BONE CEMENT
• Polymethylmethacrylate remains one of the
most enduring materials in orthopaedic
surgery.
• It has a central role in the...
• The major breakthrough in the use of PMMA
in total hip replacement (THR) was the work of
Charnley
• In 1970 who used it ...
INDICATIONS
• Joint Replacement Surgery
• Spinal Compression Fractures
• Chronic Osteomyelitis
• Tumours
IN ARTHROPLASTY
• Allows secure fixation of implant to bone
• It’s not glue – has no adhesive properties
• Mechanical inte...
MECHANICAL PROPERTIES
• Poor tensile strength of 25 Mpa
• Moderate shear strength of 40 Mpa
• Strongest in compression of ...
Viscoelasticity
• Materials properties vary with rate of
loading
• Behaves like both fluid and solid
• examples – ligament...
1. Creep
• Time-dependent deformation under constant
load (also known as plastic deformation)
• Creep rate reduces with ti...
2. Stress relaxation
• The change in stress / force with time under
constant strain (deformation) caused by a
change in th...
3. Hysteresis
• The loading and un loading curves are not
identical.
• Not all the energy applied to the specimen
during l...
STERILISATION
• Gamma radiation shortens the polymer
chains, probably affecting many mechanical
properties,
• but this doe...
COMPOSITION
Polymerization process (curing)
• carbon-to-carbon double bonds broken
• new carbon single bonds form
• Linear long-chain ...
• Initiator BPO + Activator DMpT = free radicals
• Results in growing polymer chain
• When two growing polymer chains meet...
• Initiator BPO + Activator DMpT = free radicals
• Results in growing polymer chain
• When two growing polymer chains meet...
PHASES
Mixing Phase
• Starts with the addition of the liquid to the
powder and ends when the dough is
homogenous and stirring bec...
Waiting Phase
• Allows further swelling of the beads and to permit
polymerization to proceed.
• This leads to an increase ...
Working Phase
• The cement is no longer sticky, but is of sufficiently low viscosity to
enable the surgeon to apply the ce...
Hardening or Setting phase
• The polymerization stops and the cement
cures to a hard consistency.
• The temperature of the...
Curing process time periods
• Dough time: mixing >> non sticky
(approximately 2-3 minutes)
• Working time: difference betw...
typical curing curve for acrylic bone cement where Tmax is the
maximum temperature reached, Tset is the setting temperatur...
• However, the rates of curing are very sensitive
to environmental factors.
• Low ambient temperatures during storing and
...
Heat production during
polymerisation
• The polymerisation of PMMA is exothermic.
• Can lead to thermal damage to bone.
• ...
• In vitro studies have shown that the
production of heat is increased by-
1. thicker cement mantles,
2. higher ambient te...
Factors that Affect Bone Cement
Preparation
• The ambient temperature - higher the temperature, the shorter
the phase and ...
Cementing techniques
• First generation
• Original technique of Charnley:
• Hand mixing of the cement
• Finger packing of ...
Second generation
• Femoral canal plug
• Cement gun to allow retrograde filling
• Pulsatile lavage
• Cement restrictor
Third generation
• Pressurization of cement after insertion
• Some form of cement porosity reduction
(vacuum or centrifuga...
Cartridge mixing and delivery
• Latest advancement in bone cement mixing
technique
• It is a simple, universal power mixer...
Antibiotics & Bone Cement
• Ideal antibiotic properties
1. Preparation must be thermally stable
2. Antibiotic properties n...
• Gentamycin (most common) and tobramycin
are commonly used
• Vancomycin and ciprofloxacin are also tried
• Ciprofloxacin ...
• Vancomycin p (ultrafine powder) is used as
lyophilised vancomycin greatly reduces fatigue
strength
• > 4.5 g gentamycin ...
• Vacuum mixing increases fatigue strength
• ↑ed surface area leds to ↑ed drug elution
Antibiotic may be used in low doses or
high doses
 Low dose
• Antibiotic content is 0.5 – 1 gm per 40 gm of
cement
• Used...
