to the identification of new genodermatoses. It is imp;&t to be familiar with these conditions as they enter into the differential diagnosis of many different dermatoses. Genodermatoses affect the epidermis and its adnexae, the melanogenesis system, the dermo- epidermal junction and the dermis. In this chapter, the following conditions are reviewed: hereditary greasy seborrhoea of the Persian, congenital hypotrichosis, follicular dysplasia, hair dysplasia, pili torti, genetic abnormalities of melanin pigmentation, hereditary cutaneous asthenia, and urticaria pigmentosa of the Sphinx. 17 Skin conditions associated with behavioural disorders Catherine Mege Sldn conditions associated with behavioural disorders are probably rare hut remain under- diagnosed in the cat. They are characterised by self-induced lesions (e.g. alopecia, nail chewing and various mutilations). Advances in the study of animal behaviour have enabled these conditions to be placed in the context of behavioural disorders (e.g. anxiety, depression and dysthymia). Thanks to a better understanding of the behaviour of the domestic cat and the availability of new psychotropic drugs, pheromones and behavioural therapies, specific diagnosis and effective treatment are now possible.
www.vet4arab.co.cc1 1 8 ~ i a ~ n o s tapproach to pruritic dermatoses ic 2.Alhaidari The diagnostic approach to felme pruritic dermatoses must be methodical and should include certain fundamental diagnostic steps: a detailed history, thorough clinical examination, and carefully chosen diagnostic tests, selected according to the differential diagnosis. An initial range of tests (e.g. skin scrapings, tape strips, mycological investigations and skin smears) should be performed routmely, given the incidence of ectoparasitic infestation and dermatophytosis in the cat. Differential allergy diagnosis is based on avoidance measures (e.g. flea control and restricted diet) as allergy tesimg remains unreliable in this species. Skin biopsies are indicated when the history and clinical examination suggest a dermatosis that requires histological diagnosis.1 1 9 Diagnostic approach to alopecia 2.Alhaidari The diagnostic approach to alopecia must be methodical, and should involve certain fundamental steps: a detailed history, thorough clinical examination, and carefully chosen diagnostic tests, selected according to the differential diagnosis. An initial range of tests (e.g. skin scrapings, tape strips, and mycological investigations) should he performed routinely, given the incidence of ectoparasitic infestation and dermatophytosis in the cat. Differential allergy diagnosis is based on avoidance measures (e.g. flea control and restricted diet) as allergy testing remains unreliable in this species. Skin biopsies are indicated when the history and clinical examination suggest a dermatosis that requires histological diagnosis.1 2 0 Diagnostic approach to crusting dermatoses E. Bensignor Crusting dermatoses are a common reason for consultation in feline dermatology. Crusts can be defined as a mixture of blood. serum. exudate. andlor us which has dried on the surface of the skin and to which scale and hairs have become stuck. t o make a specific diagnosis and institute effective treatment requires a good knowledge of the clinical aspects and causes of crusting dermatoses. The diagnostic approach rests on the history, clinical examination and appropriate diagnostic tests. It is important to distinguish 1) crusts secondary to excoriation, for which the diagnostic approach is the same as that of the pruritic dermatoses, 2) large, spontaneously- appearing crusts associated with erosions and their dried-up exudate, and 3) punctate crusts seen in miliary dermatitis, a cutaneous reaction pattern usually associated with ectoparasitic infestation or flea allergy dermatitis, and occasionally with dermatophytosis, bacterial folliculitis or atopic dermatitis. 21 Diagnostic approach to erosive and ulcerative dermatoses E. Bensignor In the cat, erosive and ulcerative dermatoses are a common reason for consultation, probably because of the thinness of the epidermis. Erosions and ulcers K&ed to self-excoriation should be distinguished from those which appear spontaneously. They are usually secondary lesions with little diagnostic significance. The diagnostic approach should involve taking the history, conducting a thorough clinical examination (general and dermatological), and performing appropriate diagnostic tests, especially cytology and skin biopsies.
www.vet4arab.co.cc1 2 2 ~ia~nostic approach to otitis externa E. Bensignor Long thought of as a local phenomenon, otitis externa should be reclassified in a broader dermatological context, as it is usually one local manifestation of an underlying dermatosis. The diagnostic approach should be rigorous, including a history, thorough clinical examination (general and dermatological), and simple, appropriate diagnostic tests, especially auroscopic examination, direct microscopical examination of cerumen, cytology and bacteriology. Occasionally, radiography, CT scanning of the tympanic bullae, paracentesis and biopsies are indicated.1 2 3 Diagnostic approach to facial dermatoses Pascal Prilaud - Eric Guag3re Facial dermatoses are a very important and diverse group of diseases. In some cases, the face is affected directly whereas in others, facial involvement is a consequence of systemic disease. One reason why the face is frequently involved is that it is a very exposed part of the body, not easy to groom, and with sparse hair cover offering scant protection. Mucocutaneous junctions (e.g. lips, nose and eyelids) are predisposed to infectious, parasitic and immune-mediated dermatoses. W e is such a plethora of potential causes of facial dermatoses that a very rigorous and methodical diagnostic approach is essential. The history and clinical examination (general and dermatological) are used to formulate a differential diagnosis, which can be narrowed down by performing weU-chosen diagnostic tests. The main facial dermatoses (excluding those of the external ear) are dermatophytosis, allergic dermatoses, superficial pemphigus conditions and squamous cell carcinoma. Diagnostic approach to feline pododermatoses124 Eric GlcaguPre - Pascal Prdlaud - Blaise Hubert Pododepnatoses are a very important and diverse group of diseases. In some cases, feet are affected directly whereas in others, pedal involvement is a consequence of systemic disease. Although pododermatoses are a less frequent reason for consultation than in the dog, the foot can be targeted directly in various specific conditions: bacterial paronychia, plasma cell pododermatitis and cutaneous metastasis of a pulmonary adenocarcinoma. Pedal involvement may also be part of a more generalised dermatological condition. There is such a plethora of potential causes of pododermatoses that a very rigorous and methodical diagnostic approach is essential. The history and clinical examination (general and dermatological) are used to formulate a differential diagnosis, which can be narrowed down by performing weU-chosen diagnostic tests. Used alongside routine diagnostic tests (e.g. Woods lamp examination, direct examination of hairs and scale, skin scrapings, fungal culture and cytology), the skin biopsy is often the key to diagnosis.1 2 5 Zoonotic dermatoses Maire Verde The term zoonotic dermatoses refers to those zoonoses in which the causal agent causes sldn lesions. The most important feline zoonotic dermatoses are dermatophytosis, flea infestations - involving possible transmission of cat scratch disease and the plague - cheyletiellosis and notoedric mange. Other zoonotic dermatoses are less common: sporotrichosis, blastomycosis, histoplasmosis, otodectic mange, tuberculosis and poxvirus infection. A detailed knowledge of these diseases in man is essential for clinicians involved in feline dermatology.
