Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
Sepsis 2009 update final
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Sepsis 2009 update final

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Goal Directed Therapy For Sepsis

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  • In ancient Egypt, Imhotep, the chief minister to King Djoser in the third millennium BC, was the first physician to gain wide recognition, and in later years, he became known as the Egyptian god of medicine.
    Edwin Smith, an Egyptologist, found clinical case histories recorded on Egyptian papyrus dating from circa 1600.
  • Emperor Shen Nung’s treatise is thought to be one of the first scientific papers. It described the antifever capabilities of ch’ang shan, an herbal substance, which since has been found to contain antimalarial alkaloids.
  • The Code of Hammurabi, King of Babylon, addresses various issues, including personal injury and punishment.
  • Marcus Terentius Varro, in De re rustica libri III (three books on agriculture), was the first to articulate the notion of contagion.
    Marcus Terentius Varro, in De re rustica libri III (three books on agriculture), was the first to articulate the notion of contagion.
    Marcus Terentius Varro, in De re rustica libri III (three books on agriculture), was the first to articulate the notion of contagion.
    Marcus Terentius Varro, in De re rustica libri III (three books on agriculture), was the first to articulate the notion of contagion.





  • SST…septic survival team…Dr.Stein Olive View UCLA, David Tallon and Gregory Moran



  • Sepsis is a heterogenous clinical syndrome that can be caused by any class of microorganism. Although both gram negative and gram positive bacteria account for the majority of cases, fungi, mycobacteria, viruses, protozans, and rickettsai may cause similar presentations. For example in children it often begins with nasopharyngeal colonization and then hematogenous spread of encapsulated organisms which in turn stimulates a release of inflammatory mediators….and if not corrected host defense mechanisms can fail resulting in severe sepsis refractory hypotension and death.
  • SST…septic survival team…Dr.Stein Olive View UCLA, David Tallon and Gregory Moran
  • SST…septic survival team…Dr.Stein Olive View UCLA, David Tallon and Gregory Moran
  • SST…septic survival team…Dr.Stein Olive View UCLA, David Tallon and Gregory Moran
  • SST…septic survival team…Dr.Stein Olive View UCLA, David Tallon and Gregory Moran

  • SST…septic survival team…Dr.Stein Olive View UCLA, David Tallon and Gregory Moran




  • Mixed venous oxygen saturation has been shown to be a surrogate for the cardiac index as a target for hemodynamic therapy

  • Once severe sepsis and septic shock are established, interventions to reverse the syndrome frequently are ineffective
  • Those that were in the GDT group got GDt for 6 hours and then went to the ICU, the intensivists that managed the patients in the unit were blinded to the treatment received in the ED.



  • From 7 to 72 hours








  • 50mg hydrocortisone q6hr.


  • 50mg hydrocortisone q6hr.








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