Xmatrx ELITE is BioGenx's All-in-One and All-at-Once fully automated system that provides an adaptable workflow solution for efficiency, productivity and profitability. The system consists of platform technology that standardizes complete automation from microtome to microscope in three simple steps (load, click and view) for any slide-based assays such as immuno-histochemistry (IHC), in situ hybridization (ISH), fluorescence in situ hybridization (FISH), co-detection and multiplex applications (double and triple stains; IHC/ISH), in situ PCR, micro-RNA and special staining. Hence, Xmatrx ELITE maximizes testing capacity, minimizes hands-on time, reduces errors and produces consistent results. For more information contact Customer support at customer.service@biogenex.com

1. Xmatrx ELITE

2. 2
All-in-One All-at-Once
• All-in-One All-at-Once – IHC, ISH, SS,
Multiplexing and Co-detection
• FISH*
• Fully Automated System from
Microtome to Microscope

3. Structural Components
3
A True Fully Automated Molecular Pathology Workstation
for Laboratories of Today, Tomorrow and Beyond…

4. Key Features & Benefits
• Fully Automated System from Microtome to
Microscope
• All-in-One All-at-Once – IHC, ISH, SS, Multiplexing
and Co-detection
• FISH*
• Standardized process from baking through final glass
cover slip in 3 simple steps: Load – Click – View slides
• Automates technologies of Today…IHC, ISH, SS,
FISH*, Multiplexing and Co-detection of Nucleic Acid
and Protein Biomarkers
• Designed to automate the technologies of Tomorrow
and Beyond…Gene Expression Profiling, In Situ PCR,
miRNA… and more
• Meets Global regulator requirements and safety
standards
*Optional Software

5. Key Features & Benefits
• Multi-functional system – IHC, ISH, FISH*, SS,
Multiplexing and Co-detection
• Clean, intense, reliable and reproducible stains with
standardized process for complete automation
from Baking to final cover slip
• Multiple slide processing options – Random,
Continuous and STAT
• Multi-format specimen processing – Frozen and
FFPE sections, Cell preparations, Smears and FNAs
• Optimized protocols and ready-to-use reagents
• Efficient resource utilization
• Predictable, reliable and transparent cost structure
*Optional Software

6. Efficient, Productive and Profitable System
• High throughput - 100 slides per day (60 slides in
eight hour shift and 40 slide in a overnight run)
• Start overnight run and return to view completed
slides the next morning
• Low cost of ownership
6

7. Compliance
7
• Meets Globally accepted safety standards
• ISO 13485:2003 (CMDCAS)
• ISO 9001:2008
• Regulatory Compliant
• USFDA
• IVD - CE

8. Easy to Use
• Top loading of slides and reagents
• Color coded GUI with real time assay parameters
display
• Real time audio and visual alerts
• Color coded bulk reagent carboys
• Complete information log for every slide
• Short learning curve allows cross-training and
rotation of personnel
*Optional Software

9. Reproducible, Reliable and Consistent Results
• User defined customized protocols – Clean, intense
stain with Ready-to-use reagents
• Factory protocols for ease of use
• User defined protocols for convenience
• Liquid level sensor for accurate dispensing and real
time reagent tracking – avoid false results
*Optional Software

10. On-Board Dehydration and
Final Coverslip
Reaction Micro-chamber
and Micro-fluidics
eXACT™ Temperature
Control on Every Slide
Liquid Level Sensor &
Reagent Dispensing System LIS Enabled
RFID and Barcode
Enabled
Enabling Technologies

11. Reaction Micro-Chamber with Micro-fluidics
• Reaction micro-chamber: 25 µL to 100 µL
• Reduced reagent consumption up to 75%
• Even distribution of reagents for uniform staining
without edge effect
• Overnight incubation/hybridization without drying
of specimen

12. eXACTTM Temperature Control on Every Slide
• 40 independent thermocyclable (PCR) work
stations
• No cross talk - High precision active heating and
cooling maintains accurate temperature on each
slide at all times
• Temperature uniformity + 2°C
• Temperature range from Ambient to 105°C for
robust antigen retrieval
• Thermocycling - Ambient 95°C
< 2 min

