What I Did With My Biological Sciences Degree by Thaddus WilkersonPresentation Transcript
Working as an Infectious Diseases Clinical Pharmacy Specialist
Minimizing the Impact through Antimicrobial Stewardship
Antibiotic Resistance is a Public Health Crisis
At this time, I vow to devote my professional life to the service of
all humankind through the profession of pharmacy.
I will consider the welfare of humanity and relief of human
suffering my primary concerns.
I will apply my knowledge, experience, and skills to the best of
my ability to assure optimal drug therapy outcomes for the
patients I serve.
I will keep abreast of developments and maintain professional
competency in my profession of pharmacy.
I will maintain the highest principles of moral, ethical, and legal
I will embrace and advocate change in the profession of
pharmacy that improves patient care.
I take these vows voluntarily with the full realization of the
responsibility with which I am entrusted by the public.
Mission: Protect, promote and advance the health and safety of our nation.
Corps officers are involved in
disease control and prevention
regulation of food and drugs
mental health and drug abuse
health care delivery
The origins of the Public Health Service are to be found with sailors and medical care.
July 16, 1798 – 5th Congress passed an Act, signed by President John Adams
Rapid and effective response to public health needs
Leadership and excellence in public health practices
Advancement of public health science
“to provide for the accommodation of sick and disabled seamen.”
Today: more than 6,500 active-duty officers working to create a global world free of
preventable disease, sickness, and suffering.
American Association of Colleges of Pharmacy
Calculus, Statistics, Physics with lab
General biology with lab
Human anatomy & physiology
Microbiology with lab
Upper division bioliogy (ex Molecular)
General Chem with lab, organic chem with lab
Reading & writing for college or equivalen
Liberal arts / Humanities
Human Behavior (social,behavioral, psych)
Sante Fe – Policy &
DC – AAIP
VA – ambulatory care
Clinics & volunteering
with health fairs
Oral and IV
Works by inhibiting
topoisomerase II, IV
◦ Enzyme needed to
◦ Blocks cell division
◦ Efflux pumps
resistance genes for
proteins that block
◦ Mutations in DNA
More than 2 million people are
infected by drug-resistant germs each
23,000 die of their infections
The biggest killer is C. difficile
Up to half the antibiotic Rx written are
These unneeded antibiotics are
making the superbug problem worse.
There are not any new antibiotics
immediately in development that will
Older antibiotics with toxic side effects
are the last line defense.
NBC NEWS Sept 16, 2013
Abx resistant TB
Mycobacterial efflux pump promotes intracellular
survival and may mediate tolerance to antimicrobials
Verapamil – drug for heart disease
C3HeB/FeJ mice model of TB – lung lesions like
◦ Infected with aerosol M. tuberculosis
◦ Given standard anti-TB treatment (RIPE) + Verapamil
◦ Lung colony-forming units progressively decreased and lower
than standard treatment at 2, 4, 8, & 12 weeks
◦ All mice culture negative at 4 months with verapamil
◦ Lower 3-month relapse
J Respir Crit Care Med 2013 Sep 1
Treat infection not
Use the most effective
drug, dose with the
Minimize the spread of
Thaddus D. Wilkerson, Pharm.D., BCPS