www.vet4arab.co.cc1 2 6 Therapeutic tables Pascal Prdlaud - Eric Guaguere This chapter lists the principal medications used in feline dermatology. Dose, route of administration, indications and whether a product licence exists are outlined for each drug.1 2 7 General index1 2 8 Index of illustrations
www.vet4arab.co.cc-l Foreword The cat has long been neglected, even ignored, by veterinary medicine,for reasons that are partly cultural andpartly economic. It was only with the development of companion anlmal medicine, in the 1960s, that the cat was seen as an animal species worthy of veterlnary interest. Back in 1964, E.J. Catcotts Felme Medicine and Surgery, thefirst veterinary text book devoted exclusively to the cat, was already predicting the huge increase in impiXZce of the cat as a companion animal. Yet,for a long time, the cat was treated merely as ifit were a small dog. Furthermore, thefact that cats tolerate high doses of corticosteroids so well meant that there was little incentive to research and develop alternative therapies in this species. The 1980s saw the birth of a more spec@ feline medicine, triggeredprobably by the discovery of the retroviruses and diseases that were unique to the cat. Pharmaceutical companies began to show a growing interest in researching new treatments for cats. At the same time, academic bodies like the American Association of Feline Practitioners and the European Society of Feline Medicine and journals - such as Feline Practice, and more recently Journal of Feline Medicine and Surgery - dedicated entirely to the cat, appeared on the scene. Today,feline dermatology is a thriving discipline in its own right, no longer confined to a few paragraphs at the end of a chapter in a small animal dermatology book or severalpages in afeline general medicine text. To our knowledge, the first atlas dedicated entirely to feline dermatology was G.H. Mullers Feline Skin Lesions, in 1974, which contained 35pages on the principal dermatoses. Then came the celebrated monographs by D.W. Scott which appeared in 1980, 1987 and 1990 in the Journal of American Animal Hospital Association. These were to provide the real foundation of modern feline dermatology. In 1981, J.M. Keep, in Australia, produced a series of three dermatology books, each on a different species, one of which was the cat. Finally, in 1995, Veterinary Clinics of North America (Small Animal Practice) asked Gail Kunkle to produce a special Feline Dermatology issue, still seen today as a milestone. We have deliberately excludedfrom our list all the dermatology text books which include chapters on feline dermatology. Our aim, here, has been to provide a guide which is both instructive and easy to read, but without any claim to being an encyclopaedia. We have tried toproduce a book that will allow each vet to develop his or her own expertise infehne dermatology. Such an ambitious project could come to fruitlon only within the framework of internatlonal collaboration between expertsfrom various backgrounds. Veterinary dermatology belng a large family that embraces enthusiasts everywhere, irrespective of nationality or university status, it was easy for us, as scient$c editors, to assemble a team of authorsfrom all corners of the globe. We have been overwhelmed by the enthusiasm shown by the twenty-six authors recruitedfrom eight different countries. We would like to thank them for the excellence of their contributions, as well as for their kindness, encouragement andfriendship. A Practical Guide to Feline Dermatology is divided into two main sections. The first is a detailed study of the main topics in feline dermatology, presenting the most up-to-date information alongside high quality colour plates. The second section, which outlines diagnostic approaches to all the pr~ncipaldermatoses, isreadily accessible to the vet in practice, struggling to make the correct diagnosis.
www.vet4arab.co.cc We would like to extend our very sincere thanks to one of our mentors, Professor D.W. Scott for doing us the honour of writing the preface. He can be assured of our deepest respect and admiration for his outstanding contribution tofeline dermatology, which he refers to as his own professional hobby.Lastly, A Practical Guide to Feline Dermatology would not have been possible without the interest and enthusiasm ofMerial, under the direction of Doctors Daniel Gouffd and Ronan Gillard who have had the foresight to see that, in the21st century, the cat will be the animal species with the greatestpotential for medical development. We hope that thisbook will instill in you, as it has in us, a new passion for feline dermatology and dispel forever the notion that it isabout nothing more than reaching for the bottle of long-acting corticosteroid!2 September, 1999Restaurant le Pamphlet, Paris.Eric GuaguPre Pascal PrdlaudDocteur Vdtdrinaire Docteur VdtdrinaireCertGed in Veterinary Dermatology Cert$ed in Veterinary DermatologyDiplomate of the European Diplomate of the EuropeanCollege of Veterinary Dermatology College of Veterinary Dermatology
www.vet4arab.co.cc 1 Structure and functions of skin and coat The skin and its adnexae make up the most important organ of the body and form an essential anatomical and physiological harrier between the external environment and the internal organism. Knowledge of the anatomy and histology of the various cutaneous structures, some of which are specitic to cats, allows better understanding of all the functions of the skin in the cat. The skin also acts as a mirror which reflects the health and comct functioning of the organism.Structure of the skin and its adnexae The skin of cats is thinner than that of dogs, 0.4 to 2 mm thick on average. It is thicker on the dorsal regions and proximal limbs, and thinner on the ventrum and distal limbs . Epidermis The epidermis is a squamous keratinised epithelium made up of 3 to 5 cellular layers (excluding the horny layer), 25 pm thick (Diagram 1 : 1) (Fig. 1 : 1). In the non-hairy areas (nasal planurn, footpads), it is thicker (up to 900 p) lined by a more developed horny layer (Fig. 1 : 2). The thickness of the horny and layer is between 3 and 20 p in the hairy areas and between 