Cancer is the one of the dreadful diseasewhich is not yet conquered by man. Scientificobservations   and experiences     a...
* Survey by National cancer registry programme of the Indian council of medical research ( ICMR) -2011.* As on March 2011 ...
The most common risk factors for cancer are*Growing older*Tobacco*Ionizing radiations*Certain chemicals and other substanc...
Cancer type     Total       More developed   Less developed                             countries       countriesAll      ...
Definition :       Bioactive compounds in plants are thecompounds      produced    by   plant   havingpharmacological or t...
Plant source          Compound             Family Allamanda cathartica     Allamandin        Apocynaceae   Ipomoea batatas...
Jatropha gossypiifolia     Jatrophone       Euphorbiaceae   Taxus brevifolia           Taxol           TaxaceaeBrucea anti...
Podophyllum peltatum     α-and β-peltatin   Berberidaceae    P.hexandrum,         Podophyllotoxin    Berberidaceae     P.p...
Fagara zanthoxyloides          Nitidine            Rutaceae    F.macrophylla              Nitidine            Rutaceae Tyl...
C.roseus             Vinblastine    Apocynaceae       C.roseus             Vincristine    Apocynaceae Maytenus buchananii ...
*Nine   plant derived compounds have been approved for use as anticancer drugs ( INDIA)*Vinblastin*Vincristine*Etoposide*T...
*10 - Hydroxy camptothecin*(- ) – Sophocarpine*Monocrotaline*d- tetrandrine*Lycobetaine*Indirubin*Colchicinamide*Curcumino...
Before investing time, effort and money in phytochemicalscreening it is very important to select a promising plant.   The ...
Biological source       Local     Parts used    Preparations& Family                nameAbrus precatorius       Gunja     ...
Albizia lebbeck         Sirsa    Flower and     Flowers in form of aqueous extract appliedFabaceae                        ...
Butea monosperma      Parsa       Leaves and      Leaf juices & fruit powder.Fabaceae                          fruitsCalot...
Datura species         Dhatra         Leaf and flower   Dhatura leaf juice, opium and sonthSolanaceae                     ...
Ficus religiosa         Pipal      Leaves       Leaf extract   Moraceae                        and fruitsGloriosa superba ...
Melia azedarach     Bakain        Root, bark and   Dried root powder is givenMeliaceae                         fruits     ...
There is a research gap on this topic still exist.This gap should be filled by quality researchers.The    whole world is w...
Potential anticancer componds from natura l sources by Dr.U.Srinivasa, Professor, Srinivas college of pharmacy, Mangalore ...
Potential anticancer componds from natura l sources by Dr.U.Srinivasa, Professor, Srinivas college of pharmacy, Mangalore ...
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Potential anticancer componds from natura l sources by Dr.U.Srinivasa, Professor, Srinivas college of pharmacy, Mangalore

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Potential anticancer componds from natura l sources by Dr.U.Srinivasa, Professor, Srinivas college of pharmacy, Mangalore

  1. 1. Cancer is the one of the dreadful diseasewhich is not yet conquered by man. Scientificobservations and experiences are going onday and night throughout the world to conquerthis disease. We hope a day will come when thecancer is within the control of man .That day isnot too long. In this conxet “ Natural bioactivecompounds with anticancer potential ’’It is to be discussed in length and breadth.
  2. 2. * Survey by National cancer registry programme of the Indian council of medical research ( ICMR) -2011.* As on March 2011 – 28,00,000 Cancer patients in India.* Every year 1.2% of cancer patients rises.(an increment of 10,000)* Every year 5,00,000 peoples dies due to cancer* Cost of bioactive compounds is very high ,* Eg- 1gm of vinblastine – US $ 6800* Eg – 1mg of Withaferin A -£ 69
  3. 3. The most common risk factors for cancer are*Growing older*Tobacco*Ionizing radiations*Certain chemicals and other substances*Some viruses and bacteria*Certain hormones*Family history of cancer*Alcohol*Poor diet*Lack of physical activity OR being overweight
  4. 4. Cancer type Total More developed Less developed countries countriesAll 53,17,905 25,03,772 28,14,132Breast 10,50,346 5,79,285 4,71,063Colon/ rectum 4,98,574 3,18,694 1,80,059Kidney 1,18,255 79,090 39,158Leukemia 1,44,321 58,416 85,912Liver 3,98,364 73,270 3,25,108Lung 9,01,746 4,70,836 4,30,919Melanoma 65,177 50,608 14,571Oral cavity 1,69,524 59,959 1,09,553Ovary 1,92,379 91,307 1,01,060Prostate 5,42,990 4,15,568 1,27,419Stomach 5,58,458 2,08,282 3,50,176
  5. 5. Definition : Bioactive compounds in plants are thecompounds produced by plant havingpharmacological or toxicological effects. These bioactive compounds providesunique lead compounds for drug and drugdevelopment.They are secondary metabolites.
