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Concept of Biologically Effective Equivalent Uniform Dose to compute Tumor Control Probability and Normal Tissue Complication Probability for IMRT Plans.   T. S. KEHWAR , D.Sc., Ph.D. M. Saiful Huq, PhD and Dwight E. Heron,   MD University of Pittsburgh Cancer Institute UPMC Cancer Centers, Pittsburgh
[object Object],[object Object],[object Object],OBJECTIVES
[object Object],[object Object],[object Object],BEEUD for Tumors Tumor with non-uniform dose distribution  SANCHEZ-NIETO, B & NAHUM, AE. THE DELTA-TCP CONCEPT: A CLINICALLY USEFUL MEASURE OF TUMOR CONTROL PROBABILITY. Int. J. Radiation Oncology Biol. Phys., Vol. 44, No. 2, pp. 369–380, 1999
[object Object],[object Object],[object Object],[object Object],Tumor with uniform dose distribution
BEEUD for normal tissues ,[object Object],[object Object]
[object Object],[object Object],Tumor Normal tissue/organ D ref
[object Object],[object Object],[object Object],[object Object],[object Object],BEEUD for normal tissues
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Normal tissue with Uniform dose distribution
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],RESULTS AND DISCUSSION
TCP for prostate for published values of   ,   /   and clonogenic cell density (ρ) for two IMRT plans.  Brenner, D. J., Hall, E. J., 1999.  Fractionation and protraction for radiotherapy of prostate carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 43(5), 1095 – 1101. King CR, Mayo CS. Is the prostate    ratio of 1.5 from Brenner & Hall a modeling artifact? Int J Radiat Oncol Biol Phys 2000; 47(2): 536 – 538. Wang JZ, Guerrero M, Li XA. How low is the / ratio for prostate cancer?  Int J Radiat Oncol Biol Phys  2003;55:194–203
NTCP calculation ,[object Object],[object Object],[object Object],[object Object]
Clinical Plans
CONCLUSIONS ,[object Object],[object Object],[object Object]
Thanking you all

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Biologically Effective Equivalent Uniform Dose to compute Tumor Control Probability and Normal Tissue Complication Probability

  • 1. Concept of Biologically Effective Equivalent Uniform Dose to compute Tumor Control Probability and Normal Tissue Complication Probability for IMRT Plans. T. S. KEHWAR , D.Sc., Ph.D. M. Saiful Huq, PhD and Dwight E. Heron, MD University of Pittsburgh Cancer Institute UPMC Cancer Centers, Pittsburgh
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  • 10. TCP for prostate for published values of  ,  /  and clonogenic cell density (ρ) for two IMRT plans. Brenner, D. J., Hall, E. J., 1999. Fractionation and protraction for radiotherapy of prostate carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 43(5), 1095 – 1101. King CR, Mayo CS. Is the prostate  ratio of 1.5 from Brenner & Hall a modeling artifact? Int J Radiat Oncol Biol Phys 2000; 47(2): 536 – 538. Wang JZ, Guerrero M, Li XA. How low is the / ratio for prostate cancer? Int J Radiat Oncol Biol Phys 2003;55:194–203
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Editor's Notes

  1. Good afternoon In my talk I am presenting a new concent of BEEUD to calculate TCP and NTCP for non uniform dose distribution.