15 and 35 pm on the footpads . The epidermis does not contain any blood vessels, its nutrients being provided by diffusion fmm the dermal hlocd supply. Keratinocytes make up the majority (85-90%) of the epidermal cells. Other epidermal cells, such as Langerhans cells (3-8%), melanocytes (2-5%) and Merkel cells, appear as clear cells under the light microscope. Lymphocytes and occasionally mast cells can also be found (Fig. 1 : 3). Keratinocytes undergo keratinisation or comification, a differentiation and maturation process which progressively transforms the small, round, basal layer cells into large, flat, anuclear, polyhedral corneocytes (Diagram 1 : 1). The corneocytes are shed by desquamation. The replacement rate of keratinocytes has not yet been determined in cats. In dogs (Beagles), it takes 22 days for a basal cell to reach the horny layer . Diagram 1 : 1 : Schematic diagmm of the epidermis Horny layer Granular layel Spinous (Malpighian) layer Basal layer Basement membrane
www.vet4arab.co.cc Melanocytes are dendritic cells which synthesise melanin pigments in specific structures called melanosomes, situated in the epidermal basal layer or in the hair follicle matrix. They generally appear as clear cells, without specific colouration, under the light microscope. In black or grey cats, these melanocytes are easily recognisahle due to their intracytoplasmic black p u l e s . The melanocytes, via their dendrites, are in contact with several keratinocytes to which they transfer their pigment granules. There are up to 25 keratinocytes per melanocyte in the epidermis. Langerhans cells are antigen-presenting cells which phagocytose antigens at the skin surface, and migrate into the drainmg lymph node where they present the captured antigen to T lymphocytes. They are responsible for triggering specific immune reactions. Langerhans cells contain specific intracytoplasmic organelles, shaped like rackets, called Birbeck p u l e s 4. Their immunophenotypes are CDlat, M H C P and C D ~ +In cats, the density of Langerhans cells in the skin is higher on the p m a e and middle of the . back, and lower on the abdomen I. Merkel cells are mechanoreceptor cells situated in the basal layer, in contact with nerve fibres.Basement membrane The keratinocytes of the basal layer sit on the basement membrane which separates the epidermis from the dermis. They are attached to it by hemidesmosomes and other adhesion molecules. The basement membrane acts as mechanical supporl for the epidermis and regulates metabolic transfer between the dermis and epidermis. It is around 40 nm thick. It can be seen under the light microscope usimg special stains such as Periodic Acid-Schiff (PAS). Ultrastructural studies have enabled three zones to be disimguished: the lamina lucida, in contact with cells of the basal layer, the lamina densa and the sublamina densa which permits adhesion to dermal collagen.Dermis The dermis is a rich network of fibres, intercellular ground substance, blood and lymphatic vessels, nerves, muscles and cells. Collagenfibres produced by fibroblasts are made up of 90% collagen, a filamentous protein with great tensile strength. Elastinfibres make up around 4% of dermal fibres and form a network in the dermis beneath the pilo- sebaceous units. Reticulinfibres are very h e fibres which form a loose network around collagen fibres and other dermal structures. Dermal ground substance is made up of proteoglycans, glycoproteins and large quantities of water. It appears as an amorphous gel, produced by fibroblasts, and has an important barrier function with regard to micro-organisms and large molecules passing between the epidermis and subcutaneous tissue. Three interconnected vascularplenare found in the dermis. The uppermost sub-epidermal plexus brings nutrients to the epidermis and hair follicle infundibula. The middle plexus, situated at the level of the sebaceous glands, provides a blood supply to the glands, muscles and follicular isthmus. The deep plexus below the hair follicles, supplies the dermal papilla, apocrine glands and the two other plexi. Arteriovenous shunts, situated mainly in the distal limbs, are associated with thermoregulation. Lymph vessels in the deep dermis enable drainage of cutaneous fluids and maintain homeostasis. Nervefibres follow the blood capillaries and are organised in three plexi. Free nerve endings reach the epidermis or form more complex structures such as Pacinian corpuscles.. Dermal cells are numerous. Fibroblasts responsible for collagen synthesis and production of dermal ground substance also produce enzymes, notably a collagenase and a gelatinase, capable of catabolising ground substance and fibres. The fibroblasts are therefore responsible for maintaining the dynamic homeostasis of the dermis. They also play an important role in inflammation and healing. The numerous mast cells in cat skin are situated mainly in the perivascular region and synthesise a range of enzymes (chymase, tryptase) (Fig. 1 : 3). Other cells found in the dermis include macrophages, lymphocytes, neutrophils, eosinophils and plasma cells.
www.vet4arab.co.cc 1 : Strucw and functions of sldn and coatFigure I :I : Normal cot epidermis: note thinness of the epidermis Figure 1 :2: Normalfoofpadepidermis: note thickness of the horny layer(HE,x 402) (HE,x l wFigure I :3 :Intraepidermal mast cells, (+) (Tolu~dlne x 100) blue, Figure 1 :4 : I n ~ u l w of a normal hairfoNicle (HE,x 460) nPigave 1 :5 :Hairfoll~clebulb in nnagenphose(HE,x400) Fkure I : 6 : Tr~ctwgmmof central pnmmy, lateral primnry and secondary h r s (x 100)
