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Back to the stemhood (teaser talk)
Back to the stemhood (teaser talk)
Back to the stemhood (teaser talk)
Back to the stemhood (teaser talk)
Back to the stemhood (teaser talk)
Back to the stemhood (teaser talk)
Back to the stemhood (teaser talk)
Back to the stemhood (teaser talk)
Back to the stemhood (teaser talk)
Back to the stemhood (teaser talk)
Back to the stemhood (teaser talk)
Back to the stemhood (teaser talk)
Back to the stemhood (teaser talk)
Back to the stemhood (teaser talk)
Back to the stemhood (teaser talk)
Back to the stemhood (teaser talk)
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Back to the stemhood (teaser talk)

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Transcript

  • 1. a Systems Biology approachidentifying external relays involved in stemnessof human embryonic stem cells
  • 2. hESCsBlastocyst
  • 3. Stemness
  • 4. • Fundamental research•Regenerative medicine• Drug screeningThe human embryonic stem cells
  • 5. Data analysisMicroarrays
  • 6. InteractomeData analysisModel designMicroarraysTranscriptomeProtein-Protein interaction network• Node = Protein• Edge = Physical interaction
  • 7. EnrichmentsInteractomeData analysisModel designDRY / In silicoexperimentsMicroarraysTranscriptome
  • 8. EnrichmentsInteractomeData analysisModel designPredictions/HypothesisDRY / In silicoexperimentsMicroarraysTranscriptomeCandidates
  • 9. EnrichmentsInteractomeData analysisModel designPredictions/HypothesisDRY / In silicoexperimentsMicroarraysTranscriptomeCandidates
  • 10. EnrichmentsInteractomeData analysisModel designPredictions/HypothesisDRY / In silicoexperimentsMicroarraysTranscriptomeCandidates
  • 11. 012345hESCsDifferentiated cellsEnrichmentsInteractomeData analysisModel designExperimentaldesignPredictions/HypothesisDRY / In silicoexperimentsMicroarraysTranscriptomeCandidatesqPCR
  • 12. 012345hESCsDifferentiated cellsEnrichmentsInteractomeData analysisModel designExperimentaldesignPredictions/HypothesisDRY / In silicoexperimentsMicroarraysTranscriptomeCandidatesqPCR
  • 13. EnrichmentsInteractomeData analysisModel designWET / In vitroexperimentsExperimentaldesignPredictions/HypothesisDRY / In silicoexperimentsMicroarraysTranscriptomeCandidateshESCHEK 293TRNA interferenceqPCR
  • 14. EnrichmentsInteractomeData analysisModel designWET / In vitroexperimentsExperimentaldesignPredictions/HypothesisDRY / In silicoexperimentsMicroarraysTranscriptomeCandidatesRNA interferenceqPCR
  • 15. Understanding better the stemnessIn order to mobilise the potential of hESCsThe human embryonic stem cells@VMournetAlper Uzun, PhD.

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