Early Alzheimer's Disease Webinar_Landau
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Early Alzheimer's Disease Webinar_Landau



Presentation delivered November 30, 2012 by Dr. Susan Landau at the P

Presentation delivered November 30, 2012 by Dr. Susan Landau at the P



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Early Alzheimer's Disease Webinar_Landau Early Alzheimer's Disease Webinar_Landau Presentation Transcript

  • Early detection of Alzheimer’s disease Susan Landau Helen Wills Neuroscience Institute University of California, Berkeley Lawrence Berkeley National Lab
  • DefinitionsDementia A global, progressive loss of cognitive ability that ultimately impairs independent functionAlzheimer’s disease The most common cause of dementia Begins with subtle memory loss Characteristic brain pathology
  • Risk Factors/Protective FactorsIncreased RiskAgeGenetics/family historyHead InjuryDecreased RiskEducationCognitive EngagementPhysical Exercise
  • Neuropathology of Alzheimer’s disease: Neuritic Plaques (amyloid) and Neurofibrillary Tangles (tau)neuro-fibrillarytangle(tau) amyloid (Ab) plaque
  • Amyloid Imaging with Positron Emission Tomography (PET) Fibrillar AbAmyloid Plaques PET Imaging
  • Amyloid Imaging withPositron Emission Tomography (PET) Fibrillar Ab PET Imaging
  • Amyloid PET Imaging in AgingAlzheimer’s DiseaseNormal Aging (Amyloid Negative)Normal Aging (Amyloid Positive) 30% of normal older people are amyloid positive
  • Amyloid is associated with cognitive decline over time Cognitive function (worse ) Individuals without amyloid Cognitive function (worse ) Individuals with amyloid Time (years)
  • Lifestyle factors and Alzheimer’s disease riskLifestyle practices Improved cognitive function Less Decreased AD riskCognitive, physical, social,occupational engagement amyloid ? Slower decline
  • Lifetime cognitive activity and amyloid Figure 2 a b 2.0 Cortical PiB uptake Amyloid deposition 1.5 1.0 0.5 Lowest Moderate Highest cognitive cognitive cognitive activity activity activity Alzheimer’s Older Young patients controls controls Landau et al. Arch Neurol 2012
  • Brain atrophy in Alzheimer’s Disease Normal Hippocampus (involved inMild Cognitive memory Impairment function) is particularly affected in AD Alzheimer’s Disease(Hippocampal Atrophy)
  • FDG-PET: Hypometabolism in Alzheimer’s vs Normal Aging
  • The Amyloid Hypothesis of Alzheimer’s DiseaseAmyloid Cognitive Decline and Dementia neural function atrophy
  • Early detection of amyloidAmyloid PET imaging is an important tool in research and clinical trials -- but is currently not appropriate for routine clinical screening in cognitively normal peopleAmyloid is linked to future cognitive decline, but : Decline may occur >10 yrs after amyloid appears Some individuals may not declineInterventions or preventative treatment may only be effective early, since loss of cognitive and neural function may be irreversible
  • Resources and volunteer opportunities• Alzheimer’s Disease Neuroimaging Initiative (ADNI)• National Institute on Aging
  • Thank youUniversity of California, BerkeleyWilliam Jagust Robert WilsonElizabeth Mormino Gil Rabinovici ADNI participants and staffHwamee Oh Shawn Marks Avid RadiopharmaceuticalsAlzheimer’s Disease Neuroimaging InitiativeMichael WeinerBob Koeppe Ronald PetersenDanielle Harvey Paul AisenLaurel Beckett Michael DonohueLeslie Shaw Anthony GamstJohn Trojanowski Art TogaClifford Jack Karen CrawfordChester Mathis Eric ReimanAndrew Saykin Kewei ChenNorman Foster