www.vet4arab.co.ccSubcutaneous connective tissue Subcutaneous tissue is composed of a layer of connective tissue, rich in adipose cells. It has many roles, the most important of which are storage of lipids and fat-soluble substances, thermal insulation and protection from physical trauma.Hair follicles Hair follicles are epidermal invagimations into the dermis, which synthesise and provide support for the hair. Hair follicles are divided into three regions (Diagram 1 :2): the infundibulum (Fig. 1 :4), the isthmus and the bulb (Fig. 1 : 5). In the adult cat, each follicle has its own bulb and isthmus but several follicles share the same infundibulum. These are called compound hair follicles. Ten to twenty hairs are present per infundibulum. The density of the coat is around 250 hairs/cmi. The coat is denser on the abdomen than on the back. Newly-born kittens up to the age of 3-4 months have simple hair follicles. Types of hair Hair follicles generally contain one central primary hair, up to five lateral primary hairs and up to twenty secondaq hairs. The clusters of follicles on the back have larger primary hairs and fewer secondaq hairs than those on the abdomen. Central primary hairs (40 to 80 p in diameter) have a large medulla and thin cortex (Fig. 1 : 6). They are rigid, cover the whole skin surface, provide protection against the rain and are responsible for coat colour. The primary hair follicles are the largest and longest in the follicular cluster, extending into the deep dermis. They are associated with sebaceous glands, apocrine sweat glands and an m c t o r pili muscle. Lateralprimary hairs (25 to 40 pm in diameter) are moderately supple . They have a different orientation to the undercoat, therefore providing better thermal insulation. They are characterised by a sub-apical bulge at the base of the hair. Secondary hairs (10 to 20 pm in diameter) are fine and supple with a relatively thin medulla and a thick cortex (Fig, 1 : 6). They form the undercoat responsible for maintaining temperature. Secondary follicles can sometimes have a single sebaceous gland, but never apocrine sweat glands nor m c t o r muscles. Hair shrcture The hair consists of a colunm of comified, vety adherent, stratified cells, arranged in a cuticle, a cortex and a medulla (Diagram 1 : 2). The cuticle is made up of a single layer of cuboidal epithelial cells which dierentiate into anuclear, flat and adherent comeocytes. These comeocytes line and protect the hair, like tiles on a roof, and are orientated towards the isthmus. The cuticle cells are oriented in the opposite direction to those of the inner follicular root sheath and are therefore overlapping. This protects the hair follicle and ensures support for the hair during its growth phase in the deep p a s of the hair follicle. In cats, the cuticle cells are thin and arranged in a very smooth flattened manner, which is why cat hair feels softer to the touch than dog hair. The cortex consists of elongated comified cells arranged parallel to the axis of the hair. In primary hairs, the cortex makes up a sixth of the diameter of the hair 3. Secondaq hairs have a relatively thicker cortex than the primary hairs which have a much larger medulla. The medulla is the internal part of the hair. It is produced by the hair matrix and generally contains air, glycogen vacuoles or pigments. The medullary cells of cats are flatter than those of dogs and arranged at a 90" angle to the axis of the hair 9. Structure of the hair follicle The base of the hair follicle is made up of a bulb matrix, a dermal papilla and a hair bulb. Above the bulb are the inner and outer epithelial root sheaths which are surrounded and supported by a layer of dense connective tissue (Diagram 1 : 2). The bulb matrix is formed from small, round, basophilic epithelial cells which divide actively at the centre to create the hair, and at the outside to create the inner root sheath. Melanocytes ate responsible for pigmentation by transfer of melanosomes to the cells of the hairs cortex and medulla. The bulb matrix is nourished by the dermal papilla, made up of connective tissue rich in blood vessels and nemes within a mucopolysaccharide matrix.
www.vet4arab.co.cc 1:Smcture and functlons of skin a d coat nF w e I :7 : fdllirle In anugen p b e (HE,&Oil] Xar Pigm 1 : : 8 Holrfollicie inmagenirelogenphme (HE,x 400)F i g m I :9 : Sebaewur $ I d s ( H E , 4WJ corpuscle (PAS, x IW)Fipre 1 :11 :Pac~nran Figure I :12 :Whrsker note the blood slnur a m m i the h l r (HE,x 100)
www.vet4arab.co.cc Diagram 1:2 : Schematic diagram of a hair follicle Hair Cuticle MedullaIsthmus Inner root sheath Outer root sheath Apocrine sweat gland Dermal papilla At the base of the follicle above the bulb matrix, the hair is surrounded by two concentric sheaths. The outer root sheath represents an invagimation of the superficial epidermis into the dermis. In the deeper part of the isthmus and in the bulbal zone, the outer root sheath is not cornifid. In the isthmus and upper bulbal zone, the cells of the outer root sheath appear larger and clearer due to high levels of glycogen. In the deeper parts of the bulb, they appear small and basophilic, like the mahix cells. The inner root sheath swounds and supports the hair, from the matrix where it is produced, up to the isthmus where it is destroyed. Follicular cycle Hair growth consists of diierent phases: a growth (anagen) phase (Fig. 1 : 7), an intermediate (catagen) phase (Fig. 1.8) and a resting (telogen) phase. Duration of the anagen phase depends on breed and region of skin. Long-haired cats have a longer anagen phase than short-haired cats. Dorsal hair has a longer anagen phase than nasal hair. Hairs grow from 0.04 to 1 mm each day and long hairs grow faster than short hairs. The genetics of different coat types Hair length is influenced by various genes, a dominant, L "short hair" gene (average 4.5 cm) and a recessive, I "long hair" gene (up to 13 cm). Other lengths (very long as in the Persian, mid-length as in the Norwegian or the Maine Coon) are produced by polygenes or modifier genes. Genes of the series "I", "h" and " W engender important modifications to the texture and structure of hairs. The "I" series is seen in "Rex" cats which do not have central primary hairs, and whose lateral primary and secondary hairs and whiskers are abnormal. There are different types of Rex cats (Cornish, Devon, Oregon, Dutch and Sekirk) depending on recessive or dominant mutations of this gene. The "h" series is expressed in the Sphinx, (no relation to the Rex), which has no primary hairs. However, secondary hairs are present on the extremities (nose, pinnae, limbs, tail). The dominant "Wh" gene is responsible for the development of very curly hair. In this case, the three types of hair are entwined.