HIGH DOSE
• Contains > 3.6 gm of antibiotic per 40 gm of
cement
• Used in
1. Spacers and beads
2. Second stage of two stag...
The Dangers
• Hypotension
• cardiac arrest
• cerebrovascular accident
• pulmonary embolus
• hypersensitivity reactions
BCIS
(bone cement implantation syndrome)
• BCIS is characterized by hypoxia, hypotension
or both and/or unexpected loss of...
• it is characterized by a number of clinical
features that may include-
• hypoxia,
• hypotension,
• cardiac arrhythmias,
...
Proposed severity classification of bone
cement implantation syndrome
• Grade 1: moderate hypoxia (SpO2-94%) or
hypotensio...
ETIOLOGY
• Several hypothesis
1. Monomer absorption into circulation – but
very low levels of MMA in circulation are
found...
2. Embolisation
• Embolization occurs as a result of high
intramedullary pressures developing during
cementation and prost...
• Embolic showers have been detected using
echocardiography in the right atrium, RV, and
pulmonary artery during surgery.
...
Pulmonary vessel with embolus comprising fat, platelets, fibrin, and marrow
debris. (1) Reflex vasoconstriction and endoth...
the increased Pulmonary Vascular Resistance
↓
reduced right-ventricular ejection fraction
↓
the compliant right ventricle ...
• When cement is inserted into the femur using
a cement gun, the pressures generated are
almost double those seen when man...
• It has been demonstrated that this debris
includes-
• fat,
• marrow,
• cement particles,
• air,
• bone particles,
• and ...
3.Histamine release and
hypersensitivity
• Anaphylaxis (Type 1 hypersensitivity) was
implicated as a potential cause for a...
4.Complement activation
• The anaphylatoxins C3a and C5a are potent
mediators of vasoconstriction and
bronchoconstriction....
Multimodal model
• It is likely that a combination of the above
processes is present in any individual patient
who develop...
Patient risk factors
Numerous patient-related risk factors have been
implicated in the genesis of BCIS, which are :-
1. o...
• These latter three factors are associated with
increased or abnormal vascular channels
through which marrow contents can...
Surgical risk factors
• Patients with a previously un-instrumented femoral
canal may be at higher risk of developing the s...
Anaesthetic risk reduction
• In high risk cases discussion should occur
between the surgeon and anaesthetist
regarding the...
• Increasing the inspired oxygen concentration
should be considered in all patients at the
time of cementation.
• Avoiding...
• The use of an intraoperative pulmonary artery
catheter or trans oesophageal
echocardiography has been suggested in high
...
Surgical risk reduction
• Medullary lavage,
• good haemostasis before cement insertion,
• minimizing the length of the pro...
• Venting the bone permits the air to escape
from the end of the cement plug and reduces
the risk of an air embolus.
• Can...
• If cement is used, insertion with a cement gun
and retrograde insertion have been suggested as
ways of reducing the inci...
• Vacuum mixing of cement reduces mortality
due to BCIS.
• reduction of the prosthetic femoral head is
also a time of increased risk because
previously occluded vessels are re-ope...
Management
• Early signs of BCIS in the awake patient
undergoing regional anaesthesia include
dyspnoea and altered sensori...
• Haemodynamic instability should be treated
with the potential aetiology in mind.
• Sympathetic a1 agonists should be fir...
Calcium Phosphate Cement
• Mainly used as bone graft substitute
• Is capable of hardening into calcium deficient hydroxyap...
USES
• Bone replacement ( instead of bone grafts) e.
g. osteoporotic bone, bone loss due to trauma
or tumor surgery, kypho...
Calcium Phosphate
•Injectable
•Very high compressive strength once
hardens
•Some studies of its use have allowed
earlier w...
Tricalcium Phosphate
• Wet compressive strength slightly less than
cancellous bone
• Available as blocks, wedges, and gran...
Fracture Fixation
Bioactivity analysis
• The liquid and powder (ratio of 0.34ml/g) undergoes a solid-
state reaction at 370 C forming silico...
