QPR-Colon Disorders

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Quick Review of Pathology for clinicians and senior students.
Colon disorders, colon cancer

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QPR-Colon Disorders

  1. 1. “It has been my personal experience that the true flavour, the real fun, the continuous excitement of work lie in the process of doing it rather than in having it over and done with.” - Wings of Fire: An Autobiography of Dr. APJ Abdul Kalam.<br />
  2. 2. Quick Pathology Review<br />Pathology of <br />Colon disorders<br />System : Gastro-Intestinal System<br />Class : Large Intestinal disorders<br />Topic : ca. colon, diverticulosis, appendicitis...<br />Shashidhar Venkatesh Murthy<br />A/Prof.& Head of Pathology<br />School of Medicine & Dentistry <br />James Cook University Australia.<br />
  3. 3. CPC 24- GIT-PUD: Core Learning Issues(CLI)<br />Major CLI:<br />Polyps of colon - Polyposis syndromes Lynch/HNPCC, FAP (others minor).<br />Carcinoma colon – right & left types.<br />Appendicitis* – Self study.<br />Diarrhoeal disorders* – microbiology - Richa.<br />Minor CLI:<br />Familial polyposis syndromes:, Peutz-Jeghers, Gardner, Cowden, Turcot etc.<br />Diverticulosis & Diverticulitis.<br />Angiodysplasia & Ishchemic disorders of Intestines.<br />Pseudomembranous colitis.<br />
  4. 4. ?<br />2x2cm<br />* Polyps, diverticulosis<br />Adeno carcinoma & diverticulosis<br />Diverticula & hyperplastic polyp.<br />Mecklesdiverticulum & adenoma<br />Angiodysplasia & adenoma<br />Adenoma & diverticulosis<br />
  5. 5. ? Diagnosis<br />Hyperplastic polyp.<br />Juvenile Polyp.<br />Retention Polyp.<br />tubular adenoma.<br />Villous adenoma.<br />
  6. 6. ?<br />Adenocarcinoma colon.<br />Internal hemorrhoids.<br />Rectal Squamous carcinoma<br />Angiodysplasia.<br />Mesenteric vein thrombosis<br />* GITAngiodysplasia<br />
  7. 7. ? Diagnosis<br />Colon Diverticulitis.<br />Crohn’s disease with fistula.<br />Acute appendicitis & perforation.<br />Ulcerative colitis with toxic megacologn.<br />Intestinal obstruction.<br />
  8. 8. ? Diagnosis<br /> Cowden Syndrome..<br />Peutz-Jeghers syndrome.<br />Familial AdenomatousPolyposis (FAP).<br />Lynch Syndrome (HNPCC).<br />Gardner Syndrome..<br />
  9. 9. ? Diagnosis<br />Familial AdenomatousPolyposis.<br />Lynch Syndrome-HNPCC.<br />Peutz-Jeghers syndrome.<br />Gardner Syndrome.<br />Hyperplasticpolyposis.<br />
  10. 10. ? Genetic Abnormality<br />APC gene mutations.<br />DNA Mismatch repair genes.<br />LKB1/STK11<br />PTEN.<br />SMAD4.<br />FAP<br />HNPCC<br />Peutz-Jeg.<br />Cowden<br />Juvenile p<br />
  11. 11. ? Diagnosis<br />9x8cm<br />Villous adenoma.<br />Adenocarcinoma.<br />Tubular adenoma.<br />rentention polyp<br />Large hyperplastic polyp.<br />
  12. 12. ? Diagnosis<br />Crohns disease.<br />Villous adenoma.<br />Adenocarcinoma-Right type.<br />Adenocarcinoma-Left type.<br />Adenocarcinoma diffuse infiltrating.<br />
  13. 13. What is the type of Polyp ?<br />7x5 cm<br />5x5 cm<br />?<br />Tubular adenoma.<br />Villous adenoma<br />Hyperplastic polyp.<br />Pseudo polyp.<br />Harmatomatous polyp.<br />
  14. 14. ?<br />Peutz-Jeghers syndrome.<br />FAP syndrome. <br />Carcinoid syndrome.<br />Gardner syndrome.<br />Lynch syndrome.<br />
  15. 15. ? Diagnosis<br />Hyperplastic polyps.<br />Peutz-Jeghers syndrome.<br />Familial AdenomatousPolyposis.<br />Multiple tubular adenoma.<br />Lynch syndrome.<br />4x4 mm<br />
  16. 16. 56y male sudden severe abdominal pain & intestinal obstruction. Surgical specimen ? Diagnosis<br />Volvulus<br />Adenocarcinoma & Obstruction.<br />Intusussception.<br />Adhesions & obstruction.<br />Herniation of intestine.<br />
  17. 17. ? Diagnosis<br />Colon Diverticulitis.<br />Crohn’s disease<br />Acute appendicitis.<br />Ulcerative colitis.<br />Meckles diverticulitis..<br />
  18. 18. ? Diagnosis<br />Peutz-Jeghers syndrome.<br />Familial AdenomatousPolyposis.<br />Multiple tubular adenoma.<br />Villous adenoma.<br />Hyperplastic polyps.<br />
  19. 19. “One of the important functions of prayer, I believe, is to act as a stimulus to creative ideas. Within the mind are all the resources required for successful living. Ideas are present in the consciousness, which when released and given scope to grow and take shape, can lead to successful events. Within us there is a great potential strength and ability. Prayer helps to tap and develop these powers.” - Wings of Fire: An Autobiography of Dr. APJ Abdul Kalam.<br />

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