Dr. Mark Allen - Present & Future: Bovine Genetic & Reproductive Technologies


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Present & Future: Bovine Genetic & Reproductive Technologies - Dr. Mark Allan, Director Marketing and Genomics, Trans Ova Genetics, from the 2014 NIAA Annual Conference titled 'The Precautionary Principle: How Agriculture Will Thrive', March 31 - April 2, 2014, Omaha, NE, USA.

More presentations at http://www.trufflemedia.com/agmedia/conference/2014_niaa_how_animal_agriculture_will_thrive

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Dr. Mark Allen - Present & Future: Bovine Genetic & Reproductive Technologies

  1. 1. Present & Future: Bovine Genetic & Reproductive Technologies Dr. Mark Allan Director Marketing and Genomics Trans Ova Genetics
  2. 2. The Value of Our Technology! • By 2045 the world’s population reaches 9+ Billion • Animal protein (milk) needs double as developing countries improve nutrition • 70% of the increase must come from technology
  3. 3. Outline • Review of genomics & genetic gain • Toolbox of Assisted Reproductive Technologies (ART) • In Vitro Fertilization (IVF) Applications • Cloning Applications • Bio Medical Applications • Genetic Modified Cattle -Gene Editing • Conclusion
  4. 4. Why use ART? • Assisted reproduction tools coupled with Genomic Selection will accelerate: genetic gain 2X – 8X – AI started in 1950’s – ET started in 1970’s – IVF started in 1990’s – GP/Cloning started in 1990’s – SS started in 2000’s GG = Var x Acc x Selection Intensity Gen. Interval
  5. 5. The Toolbox Embryo Transfer In Vitro Fertilization Cloning Gene Editing Sorted Semen Reproductive Toolbox Recipient Solutions Genetic Resources
  6. 6. TOG’s IVF Centers and Satellite Locations
  7. 7. Donor & Recipient
  8. 8. Collection & Handling
  9. 9. Live Calf
  10. 10. IVF • IVF provides embryo production on open, pregnant, subfertile and pre-puberal females • Best place to use Sexed Semen • More than one calf per year out of those really good cows and heifers • ….of the sex you desire most.
  11. 11. Transvaginal Ovum Pick-up (OPU)
  12. 12. Sexed Semen •Semen can be Sexed/Sorted. •Over 90% accuracy for sex •Reverse sorted semen for IVF
  13. 13. 1) Qualify donors via high density genomic chips 2) Collect juvenile donors 4) Gestate all embryos 3) IVF with sexed semen Today’s Elite Genetic Selection
  14. 14. Cloning
  15. 15. Why Do Dairy Producers Use this Technology? Maximizing Production • Multiple copies of elite animals Continuing Influence of Compromised • Genetic donor in poor health. Cloning used to produce a healthy bull with excellent semen production. • Estimate >100,000 units produced and sold domestically &internationally.
  16. 16. Why do Beef Producers Use this Technology? Maximizing Production from Outliers • The leading terminal sire 10 yrs. Contributing to the Genetic Pool • Genetic Outlier that died young. Eliminating Recessive Genes • Going back to a “free” founder. Extending Reach of Rare Genetics • Proven performer in high demand.
  17. 17. What About Product Safety? • FDA Cloning Risk Assessment (2008) o Food from clones of cattle, swine and goats are safe and do not require any more regulation than food from conventionally produced animals. o France, Japan, New Zealand and EFSA have had similar findings. • Supply Chain Management Program o We operated this program from 2008 to 2012. Competitors would not participate in our SCM. o In five years, it was never once accessed by industry. Nor did we make one animal incentive refund. o Ineffective. Discontinued.
  18. 18. Additional Applications of Biotechnology TOG also produces animals with applications in Biomedical: • Pharmaceutical production in milk • Recombinant human albumen • Human Antibodies • Pigs as medical models • Organ transplant • Medical devices
  19. 19. Genetically Enhance Crops
  20. 20. Genetic Engineering: Agricultural applications Lactoferrin, Lysozyme Dairy Cattle (Mastitis Resistance,Nutraceutical) Polled Prion KO cattle, BSE Resistance Influenza resistant swine
  21. 21. Near Future Genetic Selection Select Juvenile donors genomic enhanced Collect juvenile donors IVF with sexed semen Biopsy – freeze embryos Screen embryos via genomic chips Transfer selected embryos GG = Var x Acc x Selection Intensity Gen. Interval
  22. 22. The value of our technology Consumer benefits: – Animal health via disease resistance – Animal soundness and welfare – Animal longevity – Product quality • Decreased external fat • Increased marbling/quality • Improved tenderness/taste • Lower somatic cell counts in milk • Selection for favorable fatty acid profile – Decreased product cost via improved efficiency and health – Diminished environmental footprint – Bio-medical models, pharmaceuticals, xenotransplantation
  23. 23. Biotechnololgy Has Always Faced Acceptance Challenges WHICH TECHNOLOGY DO THESE QUOTES REFERENCE? • “It is unknown what long term health consequences may unfold. The studies are not adequate. Furthermore, this will likely not be available or cost effective for small farmers, it will decrease product acceptance and consumption, and will be catastrophic to small farming operations”. • (Quote from the introduction of the Pasteurized Milk Ordinance in 1924) • “We are talking about the possibility of human-animal hybrids, monstrous babies and reproductive engineering” “Children conceived this way will have no soul.” • (Quotes in 1978 following the birth of baby Louise Brown….and proceeding the birth of over 2M IVF babies)
  24. 24. QUESTIONS? www.transova.com www.viagen.com