Pharmapack 2012 Competitive Intelligence Report
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Pharmapack 2012 Competitive Intelligence Report

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At Pharmapack Europe 2012 we saw this year that compliance is a big topic amongst suppliers of packaging solutions for the pharmaceutical industry. Many packaging solutions for this industry now go ...

At Pharmapack Europe 2012 we saw this year that compliance is a big topic amongst suppliers of packaging solutions for the pharmaceutical industry. Many packaging solutions for this industry now go far further from their primary function of protecting the content, and include features like easy dosage and application, child resistance, senior friendliness and tamper evidence. Electronics is also making its way towards providing intelligent information to patients to improve compliance. The other major trend ...

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Pharmapack 2012 Competitive Intelligence Report Pharmapack 2012 Competitive Intelligence Report Document Transcript

  • 13-14 February 2012 Paris – Grande Halle de la Villette Pour tous renseignements : contact@veillesalon.com Tél. 08 71 57 21 78 - Fax. 01 34 35 04 89 Une prestation réalisée par la société VIEDOC Un site produit et édité par VIEDOC Solutions 8 rue de Malleville, 95880 8 rue deles bains Enghien Malleville, 95880 Enghien Les Bains, Pour tous renseignements : contact@veillesalon.com - Tél : +33(0)9 71 57 21 78 Sites web : www.veillesalon.com et www.viedoc.fr
  • Page |2 TABLE OF CONTENT Abstract ...................................................................................................................................................... 4 Introduction................................................................................................................................................ 5 Ease of use and accurate dosing ................................................................................................................ 6 1.1 Ease of use .................................................................................................................................. 6 1.1.1 Coradin: Ecodis ................................................................................................................... 6 1.1.1 Neutroplast: Cost effective drug dispensers ...................................................................... 7 1.2 Accurate dosing ........................................................................................................................ 10 1.2.1 SLG Pharma: TubeDose, a new generation of tube dispenser ......................................... 10 1.2.2 Primequal: Preciquant for automatic dispensing-dosing-injecting .................................. 13 1.2.1 Aptar Pharma: e-Device technologies .............................................................................. 16 Child resistance and product protection .................................................................................................. 18 1.3 Child Resistance ........................................................................................................................ 18 1.3.1 Faudel & Co. Nachfolger: Child resistant blister pack....................................................... 19 1.3.2 Burgopak Healthcare: Child resistant slider ..................................................................... 23 1.4 Product protection and closures .............................................................................................. 27 1.4.1 LOG: New desiccant cap ................................................................................................... 27 1.4.1 Süd-Chemie: Child-proof integrated desiccant closure .................................................... 28 1.4.1 ARaymondlife: Plastic closure for vials ............................................................................. 29 Glass replacement .................................................................................................................................... 31 1.5 COC from Topas ........................................................................................................................ 31 1.5.1 Schott: Prefillable COC syringes ........................................................................................ 33 1.5.2 Promens: ClearVial made from COC ................................................................................. 34 1.6 Other resins and additives........................................................................................................ 34 1.6.1 Eskiss: Polypropylene Unicadose vial ............................................................................... 34 1.6.2 MGC: New amorphous polyester pellets for medical bottles .......................................... 37 Conclusion ................................................................................................................................................ 40 A Propos de Veille Salon ........................................................................................................................... 41 Présentation de Viedoc Sarl ..................................................................................................................... 42 © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • Page |3 DISCLAIMER Ce rapport a été élaboré à partir des interviews réalisées par nos soins auprès des exposants présents sur l’événement incriminé, de la collecte d’information et de son analyse lors des conférences qui s’y sont tenues et de la compilation des résultats de recherches issus d’une veille internet postévénement. Ainsi, les données qui figurent dans ce rapport ont strictement valeur d’information. Bien que l’objectif soit de diffuser des informations actualisées et exactes, VEILLE SALON ne peut pas garantir le résultat et tout préjudice qui pourrait résulter de l’utilisation de ces informations ne pourra lui en être imputé. L’utilisation ou la reproduction de tout ou partie de ce document est interdite sans l’accord écrit préalable de VEILLE SALON. Pour obtenir l’intégralité des conditions d’utilisation de ce rapport, merci de nous contacter. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • Page |4 ABSTRACT Abstract: At Pharmapack Europe 2012 we saw this year that compliance is a big topic amongst suppliers of packaging solutions for the pharmaceutical industry. Many packaging solutions for this industry now go far further from their primary function of protecting the content, and include features like easy dosage and application, child resistance, senior friendliness and tamper evidence. Electronics is also making its way towards providing intelligent information to patients to improve compliance. The other major trend that we have noticed is the increasing use of lighter and safer polymer materials for applications where glass is traditionally used like for bottles, vials and syringes. Key words: Compliance, adherence, convenience, ease-of-use, efficiency, dosage, child resistant, cap, desiccant, senior friendly, slider pack, blister pack, glass replacement, pipette, tube, container, dropper, dispenser, device, syringe, prefilled, vial, bottle, COC, cyclic olefin copolymer, plastic, polymer, polypropylene, PP, polyester. *** Résumé: Au salon Pharmapack Europe 2012, nous avons vu cette année que le respect du traitement par les patients est une problématique que les fournisseurs de solutions d'emballages pharmaceutiques intègrent de plus en plus dans leurs offres. Aujourd'hui, certaines solutions d’emballage pour cette industrie vont beaucoup plus loin que leur fonction première de protection du contenu, et intègrent des caractéristiques telles que la facilité de dosage et d'application, la sécurité enfants ou la sécurité anti-effraction. L’électronique fait également son entrée permettant le développement d’emballages intelligents qui aident les patients dans la prise et le respect de leur traitement. L'autre grande tendance que nous avons remarquée est l'utilisation croissante de matériaux polymères légers et plus resistants à la casse pour les applications où le verre est traditionnellement utilisé, comme pour les flacons, ampoules et seringues. Mots clés: Respect du traitement, commodité, practicité, facilité d'utilisation, efficacité, dosage, sécurité enfants, bouchon, dessicant, facilité d’ouverture, emballage-coque, , boite, remplacement du verre, pipette, tube, contenant, compte-gouttes, distributeur, dispositif, seringue préremplie, flacon, bouteille, COC, copolymère d'oléfine cyclique, plastique, polymère, polypropylène, PP, polyester. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • Page |5 INTRODUCTION This year, VeilleSalon went for the first time to Pharmapack Europe in Paris. This International conference and exhibition is dedicated to innovation in pharmaceutical packaging and drug delivery systems. It is a place where manufacturers and suppliers of medical devices, packaging, and production equipment present their products and innovations. The 2012 edition attracted over 2,800 visitors from medical and pharmaceutical companies, biopharmaceutical and veterinary laboratories. Over 260 international companies presented their latest innovations, products and services for the design and manufacture of packaging and dispensing systems for medicinal products. In this document we report on what VeilleSalon will remember from Pharmapack Europe this year. Glass replacement is a big topic across all industrial sectors as lighter materials are sought in order to reduce the impact on the environment of human activities. Glass has been traditionally used for pharmaceutical packaging and delivery systems as it is inert and transparent. Some plastics are now able to advantageously replace glass offering transparency, inertness, lightness and greater resistance to breakage. These polymers are further optimized to provide suitable properties like gas and moisture barriers. Easy application and easy dosage was another big topic as patient’s compliance is highly dependent on packaging ease of opening and use. At the same time, medical packaging must not be opened too easily and should feature some degree of security in order to prevent children from ingesting drugs. Although Child Resistant & Senior Friendly packaging have had a lot of success across the Atlantic over the past decade, these types of packaging are not yet widely used in France, albeit the child resistant cap that even adults sometimes find difficult to open. The three other packaging exhibitions VeilleSalon went to or will go to this year are: PCD and Aerosol&Dispensing Forum (February), CFIA (March), and Emballage (November). For each one of the events, VeilleSalon will write up a report, and at the end of the year a summarized document will also be issued and sent to our subscribers. For more information about the offer, please contact Bruno Galimand on +33 (0)1 43 45 27 or at bgalimand@viedoc.biz. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • Page |6 EASE OF USE AND ACCURATE DOSING Compliance is a major issue within healthcare today as non-adherence to prescribed medications may cause death. Non-adherence can constitute many forms: not having prescriptions filled, taking incorrect dose at incorrect times, forgetting doses or stopping before the recommended time. Non-adherence is one of the most common causes of uncontrolled chronic conditions while adherence, also called compliance, has shown to improve life expectancy by reducing the development of complications. Compliance describes the extent to which patients follow the recommendations of their healthcare provider on medication, diet and lifestyle modification to ensure favorable clinical outcomes. With the current difficulties in the world economy and the subsequent pressure on healthcare costs worldwide, companies are looking into patient compliance as a means of reducing the burden on the healthcare system while improving patients’ health condition. Convenience, ease-of-use, efficiency and accurate dosage are therefore of critical importance for drug delivery, be it for patients themselves or for practitioners. 1.1 EASE OF USE 1.1.1 Coradin: Ecodis Address Coradin Parc d’Activité de l’Argile VI 460 Avenue de la Quiéra F-06370 Mouans-Sartoux France www.coradin.com Contact Florence Bidamant Sales & Marketing Director Florence.bidamant@coradin.com Phone: +33 (0)4 92 28 80 00 Mobile: +33 (0)6 13 41 58 96 Coradin is a plastic injection molding company that offers packaging solutions for cosmetics and pharmaceuticals. At Pharmapack 2012, Coradin presented their recently launched eco-responsible packaging range. Ecodis is produced with 100% recyclable raw materials, and the design has been optimized to keep weight to the strict minimum as well as using only as much plastic material as needed. The container, dropper and protection cap are made of polypropylene (PP) and the soft part to fill out the product is made of thermoplastic elastomer (TPE). With Ecodis, the cosmetic product application is done with new actuation. Indeed, by simply pressing on the supple bottom part of the rigid tube, the cosmetic product is applied onto the skin. Ecodis is currently available in 10ml, 15ml and 30ml sizes. The other original aspect of Ecodis is to propose a 2in-1 version composed of a cartridge which is simply opened by pressing on the soft bottom part of Ecodis. After shaking, the formulation is reconstituted and is ready for use. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • Page |7 Ecodis has been designed for skin care fluid products, make-up (foundation) or hair care formulations. It can be decorated on request, and is easy to fill, assemble, transport and use. Depending on product's viscosity, different droppers are available with diameters ranging from 0.2mm to 3.0mm. → Ecodis’ patent details Title: Container assembly for mixing solute and solvent, has container with base comprising lower wall that is displaced for modifying pressure inside container to transfer product from container to another container, when containers are assembled Patent number: FR2940963 Publication date: 2010-07-16 Abstract: The assembly has containers for containing two products e.g. solvent and solute, respectively. The containers are assembled for moving the product in one of the containers towards another container by deformation of the former container. The former container has a base (40) equipped with a flexible lower wall. The wall is displaced with respect to an opening of the former container to modify the pressure inside the former container to transfer the product from the former container towards the latter container, when the containers are assembled. 1.1.1 Neutroplast: Cost effective drug dispensers © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • Page |8 Address Neutroplast Zona Industrial Casal Espinheira, Lote 10 P2590-057 Sobral Monte Agraço Portugal Phone: +49 5661 7309-0 www.neutroplast.com Contact Antonio Soares Business Development Phone: +351 261 943 175 antoniosoares@neutroplast.com Neutroplas is a Portuguese company that specializes in the production of plastic primary packaging and dosage devices for the healthcare and pharmaceutical markets. It is a family owned SME focused on catering to niche markets in the pharmaceutical industry and its presence ranges from Europe and the North of Africa to the Middle-East and the GCC. At Pharmapack 2012, Neutroplast promoted their smart containers aimed at generic pharmaceuticals. Taking into account core elements like compliance, senior friendly characteristics, and integration with the electronic- and communication-oriented medium the company has chosen to bet on stable commercial forms that can be improved to create smart packaging. Vaginal dispenser Neutroplast has developed a drug-delivery device designed to provide maximum ease of use, comfort and efficiency for the delivery of ovules, vaginal pills and creams. It features an ergonomic format together with an innovative release system that allows for the handling of the device with one hand only, maximizing the results both in compliance of the administration as well as in comfort for the user. As this is a single use, disposable item, cost efficiency was also a concern, therefore the delivery device is built using injection molded plastic parts, allowing for competitive prices, thus allowing pharmaceutical companies to launch their products using this new technology without hampering commercial results. Features and benefits: - One size fits all - one single body accommodates the main formats of available drug delivery - Genuine medical improvement — easier and friendlier focusing on users with restricted movement - The vaginal applicator forms a distinguishing feature between brands - Aesthetical appeal brings “cool” factor to your product - User friendly and safe design Single pill dispenser © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • Page |9 The company developed a single pill dispenser bottle that allows for the release of one pill at a time, through exclusively mechanical means. Future developments will incorporate such diverse aspects as traceability, communication with end-users and point of care structures, as well as electronic monitoring. Features and benefits: - Simplified mechanism warrants long term durability under any conditions - Easy to use specially for elderly, arthritic and handicapped patients - Higher capacity than blisters for unit dosage with less cost and more Senior Friendly - Improves on the benefits of blisters by providing the same unit-dosage, safety in hygiene and in terms of Child Resistant - Protects the integrity of the drug in a hermetically sealed, closed and controlled environment - Patient only comes in contact with the dose dispensed and to be administered - Starting point for increased levels of interaction with health providers Dry powder inhaler capsule-based The device developed by Neutroplast allows novel capsule formulations and joint-development possibilities for vaccines, gene therapy, hormone therapy, anti-infectives, analgesics, biologics and a continuously expanding range of therapies Features and benefits: - High performing, easy to use, competitively priced, simple to manufacture inhaler - Designing for Patient Relief: maximum amount of drug reaches lungs with minimal patient effort; high dose payloads possible - No propellants - avoiding patient exposure to CFC or HFA - Automatic Coordination between drug delivery and inhalation : Passive Device - Potential Drug Stability Advantages — Potentially High Dose Carrying Capacity Senior-friendly container Their senior-friendly packaging solution relates to the fifteenth anniversary in production of its renowned triangular bottle, which has now been improved in terms of usability to achieve better results for a growing elderly population. This product, which is an evolution of a tried and tested process at Neutroplast, was hallmarked by other companies as it was Neutroplast that first introduced triangular bottles into the Pharmaceutical market. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 10 Features and benefits - Increased usability - patient with reduced hand strength can actually open the package and access the content in a satisfying way - No demand for coordination, precision or squeezing strength - Large contact surface against the hand, increased grip by format - Low use of power/strength - no need for technical aids - Tamper-evident closure combined with Senior Friendly access - avoid “squeeze-and-turn” outdated solutions - Lid can include solutions to control the tight environment inside the bottle, such as humidity or oxygen scavengers - Increased market differentiation with a cost effective solution based on 15 years of manufacturing experience for this particular format 1.2 ACCURATE DOSING 1.2.1 SLG Pharma: TubeDose, a new generation of tube dispenser Address SLG Pharma GmbH & Co. KG Gewerbegebiet Gässle 1 79872 Bernau/Schwarzwald Germany Phone: +49 (0)7675-90510 www.slg-pharma.com Contact Eric Schliemann Sales&Marketing Phone: +49 (0)7738-923 330 Mobile: +49 172 54 64 435 eric.schliemann@slg-pharma.com SLG Pharma GmbH & Co. KG is as a subsidiary of SLG Kunststoff GmbH that was founded in 2009. SLG Pharma develops and produces innovative dosing systems. Their product portfolio includes PickDose, TubeDose and TubeDose Linear. PickDose is a precise measuring pipette with a variably lockable dosing volume. The measuring scale is set to the desired dosing volume by twisting. To pick up precisely the set quantity, PickDose is simply filled by drawing up to the limit. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 11 Safe handling: The innovative sealing system guarantees clean product discharge. Materials: PickDose is manufactured under clean room conditions. All materials have EP and USP approval and can be sterilized. Use: PickDose is indispensable if high-precision requirements have to be fulfilled. The pipette is suitable as an application aid in pharmaceutical, human and veterinary medicine and also laboratory technology. With a modified design, the system can also be used for dental medicine, cosmetics and technology. Supplementary options: Precise fluid quantities can be applied or sprayed by fitting a distributor sponge or a spray head. PickDose is also available as a mixing system which can mix precise doses of different fluids in one operation. TubeDose is a dosing cap for tubes with an integrated quantity regulator for precise, simple and clean dosing of viscous substances. The desired strand length is variably adjusted on a numbered scale and can be firmly locked (Patent pending). The dosing system is manufactured under clean room conditions and is suitable as an application and measuring aid for human and veterinary medical ointments, creams, lotions and gels, for cosmetic products and also technical applications. It saves the manufacturer from having to give vague dosing instructions involving “pea-sized” quantities which have never been made for reliable and safe treatment. Exact volume extraction in three steps: 1. Set the quantity by setting the recommended dose on the quantity scale accordingly. 2. Press the tube to fill the dosing feeder precisely with the set quantity. The user can see this from the dosing arrow, which gradually moves up to the limit on the marker. 3. Remove the product by opening the lid and pushing back the dosing arrow to its initial position. The marker remains in place and only moves at the next application if the therapy requires a different dose. TubeDose Linear is a new development of TubeDose that was presented of Pharmapack 2012. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 12 TubeDose Linear can deliver from 0.5 to 2 g of product in a very clean and simple manner. Just like for TubeDose, volume extraction is achieve in 3 steps: 1. Select the quantity by setting the recommended dose on the quantity scale accordingly. 2. Press the tube to fill the dose chamber precisely with the set quantity. In parallel the dosing cap moves upwards. 3. Dispense the product by opening the lid and pushing down the dosing cap to its initial position. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 13 → SLG’s patent Title: Filling injection device Patent number: EP2383005 Publication date: 2011-11-02 Abstract: The syringe (R) has a nozzle (4) arranged at a nozzle-side end of a receiving sleeve (1). A plunger (2) is connectable with the receiving sleeve in transport state at the nozzle-side end of the receiving sleeve. Periphery of the plunger is variable. A sealing (7) is arranged in the receiving sleeve and connected with the plunger. The receiving sleeve comprises grooves at inner side, where the grooves run in stepwise or straight form. The plunger comprises a curve cam cooperating with the grooves. The plunger is partly inserted into the receiving sleeve for a working state. 1.2.2 Primequal: Preciquant for automatic dispensing-dosing-injecting Address Primequal Avenue du Mont Blanc 31 1196 Gland Switzerland www.primequal.com Contact Sacha Nikolic Head of Sales Phone: +41 22 354 05 50 snikolic@primequal.com Primequal is a Swiss company specialized in prefilled syringes and injection devices for pharmaceutical drug delivery. Primequal has developed a new type of Dispenser - Doser - Injector. Based on a patented lever activated system, Primequal Preciquant™ propels a gauged amount of liquid, gel or paste each time you press on the lever. The precision of the dose is given by the crank step size and the number of pressures that are applied on the lever. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 14 This step-by-step doser available in a single use – disposable device is fully adapted to each field of application. The parameters that can be adapted are: size, liquid volume, step size, raw materials depending on the chemicals, with or without glass vials, with or without cartridge, Luer slick, Luer lock, shred, strait needle, needle with a working angle, etc. The device is made in a way that it cannot be re-opened and cannot be re-filled. When the product to be injected has been expelled, the device locks itself and is then unavailable for a second use. This device therefore offers the highest levels of medical and pharmaceutical safety. Preciquant is an automatic injection device developed especially for painless injections and is therefore very suitable for children and nervous patients. Preciquant Painless has an award-winning design which alleviates patient anxiety and features SmoothJect™ which enables a truly painless injection. SmoothJect is a patented pressure-control mechanism which ensures that the liquid is released gradually and without over-pressure. The AutomInject™ patented technology allows the Preciquant Dispenser - Doser - Injector to deliver a precise dose each time you press on the lever. It is a full automatic dose per dose delivery from the first to the last dose. AutomInject produces a « click » sound after every dose, allowing the practitioner to effectively monitor the correct dosage: 1 click = 1 dose. The treatment is thus greatly simplified to a click based procedure. The device can deliver from 1 up to 200 clicks. Number of clicks is linked to the application. AutomInject allows practitioners to perform right from day one a painless injection without any training, saving time and money and providing increased comfort to their patients. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 15 The Preciquant dispenser uses a patented airless propelling system based on a lever. It can be equipped with a specific nozzle that does not allow oxygen to enter the container. The efficiency of the product to dispense is preserved and treatment efficiency is thus increased. Primequal Preciquant received the International « Reddot design award » in 2007 and Pharmapack Award in 2011. In December 2010, Primequal launched the world’s first automatic dosing system for botulinum toxin. Talent BT is an automatic single button injection device developed to allow a safer, faster and repeatable dose delivery for unit based botulinum toxin injections. Talent BT is transforming the injection into something much easier and more convenient for both practitioners and patients. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 16 → Primequal’s patent details Title: EJECTION DEVICE FOR EJECTING SMALL DOSES Patent number: WO2011070112 Publication date: 2011-06-16 Abstract: The invention relates to a device for ejecting a liquid or paste product, including a body (2) having a recess (11) for receiving a product to be ejected, characterized in that it includes a threaded rod (3), which is translatably movable so as to act on the product to be ejected, a bolt (5), which is mounted so as to engage with the threaded rod (3) in order to cause same to translatably move, and a lever (1) acting on the bolt (5) by means of a control means for causing the rotation thereof. 1.2.1 Aptar Pharma: e-Device technologies Address Aptar Pharma 36 – 38 rue de la Princesse 78 430 Louveciennes France Phone: +33 (0)1 39 17 20 20 www.aptar.com/pharma Contact Dario Brambilla Director of Sales EMEA Consumer Health Care Division dario.brambilla@aptar.com Phone: +41 91 935 61 02 Mobile: +41 79 621 71 55 Aptar Pharma is developing a platform of eDevice technologies to address compliance needs which can be incorporated as part of the drug delivery systems. In doing so, Aptar is turning high performance drug delivery devices into ‘smart devices’. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 17 Such spray devices can help the patients count their doses and consequently see how many doses remain before they need to refill their prescriptions (e-Dose Counter platform). e-Dose Counter is a cost effective solution which meets regulatory recommendations for nasal and sub-lingual spray delivery of controlled substances. The use of electronics allows the counting display to be large and highly visible making it suitable for patients of all conditions and ages. Electronics can also provide patient comfort features such as acoustic feedback and flashing displays to inform and warn. In addition electronics can allow self dosing of treatments such as breakthrough pain medication without direct healthcare professional supervision and can protect the patient with lockout systems that would prevent accidental overdosing and diversion with potent controlled substances for example. e-Lockout counts and displays the number of actuations and also prevents the device from being used for a period of time after a pre-defined number of actuations. Its locking system which warns of overdosing is recommended by regulators for nasal and sub-lingual spray delivery of controlled substances used in breakthrough pain management. In addition to counting and displaying the number of actuations and locking, some of the key features which can also be incorporated into e-Lockout include patient aids and feedback as well as data transmission. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 18 CHILD RESISTANCE AND PRODUCT PROTECTION According to the World Health Organization (WHO), in the European region, the third-leading cause of unintentional death in children through age 14 is acute poisoning. WHO estimates that 3,000 children in that age group die each year, and that 90% of those poisonings take place in the home. In its World Report on Child Injury Prevention, published in 2008 The WHO said that “Child resistant packaging is one of the best-documented successes in preventing the unintentional poisoning of children.” Data were cited for a number of affluent nations. In England and Wales for example, according to the WHO, unintentional poisoning deaths amongst children under the age of 10, fell from 151 per 100,000 in 1968 to 23 per 100,000 in 2000. Reliable child-proof packaging must however combine two contradictory needs: safety against unauthorized access by children and user-friendliness, especially for senior citizens. Child-resistant packaging is supposed to make drug access more difficult for children whereas senior-friendly packaging should facilitate the intake of medicines. The other feature packages for drugs must incorporate is product protection against moisture and gaz. This is usually achieved through a desiccant that prevents the medicine to degrade following the opening of the bottle. Desiccants may however saturate and become inefficient towards drug protection. Some companies have come up with solutions to overcome this drawback. 1.3 CHILD RESISTANCE Many prescription drugs still do not enjoy the protection of child resistant packaging. In the early 1970’s when child resistant packs first appeared, blister packs were uncommon. The converse is true today, as now more than 50% of prescription drugs are dispensed in easy open blister packs that represent a real danger of child poisoning. Progress has been made towards developing inexpensive and effective child resistant blister packs, and there is a European standard (EN 14375) against which to test them. As a packaging system for medicines and a range of other products the blister pack is excellent. Indeed, blister packs incorporate a perfect seal, preventing contact either with the atmosphere or with other products and permitting dispensing with no risk of contamination at the retail level. For blister packs, there is however a disagreement as to the definition of an opening. How many units need to be extracted before the pack is considered to be open? In the United States every medicine is accorded a ‘toxicity value’. So for some, a pack is considered open when one unit is extracted, whilst for others up to nine tablets need to be accessed before the pack is regarded as open. Here in the EU, there is not a common regulation for medicine packaging as for non-medicinal chemicals (EC 1272/2008). Therefore, whilst the standard setters have defined an opening for blister packs in EN14375(6) as ‘more than eight units’, the industry has developed products that exceed that standard. Thus far though, big pharma in the EU has only toyed with CR blisters and EU manufactured prescription drugs for the US market are often dispensed in containers with traditional CR closures. The trusted bottle and CR closure manufactured throughout the EU is inexpensive and very effective. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 19 Referred to as reclosable child resistant packaging CR containers comply with an international standard (ISO8317:2003) that tests their resistance to child opening and their ease of opening by adults. Children, 80% of a panel aged 42-51 months, must be unable to open the pack in ten minutes, even after a demonstration; and 90% of a panel of 50-70 year old adults must be abble to open and reclose the pack in one minute. At Pharmapack 2012, Heinlein Plastik-Technik (www.heinlein-plastik.de) presented closures combining the advantages of proof against tampering with child-resistance. The advantages of the closures suitable for syrup bottles include: - Screw cap and tamper-evident ring are manufactured in one part in a working cycle - Soft transitions and 60-fold riffle - Embossing on the lid possible (push+turn, etc.) - Dimensions according to market standards - Senior-friendly (easy handling) 1.3.1 Faudel & Co. Nachfolger: Child resistant blister pack Address Faubel & Co. Nachfolger GmbH Schwarzenberger Weg 45 34212 Melsungen Germany Phone: +49 5661 7309-0 www.faubel.de Contact Olof Malmgren Business Development Manager Phone: +49 5661 7309-125 Mobile: +49 173 8920759 info@faubel.de o.malmgren@faudel.de As one of the leading system suppliers of booklet labels, custom labels, mini brochures and package inserts, Faubel have specialized in meeting the needs of the pharmaceutical industry supplying multipurpose labels for clinical trials. Today’s most prominent example of their pioneering work is CRSF labels that are both child resistant and senior friendly. