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Cytopathology Conference 10/20/05 - Case 3
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Cytopathology Conference 10/20/05 - Case 3

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Cytopathology Conference 10/20/05 - Case 3

Cytopathology Conference 10/20/05 - Case 3

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  • 1. Cytopathology Conference 10/20/2005
  • 2. Case 3 13-year-old girl with a 3 cm left cheek mass.
  • 3.  
  • 4.  
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  • 7. Differential Diagnosis
    • Pleomorphic adenoma
    • Monomorphic adenoma
  • 8. Diagnosis?
  • 9. Pleomorphic Adenoma
  • 10. Pleomorphic Adenoma
    • Most common salivary gland neoplasm
    • Parotid gland (superficial lobe)
    • Females>males (4:1)
    • Rx: Excision with good margin of tissue
  • 11. Pleomorphic Adenoma: variable appearance Epithelial and mesenchymal elements present. Cystic, papillary, hyalinized or tubular. Backround can have chondroid, myxoid, osteoid.
  • 12. Pleomorphic Adenoma The stroma is the most outstanding feature. It is intensely metachromatic and stains a beautiful bright (fibrillary) magenta on diff-quick .
  • 13. Pleomorphic Adenoma Hyaline cells
  • 14. Pleomorphic Adenoma Mucous metaplasia and squamous metaplasia
  • 15. Pleomorphic Adenoma Oncocytic metaplasia and sebaceous metaplasia
  • 16. Pleomorphic Adenoma Tyrosine crystals and focal atypia
  • 17. Pleomorphic Adenoma Hyaline Cells
  • 18. Pleomorphic Adenoma Hyaline Globules: differential - adenoid cystic carcinoma - pleomorphic adenoma - monomorphic adenoma - mucus producing adenocarcinoma - acinic cell carcinoma - others with myoepithelial cells

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