13. RFID and Barcode Enabled Technology
• RFID tagged reagent vials – Accurate and precise
real time reagent usage tracking irrespective of
Xmatrx system
• Barcoded slides – eliminates human errors, correct
protocols on each slide delivering accurate results

14. Liquid Level Sensor and Reagent Dispensing System
• Redundant automated process to eliminate human
errors
• Accurate dispensing of micro-reagent volumes
• Error free reagent dispensing – delivers optimum
stains, eliminates false negatives
• Disposable pipette tips allows multiple
technologies on the same platform without cross
contamination

15. On-board Dehydration and Final Coverslip
• Dehydration
• Clearing
• Permanent mounting with glass cover slip

16. Intuitive Software System - LIS Enabled
• Easy to use user friendly GUI
• Multiple standardized and custom reporting
capabilities
• Usage tracking
• Inventory management
• Regulatory compliant
• LIS Enabled data tracking and management*
*Optional

18. Xmatrx ELITE – A Unique Value Proposition
• All-in-One All-at-Once
• Multiple technologies on a single platform - IHC,
ISH, SS, Multiplexing and Co-detection
• FISH*
• Fully automated system with standardized process
from baking through final glass cover slip in
3 simple steps: Load – Click – View slides
• Reduced reagent consumption by up to 75%
through the use of Reaction Micro-chamber with
Micro-fluidics
• Walkaway Automation through RFID and Barcode
enabled platform
• Disposable pipette tips allow multiple technologies
on the same platform
*Optional Software

19. Value Proposition - Pathologist
• All-in-One All-at-Once
• Multiple technologies on a single platform -
IHC, ISH, SS, Multiplexing and Co-detection
• FISH*
• Clean, intense, consistent and reproducible results
• High throughput system - 100 slides per day, 60
slides in eight hour shift and 40 slides in a
overnight run
• Disposable pipette tips allow multiple technologies
on the same platform
• Wide variety of antibodies, different clones and
compatible reagents provide complete portfolio
for the system
• Multiple technologies on the same system
*Optional Software

20. Value Proposition - Management
• Fully automated All-in-One All-at-Once system
• Low cost of ownership
• Eliminate requirement to purchase multiple
instruments for different technologies
• High throughput, efficient, productive and
profitable system
• Optimize resource utilization and cross training
• Predictable, reliable and transparent cost structure
• Eco-friendly and Cost savings – up to 75% reduced
reagent consumption and waste generation
through cutting edge technologies
• LIS enabled intuitive software system for accurate
usage tracking, inventory management and
generating regulatory compliant reports
*Optional Software
TIME
COST
QUALITY

21. Value Proposition - Lab Personnel (1/2)
• All-in-One All-at-Once
• Multiple technologies on a single platform - IHC,
ISH, SS, Multiplexing and Co-detection
• FISH*
• Fully automated system with standardized process
from Baking through final glass cover slip in 3
simple steps: Load – Click – View slides
• High throughput - 100 slides per day, 60 slides in
eight hour shift and 40 slide in a overnight run
• Advanced Enabling Technologies - RFID, Barcode,
Liquid Level Sensor, eXACT Temperature Control
and Reaction Micro-chamber with Micro-fluidics
• On-board dehydration, clearing and permanent
mounting with glass cover slip
*Optional Software

22. Value Proposition - Lab Personnel (2/2)
• Multiple slide processing options – Random,
Continuous and STAT
• Multi-format specimen processing – Frozen and
FFPE sections, Cell preparations, Smears and FNAs
• Easy to use user friendly GUI
• Factory protocols for ease of use
• User defined customized protocols for
convenience
• Real time audio and visual alerts
• Short learning curve allows cross-training and
rotation of personnel
• Multiple standardized and custom reporting
capabilities for Usage tracking, Inventory
management and Regulatory compliance
*Optional Software

23. Applications
IHC
Special Stains
ISH
Multiplexing IHC/ISH
Multiplex Stains
FISH

24. Thank You
Please visit www.biogenex.com for more details on our product portfolio
24