Potential anticancer componds from natura l sources by Dr.U.Srinivasa, Professor, Srinivas college of pharmacy, Mangalore
Cancer is the one of the dreadful diseasewhich is not yet conquered by man. Scientificobservations and experiences are going onday and night throughout the world to conquerthis disease. We hope a day will come when thecancer is within the control of man .That day isnot too long. In this conxet “ Natural bioactivecompounds with anticancer potential ’’It is to be discussed in length and breadth.
* Survey by National cancer registry programme of the Indian council of medical research ( ICMR) -2011.* As on March 2011 – 28,00,000 Cancer patients in India.* Every year 1.2% of cancer patients rises.(an increment of 10,000)* Every year 5,00,000 peoples dies due to cancer* Cost of bioactive compounds is very high ,* Eg- 1gm of vinblastine – US $ 6800* Eg – 1mg of Withaferin A -£ 69
The most common risk factors for cancer are*Growing older*Tobacco*Ionizing radiations*Certain chemicals and other substances*Some viruses and bacteria*Certain hormones*Family history of cancer*Alcohol*Poor diet*Lack of physical activity OR being overweight
Cancer type Total More developed Less developed countries countriesAll 53,17,905 25,03,772 28,14,132Breast 10,50,346 5,79,285 4,71,063Colon/ rectum 4,98,574 3,18,694 1,80,059Kidney 1,18,255 79,090 39,158Leukemia 1,44,321 58,416 85,912Liver 3,98,364 73,270 3,25,108Lung 9,01,746 4,70,836 4,30,919Melanoma 65,177 50,608 14,571Oral cavity 1,69,524 59,959 1,09,553Ovary 1,92,379 91,307 1,01,060Prostate 5,42,990 4,15,568 1,27,419Stomach 5,58,458 2,08,282 3,50,176
Definition : Bioactive compounds in plants are thecompounds produced by plant havingpharmacological or toxicological effects. These bioactive compounds providesunique lead compounds for drug and drugdevelopment.They are secondary metabolites.
Before investing time, effort and money in phytochemicalscreening it is very important to select a promising plant. The choice of promising plant depends upon thefollowing: 1- A plant which have a biological activity. 2- A plant used in folk medicine. 3- A plant which show a particular toxicities.
Biological source Local Parts used Preparations& Family nameAbrus precatorius Gunja Roots and Leaves decoction, flowers internally andFabaceae leaves aqueous extract of roots in treatment of blood cancerAcacia nilotica Bambri, Stem and Stem and root barks decoction andFabaceae babul root barks patients are advised to gargle with this decoctionAdhatoda vasica Arusa Roots, Juice/extract given internally,Acanthaceae leaves, plant is burnt and the patients are advised flowers and to inhale the fume stemAegle marmelos Bael Bark and The roots, leaves, bark and flowersRutaceae flower decoctionAlangium salviifolium Ankol Roots, bark Bark decoction or boil the fresh bark inAlangiaceae and fruits base oil to prepare special oil is considered beneficial for the cancerous wound, fruits for lung cancer
Albizia lebbeck Sirsa Flower and Flowers in form of aqueous extract appliedFabaceae bark externally and bark in the form of powder given internallyAnthocephalus Kadam Fruits and Consuming Kadam fruits during growingcadamba leaves season, dried leaves powders internallyRubiaceaeArtocarpus Kathal Seed, bark Few pinches of root powder are givenheterophyllus and roots internally and the roots decoctionMoraceaeAstercantha ongifolia Mokhla Root Aqueous extractAcanthaceaeBalanites aegyptiaca Hingot Bark and Dried bark powder, fruits pulps for bloodBalanitaceae fruits cancerBambusa sp. Bans Leaves, bark Leaf juice and bark decoction internally,Poaceae and seed seeds with Shahad (Honey).Bauhinia variegata Son Flower and Flower given with cow milk, leavesFabaceae Patta leaves decoctionBuchanania lanzan Char Seed, bark Roots are used in form of dry powder, inAnacardiaceae and root form of decoction, bark powder with cow milk and honey
