Praxeon : Getting to Market with Amazon AWS September 2007

About Us Founded in 2005 with a scientific focus Developed medical search technology based on chemical fingerprints and ideas from natural language Dr. Dennis Underwood, Ph.D. Chief Executive Officer Chemistry, Computational Sciences Big pharma and small pharma R&D Nicolas Encina President, Chief Operating Officer Comuter Science, Biology Small pharma Rishi Sikka , MD Chief Medical Officer Practicing physician Kevin Gilpin Chief Technical Officer Computer Science, Aerospace engineering Enterprise software, small pharma

Founded in 2005 with a scientific focus

Developed medical search technology based on chemical fingerprints and ideas from natural language

Dr. Dennis Underwood, Ph.D. Chief Executive Officer

Chemistry, Computational Sciences

Big pharma and small pharma R&D

Nicolas Encina President, Chief Operating Officer

Comuter Science, Biology

Small pharma

Rishi Sikka , MD Chief Medical Officer

Practicing physician

Kevin Gilpin Chief Technical Officer

Computer Science, Aerospace engineering

Enterprise software, small pharma

Fingerprint.MD Technology Change the representation of a document (journal, patent, news, etc.) from words to concepts Applies a domain model to create a Semantic Fingerprint. Uses whole ideas to search, organize and analyze information. Enables intelligent search results to sophisticated questions in the language of medicine Anticancer IPI-504 Cancer Infinity Pharmaceuticals, Inc. inhibitor Heat Shock Protein multiple myeloma Hsp90 small molecule cancer cell apoptosis homeostasis programmed cell death IPI-504 compounds Anticancer IPI-504 Cancer Infinity Pharmaceuticals, Inc. inhibitor Heat Shock Protein multiple myeloma Hsp90 small molecule cancer cell apoptosis homeostasis programmed cell death IPI-504 compounds

Change the representation of a document (journal, patent, news, etc.) from words to concepts

Applies a domain model

to create a Semantic Fingerprint.

Uses whole ideas to search, organize and analyze information.

Enables intelligent search results to sophisticated questions in the language of medicine

Finding our way with Amazon AWS Finding the Product + Market Fit So you have a technology idea? How do you find the right audience for it? The demand is to build real enough software that people can use it while staying extremely adaptable and agile Maximum time spent on your technology and functionality, the minimum possible time on ‘plumbing’ Using Amazon AWS helps us to spend more time on our core technology “ The line for technology with no business model is over there…”

Finding the Product + Market Fit

So you have a technology idea? How do you find the right audience for it?

The demand is to build real enough software that people can use it while staying extremely adaptable and agile

Maximum time spent on your technology and functionality, the minimum possible time on ‘plumbing’

Using Amazon AWS helps us to spend more time on our core technology

What is the application? Drug discovery and development Internal IT in pharma and biotech Discovery of new knowledge ; lead generation and new IP Search application for medical professionals Physicians, hospitals, insurers Profile-driven search : find the best evidence from a patient record Integrate to EMR systems Search application for patients Profile-driven search Profile-driven news Technology platform “ Fingerprint.MD is the medical intelligence engine”

Drug discovery and development

Internal IT in pharma and biotech

Discovery of new knowledge ; lead generation and new IP

Search application for medical professionals

Physicians, hospitals, insurers

Profile-driven search : find the best evidence from a patient record

Integrate to EMR systems

Search application for patients

Profile-driven search

Profile-driven news

Technology platform

“ Fingerprint.MD is the medical intelligence

engine”

Timeline : Finding Users Utilization Physician Search Profile-Driven Search & News Fingerprint.MD API Drug Discovery October 2005 October 2006 October 2007

MyDailyApple : Personalized News

MyDailyApple : Personalized Search

Timeline : Complexity of the Infrastructure October 2005 October 2006 October 2007 Physician Search Profile-Driven Search & News Fingerprint.MD API Drug Discovery Servers Documents (K) Applications Environments Amazon AWS 3 3 2 1 5 4 2 1 5000 2000 1000 250 8 5 3 1

Tangible Benefits No self-hosted infrastructure; no sys admin Storage Freed from worries of scale and failure Locally cached on EC2 instance Provisioning First a single machine. Then proof of concept to test S3 integration Added separate production environment with no additional effort Built some simple tools to provision and manage the instances using Capistrano Security EC2 provides port security and instructions on how to issue and use credentials. Future Being in EC2 enables us to start thinking about using value-added services like Mashery for the Fingerprint.MD API and RightScale for scaling up the application layer and we know that everything is co-located.

No self-hosted infrastructure; no sys admin

Storage

Freed from worries of scale and failure

Locally cached on EC2 instance

Provisioning

First a single machine. Then proof of concept to test S3 integration

Added separate production environment with no additional effort

Built some simple tools to provision and manage the instances using Capistrano

Security

EC2 provides port security and instructions on how to issue and use credentials.

Future

Being in EC2 enables us to start thinking about using value-added services like Mashery for the Fingerprint.MD API and RightScale for scaling up the application layer and we know that everything is co-located.

Where we are Today www.curbside.md Since April 2007 “ Evidence-based answers to real medical questions” Supported by 10 disease advocacy organizations including the National MS Society and the Accelerated Cure Project Answered thousands of professional medical questions www.mydailyapple.com Since September 2007 “ Personalized news and search for patients” Won audience poll for best search engine over Helia, MedStory, Kosmix, Healthline at Health 2.0 conference www.fingerprint.md “ Medical intelligence API” ReST-ful web services to search, organize, comprehend Starting pilot program in October

www.curbside.md

Since April 2007

“ Evidence-based answers to real medical questions”

Supported by 10 disease advocacy organizations including the National MS Society and the Accelerated Cure Project

Answered thousands of professional medical questions

www.mydailyapple.com

Since September 2007

“ Personalized news and search for patients”

Won audience poll for best search engine over Helia, MedStory, Kosmix, Healthline at Health 2.0 conference

www.fingerprint.md

“ Medical intelligence API”

ReST-ful web services to search, organize, comprehend

Starting pilot program in October