Cytopathology Conference 11/17/05 - Case 1

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Cytopathology Conference 11/17/05 - Case 1

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Cytopathology Conference 11/17/05 - Case 1

  1. 1. Cytopathology Conference: A Few Interesting Cases November 17, 2005
  2. 2. Case #4 <ul><li>Cervicovaginal thinprep from a 55-year-old female. </li></ul>
  3. 8. Diagnosis?
  4. 9. Endocervical Adenocarcinoma in Situ (AIS)
  5. 11. Adenocarcinoma in Situ <ul><li>Groups </li></ul><ul><ul><li>Very crowded </li></ul></ul><ul><ul><li>Stratified strips </li></ul></ul><ul><ul><li>Rosettes </li></ul></ul><ul><ul><li>Conventional slides: “feathering” </li></ul></ul><ul><ul><li>Liquid-based slides: “knuckles ” </li></ul></ul>
  6. 12. Adenocarcinoma in Situ <ul><li>Nuclei </li></ul><ul><ul><li>High N/C ratio </li></ul></ul><ul><ul><li>Oval to elongated or regular </li></ul></ul><ul><ul><li>Marked hyperchromasia </li></ul></ul><ul><ul><li>Coarse chromatin </li></ul></ul><ul><ul><li>Nucleoli typically inconspicuous </li></ul></ul>
  7. 13. Adenocarcinoma in Situ <ul><li>No diathesis </li></ul><ul><li>Frequently associated with squamous lesions </li></ul>
  8. 14. Case #4 <ul><li>64-year-old female with a history of a left breast mass. </li></ul>
  9. 18. Diagnosis?
  10. 19. Mucinous Neoplasm or Lesion <ul><ul><li>Suspicious for mucinous carcinoma </li></ul></ul><ul><ul><li>Differential includes mucocele-like lesion </li></ul></ul>
  11. 26. Case #5 <ul><li>55-year-old male with an FNA from a right inguinal lymph node. </li></ul>
  12. 33. Diagnosis?
  13. 34. High-grade mostly necrotic malignant neoplasm
  14. 36. Immunohistochemistry <ul><li>Vimentin: Positive </li></ul><ul><li>Pan-Keratin, CK7, CK20, LCA, CD20, CD3 and c-kit: negative </li></ul>
  15. 37. Final Diagnosis <ul><li>High-grade mostly necrotic malignant neoplasm </li></ul>

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