Cytopathology Conference 10/20/05 - Case 3
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Cytopathology Conference 10/20/05 - Case 3

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Cytopathology Conference 10/20/05 - Case 3

Cytopathology Conference 10/20/05 - Case 3

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    Cytopathology Conference 10/20/05 - Case 3 Cytopathology Conference 10/20/05 - Case 3 Presentation Transcript

    • Cytopathology Conference 10/20/2005
    • Case 3 13-year-old girl with a 3 cm left cheek mass.
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    • Differential Diagnosis
      • Pleomorphic adenoma
      • Monomorphic adenoma
    • Diagnosis?
    • Pleomorphic Adenoma
    • Pleomorphic Adenoma
      • Most common salivary gland neoplasm
      • Parotid gland (superficial lobe)
      • Females>males (4:1)
      • Rx: Excision with good margin of tissue
    • Pleomorphic Adenoma: variable appearance Epithelial and mesenchymal elements present. Cystic, papillary, hyalinized or tubular. Backround can have chondroid, myxoid, osteoid.
    • Pleomorphic Adenoma The stroma is the most outstanding feature. It is intensely metachromatic and stains a beautiful bright (fibrillary) magenta on diff-quick .
    • Pleomorphic Adenoma Hyaline cells
    • Pleomorphic Adenoma Mucous metaplasia and squamous metaplasia
    • Pleomorphic Adenoma Oncocytic metaplasia and sebaceous metaplasia
    • Pleomorphic Adenoma Tyrosine crystals and focal atypia
    • Pleomorphic Adenoma Hyaline Cells
    • Pleomorphic Adenoma Hyaline Globules: differential - adenoid cystic carcinoma - pleomorphic adenoma - monomorphic adenoma - mucus producing adenocarcinoma - acinic cell carcinoma - others with myoepithelial cells