  6. 6. Plant source Compound Family Allamanda cathartica Allamandin Apocynaceae Ipomoea batatas 4-ipomeanol Convolvulaceae Penstemon deutus Penstimide ScrophulariaceaeBaccharis megapotamica Baccharin Compositae Helenium autumnale Helenalin Compositae Liatris chapmanii Liatrin CompositaePhyllanthus acuminatus Phyllanthoside Euphorbiaceae Vernonia hymenolepis Vernolepin CompositaePhyllanthus acuminatus Gnidin Thymelaeaceae
  7. 7. Jatropha gossypiifolia Jatrophone Euphorbiaceae Taxus brevifolia Taxol TaxaceaeBrucea antidysenterica Bruceantin Simaroubaceae Simarouba glauca Glaucarubinone Simaroubaceae Holacantha emoryi Holacanthone Simaroubaceae Marah oreganus Cucurbitacin Cucurbitaceae Acernegundo Acer saponin P Aceraceae Bersama abyssinica Hellebrigenin MelianthaceaeAcnistus arborescens Withaferin A Solanaceae Combretum caffrum Combretastin A-4 Combretaceae
  8. 8. Podophyllum peltatum α-and β-peltatin Berberidaceae P.hexandrum, Podophyllotoxin Berberidaceae P.peltatum Steganotaenia Steganacin Umbelliferae araliaaceae Jacaranda caucana Jacaranone Bignoniaceae Stereospermum Lapachol Bignoniaceae sauveolensCrotalaria spectabilis Monocrotaline LeguminosaeHeliotropium indicum Indicine-N-oxide Boraginaceae Cephaelis acuminata Emetine Rubiaceae Cyclea peltata Tetrandrine MenispermaceaeThalictrum dasycarpum Thalicarpine Ranunculaceae
  9. 9. Fagara zanthoxyloides Nitidine Rutaceae F.macrophylla Nitidine Rutaceae Tylophora crebiflora Tylocrebine Asclepiadaceae Acronychia baueri Acronycine Rutaceae Ochrosia elliptica, Ellipticine Apocynaceae O.moorei O.maculata 9-methoxyellipticine ApocynaceaeCamptotheca acuminata Camptothecin Nyssaceae Cephalotaxus Harringtonine Cephalotaxaceae harringtonia C.harringtonia Homoharringtonine Cephalotaxaceae Catharanthus lanceus, Leurosine Apocynaceae C.
  10. 10. C.roseus Vinblastine Apocynaceae C.roseus Vincristine Apocynaceae Maytenus buchananii Mytanacine CelastraceaeM.buchananii, M.serrata Maytansine Celastraceae Maytenus buchananii Maytanvaline CelastraceaeColchicum speciosum Colchicine Liliaceae Bouvardia ternifolia Bouvardin Rubiaceae B.ternifolia Deoxybouvardin Rubiaceae
  11. 11. *Nine plant derived compounds have been approved for use as anticancer drugs ( INDIA)*Vinblastin*Vincristine*Etoposide*Teriposide*Taxol*Navelbine*Taxotere*Topotecan*Irinotecan
  12. 12. *10 - Hydroxy camptothecin*(- ) – Sophocarpine*Monocrotaline*d- tetrandrine*Lycobetaine*Indirubin*Colchicinamide*Curcuminol*Curdione*Gossypol*Homoharringtonise
  13. 13. Before investing time, effort and money in phytochemicalscreening it is very important to select a promising plant. The choice of promising plant depends upon thefollowing: 1- A plant which have a biological activity. 2- A plant used in folk medicine. 3- A plant which show a particular toxicities.