www.vet4arab.co.cc 1 : Structure and functions of skin and coat Genetics of hairpigmentation The colour of the skin and coat depends on the quantity, type and location of melanin pigments in the skin. There are two types of melanin, eumelanin @lack/brown)and phaeomelanin (red/yellow). The large number of colours seen in the various breeds of cats depends on the prevalence, combination and distribution of these two types of melanin in the skin. White colouration occurs through an absence of pigmentation resulting from lack of melanisation of melanocytes. This is called albinism when complete ( i s is very light blue or red). The most important gene involved in feline hair pigmentation is the dominantA "agouti" gene responsible for the o r i g i , wild, banded pigmentation of primary hairs. Cats carrying this gene have dark-tipped hairs with one or more bands of colour. Those which express the recessive a, "non-agouti" gene, have uniformly pigmented hair. Wid cats also carry the T "tabby" gene, responsible for dark markings on a lighter, generally yellow or grey, base. There are different variants of the "tabby" gene which produce variable distribution of stripes or spots on the body. Colours seen in domestic cats are divided into phaeomelanic colours (orange / gmger (red) and cream (diluted red)) and eumelanic colom (black, grey (generally called blue, diluted black), chocolate (chestnut), lilac (diluted brown), cinnamon (light chestnut) and fawn (diluted cinnamon). As the genes responsible for hair colour are situated on the X chromosome, cats with concurrent red and black/brown colours are generally females which can carry the two red and black/brown genes on each of the two X chromosomes. Colour dilution is caused by the recessive d gene. In colour-dilute breeds, l i e the C h W u x , hairs contain irregularly distributed melanosomes grouped in melanin clusters in the melanocytes and hair cortex. A foUicular dysplasia of colour-dilute cats has been described in the Cornish Rex. Silver coats are coded by the I "colour inhibitionn gene. Colour is lost in the proximal hair which grows out white. There are different types of silver coat, depending on the extent of hair depigmentation. The recessive variants of one pdcular gene, the C gene, are responsible for "colour point" coats, typical of the Siamese. Tnis gene codes for an enzyme whose activity is temperature-dependent. This causes excessive colouration in colder regions such as the extremities. The ca gene is responsible for blue eye albinism, the c gene for red eye albinism. White spots are due to the expression of a different gene, the S "white spotting" gene, whereas generalised white colouration of the coat is encoded by the dominant W gene. This latter gene is often associated with deafness because it causes degeneration df the cochlea and atrophy of the organ of Corti.3utaneous glands Sebaceous glands Sebaceous glands are simple alveolar holocrine glands, associated with hair follicles in groups of two or thee (Fig. 1 : 9). Their excretorv ducts open into the follicular isthmus. Sebum is the product of sebaceous gland cell destruction in the Addle of the gland. It combines with sweat, produied by the apocrine glands, to form a lipid emulsion (the surface hydrolipid film) which protects the skin surface. The sebaceous glands are large and numerous in the skin around the lips and on the chin, and play a role in territorial marking when the cat rubs its face against objects and human beings. The perianal glands and supracaudal organ are modified sebaceous glands which are larger than the other glands. As development is hornonally dependant, they may be particularly large in entire male cats. Excessive accumulation of glandular secretion in this region is known as stud tail. Sweat glands Apocrine sweat glands are present over the whole surface of hairy skin and their ducts open above the sebaceous gland ducts into the follicular isthmus. Apocrine glands are simple tubular glands with a straight duct and a convolutedsecretory part surrounded by myoepithelial cells (Fig. 1 : 10).Tney produce an aqueous secretion which forms an emulsion with sebum at the skin surface (the surface hydrolipid film). Eccrine sweat glands have the same structure as apocrine sweat glands but are only found in non-hairy areas of skin l i e footpads. Their ducts open directly at the skin surface. These sweat glands are situated close to blood vessels and are controlled by blood adrenaline and noradrenaline. Hence, frightened cats sweat excessively from their footpads.
1~; ~.4hctical ~~ ~ GuidetoFehe Dermatology I www.vet4arab.co.cc Modified sweat glands make up the mammary glands, ceruminal glands and the glands of the anal sacs There are no sweat glands on the nasal planum . Functions of the skin and coat The skin and coat have many important functions including protection from the external environment, thermoregulation and maintenance of biochemical homeostasis. They also have metabolic, sensory, immunological and social functions. Mechanical protection The coat is the first barrier to mechanical trauma. It is often thick because of an undercoat covering the whole skin surface. Dermal collagen fibres impart a high tensile strength and prevent skin tearing. Protection against water Thanks to this thick coat and the surface hydrolipid film,water does not readily reach the skin surface. The orientation of primary hairs ensures that water droplets are quickly shed. Constant grooming keeps primary hairs clean and ensures optimal protection from water. Certain breeds, such as the Norwegian Forest, exhibit a very hydrophobic coat. This characteristic is often tested by show judges who let several drops of water fall on the hairs to see if the drops slide off the coat without wetting the animal. I water f does reach the skin surface, it cannot pass through it because intercellular spaces in the horny layer contain lipids impermeable to water and water-soluble substances. Protection from light The coat is an excellent barrier to visible light and ultra-violet (UV) rays. In the areas where the coat is sparse or absent, pigments (mainly melanins), keratin, proteins and blood absorb the UV rays and prevent certain skin lesions. Nevertheless, in white or light-coated cats with little pigment, solar keratotic lesions and epidermal carcinomas can appear in sparsely-haired areas such as the pinnae, nose, eyelids and the a m behind the ears, following prolonged or frequent exposure to the sun. Thermoregnlation Temperature regulation is also an important function of the coat and skin. The thick coat and the layer of subcutaneous connective tissue, rich in adipose cells, protect the cat when the temperature is cold. An insulating air cushion exists between the hairs. The size of the air cushion can be increased or decreased by the action of arrector muscles. The undercoat