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  1. 2. IL MANGOSTANO
  2. 3. La Medicina tradizionale asiatica usa da secoli questo delizioso e potente frutto per i suoi molteplici benefici. E' originario della Thailandia .
  3. 4. Utilizzato già da molte generazioni Thailandia: proprietà astringenti India: dissenteria, diarrea, malattie, gastriche, gotta,febbre, ecc...
  4. 5. Joe Morton il fondatore di Xango scopre il frutto nel 1995
  5. 6. Xango impiega 7 anni per creare le infrastrutture e ha una collaborazione in esclusiva con l'azienda Wild Flavors
  6. 7. <ul><li>ISO 9001:2000 Quality Standards </li></ul><ul><li>AIB (American Baking Institute) </li></ul><ul><li>NFPA (National Food Procesors Association) </li></ul><ul><li>CFPA (Canadian Food Inspection Agency) </li></ul><ul><li>C-TPAT Certification </li></ul>
  7. 8. Sono stati catalogati in natura 200 tipi di Xantoni. Principalmente si trovano nelle cortecce degli alberi e nella buccia della Frutta Il Mangostano ne possiede ben 43 tipi
  8. 9. Tabella ORAC . Oxygen Radical Absorbance Capacity : Capacita' di assorbimento dei radicali liberi Mangostano TABELLA: Jean Mayer, Centro di ricerca nutrizione umana e invecchiamento dell’USDA (Dipartimento dell’Agricoltura degli Stati Uniti) presso la Tufts University di Boston, Massachusetts.
  9. 10. Il super Antiossidante Molecola biologicamente attiva appartenente al gruppo dei fenoli. Possiede un anello coniugato di carbonio con sei legami doppi che la rendono altamente stabile.
  10. 12. Gli xantoni hanno più elettroni, quindi riducono l’effetto nocivo dei radicali liberi XANTONI RADICALE LIBERO
  11. 13. Alcune situazioni associate ai danni ossidativi: Invecchiamento Periossidazione da acidi grassi della membrana cellulare Ateriosclerosi Periossidazione dei lipidi in particelle di LDL (colesterolo cattivo) Tumore / Cancro Danno del DNA con mutazioni dello stesso Cataratta Modifica irreversibile delle proteine interoculari Malattie infiammatorie croniche Attivazione di geni relazionati con la risposta infiammatoria
  12. 14. L’ossidazione inizia a livello cellulare ed è il processo base di moltissime malattie organo sistema L’ Ossidazione cellula tessuto
  13. 15. Chi colpisce l’ossidazione ? TUTTI
  14. 18. EQUILIBRIO
  15. 19. XAN TONAS MAN GO STÁN +
  16. 21. Malattie Relazionate con le Infiammazioni Croniche: “ L’ Infiammazione sta emergendo come l’alpha e l’ omega delle malattie del cuore. - Phd Peter Libby <ul><li>Malattie Cardiovascolari </li></ul><ul><li>Diabete </li></ul><ul><li>Alzahimer </li></ul><ul><li>Parkinson </li></ul><ul><li>Cancro </li></ul><ul><li>Artriti </li></ul><ul><li>etc... </li></ul>
  17. 23. www.ammim.org Xanthones 1813 Xantoni + antiossidanti 86 Xantoni + infiammazioni 18 Xantoni+ sistema immunitario 117 Xanthones + cancro 261 SCIENZA COMPROVATA XANTHONES
  18. 24. Limits  Preview/Index  History  Clipboard  Details  Entrez PubMed PubMed Services My NCBI Related Resources NLM Catalog NLM Gateway TOXNET Consumer Health Clinical Alerts ClinicalTrials.gov PubMed Central Order Documents NLM Mobile NLM Catalog NLM Gateway TOXNET Consumer Health Clinical Alerts ClinicalTrials.gov PubMed Central 1: Free Radic Res. 1995 Aug;23(2):175-84. Mangostin inhibits the oxidative modification of human low density lipoprotein. Williams P , Ongsakul M , Proudfoot J , Croft K , Beilin L . University of Western Australia, Department of Medicine, Royal Perth Hospital, Australia. The oxidation of low density lipoprotein (LDL) may play an important role in atherosclerosis. We investigated the possible antioxidant effects of mangostin, isolated from Garcinia mangostana, on metal ion dependent (Cu2+) and independent (aqueous peroxyl radicals) oxidation of human LDL. Mangostin prolonged the lagtime to both metal ion dependent and independent oxidation of LDL in a dose dependent manner over 5 to 50 microM as monitored by the formation of conjugated dienes at 234 nm (P < 0.001). There was no significant effect of mangostin on the rate at which conjugated