THANK YOU
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  • As noted, bone cement is an acrylic, and it is similar to other plastics, in that it undergoes relaxation over time. All bone cements creep to some degree;
  • Dough time: starts from beginning of mixing and ends at the point when the cement will not stick to unpowdered surgical gloves. This occurs approximately 2-3 minutes after the beginning of mixing for most PMMA cements. ●●Working time: this is the time from the end of dough time until the cement is too stiff to manipulate, usually about 5-8 minutes. ●●Setting time: from the beginning of mixing until the time at which the exothermic reaction heats the cement to a temperature that is exactly halfway between the ambient and maximum temperature (i.e., 50% of its maximum value) and is the dough + working times; usually about 8-10 minutes.
  • Mixing Phase. The mixing phase starts with the addition of the liquid to the powder and ends when the dough is homogenous and stirring becomes effortless. When the liquid and powder components of the cement are mixed together, the liquid wets the surface of the prepolymerized powder. Because PMMA is a polymer that dissolves in its monomer (which is not the case for all polymers), the prepolymerized beads swell and some of them dissolve completely during mixing. This dissolution results in a substantial increase in the viscosity of the mixture; however, at this stage the viscosity is still relatively low, compared with the later phases of polymerization. At the end of the mixing phase, the mixture is a homogenous mass and the cement is sticky and has a consistency similar to toothpaste. ●●Waiting Phase. The mixing phase is followed by a waiting period to allow further swelling of the beads and to permit polymerization to proceed. This leads to an increase in the viscosity of the mixture. During this phase, the cement turns into sticky dough. This dough is subsequently tested with gloved fingers every 5 seconds, using a different part of the glove on another part of the cement surface on each testing occasion. This process provides an indication of the end of the waiting phase when the cement is neither “sticky” nor “hairy.” ●●Working Phase. The beginning of the working phase occurs when the cement is no longer sticky, but is of sufficiently low viscosity to enable the surgeon to apply the cement. During this period, polymerization continues and the viscosity continues to increase; in addition, the reaction exotherm associated with polymerization leads to the generation of heat in the cement. In turn, this heat causes thermal expansion of the cement, while there is a competing volumetric shrinkage of the cement as the monomer converts to the denser polymer. During the working phase, the viscosity of the cement must be closely monitored because with a very low viscosity, the cement would not be able to withstand bleeding pressure. This would result in blood lamination in the cement, which causes the cement to weaken. This phase is completed when the cement does not join without folds during continuous kneading by hand; at this point, an implant can no longer be inserted (Figure 2). Therefore, the prosthesis must be implanted before the end of the working phase.
  • Bone cement.pptx 2 its science and cementing technique and safe surgical use

    1. 1. BONE CEMENT
    2. 2. • Polymethylmethacrylate remains one of the most enduring materials in orthopaedic surgery. • It has a central role in the success of total joint replacement and is also used in newer techniques such as percutaneous vertebroplasty and kyphoplasty (tricalcium phosphate).
    3. 3. • The major breakthrough in the use of PMMA in total hip replacement (THR) was the work of Charnley • In 1970 who used it to secure fixation of the acetabular and femoral component and to transfer loads to bone.
    4. 4. INDICATIONS • Joint Replacement Surgery • Spinal Compression Fractures • Chronic Osteomyelitis • Tumours
    5. 5. IN ARTHROPLASTY • Allows secure fixation of implant to bone • It’s not glue – has no adhesive properties • Mechanical interlock and space filling • Load transferring material (from the component into bone) • Maintenance/restoration of bone stock
    6. 6. MECHANICAL PROPERTIES • Poor tensile strength of 25 Mpa • Moderate shear strength of 40 Mpa • Strongest in compression of 90 Mpa • Brittle, notch sensitive • Low Young’s modulus of elasticity (E) =2400 Mpa • Viscoelastic
    7. 7. Viscoelasticity • Materials properties vary with rate of loading • Behaves like both fluid and solid • examples – ligaments and cartilage • Viscoelastic material has three main characteristics viz. creep, relaxation and hysteresis
    8. 8. 1. Creep • Time-dependent deformation under constant load (also known as plastic deformation) • Creep rate reduces with time • load of daytime activities causes creep • Creep, essentially is a mechanical problem that slowly and steadily can erode the long-term performance of an implant. • Cements with higher porosity and viscosity are less resistant to creep deformation.
