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Back to the stemhood (teaser talk)

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Transcript

  • 1. a Systems Biology approachidentifying external relays involved in stemnessof human embryonic stem cells
  • 2. hESCsBlastocyst
  • 3. Stemness
  • 4. • Fundamental research•Regenerative medicine• Drug screeningThe human embryonic stem cells
  • 5. Data analysisMicroarrays
  • 6. InteractomeData analysisModel designMicroarraysTranscriptomeProtein-Protein interaction network• Node = Protein• Edge = Physical interaction
  • 7. EnrichmentsInteractomeData analysisModel designDRY / In silicoexperimentsMicroarraysTranscriptome
  • 8. EnrichmentsInteractomeData analysisModel designPredictions/HypothesisDRY / In silicoexperimentsMicroarraysTranscriptomeCandidates
  • 9. EnrichmentsInteractomeData analysisModel designPredictions/HypothesisDRY / In silicoexperimentsMicroarraysTranscriptomeCandidates
  • 10. EnrichmentsInteractomeData analysisModel designPredictions/HypothesisDRY / In silicoexperimentsMicroarraysTranscriptomeCandidates
  • 11. 012345hESCsDifferentiated cellsEnrichmentsInteractomeData analysisModel designExperimentaldesignPredictions/HypothesisDRY / In silicoexperimentsMicroarraysTranscriptomeCandidatesqPCR
  • 12. 012345hESCsDifferentiated cellsEnrichmentsInteractomeData analysisModel designExperimentaldesignPredictions/HypothesisDRY / In silicoexperimentsMicroarraysTranscriptomeCandidatesqPCR
  • 13. EnrichmentsInteractomeData analysisModel designWET / In vitroexperimentsExperimentaldesignPredictions/HypothesisDRY / In silicoexperimentsMicroarraysTranscriptomeCandidateshESCHEK 293TRNA interferenceqPCR
  • 14. EnrichmentsInteractomeData analysisModel designWET / In vitroexperimentsExperimentaldesignPredictions/HypothesisDRY / In silicoexperimentsMicroarraysTranscriptomeCandidatesRNA interferenceqPCR
  • 15. Understanding better the stemnessIn order to mobilise the potential of hESCsThe human embryonic stem cells@VMournetAlper Uzun, PhD.

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