Neuropathology Conference 12/01/05 - Case 1

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Neuropathology Conference 12/01/05 - Case 1

Neuropathology Conference 12/01/05 - Case 1

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  • 1. Neuropathology Case Conference 12/02/2005
  • 2. Case 1: 40 y/o Male, intermittent generalized headache
  • 3.  
  • 4.  
  • 5. Differential Diagnosis
    • Rathke’s Cleft Cyst
    • Dermoid Cyst
    • Colloid Cyst
    • Epidermoid Cyst
    • Craniopharyngioma
  • 6. Colloid cyst of third ventricle
    • Origin: neuroepithelial? vs. primitive foregut endoderm?
    • Intermittent generalized headache (rare “classical history”), “colloid cyst apoplexy”, sudden death
    • Gross: gray pultaceous material or soft cartilage-like hyaline substance slipping out like a marble.
    • Micro: cuboidal, columnar cells, goblet cells, ciliated columnar cells
    • IHC: low- and high-molecular CK, EMA: Positive, GFAP: Negativet