dienes were formed in the uninhibited phase of oxidation. Levels of thiobarbituric reactive substances (TBARS) generated in LDL were measured 4 and 24 hours after oxidation with 5 microM Cu2+ in the presence or absence of 50 microM or 100 microM mangostin. We observed an inhibition of TBARS formation with 100 microM mangostin at 4 hours (P = 0.027) but not at 24 hours (P = 0.163). Similar results were observed in the presence of 50 microM mangostin. Mangostin, at 100 microM, retarded the relative electrophoretic mobility of LDL at both 4 and 24 hours after Cu2+ induced oxidation. Mangostin (100 microM) significantly inhibited the consumption of alpha-tocopherol in the LDL during Cu2+ initiated oxidation over a 75 minute period (P < 0.001). From these results, we conclude that mangostin is acting as a free radical scavenger to protect the LDL from oxidative damage in this in vitro system. Da questi studi, concludiamo che il Mangostano agisce come INIBITORE di Radicali Liberi proteggendo dal danno ossidativo del LDL. SISTEMA CARDIO VASCULAR
  19. 25. Mahabusarakam W, Proudfoot J, Taylor W, Croft K Inhibition of lipoprotein oxidation by prenylated xanthones derived from mangostin. Free Radic Res. 2000 Nov;33(5):643-59 PMID: 11200095 {PubMed- indexed for MedLine} Chemistry Department, Prince of Songkla University, Hat Yai, Thailand Jiang DJ, Hu GY, Jiang JL, Hiang HL, Deng HW, Li YJ Relationship between protective effect of xanthone on endothelial cells and endogeous nitric oxide synthase inhibitors. Bioorg Med Chem. 2003 Nov 17; 11 (23):5171-7 PMID: 14604680 {PubMed- indexed for MedLine} STUDI DI ATTIVITA’ ANTIOSSIDANTE
  20. 26. SISTEMA RESPIRATORIO Chairungsrilerd N, Furukawa K, Otha T, Nozoe S, Ohizumi Y. Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia Mangostana Planta Med, 1996 Oct; 62(5): 471-2 PMID: 8923814 {PubMed- indexed for MedLine} Chairungsrilerd N, Furukawa K, Otha T, Nozoe S, Ohizumi Y. Pharmacological properties of alfa mangostin, a novel histamine H1 receptor antagosnist. Eur J Pharmacol, 1996 Oct; 314 (3): 351-6 PMID: 8957258 {PubMed- indexed for MedLine} Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan ALCUNI STUDI SULL’AZIONE ANTISTAMINICA
  21. 27. Limits  Preview/Index  History  Clipboard  Details  Entrez PubMed PubMed Services My NCBI Related Resources NLM Catalog NLM Gateway TOXNET Consumer Health Clinical Alerts ClinicalTrials.gov PubMed Central Order Documents NLM Mobile NLM Catalog NLM Gateway TOXNET Consumer Health Clinical Alerts ClinicalTrials.gov PubMed Central 1: Planta Med. 2002 Nov;68(11):975-9. Related Articles, Links   Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines. Ho CK , Huang YL , Chen CC . Department of Medical Research & Education, Veterans General Hospital, Taipei, ROC. Treatment of hepatocellular carcinomas (HCCs) with chemotherapy has generally been disappointing and it is most desirable to have more effective new drugs. We extracted and purified 6 xanthone compounds from the rinds (peel) of the fruits of Garcinia mangostana L., using partitioned chromatography and then tested the cytotoxic effects of these compounds on a panel of 14 different human cancer cell lines including 6 hepatoma cell lines, based on the MTT method. Several commonly used chemotherapeutic agents were included in the assay to determine the relative potency of the potential new drugs. Our results have shown that one of the xanthone derivatives which could be identified as garcinone E has potent cytotoxic effect on all HCC cell lines as well as on the other gastric and lung cancer cell lines included in the screen. We suggest that garcinone E may be potentially useful for the treatment of certain types of cancer. Publication Types: * Research Support, Non-U.S. Gov't PMID: 12451486 [PubMed - indexed for MEDLINE] Garcinone E è un derivato di xantone ed ha un potente effetto citotossico sul carcinoma hepatocelular. noi supponiamo che il Garcinone E, possa essere un potenziale utile trattamento per alcuni tipi di cancro.