is shed in the spring and re-grows in the autumn in breeds which experience large seasonal temperature variations. This is_particularlytrue in the k k i s h Van breed, origimating in central Anatolia, where the temperature variation between summer and winter can be as much as 50°C. The highly developed dermal vascular system plays an important role in thermoregulation. Vasodilatation produces heat loss and vasoconstriction causes closure of arteriovenous shunts, which prevents excessiveheat loss from the circulation. The cutaneous vascular system stores large quantities of blood and peripheral vasoddatation or vasoconstriction can also have an effect on central blood pressure. Cats have a particular way of reducing their body temperature as, unlike in humans, sweat glands are not involved in thermoregulation. Cats constantly wet their coats by licking. This produces a cooling effect as saliva evaporates from the skin surface. Biochemical homeostasis Many substances are stored in the dermis and subcutaneous comective tissue. Large quantities of water and electrolytes are associated with proteoglycans and other molecules in the ground substance, while lipids and fat-soluble molecules are stored in subcutaneous adipose tissue. Metabolic and immunological functions For a long One, the skin was considered to be an organ with only a passive protective role, not one that involved the individuals general metabolism or immunological defence mechanisms, with the exception of vitamin D synthesis. Various metabolic pathways prodicing systemic effects (for example, effect of androgens and oestrogens on smell) have recently been demonstrated in the skin. In addition, an
www.vet4arab.co.cc 1 : Structure and functions of skin and coat immunological system has been identified, capable of specitic reactions against micro-organisms, parasites or foreign antigens present on skin. Sensory functions Various different sensations such as pain, pruritus, heat, cold, pressure and touch are felt at the cutaneous level. Free nerve endimgs in the epidermis are responsible for sensations of pruritus, pain, heat and cold. Specialised structures, l i e Pacinian corpuscles (Fig. 1 : 1l), tylohich pads, whiskers " (Fig. 1 : 12), hair follicles, type C mechanoreceptors and Merkel cells all have mechanoreceptor functions 12. Social functions The colour of wild cats l i e the Lynx, enables the animal to hide easily in woods and forests (mimicry). Domesticated breeds have lost this characteristic, perhaps with the exception of black cats used in the Middle Ages, to chase mice and rats from the holds of ships. Specialised glands, like the hepatoid circumanal glands, the anal sacs, the supracaudal organ and the sebaceous glands of the lips and chin, produce pheromones. Pheromones are used in territorial marking, facilitate recognition between individuals and influence sexual attraction. Various fractions (F3, F4) have been isolated recently. Cats in dangerous situations raise the hairs on their back and tail and present themselves sideways-on to their adversary in order to appear larger.Cutaneous microbi9logy and barrier functions -- Horny layer The compact horny layer represents the f hmolecules and micro-organismsand parasitic infestations. In normal conditions, water, water-soluble t physical banier to infections cannot cross it. Constant shedding of the most supeficial cells reduces excessive bacterial colonisation which could otherwise predispose to infection. Dermis I a micro-organism or parasite enters the dennis, it must pass through a very dense network of collagen f fibres and intercellular ground substance molecules, before fmdiig itself in contact with a very active immune system. Hydrolipid surface film The sebum and sweat form an emulsion on the skin surface which acts both as a physical banier, preventing the passage of water and water-soluble substances, and a chemical banier, made possible by the presence of certain substances involved in skin defence mechanisms. These include Ransferrin which l i i t s bacterial proliferation, and free fatty acids such as linoleic acid, produced from surface higlycerides by bacterial lipases, which prevent skin colonisation by pathogenic micro-organisms. Other lipids such as glycosphingolipids arising from the decomposition of the horny layer might play an even greater antibacterial role. Specific factors, such as complement and immunoglobulins, can attach themselves to the skin surface and prevent microbial adherence and proliferation. Skin pH in cats varies between 5.73 and 6.01, with the exception of the nose and footpads (areas of eccrine secretion) where it is less acidic, between 6.81 and 7.97". A low pH has bacteriostatic and bactericidal effects. Resident microbial flora The resident surface flora, which occupies micro-ecological niches, prevents colonisation by pathogenic micro-organisms by producing antibiotics, enzymes or other toxic substances. They utilise available nutrients. Resident bacteria on cat skin include Micrococcus spp., coagulase-negative staphylococci (especially Staphylococcus simulans), a-haemolytic streptococci and Acinetobacter spp. 12. It is possible to isolate more bacteria from cats in close contact with humans than froiii cats living in catteries, which suggests that humans may be involved in transmitting bacteria to cats ". Transient bacteria, isolated from cat skin, include R-haemolyhc streptococci, Escherischia coli, Proteus mirabilis, Pseudomonas spp., Alcaligenes spp., Bacillus spp., and staphylococci 12. These hacteria can occasionally become pathogenic if conditions are favourable for multiplication. Yeasts of the genus Malassezia are commensal micro-organisms found on the skin of cats, especially in
www.vet4arab.co.cc humid regions such as ears, penanal and inguinal regions Id. Malassezia pachydermatis, Malassezia sympodialis and Malassezia globosa have been isolated from cat skin 14. Vanous saprophytic fungi can be isolated from the skin and coat of normal cats. These include Alternaria spp., Aspergillus spp., Cladosporium spp., Mucor spp., Penicillium spp. and Rhodotorula spp. ",. Microsporum canis isolated from normal cats must always be considered a pathogen 16. REFERENCES 1. Strickland, J. H. & Lois Calhoun, M. Amer J Vet. Res. 24, 1018-1029 (1963). 2. Scott, D. W Vet.Dermatol. 1,6569 (1990). 3. Baker, B. B. Amer. J. Vet. Res. 3,93 (1973). 4. TsagaraIds, C., Marchd, T., Magnol, J. P., Fournel, C., Dezutter-Dambuyant, C. & Schmitt, D. Research in Virology 145,245-249 (1994).I 5. Saint-Andr6 Marchal, I., Dezutter-Dambuyant. C. & Mutin, I. P and others Br. J. Dermarol. 136,961-965 (1997). . 6. Badleston, D. L., Roosje, P. & Goldschmidt, M. H. J. Vet. Allergy Clin. Immunol. 5,54-58 (1997). 7. Blazej, A. Galatik, A. Galatik, I. Krul, Z. & Mladek, M. Atlas of Microscopic Structures of Fur Skins (Elsevier, Amsterdam, 1989). 8. Lochte, m.Atlas der Menschlichen und TierischenHaare (Paul Schps Verlag, Leipzig, 1938). 9. Creed, R. E S. Vet.Rec. 70, 171-175 (1958). 10. Kumamoto, K., Takei, M., Kinoshita, M., Ebara, S. & Matsuura, T. J. Anat. 182,23-28 (1993). 11. Ikeda, M. & Okada, S. Okajimas Folia Anaromia Japanensis 67,365-369 (1990). 12. Scott, D. W Miller Jr, W. H. & Griffin, C. E. Muller & Kirks Small Animal Dermatology,5th edihon (Saunders, W.B., Philadelphia, 1995). 13. Meyer, W. & Neurand, K. Arch. Dermatol. Res. 283.16-18 (1991). 14. Bond, R., Howell, S.A.,Haywood, P. I. & Lloyd, D. H. Vet. Rec. 141,200-201 (1997). 15. Moriello, K. A. & DeBoer, D. J. Amer J. Vet. Res. 52,602-606 (1991). 16. Moriello, K. A,, Kunkle, G. A. & DeBoer, D. J. Vet. Dermatol. 5,57-62 (1994). AKNOWLEDGEMENTS Diagrams 1 : 1 and 1 : 2 have been reprinted with kind permission fmm Peters S.: "Haut und Haarkleid k m Hund", Ferdinand EnkeVerlag, 1997,Pages 4 and 21. i
