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Osteoarthitis and its possible treatments
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Osteoarthitis and its possible treatments






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Osteoarthitis and its possible treatments Osteoarthitis and its possible treatments Presentation Transcript

  • Osteoarthritis and its Possible Treatments VALERIA RIVERA Biol. 3095 December, 2010
  • What is Osteoarthritis?
    • It is one of the most common types of arthritis (joint degradation and inflammation).
    • It can be caused by:
      • Injuries
      • Obesity
      • Inheritance
      • Joint malformation
  • Who can have arthritis?
    • Everyone, specially women and men over 40
    • Also common in animals like dogs, cats and horses
    • 25% to 30% of dogs suffer from arthritis and hip dysplasia (associated with abnormal joint structure)
    View slide
  • Symptoms:
    • Pain
    • Lameness (weakness)
    • Muscle atrophy (degeneration)
    • Swelling of joints (accumulation of fluids)
    • Stiffness
    • Lost of mobility
    View slide
  • Treatments:
    • The most widely used treatments are: non steroidal anti inflammatory drugs (NSAID)
    • Glucosamine/Chondroitin sulfate (nutrients)
    • Col 3 inhibition
    • Physical rehabilitation
    • Surgery
    • What it does?
      • Inhibits prostaglandins (chemical found in the body, causes inflammation)
      • Types of NSAID
      • Deramaxx is used in the veterinary market to control pain and inflammation
      • Carprofen is one of the newest NSAID being accepted for treating dogs as well as humans
  • Glucosamine/Chondroitin Sulfate
    • Used as a treatment for dogs with Osteoarthritis
    • The research revealed positive effects from day 70
      • It inhibits degradative enzymes within the synovial fluid
      • Tested on 35 dogs- 16 with Glu/CS and 19 with carprofren (positive control)
          • (McCarty et al. 2006)
  • Col-3 inhibition
    • Col-3 I was tested with 33 client dogs (Muir P et al. 2007)
    • This test shows Col-3:
      • Col-3 inhibits production of MMPs (matrix metalloproteinase; protease degrade proteins)
    • Is used to ameliorate joint degradation
      • Cranial cruciate ligament CCL (important ligament in the knee)
  • Physical rehabilitation
    • Involves the use of physical agents consisting of heat, cold, electricity, exercise, and water (Johnston et al.).
    • Also involves the use of:
      • physioballs
      • PROM
    • Improves:
      • Circulation
      • Joint movement
      • Promotes awareness
  • Surgery
    • Arthroscopy
      • cleans bone segments where inflammation occurs ( minor surgery)
    • Arthroplasty
      • Replaces joint with prosthetic joint implants
    • Osteoplasty
      • Surgical repairs deteriorating bone from joint
          • (Springhouse, 2005)
  • Conclusion
    • A variety of new treatments are being examined
      • Pros and cons depend on side effects
    • Investigations with current treatments like Glucosamine Chondroitin Sulfate are promising
    • Further research should continue in modifying the present drugs