  22. 28. Limits  Preview/Index  History  Clipboard  Details  Entrez PubMed PubMed Services My NCBI Related Resources NLM Catalog NLM Gateway TOXNET Consumer Health Clinical Alerts ClinicalTrials.gov PubMed Central Order Documents NLM Mobile NLM Catalog NLM Gateway TOXNET Consumer Health Clinical Alerts ClinicalTrials.gov PubMed Central 1: Fitoterapia. 2004 Jun;75(3-4):375-7. Related Articles, Links   Antiproliferative activity of Thai medicinal plant extracts on human breast adenocarcinoma cell line. Moongkarndi P , Kosem N , Luanratana O , Jongsomboonkusol S , Pongpan N . Department of Microbiology, Faculty of Pharmacy, Mahidol University, Rajdhevee, Sri Ayudthaya Rd, Bangkok 10400, Thailand. pypmk@mahidol.ac.th Ethanolic extracts of selected nine Thai medicinal plants were tested for antiproliferative activity against SKBR3 human breast adenocarcinoma cell line using MTT assay. Garcinia mangostana showed the most potent activity . However, all plant extracts showed activity in potential range for further investigation on cancer cells. Copyright 2004 Elsevier B.V. Publication Types: * Research Support, Non-U.S. Gov't PMID: 15158999 [PubMed - indexed for MEDLINE] Attività antiproliferativa del cancro al seno nell’estratto della pianta medicinale Tailandese
  23. 29. Limits  Preview/Index  History  Clipboard  Details  Entrez PubMed PubMed Services My NCBI Related Resources NLM Catalog NLM Gateway TOXNET Consumer Health Clinical Alerts ClinicalTrials.gov PubMed Central Order Documents NLM Mobile NLM Catalog NLM Gateway TOXNET Consumer Health Clinical Alerts ClinicalTrials.gov PubMed Central 1: J Nat Prod. 2003 Aug;66(8):1124-7. Related Articles, Links   Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines. Matsumoto K , Akao Y , Kobayashi E , Ohguchi K , Ito T , Tanaka T , Iinuma M , Nozawa Y . Gifu International Institute of Biotechnology, 1-1 Naka-Fudogaoka, Kakamigahara, Gifu 504-0838, Japan. kmatsumoto@giib.or.jp We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects . Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis. PMID: 12932141 [PubMed - indexed for MEDLINE] Gli Xantoni del mangostano inducono rallentamenti (della leucemia)
  24. 30. J Ethnopharmacol. 2005 Oct 3;101(1-3):330-3. Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria. Chomnawang MT, Surassmo S, Nukoolkarn VS, Gritsanapan W. Department of Microbiology, Faculty of Pharmacy, Mahidol University, 447 Sri Ayudthaya Road, Rachathevi, Bangkok 10400, Thailand. scmtd@mahidol.ac.th Propionibacterium acnes and Staphylococcus epidermidis have been recognized as pus-forming bacteria triggering an inflammation in acne. The present study was conducted to evaluate antimicrobial activities of Thai medicinal plants against these etiologic agents of acne vulgaris. Crude extracts were tested for antimicrobial activities by disc diffusion and broth dilution methods. The results from the disc diffusion method showed that 13 medicinal plants could inhibit the growth of Propionibacterium acnes. Among those, Senna alata, Eupatorium odoratum, Garcinia mangostana, and Barleria lupulina had strong inhibitory effects. Based on a broth dilution method, the Garcinia mangostana extract had the greatest antimicrobial effect. The MIC