    9. 9. 2. Stress relaxation • The change in stress / force with time under constant strain (deformation) caused by a change in the structure of the cement polymer • at night reduced load allows stress relaxation
    10. 10. 3. Hysteresis • The loading and un loading curves are not identical. • Not all the energy applied to the specimen during loading is recovered on unloading.
    11. 11. STERILISATION • Gamma radiation shortens the polymer chains, probably affecting many mechanical properties, • but this does not occur with ethylene oxide sterilisation
    12. 12. COMPOSITION
    13. 13. Polymerization process (curing) • carbon-to-carbon double bonds broken • new carbon single bonds form • Linear long-chain polymers • free of cross-linking • volume shrinkage (7%)
    14. 14. • Initiator BPO + Activator DMpT = free radicals • Results in growing polymer chain • When two growing polymer chains meet the chains are terminated
    15. 15. • Initiator BPO + Activator DMpT = free radicals • Results in growing polymer chain • When two growing polymer chains meet the chains are terminated
    16. 16. PHASES
    17. 17. Mixing Phase • Starts with the addition of the liquid to the powder and ends when the dough is homogenous and stirring becomes effortless. • The liquid wets the surface of the prepolymerized powder. • Because PMMA is a polymer that dissolves in its monomer (which is not the case for all polymers), the prepolymerized beads swell and some of them dissolve completely during mixing. • At the end of the mixing phase, the mixture is a homogenous mass and the cement is sticky and has a consistency similar to toothpaste.
    18. 18. Waiting Phase • Allows further swelling of the beads and to permit polymerization to proceed. • This leads to an increase in the viscosity of the mixture. • The cement turns into sticky dough. • This dough is subsequently tested with gloved fingers every 5 seconds, using a different part of the glove on another part of the cement surface on each testing occasion. • This process provides an indication of the end of the waiting phase when the cement is neither “sticky” nor “hairy.”
    19. 19. Working Phase • The cement is no longer sticky, but is of sufficiently low viscosity to enable the surgeon to apply the cement. • Polymerization continues and the viscosity continues to increase; • Heat of polymerization causes thermal expansion of the cement, while there is a competing volumetric shrinkage of the cement as the monomer converts to the denser polymer. • With a very low viscosity, the cement would not be able to withstand bleeding pressure. This would result in blood lamination in the cement, which causes the cement to weaken. • This phase is completed when the cement does not join without folds during continuous kneading by hand; • Therefore, the prosthesis must be implanted before the end of the working phase.
    20. 20. Hardening or Setting phase • The polymerization stops and the cement cures to a hard consistency. • The temperature of the cement continues to be elevated, but then slowly decreases to body temperature. • During this phase, the cement continues to undergo both volumetric and thermal shrinkage as it cools to body temperature.
    21. 21. Curing process time periods • Dough time: mixing >> non sticky (approximately 2-3 minutes) • Working time: difference between dough time and setting time (end of dough time until the cement is too stiff to manipulate, usually about 5-8 minutes) • Setting time: mixing >> surface temperature is half maximum (usually about 8-10 minutes)
    22. 22. typical curing curve for acrylic bone cement where Tmax is the maximum temperature reached, Tset is the setting temperature and Tamb is the ambient temperature.
    23. 23. • However, the rates of curing are very sensitive to environmental factors. • Low ambient temperatures during storing and mixing, and high humidity both prolong setting time.
    24. 24. Heat production during polymerisation • The polymerisation of PMMA is exothermic. • Can lead to thermal damage to bone. • Recorded temperatures range between 70°C and 120°C.
