Prescription drug abuse is an epidemic in the Appalachian region that is impacting public health, education, economic development and family life. This talk will examine epidemiologic factors associated with prescription and over-the-counter drug misuse. Commonly abused prescription and over-the-counter drugs will be discussed and safe patient and prescriber factors that can increase the risk of prescription drug abuse will be compared. The strengths and limitations of prescription-drug monitoring programs will be explained. Session participants will discuss actions they have taken in their community to fight prescription drug abuse.