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  1. 1. 96 7 Trin-51 (Trimethoprim-Sulfanethoxazole)
  2. 2. -- Protozoa sporozon coccidia oocyst sporozoite sporulation
  3. 3. Coccidiosis Coccidiosis (Isospora and Sarcocystis species) is an enteric infection, traditionally associated with Isospora canis (dogs) and Isospora felis (cats) as potential pathogens. Other species of Isospora may be present. Strictly host specific, i.e., no cross-transmission. Coccidia is one of the most commonly seen parasites in cats, and is most common in young kittens and more likely to be seen where conditions of poor sanitation, stress and crowding exist. Several references in veterinary literature suggest that almost every cat will become infected by coccidia at some point in their life. Cats acquire the parasite by ingesting any source that has been contaminated by infected cat feces or by ingestion of infected rodents or other meat sources. These organisms reproduce themselves inside the lining cells of the intestinal tract. As the new organisms emerge from these host cells, the intestinal cell is killed in the process. The life cycle of Coccidia takes only a few hours to a few days and new organisms are again passed in the feces. This cycle is the major cause of re-infection which may appear as a persistent infection. Infected cats may exhibit weight loss, weakness, dehydration and diarrhea with possibly blood and/or mucus being present. Kittens, immunocompromised or otherwise weakened cats will have more severe symptoms. Older and otherwise healthy cats may exhibit no symptoms whatsoever. http://maxshouse.com/Parasites_Internal.htm
  4. 4. Isospora felis Common name: Coccidia Kingdom: Animalia Phylum: Apicomplexa Class: Sporozoea Order: Eucoccidiida Family: Sarcocystidae Genus: Isospora Species: felis
  5. 5. www.capcvet.org/downloads/Coccidiaimages.pdf
  6. 6. Life Cycle: The unsporulated oocyst leaves the cat in the feces. It takes 3 days in the environment to develop to the infective, sporulated stage (which contains 4 sporozoites in each of 2 sporocysts). The cat can become infected by ingesting a sporulated oocyst or a mouse which has ingested an infective oocyst. When a rodent ingests the infective oocyst, the sporozoites invade intestinal cells and encyst as bradyzoites. The bradyzoite is infectious to the cat. When the cat eats an infective oocyst or a rodent with bradyzoites in its tissues, the zoites invade the intestinal cells and develop to the schizont stage. The schizonts release more zoites which invade new cells and give rise to the next generation of schizonts. There are 3 generations of schizonts. Zoites released from the last generation of schizonts invade cells and form gametocytes. The male gametocyte releases gametes which fuse with the female gametocytes and form oocysts. The oocysts rupture out of the cells and are voided with the feces. It is 7 or 8 days between the initial infection of the cat and the release of oocysts. During its first infection a cat will shed oocysts for 10 to 11 days. http://cal.vet.upenn.edu/dxendopar/parasitepages/protozoa/isofelis.html
  7. 7. Trin-51
  8. 8. 96 7 / 100   (Direct Smear) Trin-5I(Trimethoprim-Sulfanethoxazole) Trin-51(Trimethoprim- Sulfanethoxazole) 0.1ml/ kg, bid, 24