www.vet4arab.co.ccIF D. N. Carlotti - D. Pin Diagnostic approach The diagnostic approach in feline dermatology must be methodical and include the various steps of a conventional medical consultation as well as additional ones relevant t o feline dermatology. Information gleaned from the history and clinical examination, both general and dermatological, allow the practitioner to construct a differential diagnosis. Appropriate diagnostic tests are then chosen to narrow down this list and produce a definitive diagnosis 14. History The history is an essential part of the diagnostic approach, and 10-15 mlnutes should be allocated to taking the htstory before examming the ammal. Sometimes, the history alone will suggest the diagnosis. The best method is to use a printed sheet which details most of the questions to ask the owner. This ensures that nothing is forgotten. It also allows the time scale of events to be appreciated, enables the climlcian to gain some time, and demonstrates to the owner that interest 1s being taken in the case 14. Signalment Breed :Breed predispositions should be known but are less important than in the dog 35-" (Table 2 : 1). However, be careful, knowing the breed alone is not enough to make a diagnosis! Sex :Entire male cats are often aggressive. They are prone to subcutaneous abscesses arising from bites and scratches, certain specific bacteria infections (e.g. nocardiosis and actinomycosis), and indirectly to opportunistic dermatoses associated with retroviral infection. Age :Some dermatoses are more common in certain age groups. For example, parasitic dermatoses (e.g. otitis caused by Otodectes cynotis, cheyletiellosis, demodicosis) and dermatophytosis are more common in kittens. Genodermatoses (e.g. junctional and dystrophic epidermolysis bullosa, follicular dysplasias and cutaneous asthenia) are more likely to be seen in the young cat (aged under a year). Allergic dermatoses tend to appear between 6 months and 3 years. Cats of 10 years and over are more susceptible to auto-immune dermatoses, tumours or systemic diseases with dermatological manifestations. It should be appreciated that age of onset of clinical signs is not always the same as age at diagnosis. Age at diagnosis of an allergic dermatitis varies from 1to 10 years! Colour : White cats, or cats with white ears, are prone to solar dermatitis and squamous cell carcinoma, whereas gimger cats are prone to lentigo simplex. Persian cats with a mutation for the beige gene are predisposed to Chediak-Higashi Syndrome. Weight : Weighmg the cat helps determine if the patient is in the correct weight range. It also allows correct dosing of medications and accurate interpretation of water intake over 24 hours (e.g, if hyperadrenocorticism is suspected). Diet:Knowledge of the diet is essential in order to institute an appropriate elimmation diet. Origin :Some colonies or pet stores may be known for their poor hygiene and incidence of contagious dermatoses (e.g. dermatophytosis, Otodectes otitis, cheyletiellosis, etc ...). Stray cats should be examined meticulously and checked thoroughly for retroviruses. Some dematoses have been reported to affect cats of the same line: urticaria pigmentosa in the Sphinx, dystrophic epidermolyis bullosa in the Persian, eosinophilic granuloma complex in a lime of Specific Pathogen Free cats 13.
1 A h r i c a l Gude to F h e Dermatology I www.vet4arab.co.cc Persian Dematophytosis Cheyletiellosis Histoplasmosis Lupus erythematosus Idiopathic facial dermatitis Facial interhigo Hereditary greasy seborrhoea Congenital hypotrichosis Chediak-Higashi syndrome Dystrophic epidemolysis bullosa Exotic Short Hair Hereditary greasy seborrhoea6 Siamese Demodicosis Self-induced alopecia of behavioural origin Food intolerance? Sporotrichosis Cryptococcosis Lupus erythematosus Vitiligo Junctional epidetmolysls bullosa Periocular leucohichia Histiocytic mastocytoma Abysinnian Self-induced alopecia of behavioural origin Blastomycosis Cryptococcosis Follicular dysplasia Havana Blastomycosis Sphinx Urticaria pigmentosa Alopecia universalis Birman Congenital hyponichosis I Burmese Demodicosis Self-induced alopecia of behavioural origin Congenital hypotrichosis Devon Rex Urticaria pigmentosa " Himalayan Lupus erythematosus Ehlers-Danlos syndrome Hereditary greasy seborrhoea " The environment Meticulous details of internal and external surroundings must he documented: being confmed to inside the house, and the presence of rngs and carpets, expose the cat to a high level of house dust mite allergens. Old houses and frequent visits to the cellar and attic favour the multiplication of fleas and consequently flea allergy dermatitis. An outdoor country life predisposes to certain parasitic dermatoses (e.g. Otodectes otitis and tromhiculiasis), allergies (e.g. mosquito bite hypersensitivity), fungal infections (dermatophytosis) and viral infections (e.g. poxvuus infection reported in cats that hunt small rodents). If dermatological signs are worse when the cat is in certain locations, this may suggest atopic dermatitis. Any tips abroad or to different regions should be documented. Notoedric mange is prevalent in the French overseas territories, and parts of Italy, Switzerland, Spain, Slovenia and Croatia. Some systemic mycoses occur in particular geographical regions. The presence of other animals in the house and evidence of transmission to other animals or people: the presence of in-contact animals favours the development of certain dermatoses such as flea allergy dermatitis or contagious dermatoses like dermatophytosis, Otodectes otitis and cheyletiellosis. Evidence of transmission to man suggests dermatophytosis or a parasitic dermatosis like notoedric mange or cheyletiellosis. Changes in the environment: changes in the family situation (moving house, new furniture, new arrival or death of an animal or person) may cause behavioural disorders that can have dermatological manifestations.
