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Raman Spectroscopy & Applications Dr. Tong Zhang Sales Manager – UK & Ireland Renishaw PLC
Dr. Sir C. V. Raman  (1888-1970) Process Monitoring & Reaction Control Hospital Universities & research units Justice & Custom Archaeology & gemmology
Outline ,[object Object],[object Object],[object Object],[object Object],[object Object]
Raman Principles ,[object Object],[object Object],[object Object],[object Object],Excitation Energy Electronic Ground State 1st Electronic Excited State Vib. states 2nd Electronic Excited State Raman Stokes Anti-Stokes fluorescence Impurity IR fluorescence Resonance  Raman Raleigh 3.2 3.44 ZnO 1.43 1.52 GaAs 0.17 0.23 InSb 1.11 1.17 Si RT 0 K Energy gap (eV) Material
Raman Instrument
Renishaw Incoming light Scattered light
Raman Strength & Limitations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Raman Applications -  Moving from Discovery to Practice ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
In vivo Source: National Institutes of Health, US ,[object Object],[object Object],[object Object],[object Object],Diode Laser CCD 830 nm Raman probe 1 cm 2.5 mm Probe inside breast biopsy needle FC ( Collagen) 20 40 60 80 100 10 20 30 40 50 60 70 Fibrocystic  change Cancer Normal FC (Fat) 0 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Material Science Source: Imperial College, Hong Kong Poly Univ. & Jasco Conducting polymers Textile & fabrics Citrine   Topaz Gemmology
Raman Challenge ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Raman Challenge - SERS Source: Imperial College 731 725 1327 652 DNA sequence identification Pillar Multiple Torus DS-DNA SS-DNA
Raman Challenge - TERS Source: Rochester Univ. Raman on SWNT: Spatial Resolution (~15 nm) Raman TERS Diffraction limit to beat
Summary ,[object Object],[object Object],[object Object],Thank you!

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Raman Spectroscopy Applications in Pharma, Materials & Forensics

  • 1. Raman Spectroscopy & Applications Dr. Tong Zhang Sales Manager – UK & Ireland Renishaw PLC
  • 2. Dr. Sir C. V. Raman (1888-1970) Process Monitoring & Reaction Control Hospital Universities & research units Justice & Custom Archaeology & gemmology
  • 3.
  • 4.
  • 6. Renishaw Incoming light Scattered light
  • 7.
  • 8.
  • 9.
  • 10. Material Science Source: Imperial College, Hong Kong Poly Univ. & Jasco Conducting polymers Textile & fabrics Citrine Topaz Gemmology
  • 11.
  • 12. Raman Challenge - SERS Source: Imperial College 731 725 1327 652 DNA sequence identification Pillar Multiple Torus DS-DNA SS-DNA
  • 13. Raman Challenge - TERS Source: Rochester Univ. Raman on SWNT: Spatial Resolution (~15 nm) Raman TERS Diffraction limit to beat
  • 14.