  9. 9. Trin-51
  10. 10. (+) (-) (%) 3 14 58 72 19.2% 3 ~1 2 16 18 12.5% 1 0 10 10 0% 16 84 100 16%
  11. 11. (+) (-) (%) 3 14 58 72 19.2% 3 ~1 2 16 18 12.5% 1 0 10 10 0% 16 84 100 16%
  12. 12. 15.00 (14) 11.25 (9) 7.50 3.75 (2) (1) 0 ȣ
  13. 13. ཞ1 0~3 3 1
  14. 14. 15.00 (14) 11.25 (9) 7.50 62.5% 3.75 (2) (1) 0 ȣ
  15. 15. ཞ1 0~3 3 1
  16. 16. 15.00 (14) 11.25 (9) 7.50 62.5% 3.75 (2) (1) 0 ȣ
  17. 17. ཞ1 0~3 3 1
  18. 18. Trin-51 Trin-51 (Trimethoprim-Sulfanethoxazole) 12 10 Trin-51 2 Trin-51 5 5 2 Trin-51
  19. 19. Trin-51(Trimethoprim-Sulfanethoxazole) 96052547 + +( ) 96061515 + +( ) *96062241 +++ +++ 96062242 +++ ++ +( ) 96062401 ++ +( ) 96062609 + — 96062811 + — 96062926 +++ ++ 96070301 + — 96070303 + — *96071731 ++ ++ 96072520 + — * Trin-51
  20. 20. no distortion of parasites)
  21. 21. 3
  22. 22. Trin-51 83% Trin-51(Trimethoprim-Sulfanethoxazole) 3 (96061519 96061520 96061259)
  23. 23. 96062926 96061515
  24. 24. Isospora felis Meloni BP 1993 West Kimberley, Australia Isospora felis (15.1%)[6] Tung KwongChung 2003 338 Isospora felis 9 2.66% 84.32%[7] Burgu, A 1985 Ankara, Turkey 1981 1984 100 43 Isospora felis 43%[8] 16%
  25. 25. 15% 15/100 1
  26. 26. ) 96032201 1~3 — — 96042434 1~3 — — 96051420 3~7 — — 96052117 1~3 — — 96052547 1~3 — ++ 96060802 1~3 — — 96060901 1~3 — + 96061234 1~3 — + 96061515 1~3 +( )/++ — 96061519 1~3 — — FRB 96061520 1~3 — — FRB 96061525 1~3 — +( ) FRB 96062241 1~3 +++ 7/13 96062242 1~3 +++ 96062244 1~3 — — 96062305 1~3 — — 96062401 1~3 ++( ) — 96062608 1~3 — — 96062609 1~3 +( ) — 96062610 1~3 — — 96062726 3~7 — — 96062811 1~3 +( )/+++ — 96062815 1~3 — — 96062840 1~3 — — 96072728 1~3 — —
  27. 27. ) 96062841 1~3 — — 96062842 1~3 — — 96062843 1~3 — — 96062926 1~3 —/+++ — 96062941 1~3 + F28 1~3 — —/++ 96070105 1~3 — — 96070201 1~3 — — 96070301 1~3 + + 96070303 1~3 +( ) — 96070517 1~3 — — 96070525 3~7 — — 96070605 1~3 — — 96070622 1~3 — — 96070701 6 ~1 — — 96070902 1~3 — — 96070903 1~3 — — 96070920 1~3 — — 96070935 1~3 — — 96071011 1~3 — — 96071022 6 ~1 — +++ 96071105 1~3 + — 96071122 1~3 — — 96071127 3~6 — — 96072722 1~3 — —
  28. 28. ) 96071210 1~2 — — 96071211 1~2 — — 96071212 1~2 — — 96071213 1~3 — — 96071214 1~3 — — 96071221 1~3 — — 96071226 1~3 — — 96071227 1~3 — — 96071228 1~3 — — 96071229 1~3 — — 96071304 3~6 — — 96071305 3~6 — — 96071306 3~6 ++ — 96071307 1~3 — — 96071412 1~3 — — 96071413 1~3 — — 96071414 1~3 — — 96071415 1~3 — — 96071503 1~3 — — 96071504 1~3 — — 96071601 1~3 — — 96071606 3~6 — — 96071612 1~3 — — FRB 96071724 3~6 — —/+ 96072623 1~3 +++ +
  29. 29. ) 96071725 3~6 ++ —/+ 96071726 3~6 — ++ 96071730 1~3 — +++ 96071731 1~3 — ++ 96071733 3~6 — — 96071734 3~6 — — 96071735 3~6 — +++ 96071736 3~6 — — 96071737 3~6 — — 96071804 3~7 — — 960719(1) 1~3 — — 960719(2) 1~3 — — 96072010 1~3 — — 96072019 1~3 — — 96072023 1~3 — — 96072101 1~3 — — 96072201 3~6 — — 96072202 1~3 — — 96072328 1~3 — — 96072430 3~6 — — 96072520 1~3 + ++ 96072609 1~3 — + 96072620 1~3 — — 96072621 1~3 — — 96072622 1~3 — —
  30. 30. 1. 131~133 2. 16~18 192 3. http://maxshouse.com/Parasites_Internal.htm 4. http://www.capcvet.org/downloads/Coccidiaimages.pdf 5. http://cal.vet.upenn.edu/dxendopar/parasitepages/protozoa/isofelis.html

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