values were the same (0.039 mg/ml) for both bacterial species and the MBC values were 0.039 and 0.156 mg/ml against Propionibacterium acnes and Staphylococcus epidermidis, respectively. In bioautography assay, the Garcinia mangostana extract produced strong inhibition zones against Propionibacterium acnes. Antimicrobial activity from fractions of column chromatography revealed one of the active compounds in Garcinia mangostana could be mangostin, a xanthone derivative. Taken together, our data indicated that Garcinia mangostana had a strong inhibitory effect on Propionibacterium acnes and Staphylococcus epidermidis. Therefore, this plant would be an interesting topic for further study and possibly for an alternative treatment for acne. Publication Types: Research Support, Non-U.S. Gov’t PMID: 16009519 [PubMed - indexed for MEDLINE] <ul><li>PELLE </li></ul><ul><li>ECZEMA </li></ul><ul><li>PSORIASI </li></ul><ul><li>ACNE </li></ul><ul><li>DERMATITE </li></ul><ul><li>ATOPICA </li></ul>La garcinia mangostana ha un potente effetto inibitorio nel Propionibacterium acnes così come nel Staphilococcus epidermis ( acne) :
  25. 31. Associazione Americana contro il Cancro
  26. 33. CONSULTA LE SEGUENTI PAGINE WEB www.xango.com Siti di medicina www.pubmed.gov (xanthones ó mangosteen) www.mangosteenmd.com www.ammim.org
  27. 34. Cosa è che rende Xango così Unico ?
  28. 35. INGREDIENTES ACTIVOS DEL MANGOSTAN GLI XANTONI Estilbenos (funghi) Quinonas (antibiotico, tetra) Tannini presenti nel vino rosso Polisaccaridi sono presenti nell'aloe Catequinas sono presenti nel te verde Proantocianidinas e Esteroles (antiossidanti) Potassio (25 mg/oz) Calcio Ferro Fosforo Vitamina B1, B2, B6 Vitamina C I Fitonutrienti del Mangostano
  29. 36. Xango può aiutarci come: Anti Infiammatorio Anti Allergico Anti Artritico Anti pirettico Anti virale Antibiotico Ansiolitico Stimolante Immunologico Cataratta e Glaucoma
  30. 37. Pelle e Allergie Sistema Respiratorio Asma Bronchiale Vertigini Eccelente nella sclerosi Multipla e Fibromialgie Artriti, osteoartrite reumatoide e degenerativa Sistema Digestivo Colite Diarrea Stitichezza Depressione Insonnia
  31. 38. Potente antiossidante Protegge il sistema Cardiovascolare Migliora il colesterolo Migliora i Trigliceridi Aiuta nell’ipertensione Aiuta a controllare il Diabete tipo I e tipo II Aiuta il Sistema Nervoso Centrale aiutando i pazienti con Alzaimer, Parkinson Previene l’Osteoporosi
  32. 39. UN’OTTIMA SOLUZIONE Senza dubbio SARA’ l’antiossidante più conosciuto di tutti i tempi ! Dr. Frederic Templeman
  33. 43. DOSI AGLI ADULTI SONO CONSIGLIATI 30 ml GIORNALIERI AI BAMBINI SONO CONSIGLIATI DA 1 A 7 ANNI: 15 ml. GIORNALIERI OLTRE I 7 ANNI: DOSI DA ADULTO PRECAUZIONI: USO DI ANTICOAGULANTI NON E' UN PRODOTTO CURATIVO
  34. 44. XANGO HA UN VALORE DI 28 EURO
  35. 45. CONSUMO RISPETTANDO LA DOSE GIORNALIERA (30ml.) SI OTTENGONO 25 PORZIONI VALORE DELLA PORZIONE CIRCA 1 € AL GIORNO, IL VALORE DI UN CAFFE' !
  36. 46. “ SPIACEVOLMENTE POCA GENTE INVESTE SULLA PROPRIA SALUTE, LA MAGGIOR PARTE SPENDE IN MALATTIE” Dott.ssa Angelita Martin Ferreira “ BERE L'ESTRATTO DI MANGOSTANO E' PARAGONABILE A UNA ASSICURAZIONE SULLA VITA”

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