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Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
Cmrr Workshop 2009
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Cmrr Workshop 2009

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  • 1. Short-Echo, Single Voxel 1H NMR Spectroscopy of the Human Brain at 7T with Multi-Channel Coils Uzay E Emir, Melissa Terpstra, Ivan Tkáč, Gülin Öz Center for Magnetic Resonance Research University of Minnesota Minneapolis, Minnesota, USA
  • 2. High-field In Vivo Single Voxel 1H NMR Spectroscopy at 7T Increase in signal-to- noise-ratio (SNR) NT = 128 Increase in chemical S/N = 130 x5 shift dispersion 6 5 4 3 2 1 ppm Glc NT = 128 S/N = 264 x5 6 5 4 3 2 1 ppm Tkáč, MRM,2009
  • 3. High-field In Vivo Single Voxel 1H NMR Spectroscopy at 7T Increase in signal-to- The precision at noise-ratio (SNR) 4T for NT 128 Increase in chemical corresponds to shift dispersion the precision at 7T Reliable quantification for NT 4. of up to 17 metabolites 1.0 1.5 CRLB (µmol/g) CRLB (µmol/g) 0.8 4T Gln 1.2 Glu 4T 0.6 0.9 0.4 7T 0.6 7T 0.2 0.3 0.0 0.0 2 4 8 16 32 64 128 2 4 8 16 32 64 128 NT NT Tkáč, MRM,2009
  • 4. High-field In Vivo Single Voxel 1H NMR Spectroscopy at 7T NAA Creatine Choline Measurement Glutathione Vitamin C Lactate Glucose GABA Fit Glutamate Glutamine Residual myo-inositol Taurine 4.0 3.5 3.0 2.5 2.0 1.5 1.0 ppm scyllo-inositol • • •
  • 5. High-field In Vivo 1H NMR Spectroscopy in Several Voxels Huntington’s disease Parkinson’s disease Spinocerebellar ataxia Alzheimer’s disease Demyelinating white matter disease
  • 6. Single Voxel, High-field In Vivo 1H NMR Spectroscopy Huntington’s disease Parkinson’s disease Spinocerebellar ataxia Alzheimer’s disease Demyelinating white matter disease
  • 7. High-field In Vivo 1H NMR Spectroscopy at 7T: Challenges Non-uniform B1 field – long RF pulses (Chemical Shift Displacement Error) – B1 shimming Short T2 relaxation times of metabolites in the human brain (Deelchand, 500 NAA ISMRM, 2009) 400 Cr T2 (ms) 300 200 100 0 0 2 4 6 8 10 Field Strength (T)
  • 8. High-field In Vivo 1H NMR Spectroscopy at 7T: Challenges Non-uniform B1 field 150 ms – long RF pulses (Chemical 80 ms Shift Displacement Error) 50 ms – B1 shimming Short T2 relaxation times 30 ms of metabolites in the 20 ms human brain (Deelchand, ISMRM, 2009) – Short TE 10 ms 8 ms 5 4 3 2 1 ppm
  • 9. Aim To demonstrate the feasibility of short echo single voxel 1H NMR spectroscopy in brain regions other than occipital cortex at 7T Phased array coil B1 shimming
  • 10. Methods 16-channel transmit/receive transmission line array (Adriany,MRM,2008) B1+ shimming (Van de Moortele,MRM,2005) B0 shimming (FASTMAP) (Gruetter,MRM,2001) 1H NMR spectroscopy, TE=8 ms (Siemens console) – VAPOR+OVS+STEAM (Tkáč, MRM,2001) – 7.5 % chemical shift displacement error LCModel – Water spectrum
  • 11. 16-Channel Transmit/Receive Transmission Line Array Transmit Receive 1.0 0.9 0.8 0.7 0.6 0.5 0.4 0.3 0.2 0.1
  • 12. Local B1+ Shimming Relative P o s ts h im Transmit Efficiency P re s h im Occipital Cortex 2.1 Posterior 1.2 Cingulate Preshim Postshim Frontal White 1.7 Matter Putamen 1.3 Substantia Nigra 1.1 Pons 1.2 Cerebellar 2.6 Vermis 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0
  • 13. Reconstruction of 1H NMR Spectrum From Multi Channel Coil Multi Channel Coil Water Suppressed Water Spectrum Spectrum Phase and Eddy Current Correction Weighting Factors Weighted Summation Natt, MRM, 2005