    25. 25. • In vitro studies have shown that the production of heat is increased by- 1. thicker cement mantles, 2. higher ambient temperatures and 3. an increased ratio of monomer to polymer. • Increases in room temperature shorten both the dough and setting times by 5% / degree centigrade
    26. 26. Factors that Affect Bone Cement Preparation • The ambient temperature - higher the temperature, the shorter the phase and the colder the temperature, the longer the phases. • The mixing process - Mixing cement too quickly or too aggressively can hasten the polymerization reaction resulting in a reduced setting time. • In general, the lower the heat of polymerization, the longer the setting time, and the greater the heat of polymerization, the shorter the setting time. • The powder to liquid ratio - If more liquid, or less powder, than required is used, setting time will be prolonged; - on the other hand, if less liquid, or more powder is used, setting time will be shortened
    27. 27. Cementing techniques • First generation • Original technique of Charnley: • Hand mixing of the cement • Finger packing of cement in an unplugged and uncleaned femoral canal and acetabulum • No cement restrictor, no cement gun and no reduction in porosity
    28. 28. Second generation • Femoral canal plug • Cement gun to allow retrograde filling • Pulsatile lavage • Cement restrictor
    29. 29. Third generation • Pressurization of cement after insertion • Some form of cement porosity reduction (vacuum or centrifugation) • Stem centraliser
    30. 30. Cartridge mixing and delivery • Latest advancement in bone cement mixing technique • It is a simple, universal power mixer that quickly mixes and then mechanically injects all types of bone cement. • This type of device reduces mix times, as it requires fewer steps to load, mix, and transfer the cement. • The rotary hand piece reduces variability, which results in consistent mix times and built-in charcoal filter reduces harmful fumes.
    31. 31. Antibiotics & Bone Cement • Ideal antibiotic properties 1. Preparation must be thermally stable 2. Antibiotic properties not affected by heat 3. Must be water soluble for diffusion into tisssues 4. Bactericidal 5. Must be released gradually over an appropriate time period 6. Minimal local inflammatory response 7. No resistance 8. Must have action against common pathogens like s. aureus, s. epidermidis ,coliforms and anaerobes. 9. Must not significantly compromise mechanical integrity
    32. 32. • Gentamycin (most common) and tobramycin are commonly used • Vancomycin and ciprofloxacin are also tried • Ciprofloxacin may inhibit soft tissue healing • Penicillins and cephalosporins exhibits stability and good elution properties. But are avoided due to their potential allerginicity.
    33. 33. • Vancomycin p (ultrafine powder) is used as lyophilised vancomycin greatly reduces fatigue strength • > 4.5 g gentamycin significantly reduces fatigue strength • > 10% reduction in fatigue strength is considered inappropriate for use in arthroplasty fixation • but weaker cement with higher antibiotic concentration may be used for spacers and antibiotic beads ( to deliver high antibiotic concentration)
    34. 34. • Vacuum mixing increases fatigue strength • ↑ed surface area leds to ↑ed drug elution
    35. 35. Antibiotic may be used in low doses or high doses  Low dose • Antibiotic content is 0.5 – 1 gm per 40 gm of cement • Used in 1. Prophylaxis in revision arthroplasty or 2. In high risk primary arthroplasty
    36. 36. HIGH DOSE • Contains > 3.6 gm of antibiotic per 40 gm of cement • Used in 1. Spacers and beads 2. Second stage of two staged revision ( content is 1-2 gm per 40 gm cement) • Cement spacer commonly contains 4 gm vancomycin and 4.8 gm of tobramycin in 80 gm of cement
    37. 37. The Dangers • Hypotension • cardiac arrest • cerebrovascular accident • pulmonary embolus • hypersensitivity reactions
    38. 38. BCIS (bone cement implantation syndrome) • BCIS is characterized by hypoxia, hypotension or both and/or unexpected loss of consciousness occurring around the time of cementation, prosthesis insertion, reduction of the joint or, occasionally, limb tourniquet deflation in a patient undergoing cemented bone surgery.