www.vet4arab.co.cc 2 : Diagnostic approach Development of the dermatosis Date of initial onset: knowing the date of onset allows the age of onset to be determined along with the duration of the condition. Acute or chronic development: Acute-onset dermatoses include cutaneous drug reactions and viral dermatoses whereas more gradually developing dermatoses include allergic dermatoses and turnours. Seasonality: conditions occurring more in autumn or summer include flea allergy dermatitis, atopic dermatitis, trombiculiasis, mosquito bite hypersensitivity or more rarely poxvirus infection. Initial nature and distribution of lesions: this information will help establish the extent to which the dermatosis has progressed. The owner should be asked precise questions: where were lesions first seen? What did initial lesions look like? The presence of pruritus, initially, or later in the development of the dermatosis: the distinction between a pruritic and non-pruritic dermatosis is arbitrary and oversimplified because a condition that is initially non-pruritic ma; later become pnuitic. here are five imp&ant aspects to be determined from the history: Did pnuitus develop before, at the same time as, or after the lesions appeared? How severe is the pruritus and how frequent is it? It is often described by the owner in a whole range of ways such as frantic, severe, constant, intermittent or occasional. How does pruritus manifest itself? Which parts of the body are affected? How does pruritus respond to corticosteroid therapy? Prior and current therapy Establishing every minute detail of prior and current treatments is essential. This must include the name of the drug, dose, frequency and duration of administration, any side-effects, whether given as instructed, and clinical response obtained. If a cutaneous drug reaction is suspected, all treatments should immediately be stopped and the cause investigated.Clinical examination ~~~~~~~~ ~ ~ - General examination A systematic general examination should he conducted. Methodical examination of the different organ systems should allow detection of general signs that might be associated with dermatological signs: for example, respiratory signs associated with atopic dermatitis, herpesvirus infection, herpesvirus-associated erythema multiforme or digital metastasis of a pulmonary adenocarcinoma; gastrointestinal signs associated with food intolerance; joint or renal signs associated with systemic lupus erythematosus; diabetes mellitus seen frequently with hyperadrenocorticism or the whole gamut of signs linked to cutaneous paraneoplastic syndromes (e.g. pancreatic paraneoplastic alopecia and paraneoplastic exfoliative dermatitis). In some cases, testing should be carried out for retroviruses. uermatological examination Identification of lesions Dermatological diagnosis depends on the morphological identification of lesions "". The dermatologist must identify and investigate primary and secondary lesions. Primary lesions make up the early lesions, representative of the dermatosis. They are sometimes transient and rapidly altered. Secondary lesions may develop spontaneously fro^ primary lesions. They may also arise as a consequence of scratching and licking, especially common in the cat, or following treatment. The identification and interpretation of these lesions is more difficult than in the dog. This is due to the dense coat of the cat and also because cats lick themselves a lot, both as normal grooming behaviour and as a sign of pruritus. There is no clear association between dermatosis and lesion: one particular lesion may suggest various different derinatoses and, conversely, one particular dermatosis may present in lots of different ways.
cal Guide www.vet4arab.co.cc Primary lesions Erythema refers to redness of the skin, diffuse or localised, which disappears when a piece of glass is pressed over it. Erythema results from vasodilatation in the superficial dermis .1,4,i. This common lesion has little diagnostic significance: Generalised erythema may suggest atopic dermatitis, food intolerance (Fig. 2 : I), cutaneous drug reaction or epitheliotropic T cell lymphoma. Localised erythema should lead to suspicion of an infection or infestation (e.g. dermatophytosis (Fig. 2 : 2) or demodicosis), or, depending on its location, actinic or contact dermatitis. Purpura refers to a dark red, non-palpable spot which does not disappear when a piece of glass is pressed over it. It results from extravasation of red blood cells from dermal vessels 2,3.14,5. Purpuric macules are called petechiae, when punctate or lenticular, and ecchymoses when more extensive (Fig. 2 : 3). Purpura is rare in the cat and should be considered a sign of disordered blood clotting (e.g. peripheral or central thrombocytopaenia) or other systemic illness. Platelet purpura occurs in thrombocytopaenia and vascular purpura in necrotising vasculitis that accompanies infectious illnesses (e.g. feline infectious peritonitis). A macule is a flat spot, with no infiltration, associated with a change in skin colour 2..4.s. Hyperpigmented macules arise from an increase in melanin pigmentation. Circumscribed areas of hypermelanosis may he congenital (e.g. lentigo) and caused by an increase in the number of melanocytes in the epidermal basal layer. They may also be acquired as in post-inflammatory melanin pigmentation (e.g. in pemphigus foliaceus or pancreatic paraneoplastic alopecia (Fig. 2 : 4)), and associated with melanocytic hyperactivity. Hypopigmented macules relate to a reduction (hypomelanosis) or absence of (amelanosis) melanin pigments. In the cat, the congenital, circumscribed hypo- or amelanoses (vitiligo) are classified separately from the generalised conditions (piebaldism, Waardenburg Syndrome and albinism). A vesicle is a small (1-3 mm in diameter), translucent elevation containing clear fluid ,.4.5. Due to the extreme thinness of the epidermis, the vesicle is a fragile, transient lesion and therefore, rarely identified. Theoretically, epidermal vesicles are seen in for example, pemphigus vulgaris and poxvirus infection, whereas subepidermal vesicles are seen in epidermolysis bullosa and bullous pemphigoid. A bulla is a large vesicle, greater than 3 mm in diameter184.108.40.206. A pustule is a raised, purulent spot, associated with an accumulation of neutrophils and modified keratinocytes i.~4.1*. Unlike in the dog, pustules are hard to identify, macroscopically, in the cat, as they are fragile and short-lived. Follicular pustules are centred around a hair and usually indicate bacterial infection (e.g. bacterial folliculitis (rare in the cat) and acne) (Figs 2 : 5,6), dermatophytosis or, very rarely, intra-follicular demodicosis. Non-follicular pustules are flat and independent of hair follicles. Also very fleeting, they are seen mostly in superficial pemphigus conditions (foliaceus and erythematosus). Both follicular and non-follicular pustules containing eosinophils are sometimes seen in allergic dermatoses, eosinophilic granuloma complex and notoedric mange. A papule is a small, raised circumscribed swelling associated with thickening of the epidermis or superficial dermis ~~"~. are classified according to their location: epidermal, follicular, Papules dermal. Epidermal papules are found in squamous cell carcinoma in situ (Fig. 2 : 7). Follicular papules are common in cats with miliary dermatitis and allergic dermatitis, in which case the infiltrate is made up mainly of eosinophils. In dermatophytosis and bacterial folliculitis, follicular papules often develop into intra-follicular pustules, progressing towards fumculosis and a granulomatous reaction. Dermal papules arise from localised infiltration in the dermis by inflammatory cells: eosinophils and mast cells in allergic dermatitis (Fig. 2 : 6), eosinophils in eosinophilic granuloma complex, and mast cells in urticaria pigmentosa. Papules sometimes join together to form plaques (eosinophilic plaques) (Fig. 2 : 8). Some dermal papules called dysmetabolic papules (Fig. 2 : 9) are associated with an intradermal excess of amorphous material which accumulates secondary to a systemic metabolic disorder. These papules are rare. They may be due to dermal accumulation of lipid (xanthoma), secondary to diabetes mellitus, or a primary lipid disorder (e.g. familial hypertriglyceridaemia).