  • 14. Phase and Eddy Current Correction Water spectrum Water suppressed spectrum Phase and Eddy current corrected spectrum Occipital cortex
  • 15. Weighted Summation Weighting Factor Occipital Cortex Substantia Nigra
  • 16. B0 Shimming Volume Linewidth of Interest [Hz] Posterior Cingulate 11 Occipital Cortex 13 Cerebellum 13 Pons 13 Frontal White Matter 14 Putamen 16 Substantia Nigra 18
  • 17. 1H Spectrum of Occipital Cortex at 7T STEAM TE = 8 ms TR = 5 s VOI = 8 ml NT = 128 NAA # of subject =1 Cr PCr Cr PCr Glu Gln Glu Cho Gln Ins NAA Ins Macromolecules Tau Asp Residual Water 5 4 3 2 1 ppm
  • 18. LCModel Analysis STEAM Tau TE = 8 ms TR = 5 s Scyllo VOI = 8 ml NT = 128 PE NAAG # of subject = 1 NAA Lac Measurement Ins GSH Glu Gln Glc GABA Fit Asp Asc Residual MAC Baseline 4.0 3.5 3.0 2.5 2.0 1.5 1.0 4.0 3.5 3.0 2.5 2.0 1.5 1.0 ppm
  • 19. Neurochemical Profile in the Occipital Cortex at 7T STEAM TE = 8 ms TR = 5 s VOI = 8 ml NT = 128 # of subjects = 5 15 Error bars = SD 10 µmol/g 5 0 NAA+NAAG GABA NAA NAAG Scyllo Ins Lac Gln Glu GPC+PCho PE Cr PCr GSH Glc+Tau
  • 20. 1H Spectrum of Posterior Cingulate at 7T STEAM TE = 8 ms TR = 5 s NAA VOI = 8 ml NT = 128 # of subject =1 Cr PCr Cr Cho PCr Glu Glu Residual Water Gln Ins Gln Ins NAA Macromolecules Tau 5 4 3 2 1 ppm
  • 21. 1H Spectrum of Frontal White Matter at 7T STEAM TE = 8 ms TR = 5 s NAA VOI = 8 ml NT = 128 # of subject =1 Cr PCr Cho Cr PCr Glu Residual Water Gln Glu Ins Gln Ins Macromolecules Tau NAA 5 4 3 2 1 ppm
  • 22. 1H Spectrum of Putamen at 7T STEAM TE = 8 ms TR = 5 s VOI = 2.5 ml NT = 256 # of subject =1 NAA Cr PCr Cr Cho PCr Glu Glu Gln Ins Gln Ins Tau NAA Macromolecules Residual Water 5 4 3 2 1 ppm
  • 23. 1H Spectrum of Substantia Nigra at 7T STEAM TE = 8 ms TR = 5 s VOI = 1 ml NT = 512 # of subject =1 NAA Cr PCr Cho Cr Glu PCrGlu Gln NAA Macromolecules Gln Ins Ins 5 4 3 2 1 ppm
  • 24. 1H Spectrum of Pons at 7T STEAM TE = 8 ms TR = 5 s VOI = 4 ml NT = 128 # of subject =1 NAA Cho Cr PCr Cr PCr Glu Glu Gln Ins Gln Macromolecules Tau NAA Residual Water Ins 5 4 3 2 1 ppm
  • 25. 1H Spectrum of Cerebellar Vermis at 7T STEAM TE = 8 ms TR = 5 s VOI = 6.25 ml NT = 128 # of subject =1 Cr NAA PCr Cho Cr PCr Glu Glu Gln Ins Gln Ins NAA Macromolecules Tau Residual Water 5 4 3 2 1 ppm
  • 26. 1H Spectrum of Pons at 7T STEAM TE = 8 ms TR = 5 s VOI = 4 ml NT = 128 # of subject =1 NAA Cho Cr PCr Cr PCr Glu Glu Gln Ins Gln Macromolecules Tau NAA Residual Water Ins 5 4 3 2 1 ppm
  • 27. Neurochemical Profiles Posterior Putamen Cingulate VOI = 2.5 ml VOI = 8 ml # of subjects = 5 # of subjects = 5 Frontal White Matter Substantia Nigra VOI = 8 ml VOI = 1 ml # of subjects = 5 # of subjects = 5
  • 28. µmol/g µmol/g 0 5 10 15 0 5 10 15 Cr Cr PCr PCr GABA GABA Glc Gln CRLB < 20 % Gln Glu Glu GSH GSH Ins Posterior Cingulate Ins Frontal White Matter NAA NAA NAAG NAAG GPC+PCho GPC+PCho Glc+Tau Glc+Tau µmol/g µmol/g 0 5 10 15 0 5 10 15 Cr Cr PCr PCr GABA GABA Putamen Gln Gln CRLB < 50 % Glu Glu GSH GSH Substantia Nigra Neurochemical Profiles Ins Ins NAA NAA NAAG NAAG GPC+PCho GPC+PCho Glc+Tau Error bars = SD Glc+Tau
  • 29. Summary Multiple brain regions-of-interest to study several neurological diseases – Multi channel coil – B1 Shimming Reliable quantification of 10-15 metabolites Increased SNR Implemented on a clinical console
  • 30. Acknowledgements Malgorzata Marjanska Funding: Pierre-Francois Van DANA Foundation De Moortele R21-AG029582 Eddie Auerbach BTRR - P41 RR008079 Gregor Adriany P30 NS057091 Greg Metzger Patrick Bolan John Strupp Dinesh Deelchand

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