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 20 The Faubel-CRSF solution: The Faubel-CRSF solution is a complex safety element which can be applied like a label on the top face of a blister package under certain conditions. With its material and structure, this solution makes the sensitive top face and the thin strip film saliva-proof, bite- and tear-resistant. This multi-layer solution can be custom-designed on three pages. The adhesive used are certified food safe. Migration is no issue because the alufoil of the blister acts as a kind of barrier. The Faubel-CRSF solution can be adapted to the most varied blister shapes and sizes as well as to specific cavity properties. Three patents actually demonstrate how pioneering our solution is. The safety concept: The Faubel-CRSF labeling solution can be opened without extra tools. It consists of four different “obstacles” based on strength, dexterity, logical thinking (ability to read, to learn and interpret pictograms) and patience (owing to the complexity of this child-proof feature, children will struggle a long time trying to open the package, become frustrated and finally lose interest). Adding a six-barrier protection: To break open this child-resistant solution featuring six barrier levels, you have to be either pretty clever or struggle a long time before getting to the medicine. Of course, any averagely talented person will manage to open this solution within seconds. The barriers can be partly overcome intuitively. Besides, the Faubel solution leaves enough room for additional content in case further details or explanations are needed. After one or two tries, the opening function can switch to an automatic operation as we know it from the pushand- turn-safety closures of cleaning agents, for example. Opening is not exactly a child‘s play, but straightforward enough to allow convenient access to the medicines required in everyday life. Safety is achieved via three mechanical and three logical barrier levels. Mechanical barriers can be overcome with dexterity and/or strength. However, it can be assumed that children in the age group at risk (i.e. between 42 and 51 months in the draft standard) only possess limited fine motor skills and cannot use – or hardly – their physical strength in a systematic way. In contrast senior citizens (according to ISO 8317, healthy persons between 50 and 70 years of age) are very well capable of overcoming obstacles involving fine motor control and of using physical strength in a coordinated manner. The next three levels of the Faubel-CRSF solution are based on logic and can only be overcome by reading and/or by interpreting pictograms, and with experience. Children in the test age group were neither able read nor could they understand pictograms. Besides, prior experiences with the opening of tamper-proof or sealed products could not be assumed. Only senior citizens who were able to read could take part in the test. From experience, adults can decrypt pictograms. As a rule, experience and intuition are helpful when it comes to opening packages. As of January 2010 it is possible to manufacture test samples for blister packagings on a machine especially designed for that purpose. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 21 How it works: Fig. 1 First barrier level: A label layer where front and back can be customdesigned is being pulled up Fig. 2 The patented top face of the childproof protection does not look easy to open at first… Fig. 3 … it’s only by reading the pictograms that you’ll find an easier way to proceed. Fig. 4 After lifting the opening grip, the next obstacle appears. Pulling the grip straight up requires considerable strength. Fig. 5 Opening becomes easier by slighting twisting it to the right, as explained in the pictogram. Fig. 6 After the first layer is peeled off, the push-through layer becomes visible. Simply pushing through is virtually impossible, even with considerable strength. Fig. 7 Here again, a more convenient way to proceed is explained by texts or pictograms. Special pre-determined breaking points are provided for in the marked section (i.e. where “open“is). If the tablet is pressed against this particular spot, it can be fairly easily pushed through. Fig. 8 With the last barrier level, the protective alufoil is torn through and the tablet can be removed. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 22 → Faubel’s patent Title: SECURITY LABEL FOR PROTECTING MEDICAMENTS CONTAINED IN AN INDIVIDUAL PACKAGING Patent number: WO2011029423 Publication date: 2011-03-17 Abstract: The invention relates to a security label for protecting medicaments contained in an individual packaging, comprising a base layer (11, 111, 211) that can be stuck to the individual packaging (10, 110), at least one opening cut (26, 226) being formed in the base layer (11, 111, 211), in the region of the medicament (16) to be inserted. A security layer (10, 110) is stuck to the base layer (11, 111, 211), and removable elements (19) are formed in the security layer (10, 11) in the region of the medicaments (16) to be inserted, in such a way that cuts (18) are made in the security layer (10, 110) on the edge of the removable elements (19), said cuts (18) following a virtual cut strip. Furthermore, a means for reducing or eliminating the adhesive force of the adhesive of the security layer (10, 110) is applied to the base layer (11, 111, 211) in the region of the removable elements (19). © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 23 1.3.2 Burgopak Healthcare: Child resistant slider Address Burgopak Ltd. Thames House 18 Park Street London SE1 9EL UK http://burgopakhealthcare.com Contact Tim Bollans Sales & Marketing Assistant pharma@burgopak.com tim.bollans@burgopak.com Phone: +44 (0)20 7089 1950 Burgopak Healthcare offer Pharmaceutical Packaging, Healthcare Packaging, Compliance Packaging, Child Resistant Packaging and Medical Device Packaging that help companies to differentiate their products in the pharmaceutical and healthcare markets. Pharmapack ‘Child-Resistant’ 2012 Award went to Burgopak’s child-resistant slider which is an innovative new packaging development based on the original Burgopak design. The pack encourages compliance by keeping the product information leaflet, blistered product and outer carton permanently connected through the sliding mechanism. The innovative pack keeps the patient information, blister and outer carton conveniently connected at all times. Essential information is always clearly displayed whenever the product is used. The design is user friendly and portable, and allows for maximum opportunity in brand communication. The pack’s high structural integrity also extends its lifespan and ensures that the patient retains the entire pack intact at all times. This pack has won the top compliance packaging awards in the US and in Europe. The child-resistant pack’s functionality is based on a pressure point locking system. The blister and product information leaflet are exposed at opposite ends of the pack when the user simultaneously pushes on two tabs and slides the pack open. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 24 This award winning, patented pharmaceutical packaging is designed around a unique system that has been optimized for fully automated production. The Burgopak machine delivers production efficiency by combining core technologies in product handling, feeding and carton forming. The pack is produced on Burgopak’s fully automated machinery and can be supplied to global pharmaceutical and healthcare companies. Burgopak’s managing director Mark Symonds, said at Pharmapack 2012 that the child-resistant package is a big focus for them this year because Burgopak has currently got packaging machines in Menphis (USA) available for delivering the package to the market later this year. Designed and built by Bosch Packaging Systems in Switzerland, these innovative machines enable speedy, economic, high volume pharmaceutical & healthcare packaging production. The machines contain a number of patented processes for the assembly of the unique Burgopak slider pack. To date, Bosch have built two Burgopak machines with combined annual production capacity of 70 million packs. Designs can be adapted to meet all requirements, and customized to accommodate nearly any pill, blister or leaflet size. Burgopak currently offers single-blister, double-blister, dual-product blister, child-resistant and senior-friendly designs. Their latest child resistant packaging design successfully achieved the U.S. Consumer Product and Safety Commission’s F=1 child resistance and senior friendly effectiveness. This is in conformity with US regulatory standards for poison prevention packaging. This was achieved with impressive results: resistant effectiveness at a pass rate of 98% and senior adult use effectiveness at 95%. Unique and complex to make, Burgopak’s sliding mechanism discourages counterfeiting and piracy. State-of-the-art counterfeit features may also be incorporated. The mechanism and related features are protected by international patents. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 25 → Burgopak’s patents Title: IMPROVEMENTS TO PACKAGING Patent number: WO2007007094 Publication date: 2007-01-18 Abstract: A package comprising first and second tab members (14, 16) which lie substantially on the same plane as each other, and a means for driving the movement of one of the tab members, wherein the drive means comprises belt means (42; 42, 58) with which the first and second tab members (14, 16) co-operate such that when the first tab member (14) is moved in a first direction said second tab member (16) is caused to move in a second direction opposite to said first direction, said movement of the tab members being in a plane parallel to the plane on which the tab members (14, 16) lie. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 26 → Burgopak’s patents Title: IMPROVEMENTS TO PACKAGING Patent number: WO2007034227 Publication date: 2007-03-29 Abstract: A package comprising an open-ended sleeve (112), a tab member (130) movable in and out of the sleeve (112) through the open end, and a closure (134) movable in response to said movement of the tab member (130), the closure (134) being movable between a closed position in which the closure (134) substantially covers the open end when the tab member (130) is within the sleeve (112) and an open position in which the closure (134) allows the tab member (130) to protrude from the sleeve (112) through the open end, wherein the closure (134) is a web having opposed ends that at one end joins the sleeve (112) at a first hinge and at another end joins the tab member (130) at a second hinge such that relative movement of the second hinge with respect to the first hinge drives said movement of the closure. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 27 1.4 PRODUCT PROTECTION AND CLOSURES 1.4.1 LOG: New desiccant cap Address LOG Kibbutz Ashdot Ya’acov Ichud 15 155 Israël www.logpac.com Contact Shimshon Avrahami New Markets Manager Phone: +972 4 675 6475 Mobile: +972 50 310 9227 shimshon@log.co.il LOG Ltd. is a pharmaceutical packaging manufacturer founded in 1971 in Israel. Its subsidiary, LOG GmbH, established in central Germany started manufacturing in 2006. LOG has developed a new family of barrier bottles that increases stability throughout the life cycle of sensitive products. The innovative design offers protection for the new range of sensitive API and excipients being launched in the pharmaceutical market. LOG’s range of barrier bottles offers continuous protection against water and/or oxygen in changing environments and complies with FDA regulations. At Pharmapack 2012, LOG launched their latest new product: a desiccant cap that delays the activation of the desiccant until the initial opening of the bottle. Once the bottle is opened, the desiccant starts to absorb the moisture that penetrates with each opening. The benefits of the new desiccant cap include: higher formulation stability once the bottle is opened and less absorbents in the bottle. Patents have been filled, and UPS testing is planned. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 28 1.4.1 Süd-Chemie: Child-proof integrated desiccant closure Address Süd-Chemie AG Lenbachplatz 6 D-80333 Munich Germany www.s-cpp.com Contact Phone: +49 (0)89 5110 435 Süd-Chemie Performance Packaging (Clariant Group) manufactures a full range of controlled atmosphere packaging solutions including desiccants, container desiccants, equilibrium sorbents, adsorbent polymers, oxygen absorbers, humidity indicators and specialty containers and closures. The IDC eliminates packaging inefficiencies by providing an all-in-one solution and streamlines the packaging operation. The IDC streamlines the packaging operation. Indeed, since the IDC integrates the desiccant into the closure, it eliminates the equipment and processing time needed to insert a drop-in desiccant separately, as well as the quality checks needed to ensure a desiccant was placed in the bottle. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 29 At Pharmapack 2012, Süd-Chemie presented their very new cap. The new IDC integrated desiccant closure integrates tamper-evident, child-resistant and twist-off cap functionalities with a built in desiccant. Furthermore, the design of the cap and bottle and molding processes used in their production creates a seal that eliminates the need for an induction seal. IDC is available with a variety of desiccant fills depending on needed adsorption parameters. • Silica gel • Bentonite • Molecular sieve • Silica gel & molecular sieve combination • Activated carbon 1.4.1 ARaymondlife: Plastic closure for vials Address ARaymondlife Rue de la Louisiane 38 120 Saint-Egrève France www.araymond.com Contact Guillaume Belle Research&Development Manager Phone: +33 (0)4 56 52 54 49 Mobile: +33 (0)7 87 02 49 33 guillaume.belle@araymond.com ARaymondlife is a pharmaceutical company with expertise in injection, bi-injection and the integration of active substances in a polymer structure. This expertise enabled them to develop innovative solutions for pharmaceutical laboratories. They have developed a range of primary packaging items. RayDyLyo® ensures the closure of sterile vials and complies with regulatory developments, particularly with regard to aseptic and freeze-drying filling. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 30 RayDyLyo’s specifications: • Material : PP, PBT et PC • Different diameters: From 13-20-28 and 32 mm • Exists in TTO and CTO • Sterilization Gamma and Autoclave • Available with caps of different colors • Possible to personalize the cap with a logo or add a sticker, label on the cap Advantages include: • Answers to the new regulation of GMP, annexe 1, assuring vial content is sterile (germ and particle free) • Suppression of crimping (liquid and freeze-dried forms: simplification of the process and productivity gains) • Elimination of all risks of environmental contamination on the distribution lines • New and ergonomic design • Optimization of the efforts to remove the cap • Reduces the risks of deterioration of the gloves • Compatible with current assembly lines • Time-saving on freeze-drying operations, rubbing down and closing in situ • Eliminates the risk of having stoppers stuck on the plate of freeze dryer RayDyLyo is a 4 parts closure for which 2 patents have been filled. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 31 GLASS REPLACEMENT A recurring market demand for pharmaceutical packaging and dispensing systems is the search for an alternative to glass packaging, which represents a significant risk of breakage. Some polymers have been developed that do provide a real alternative as these plastics are more resistant to breakage than glass and have high transparency. Furthermore they are lighter that glass and therefore provide a solution that may in some cases have a lower impact on the environment than their glass counterparts. Amongst these synthetic materials, Topas’ COC has been used for some years now for pharmaceutical applications, and glass provider Schott has been offering COC prefilled syringes for more than a decade in addition to their traditional range of glass syringes. But other types of resins, not necessarily transparent, are also trying to get a share of the glass replacement market. 1.5 COC FROM TOPAS Address Topas Advanced Polymers GmbH Paulistrasse 3 65929 Frankfurt Germany www.topas.com Contact Oliver Scuck Phone: +49 (0)69 305 46761 Mobile: +49 (0)172 6525 971 oliver.schuck@topas.com TOPAS Advanced Polymers manufactures and markets COC (cyclic olefin copolymer) for advanced packaging, medical, optical and other applications worldwide. The company is a joint venture of Daicel Chemical Industries Ltd., and Polyplastics Co., Ltd. Headquartered in Frankfurt, Germany. It operates a U.S. subsidiary in Florence (Kentucky, USA) and a 30,000 metric ton per year plant, the world’s largest, in Oberhausen (Germany). TOPAS Advanced Polymers was launched January 1, 2006 following the purchase of the TOPAS business from Ticona, a subsidiary of Celanese Corporation. COC was developed in the early 1990s by Hoechst AG. Hoechst created a new COC process in which norbornene is synthesized from dicyclopentadiene and ethylene. A second step copolymerises norbornene with ethylene by metallocene catalysis to generate cyclic olefin copolymer. The Topas COC family, in contrast to the partially crystalline polyolefins PE and PP, consists of amorphous transparent copolymers with the following properties:  High clarity, light & UV transmission  Good thermoforming  High rigidity & strength  Resistant to acids, alkalis, polar organics  Outstanding moisture barrier  Excellent dielectric & insulation properties  Heat distortion temp up to 170°C  Low birefringence  Exceptional purity & biocompatibility  Low moisture absorption  Global regulatory compliance © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 32 Topas COC resins are suitable for the production of transparent moldings for use in optical data storage, optics, e.g. lenses, sensors, and industrial products e. g. in the construction and lighting sectors. These materials are also of particular interest for primary packaging of pharmaceuticals, medical devices and diagnostic disposables. (Co)-extruded films made from COC offer opportunities in blister packaging, shrink sleeves, shrink films and stand-up pouches. New applications have been developed for blends of Topas COC, with a variety of polyolefins. The physical property values of Topas COC are given in the table below. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 33 1.5.1 Schott: Prefillable COC syringes Address SCHOTT France SAS 6 bis rue Fournier 92110 Clichy France www.schott.com/pharmaceutical_systems Contact Michele Moncelet Sales manager France Phone: +33(0)1 4087-3900 michele.moncelet@schott.com pharmaceutical_packaging@schott.com Schott, pioneer of the glass syringes, completed its portfolio by launching more than 10 years ago syringes made from COC. Schott ready-to-fill syringes are break resistant, light weight, and transparent with a glass-like appearance. SCHOTT TopPac® syringes are available from 1 ml to 50 ml. TopPac syringes show excellent barrier properties, no ion or heavy metal release, and a lower particle level than glass. The high moisture barrier enables the longterm storage of drugs – even in small containers. Terminal sterilization (autoclaving) after filling is possible. The integrated luer lock of TopPac syringes offers superior robustness and ease of application for the final user. High design flexibility allows customized solutions. TopPac syringes are packed in nests and tubs, like glass syringes. They can be processed on all common syringe filling lines. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 34 1.5.2 Promens: ClearVial made from COC Address Promens Packaging 5 rue Castellion Bellignat 01117 Oyonnax Cedex France www.packaging.promens.com Contact Bernadette Raphanel Healthcare Manager Personal & Healthcare Phone: +33 (0)4 74 81 74 81 bernadette.raphanel@promens.com With nearly 50 years’ experience in the design, development and manufacturing of specialty plastics components for the healthcare and pharmaceutical industries, Promens offers expert solutions for primary packaging and medical devices. At Pharmapack 2012, PromensMedical Packaging launched a full range of transparent vials made of COC (Cyclic Olefin Copolymer) called ClearVial. COC is a polymer that is used in applications requiring glass-like clarity for medical packaging and devices. Compared to glass, COC is said to be a CO2 friendly material to produce and to dispose of. Furthermore, with half the weight of a glass vial, ClearVial is easier on transportation costs as well as the environment. ClearVial is an economical packaging solution that makes a difference to the production costs as well as to the green accounts of pharmaceutical companies. ClearVial can be delivered irradiated to be used straight in the filling line with no need for pre-wash, drying and sterilization. The savings in terms of water and electricity are therefore quite considerable. ClearVial comes in a standard range of 5 ml, 10 ml, 20 ml, 50 ml, and 100 ml and is also available in an amber dyed version for light protection. In cases where a standard format is not applicable, Promens offer customized solutions as well as high flexibility with order sizes, special packing requirements and delivery. 1.6 OTHER RESINS AND ADDITIVES 1.6.1 Eskiss: Polypropylene Unicadose vial Address Eskiss Packaging Parc Naturopole Les Tiolans 03800 Saint-Bonnet-de-Rochefort France www.eskisspackaging.eu © VIEDOC - Pour tout renseignement : contact@veillesalon.com Contact Jacques Chicoisne Sales Manager Personal & Healthcare Mobile: +33 (0)6 33 96 41 26 contact@eskiss.eu
  • P a g e | 35 Eskiss Packaging is a French company specialized in plastic packaging for the pharmaceutical industry. Their offer include HDPE and PET pill jars; PET bottles, closures and accessories; and glass bottles, glass dropper bottles, and closures and accessories. The focus of Eskiss booth at Pharmapack 2012 was Unicadose, which is a patented polypropylene vial invented and developed by Victor Palusci in 2007. The first patents were filed in 2008, quickly followed by validation of the filling machines. Today there are several million of Unicadose sold in Europe, to the food supplements and drugstore markets. In 2011, Eskiss Packaging extended its plant of 2000 m2 to reach 4500 m2 and invested in two injection presses and one complete and special line for Unicadose. These investments have allowed the company to double its production capacity that is now able to produce 90 million units per year. Unicadose is available in 10ml and 15ml and a 5ml version is currently under development. The advantages of Unicadose are : • No more glass fragments • Unbreakable • Nomad • Sterilizable • Clean filling (addition of neutral gas, possibility of conservatives absence) • Hot filling • Color code: no more risks of medical confusion • Easy opening Unicadose presents environmental advantages over glass vials as the production and the transport of plastics vials produce less than 2.6 of CO2 than glass vials (source : ACV Bio Intelligence Service 2008). Lost plastics trays are recyclable and freight is optimized (reduction weight and space). Furthermore, Unicadose has been designed to be easily transferable on the filling lines of bi-pointed glass vials. This is to enable manufacturers to switch almost instantly from one product to another. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 36 And Unicadose does not limit itself to proven concept of breakable single-dose oral vial, but is already the subject of several derivatives to meet customer expectations: two-phase, with hair applicator, cosmetic, dermatological, ophthalmologic ... Since January 2012 Top Clean Packaging has become the exclusive partner of Eskiss Packaging to manufacture in clean room the single-dose vial Unicadose. In a press release dated January 2012, it was said that « this vial is likely to upset over the coming months the single-dose world used by the pharmaceutical industry because of its final patient's security, economic and environmental performances. » “The feedback is very positive because the product meets two major AFSSAPS requirements to ensure patient safety in single doses vials: allow easy opening without emitting harmful particles and allow easy and instant content identification. Unicadose is admirably suited to customization because its very flexible process offers a wide range of possible colors and prints, in order to avoid any confusion.” → Eskiss’s patent Title: Plastic vial for receiving predetermined amount of product in e.g. liquid form in pharmacy field, has cap with centering face, and sealed sectile zone comprising notches to provide scalability in closing position Patent number: FR2961182 Publication date: 2011-12-16 Abstract: The vial (1) has a cap with a centering face that is intended to be forcedly fixed in an opening of the vial by pressure exerted on a closed end (2b). The closed end and the centering face are connected by a sealed sectile zone (2c) to permit breaking of the closed end manually to permit free access to the vial for sampling a product. The sectile zone has notches (2c1) to provide scalability in closing position. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 37 Title: Method and device for filling several vials intended to receive a specified dose of a product Patent number: EP2192042 Publication date: 2010-06-02 Abstract: The method involves arranging a plate (3) equipped with vials (1) in a sealed enclosure (5), and emptying the interior of the enclosure for sucking caps (2). The caps positioned in complementary tracks of a drawer (6) mounted at the interior of the enclosure are maintained with displacement capacity. The enclosure and the drawer are displaced with the caps for providing free access to the vials. The vials are filled with a product. The drawer is repositioned with the caps above the vials. A pushing effort is exerted on the drawer for tilting the caps in the filled vials. 1.6.2 MGC: New amorphous polyester pellets for medical bottles Address MGC 5-2, Marunouchi 2-chome Chiyoda-ku 100-8324 Tokyo Japan www.mgc.co.jp Contact Tomohiro Suzuki Marketing & Sales Manager Phone: +81 3 3283 4912 tomohiro-suzuki@mgc.co.jp © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 38 Mitsubishi Gas Chemical (MGC) is one of the companies of the Mitsubishi Group. They have been manufacturing basic chemicals, advanced materials and oxygen absorber for many years. At Pharmapack 2012, MGC presented their new amorphous polyester for medical plastic containers, whose main features are:  oxygen permeability approximately 2 times lower than PET and 40 times mower than COC ;  water vapor permeability approximately 3 times lower than PET ;  protein adsorbability approximately 4 times lower than COC ;  high transparency ;  compatibility with various sterilization processes, easy processing… © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 39 M. Suzuki told us that a line up will soon be available for the production of T-Ester pellets and that MGC are currently developing multilayer containers with greater oxygen and water vapor barrier and low protein adsorbability, as a replacement for glass ampoules, vials and prefillable syringes. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 40 CONCLUSION Patient’s compliance, child-resistance and glass replacement were dominating trends that VeilleSalon will remember from this year’s edition Pharmapack Europe. Patient’s compliance is a complex issue and a central one for the pharmaceutical industry and health authorities. Patient-related problems can impact dramatically the efficacy of treatments and complex handling can trigger bad administration of the drugs. Inconvenient and difficult to use packages may induce the patient to neglect his or her treatment. Patient’s compliance is therefore driving the need for pharmaceutical companies to have more multifunctional, user-friendly packages that provide the consumer with a variety of functions without being too complex or cumbersome. At Pharmapack 2012, we have seen many companies presenting more convenient and easy-of-use packages for greater efficiency and accuracy of drug delivery. These included pipette with a variably lockable dosing volume, dosing cap for tubes with an integrated quantity regulator, vaginal ovule dispenser, single pill dispenser… We have also seen the emergence of electronic packaging. Smart device containing packaging helps patients monitor their treatment and gives them information like when to take their medication, when they last took their medicine, how much is left in the bottle… Smart devices may also prevent overdosing by preventing the package from being used for a period of time after a pre-defined number of actuations. Child resistant packaging was another major topic at this year’s event, and Burgopak Company received the 2012 Award for their child-resistant slider pack. Some companies now offer desiccant caps aimed at providing greater product protection against gas and moisture. As new desiccant caps delay the activation of the desiccant until the initial opening of the bottle, desiccant compounds stay active and protect the drug for longer. These caps may further include features such as child-resistance or tamper evidence. Finally, glass which has always been the material of choice for pharmaceuticals because of its inertness and transparency is more and more challenged by plastics. High performance polymers such as COC are a real alternative for bottles, vials and syringes when transparency is a prerequisite. Opaque polypropylene on the other hand may also be a material of choice for formulations that do not require high performance material, and where lighter and safer solutions are sought. Just like we have over the past two decades switched from mineral to safer and lighter organic glass for spectacles, plastic alternatives are now making their way towards replacing glass containers for pharmaceutical products. Next edition of Pharmapack Europe will take place on 13&14 February 2013 in Paris. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 41 A PROPOS DE VEILLE SALON Lancé officiellement depuis le début de l’année 2010 par la société de veille et d’intelligence économique VIEDOC Consulting, VeilleSalon.com est le premier service professionnel de veille salon destiné aux entreprises et s’appuie sur un des plus importants annuaires mondiaux des salons, colloques et autres événements internationaux. Ce nouveau service professionnel est destiné aussi bien aux visiteurs / entreprises, aux exposants qu’aux organisateurs de salons. A travers un annuaire bilingue, c’est plus de 7500 salons et évènements internationaux portant sur la plupart des secteurs industriels et tertiaires ainsi que les métiers de l’entreprise comme par exemple: Aéronautique, Agriculture, Agroalimentaire, Automobile, Matériaux, Bâtiment, Biens de consommations, Cosmétique, Electronique, Défense, Energie, Optique, Pharmaceutique, Télécommunications… pour les secteurs industriels ; Banque/assurance, Hôtellerie, Immobilier, Médias/publicités, Services à la personne, Tourisme… pour les secteurs tertiaires ; Chimie, Design/architecture, Distribution, Emballage, Enseignement/formation, Hygiène & environnement, Informatique, Innovation, Maintenance, Mécanique, Qualité, Ressources humaines… pour les métiers Outre des fonctionnalités puissantes de recherches multicritères (dates, lieux, mots-clés, secteurs, organisateurs, exposants...), le site VeilleSalon.com propose également aux visiteurs de bénéficier d'un agenda interactif et personnalisable des salons à venir, d’une newsletter mensuelle, d’un forum et bien d'autres services encore. Pour les futurs exposants et les organisateurs d’événements, le site VeilleSalon.com constitue un véritable outil de communication : inscription des nouveaux événements, présentation de votre société et de son actualité (innovations produits/process, nouveaux services), mise à disposition gratuite ou payante des proceedings de conférence sur notre espace dédiée, informations des visiteurs en temps réel… C’est également un lieu d’échange où les visiteurs peuvent prendre directement contact avec vous pour préparer au mieux leur visite et obtenir des renseignements complémentaires sur votre société. Pourquoi proposer un service professionnel de veille salon ? La veille salon est idéale pour l'identification et l’analyse de la concurrence, des fournisseurs, de nouveaux produits, équipements, services, pour détecter des transferts technologiques et des innovations, réaliser une prospection commerciale avec de nouveaux clients potentiels et optimiser sa connaissance d'un marché et de ses évolutions. C’est pourquoi l’équipe de VEILLESALON, au travers des ingénieurs consultants expérimentés et aguerris aux techniques de veille de la société VIEDOC Consulting vous propose un ensemble de prestations dans ce domaine : réalisation de veille salon en France comme à l’étranger, accompagnement individuel sur les lieux d’événements, réalisation d’enquête et d’interviews à la demande, formation de vos effectifs… Ainsi, que vous soyez une entreprise soucieuse d’optimiser sa veille salon, un futur exposant ou un organisateur d’événements, nous avons développé des solutions sur mesure susceptibles de répondre à vos attentes. Pour accéder à notre site : http://www.veillesalon.com. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 42 PRÉSENTATION DE VIEDOC SARL VIEDOC est une société au cœur de l’information. Elle constitue un véritable partenaire des entreprises de la stratégie à l’opérationnel. VIEDOC a pour vocation d’aider ses clients dans les phases amont de leurs activités (intelligence économique, knowledge management, analyse de la concurrence, veille technologique, étude de marché, veille brevets, benchmarking, transferts technologiques, état de l’art…) et couvre ainsi l’ensemble des métiers liés à la recherche et à l’analyse d’informations utiles à l’entreprises Ces métiers ne nécessitent pas impérativement des compétences permanentes dans l'entreprise. Mais, ils imposent une présence pertinente au bon moment dans son cycle de vie. VIEDOC intervient donc pour ses clients sur des durées longues et également plus courtes lorsqu'il s'agit de mettre en œuvre son expérience pour aider à la décision. VIEDOC conseille ainsi des entreprises de tous secteurs d'activité (automobile, aéronautique et défense, agroalimentaire, cosmétique, santé, matériaux, optique, packaging, télécommunications...). De part ses activités, VIEDOC peut donc aider toute entreprise ambitieuse et consciente de l'importance d'investir à ce niveau : de la PME ultra innovante avide de conseils stratégiques dans des jalons très serrés, aux grands groupes industriels soucieux de garder leur position de leadership. Méthodologie : Notre démarche se veut pragmatique et construite sur une méthodologie rigoureuse reprenant l'analyse des enjeux, la collecte, le traitement, l’analyse et la diffusion d’informations à forte valeur ajoutée. A travers une expérience multisectorielle, VIEDOC met à la disposition de ses clients sa capacité à assurer des prestations parfaitement adaptées à leurs besoins en étant à la fois à l'écoute de leurs préoccupations et disponible pour s'adapter à leurs contraintes et à leurs méthodes. Pour accompagner ses clients avec succès dans les différentes étapes du cycle de vie de leur entreprise (de la création à la reprise), de leurs produits (de la conception à la vente) ou de leurs projets (de la première étude à l’achèvement du projet), VIEDOC intervient aussi bien sur l’innovation produit que process et gère à la fois des informations techniques et économiques. Spécialistes de la recherche et de l’analyse d’information à forte valeur ajoutée, nous mettons à contribution notre expérience, nos méthodologies et notre capacité d’analyse pour vous fournir des informations qualifiées et validées de haute qualité. Experts dans l’identification des transferts technologiques, nous avons de cesse de cultiver notre vision multisectorielle en apportant notre professionnalisme et notre savoir faire à de nombreux clients, grands groupes industriels et PME/PMI, issus d’une dizaine de secteurs d’activités distincts. C'est cette expérience qui permet, aujourd'hui, de mettre à la disposition de ses clients, une analyse pertinente ne négligeant aucune des implications techniques, économiques, juridiques ou humaines de leurs travaux et ce, dans le respect total des règles de déontologie qui guident l’ensemble des activités de la société VIEDOC. © VIEDOC - Pour tout renseignement : contact@veillesalon.com
  • P a g e | 43 www.veillesalon.com Un service proposé par : VIEDOC SARL 2 rue Hélène Boucher 78280 Guyancourt (France) Tél : +33 (0)1 30 45 43 27 Email : info@viedoc.biz Site : www.viedoc.fr © VIEDOC - Pour tout renseignement : contact@veillesalon.com