Glutamate-Glutamine in Schizophrenia measured with     Proton Magnetic Resonance Spectroscopy                  Lawrence S....
Prefrontal cortex glutamine (Gln) or Glu-Gln (Glx) in                 Schizophrenia - Proton (1H) MRS studies             ...
MRS voxels        MPFCDLPFC
Glx levels in schizophrenia                          n = 22                          n = 16                          n = 1...
Glx levels in healthy humans (n = 12) -     response to ketamine infusion                 MPFC
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Kegeles slides w title

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Presentation made by Dr. Larry Kegeles, Feb 5, 2013, at the SRF hosted webinar (www.schizophreniaforum.org)

Published in: Health & Medicine
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Kegeles slides w title

  1. 1. Glutamate-Glutamine in Schizophrenia measured with Proton Magnetic Resonance Spectroscopy Lawrence S. Kegeles Psychiatry and Radiology, Columbia University NY State Psychiatric Institute
  2. 2. Prefrontal cortex glutamine (Gln) or Glu-Gln (Glx) in Schizophrenia - Proton (1H) MRS studies N OutcomeSTUDY Med Status MPFC pt / hc measureBartha et al., Archives 1997 10 / 10 naïve GlnThéberge et al., AJP 2002 21 / 21 naïve GlnThéberge et al., Br J Psychiatry 2007 13 / 16 naïve Gln 9 naïve, 7Kegeles et al., Archives 2012 16 / 22 Glx unmedicated
  3. 3. MRS voxels MPFCDLPFC
  4. 4. Glx levels in schizophrenia n = 22 n = 16 n = 16MPFC DLPFC DLPFC (Kegeles et al., Arch Gen Psychiatry, 2012)
  5. 5. Glx levels in healthy humans (n = 12) - response to ketamine infusion MPFC

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