    39. 39. • it is characterized by a number of clinical features that may include- • hypoxia, • hypotension, • cardiac arrhythmias, • increased pulmonary vascular resistance (PVR), • and cardiac arrest.
    40. 40. Proposed severity classification of bone cement implantation syndrome • Grade 1: moderate hypoxia (SpO2-94%) or hypotension [fall in systolic blood pressure (SBP) 20%]. • Grade 2: severe hypoxia (SpO2-88%) or hypotension (fall in SBP 40%) or unexpected loss of consciousness. • Grade 3: cardiovascular collapse requiring CPR.
    41. 41. ETIOLOGY • Several hypothesis 1. Monomer absorption into circulation – but very low levels of MMA in circulation are found during cementation.
    42. 42. 2. Embolisation • Embolization occurs as a result of high intramedullary pressures developing during cementation and prosthesis insertion. • The cement undergoes an exothermic reaction and expands in the space between the prosthesis and bone, trapping air and medullary contents under pressure so that they are forced into the circulation.
    43. 43. • Embolic showers have been detected using echocardiography in the right atrium, RV, and pulmonary artery during surgery. • Post-mortem studies have demonstrated pulmonary embolization in animals and man. • The physiological consequences of embolization are considered to be the result of both a mechanical effect and mediator release, which provokes increased pulmonary vascular tone.
    44. 44. Pulmonary vessel with embolus comprising fat, platelets, fibrin, and marrow debris. (1) Reflex vasoconstriction and endothelial production of endothelin 1. (2) Release of vasoconstriction mediators; platelet derived growth factor (PDGF), serotonin (5-HT), thromboxane A2 (Tx-A2), platelet activating factor (PAF), adenosine diphosphate (ADP). (3) Vasoconstriction attributable to non- cellular components of embolus including thrombin.
    45. 45. the increased Pulmonary Vascular Resistance ↓ reduced right-ventricular ejection fraction ↓ the compliant right ventricle (RV) distends ↓ the interventricular septumto bulge into the left ventricle (LV) ↓ further reducing LV filling, and therefore CO
    46. 46. • When cement is inserted into the femur using a cement gun, the pressures generated are almost double those seen when manual packing is used.
    47. 47. • It has been demonstrated that this debris includes- • fat, • marrow, • cement particles, • air, • bone particles, • and aggregates of platelets and fibrin.
    48. 48. 3.Histamine release and hypersensitivity • Anaphylaxis (Type 1 hypersensitivity) was implicated as a potential cause for a fatal case of BCIS in 1972.
    49. 49. 4.Complement activation • The anaphylatoxins C3a and C5a are potent mediators of vasoconstriction and bronchoconstriction. • An increase in C3a and C5a levels, suggesting activation of the complement pathway, has been demonstrated in cemented hemiarthroplasty.
    50. 50. Multimodal model • It is likely that a combination of the above processes is present in any individual patient who develops BCIS.
    51. 51. Patient risk factors Numerous patient-related risk factors have been implicated in the genesis of BCIS, which are :- 1. old age, 2. poor preexisting physical reserve, 3. impaired cardiopulmonary function, 4. pre-existing pulmonary hypertension 5. osteoporosis, 6. bony metastases, 7. and concomitant hip fractures, particularly pathological or intertrochanteric fractures.
    52. 52. • These latter three factors are associated with increased or abnormal vascular channels through which marrow contents can migrate into the circulation.
    53. 53. Surgical risk factors • Patients with a previously un-instrumented femoral canal may be at higher risk of developing the syndrome than those undergoing revision surgery. • There are two possible mechanisms. 1. First, there is more potentially embolic material present in an un-instrumented femur. 2. Second, once the canal has been instrumented and cemented, the inner surface of the femur becomes smooth and sclerotic and offers a less permeable surface. • The use of a long-stem femoral component increases the likelihood of developing BCIS.