Butea monosperma Parsa Leaves and Leaf juices & fruit powder.Fabaceae fruitsCalotropis gigantea Fudhar Root and Root decoction for lung cancer andAsclepiadaceae latex roots are dipped in its latex, burnt and patients are advice to inhale itCannabis sativa Bhang Leaves The leaves are crushed and with theCannabaceae help of cow milk an aqueous paste is prepared. This paste is applied externally on the woundCassia fistula Dhanbaher Leaves and Leaf juice in treatment of cancerousFabaceae fruits wound, The fruit pulp is boiled in water to prepare concentrate decoction given internallyCitrus medica Bijaura Fruit, seed, Dried fruits powder, root in the form ofRutaceae bark and root paste, bark in the form of decoctionCoriandrum sativum Dhania Seed and Boil the seed powder in water toApiaceae whole herbs prepare concentrate decoction. The patients are advised to gargle with this decoction, whole herb juice advised to take it internallyCurcuma sp. Haldi Rhizome Both internally as well as externally inZingiberaceae treatment of cancer
Datura species Dhatra Leaf and flower Dhatura leaf juice, opium and sonthSolanaceae (Dried Ginger) and in form of paste applied this combination on cancerous woundDiospyros elanoxylon Tendu Fruits and bark Bark paste with cow milkEbenaceaeEmbelia ribes Baibirang Leaves, Roots Leaves are used externally in formEuphorbiaceae and fruits of decoction and pasteEmblica officinalis Aonla, amala Leaf, roots and Leaf juices, root boil in mustard oilEuphorbiaceae bark for cancerous woundEuphorbia neriifolia Thura Latex and Fresh latex and leave extractEuphorbiaceae leavesFicus benghalensis Bargad Bark, root and Barks of Bar, Maharukh (AilanthusMoraceae , fresh latax excelsa) and Neem (Azadirachta indica) and prepare the combination, fresh latex internallyFicus glomerata Doomar Leaves, bark Leaves juice bark juice, dried rootMoraceae. and roots powder given internally
Ficus religiosa Pipal Leaves Leaf extract Moraceae and fruitsGloriosa superba Kalihari Bulb, Freshly collected bulbs are crushed andColchicaceae leaves and added in mustard seed oil. The combination seeds is boiled and when all watery contents evaporate the boiling is stopped and special oil is used after filtration. The special oil is considered beneficial for the cancerous wound, The leaves are given internally in form of juiceGmelina arborea Khamhar Leaves Leaves juice, dried fruits powderLamiaceae and fruitsHibiscus rosasinensis Jason Flowers Dried flower powderMalvaceaeMangifera indica Ama Leaves The leaves of Arusa (Adhatoda vasica),Anacardiaceae and inner Kukurmutta (Blumea lacera) and Chirchita bark (Achyranthes aspera) are mixed in equal proportion. The Ama leaves are taken in double amount of this combination and mixed thoroughly. The combination is burnt and the patients are advised to inhale the fumes for lung cancer
Melia azedarach Bakain Root, bark and Dried root powder is givenMeliaceae fruits internally, inner bark and extract the juice given internallyMoringa oleifera Munga Bark, flowers Bark decoction, dried flowersMoringaceae powderMucuna pruriens Kevatch Root, seed Patients having mouth cancer toFabaceae and whole always put the freshly collected herbs Kevatch root inside the mouth, seed powder useful in treatment of cancer painNerium odorum Kaner Root and Roots decoction is prepared. TheApocynaceae flowers patients are advised to wash the wound with the help of this decoctionNyctanthes arbor- Harshringar Leaves and Dried bark powder given internally,tristis bark leaves decoctionOleaceaeOcimum sanctum Tulsi Seed and Decoction of seed and leavesLamiaceae leaves internally
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