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Dental Implants and Osteoporosis
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Dental Implants and Osteoporosis

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  • 1. STRONTIUM RANELATE AND SODIUM FLUORIDE IN THE MANAGEMENT OF IMPLANT OSSEOINTEGRATION By : W. Jaber (KWT), N. Hassanzadeh (IRN) Scientific mentor– Ye. Vazhnichaya, D.M., professor Poltava, 2012
  • 2. Intorodoction:  Dental Implants: is an artificial tooth root that a periodontist places into your jaw to hold a replacement tooth or bridge.
  • 3.  Osteoporosis: it’s condition in which the bones become fragile and brittle, leading to a higher risk of fractures than in normal bone. Bone Mineral Density (BMD) by Dual energy X-ray Absorptiometry.
  • 4.  Research purpose: is to study the influence of strontium ranelate and its co- administration with sodium fluoride on the re-modeling of bone tissue after the tooth extraction and the osseointegration of dental implants.
  • 5.  Research methods: 15 female Wistar rats of 200 g of body weight were used in the experiments which were permitted by Bioethics commission of the Ukrainian Medical Stomatological Academy. Low molar was extracted in control and experimental rats and dental implantation was carried out immediately after the tooth extraction under the general anesthesia by ether for narcosis.
  • 6.  Why low molar is extracted ?
  • 7.  Medication used in the Experiment : 1) Strontium Ranelate: o used as water suspension containing 10 mg of strontium salt in 1 ml of liquid. o In dose 30 mg/kg body weigh (0,6 ml) orally once a day . (Strontium Ranelate) REDUCES bone Resorption , & INCREASES bone Formation.
  • 8. 2) Sodium Fluoride : o as 0,012% aqueous solution, orally, in Average dose 0,6 mg/kg. ( Sodium Fluoride ) # improve the integration of dental implants into jaw bone. # enhance the strength of teeth by the formation of Fluorapatite .
  • 9.  Research results: o Molar extraction without pharmacological correction : - Alveolus are fuzzy & rough. - Compact plate wells traced not all over. - Development of new bone tissue in the site of tooth extraction is poor.
  • 10. o Molar extraction + strontium ranelate : - hypertrophy of bone tissue which is dense at the top of extracted tooth. - density of this surplus tissue on the level of the gum is less. - Compact plate wells in a clear zone of osteosclerosis. - Spongy alveolar bone has clear smooth trabeculars sections without degradation. - Cortical plate of the alveolar process was normal.
  • 11.  Molar extraction + strontium ranelate+ sodium fluoride: - Alveolus is not viewed. (it’s filling by bone tissue faster) - Compact plate wells as a clear zone of osteosclerosis. - No signs of inflammation or hypertrophy. - Sponge alveolar bone is with clear smooth beams and without signs of degradation. - Cortical plate of the alveolar process is normal.
  • 12.  Dental implant : - Bone tissue around implant has signs of inflammation. - Sponge alveolar bone is with clear smooth beams and without signs of degradation. - Cortical plate of the alveolar process is normal.
  • 13.  Dental implant + strontium ranelate: - There is dense secondary bone tissue around it. - Formation of granulating periodontium at the top is observed. - no signs of degradation. - Hypertrophy of bone tissue of alveolar process is registered. - Cortical plate of the alveolar process is without pathology.
  • 14.  Dental implant+ strontium ranelate+ sodium fluoride: - It’s similar to treatment With Strontium ranelate BUT without hypertrophy of bone tissue. - Around the implant the bone tissue has clear trabecular structure. - No signs of degradation. - Cortical plate of the alveolar process is in the good condition.
  • 15.  Conclusion: Thus, it is shown that strontium ranelate increases the density of bone tissue and improves reparative processes in the site of tooth extraction and dental implantation in comparison with control rats without pharmacotherapy. Addition of sodium fluoride to this therapy is characterized by more intensive maturation of young bone tissue around implants as compared to previous group. The data obtained show that combination of strontium and fluoride is perspective for pharmacological management of dental implants osseointegration.
  • 16. Thank you for attention!