    54. 54. Anaesthetic risk reduction • In high risk cases discussion should occur between the surgeon and anaesthetist regarding the most appropriate anaesthetic and surgical technique, including the potential risk-benefit of uncemented compared with cemented arthroplasty. • The avoidance of nitrous oxide should be considered in high risk patients to avoid exacerbating air embolism.
    55. 55. • Increasing the inspired oxygen concentration should be considered in all patients at the time of cementation. • Avoiding intravascular volume depletion may reduce the extent of the haemodynamic changes in BCIS.
    56. 56. • The use of an intraoperative pulmonary artery catheter or trans oesophageal echocardiography has been suggested in high risk patients.
    57. 57. Surgical risk reduction • Medullary lavage, • good haemostasis before cement insertion, • minimizing the length of the prosthesis, • using non-cemented prosthesis (especially if using a long-stem implant), • and venting the medulla.
    58. 58. • Venting the bone permits the air to escape from the end of the cement plug and reduces the risk of an air embolus. • Can increase the risk of femoral fracture.
    59. 59. • If cement is used, insertion with a cement gun and retrograde insertion have been suggested as ways of reducing the incidence of BCIS. • Cement guns result in more even pressure distribution in the medullary cavity, and less reduction in oxygen saturation . • Paradoxically, it has been demonstrated that intramedullary pressures are higher when cementation is performed with a cement gun rather than finger packing.
    60. 60. • Vacuum mixing of cement reduces mortality due to BCIS.
    61. 61. • reduction of the prosthetic femoral head is also a time of increased risk because previously occluded vessels are re-opened and accumulated debris may be allowed into the circulation. • During knee arthroplasty, significant venous emboli are released at the time of tourniquet deflation and this may also be a high risk period
    62. 62. Management • Early signs of BCIS in the awake patient undergoing regional anaesthesia include dyspnoea and altered sensorium. • If BCIS is suspected, the inspired oxygen concentration should be increased to 100% and supplementary oxygen should be continued into the postoperative period. • It has been suggested that cardiovascular collapse in the context of BCIS be treated as RV failure. • Aggressive resuscitation with i.v. fluids has been recommended
    63. 63. • Haemodynamic instability should be treated with the potential aetiology in mind. • Sympathetic a1 agonists should be first-line agent in the context of right heart dysfunction and vasodilatation. • Fluid resuscitation should then be commenced if there is insufficient pre-load.
    64. 64. Calcium Phosphate Cement • Mainly used as bone graft substitute • Is capable of hardening into calcium deficient hydroxyapatite and remodeling at a similar rate to bone (1-2 years). • Different forms: monocalcium phosphate monohydrate, dicalcium phosphate dihydrate, hydroxyapatite, and alpha and beta tricalcium phosphate (TCP). • Although beta phase tricalcium phosphate is very biocompatible, it does not form calcium deficient hydroxyapatite (CDHA) in the body. • This is the reason why alpha TCP is preferred to be used as bone void fillers.
    65. 65. USES • Bone replacement ( instead of bone grafts) e. g. osteoporotic bone, bone loss due to trauma or tumor surgery, kyphoplasty.
    66. 66. Calcium Phosphate •Injectable •Very high compressive strength once hardens •Some studies of its use have allowed earlier weightbearing and range of motion
    67. 67. Tricalcium Phosphate • Wet compressive strength slightly less than cancellous bone • Available as blocks, wedges, and granules • Numerous tradenames – Vitoss (Orthovita) – ChronOS (Synthes) – Conduit (DePuy) – Cellplex TCP (Wright Medical) – Various Theri__ names (Therics)
    68. 68. Fracture Fixation
    69. 69. Bioactivity analysis • The liquid and powder (ratio of 0.34ml/g) undergoes a solid- state reaction at 370 C forming silicone induced calcium deficient hydroxyapatite (CDHA+Si). • New bone formation in silicone doped cement. • Osteoclasts are also seen in silicon doped cement (bone resorption). • Silicone has excellent osteoblastic activity, enhanced reactivity with collagen and apatite increasing the rate of bone remodeling.
    70. 70. THANK YOU
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