  14. 14. Biological source Local Parts used Preparations& Family nameAbrus precatorius Gunja Roots and Leaves decoction, flowers internally andFabaceae leaves aqueous extract of roots in treatment of blood cancerAcacia nilotica Bambri, Stem and Stem and root barks decoction andFabaceae babul root barks patients are advised to gargle with this decoctionAdhatoda vasica Arusa Roots, Juice/extract given internally,Acanthaceae leaves, plant is burnt and the patients are advised flowers and to inhale the fume stemAegle marmelos Bael Bark and The roots, leaves, bark and flowersRutaceae flower decoctionAlangium salviifolium Ankol Roots, bark Bark decoction or boil the fresh bark inAlangiaceae and fruits base oil to prepare special oil is considered beneficial for the cancerous wound, fruits for lung cancer
  15. 15. Albizia lebbeck Sirsa Flower and Flowers in form of aqueous extract appliedFabaceae bark externally and bark in the form of powder given internallyAnthocephalus Kadam Fruits and Consuming Kadam fruits during growingcadamba leaves season, dried leaves powders internallyRubiaceaeArtocarpus Kathal Seed, bark Few pinches of root powder are givenheterophyllus and roots internally and the roots decoctionMoraceaeAstercantha ongifolia Mokhla Root Aqueous extractAcanthaceaeBalanites aegyptiaca Hingot Bark and Dried bark powder, fruits pulps for bloodBalanitaceae fruits cancerBambusa sp. Bans Leaves, bark Leaf juice and bark decoction internally,Poaceae and seed seeds with Shahad (Honey).Bauhinia variegata Son Flower and Flower given with cow milk, leavesFabaceae Patta leaves decoctionBuchanania lanzan Char Seed, bark Roots are used in form of dry powder, inAnacardiaceae and root form of decoction, bark powder with cow milk and honey
  16. 16. Butea monosperma Parsa Leaves and Leaf juices & fruit powder.Fabaceae fruitsCalotropis gigantea Fudhar Root and Root decoction for lung cancer andAsclepiadaceae latex roots are dipped in its latex, burnt and patients are advice to inhale itCannabis sativa Bhang Leaves The leaves are crushed and with theCannabaceae help of cow milk an aqueous paste is prepared. This paste is applied externally on the woundCassia fistula Dhanbaher Leaves and Leaf juice in treatment of cancerousFabaceae fruits wound, The fruit pulp is boiled in water to prepare concentrate decoction given internallyCitrus medica Bijaura Fruit, seed, Dried fruits powder, root in the form ofRutaceae bark and root paste, bark in the form of decoctionCoriandrum sativum Dhania Seed and Boil the seed powder in water toApiaceae whole herbs prepare concentrate decoction. The patients are advised to gargle with this decoction, whole herb juice advised to take it internallyCurcuma sp. Haldi Rhizome Both internally as well as externally inZingiberaceae treatment of cancer
  17. 17. Datura species Dhatra Leaf and flower Dhatura leaf juice, opium and sonthSolanaceae (Dried Ginger) and in form of paste applied this combination on cancerous woundDiospyros elanoxylon Tendu Fruits and bark Bark paste with cow milkEbenaceaeEmbelia ribes Baibirang Leaves, Roots Leaves are used externally in formEuphorbiaceae and fruits of decoction and pasteEmblica officinalis Aonla, amala Leaf, roots and Leaf juices, root boil in mustard oilEuphorbiaceae bark for cancerous woundEuphorbia neriifolia Thura Latex and Fresh latex and leave extractEuphorbiaceae leavesFicus benghalensis Bargad Bark, root and Barks of Bar, Maharukh (AilanthusMoraceae , fresh latax excelsa) and Neem (Azadirachta indica) and prepare the combination, fresh latex internallyFicus glomerata Doomar Leaves, bark Leaves juice bark juice, dried rootMoraceae. and roots powder given internally
  18. 18. Ficus religiosa Pipal Leaves Leaf extract Moraceae and fruitsGloriosa superba Kalihari Bulb, Freshly collected bulbs are crushed andColchicaceae leaves and added in mustard seed oil. The combination seeds is boiled and when all watery contents evaporate the boiling is stopped and special oil is used after filtration. The special oil is considered beneficial for the cancerous wound, The leaves are given internally in form of juiceGmelina arborea Khamhar Leaves Leaves juice, dried fruits powderLamiaceae and fruitsHibiscus rosasinensis Jason Flowers Dried flower powderMalvaceaeMangifera indica Ama Leaves The leaves of Arusa (Adhatoda vasica),Anacardiaceae and inner Kukurmutta (Blumea lacera) and Chirchita bark (Achyranthes aspera) are mixed in equal proportion. The Ama leaves are taken in double amount of this combination and mixed thoroughly. The combination is burnt and the patients are advised to inhale the fumes for lung cancer
  19. 19. Melia azedarach Bakain Root, bark and Dried root powder is givenMeliaceae fruits internally, inner bark and extract the juice given internallyMoringa oleifera Munga Bark, flowers Bark decoction, dried flowersMoringaceae powderMucuna pruriens Kevatch Root, seed Patients having mouth cancer toFabaceae and whole always put the freshly collected herbs Kevatch root inside the mouth, seed powder useful in treatment of cancer painNerium odorum Kaner Root and Roots decoction is prepared. TheApocynaceae flowers patients are advised to wash the wound with the help of this decoctionNyctanthes arbor- Harshringar Leaves and Dried bark powder given internally,tristis bark leaves decoctionOleaceaeOcimum sanctum Tulsi Seed and Decoction of seed and leavesLamiaceae leaves internally
  20. 20. There is a research gap on this topic still exist.This gap should be filled by quality researchers.The whole world is weighting for searchresearch

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