Working with Histamine Overload April 2013

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We were able to reduce our son's frequent and serious histamine and mast cell reactions, by working with the body's natural functions. The body excretes histamine in similar ways as other chemicals, …

We were able to reduce our son's frequent and serious histamine and mast cell reactions, by working with the body's natural functions. The body excretes histamine in similar ways as other chemicals, so there are ways to help a functional bottleneck and support the boty's natural function.

Decreasing dietary histamine, supporting liver function, controlling the triggers that you know about can help dramatically.

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  • Type Location Function H 1 histamine receptor Found on smooth muscle , endothelium , and central nervous system tissue Causes, bronchoconstriction , bronchial smooth muscle contraction, vasodilation , separation of endothelial cells (responsible for hives ), and pain and itching due to insect stings; the primary receptors involved in allergic rhinitis symptoms and motion sickness ; sleep and appetite suppression. H 2 histamine receptor Located on parietal cells and vascular smooth muscle cells Primarily involved in vasodilation. Also stimulate gastric acid secretion H 3 histamine receptor Found on central nervous system and to a lesser extent peripheral nervous system tissue Decreased neurotransmitter release: histamine, acetylcholine, norepinephrine, serotonin H 4 histamine receptor Found primarily in the basophils and in the bone marrow. It is also found on thymus, small intestine, spleen, and colon. Plays a role in chemotaxis.

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  • 1. Methods we used to lower our young son’s histamine burden,to reduce the frequency and intensity of dangerous and painfulhistamine mediated reactions.Copyright Tiffany Blackden 2013All Rights ReservedThe Mastocytosis SocietyDC Regional Regional MeetingApril 2013
  • 2. Copyright Tiffany Blackden 2013All Rights ReservedOur family!The reasons we’ve stayed up all nightresearching and continuing to figureout ways to support health!
  • 3. Mast Cell Activation SyndromeI.SystemicAnaphylaxisFaintnessFatigueII.DermatologicFlushingRashesItchingHivesIII.CardiovascularBlood pressure changesand shockChest painRapid heart rateIV.PulmonaryWheezingCopyright Tiffany Blackden 2013All Rights Reserved
  • 4. V.MusculoskeletalBone painMuscle painDegenerative disc diseaseOsteoporosis/osteopeniaVI.GastrointestinalNauseaVomitingAbdominal painGastroesophageal refluxDiarrheaInflammation of theesophagusIntestinal cramping andbloatingMalabsorptionVII.NeurologicCognitivedifficulties/brain fogDizziness/vertigoLightheadednessMigraine headacheParesthesiaPeripheral neuropathyCopyright Tiffany Blackden 2013All Rights Reserved
  • 5. Max’s Daily MCAS PresentationHives, dermatographia, flushing, swelling, stomachaches,headaches, fatigue, stuffiness, dizziness, reflux, diarrhea,leg pain, itching from:Foods (too many to name!)FrictionHeatColdChange in tempAnimalsChemicalsSynthetic FabricsSkin Contact With Plants/GrassEtc…???Copyright Tiffany Blackden 2013All Rights Reserved
  • 6. A few of hisreactions:Copyright Tiffany Blackden 2013All Rights ReservedBlisters on both lower legsafter consuming olive oil.Rolled around onsynthetic rug…takenafter the hives calmeddown a bit.Really angry reactionfrom playing with ascratchy rope. This wasafter it was calm, wenearly went to thehospital, it coveredmuch of his torso andhis left arm.
  • 7. Max’s Health Team:Naturopathic DoctorsNationally Certified NutritionistsAcupuncturist - BioSet PractitionerChinese Medicine PractitionerOsteopathic Doctor (D.O.)ChiropractorMD HomeopathBiomedical MDHis Mommy, Daddy and SisterCopyright Tiffany Blackden 2013All Rights Reserved
  • 8. What’s in a mast cell?Copyright Tiffany Blackden 2013 All Rights ReservedToday we are focusing on HISTAMINE…Art by: Angela Canada Hopkinshttp://www.canadahopkins.com/Over 100 different molecules thatprotect the body, as well as causinginflammation.Preformed mediators :(from granules)-Serine proteases-Tryptase-Histamine-Serotonin-Proteoglycans-mainly heparinNewly formed Lipid Mediators:(eicosanoids)-Thromboxane-Prostoglandins-Leukotreines-Platelet Activating Factor-Cytokines
  • 9. The reasons we focused on loweringthe systemic histamine burden:First step in protocol for mast cell disorders isantihistamines, primarily H1 and H2 drugs.Mast cells have histamine receptors on the cellmembrance that make them more ready todegranulate or selectively secrete mediators.Dietary histamine (and other biogenic amines, liketyramine) was a primary *group* of foods that werebothering our son.Copyright Tiffany Blackden 2013All Rights Reserved
  • 10. Copyright Tiffany Blackden 2013All Rights ReservedLocal Immune Response for InjuryProtective Mechanism in ‘Boundary’ TissuesRegulates Smooth Muscle ContractionNeurotransmitter
  • 11. Histamine AffectsEvery System of the BodyNeurologicalCardiovascularMusculoskeletalGastrointestinalReproductiveRespiratoryCutaneousCopyright Tiffany Blackden 2013All Rights ReservedIt is produced in mast cells, basophils, platelets, neutrophils and someneurons…and stored intracellularly, then released when stimulated.
  • 12. Histamine Receptors:H1: Smooth Muscle, Endothelium, Central NervousSystem Tissue, Mast CellsH2: Gastrointestinal, Vascular Smooth Muscle Tissue,Mast CellsH3: Central Nervous System and Some PeripheralNervous System, Mast CellsH4 (Just discovered in 2000): Bone Marrow, Basophils,Thymus, Small Intestine, Spleen, Colon, Mast CellsCopyright Tiffany Blackden 2013All Rights Reserved
  • 13. Copyright Tiffany Blackden 2013All Rights Reserved Dtsch Arztebl 2006; 103(51–52):A 3477–83.
  • 14. Sources of Histamine:Normal Metabolic Function Throughout BodyDietary HistamineFoods That Release Histamine From Mast CellsIgE (Allergy) Mast Cell Degranulation Non-IgE (Trigger)Mast Cell DegranulationBacteriaCopyright Tiffany Blackden 2013All Rights Reserved
  • 15. Histamine Burden is cumulativeover the course of a day(sometimes persisting beyond aday, if the burden is high).Control what you CAN, to keepthe cup from overflowing with allthe factors *not* in your control.Copyright Tiffany Blackden 2013All Rights Reserved
  • 16. Histamine Overload…Copyright Tiffany Blackden 2013All Rights ReservedHistamine for Digestion (histaminesecreted to release stomach acid innormal digestion)Pineapple (contains histamine ANDcan release histamine directly fromcells)Sodium Benzoate in Soda (commonfood/beverage preservative and mcdegranulator)Cat Dander (IgE)Ragweed (IgE)Hot Day/Pressure/Friction/ Vibration(all physical mast cell triggers)Chicken Leftover in Fridge(histamine produced byproteins breaking down)Combination of IgE, endogenous (made inside the body), naturally occurring dietaryhistamine, physical triggers, and consumption of histamine releasing substances.
  • 17. Avoiding High Histamine Pitfalls…All of these can increase your histamine burden, ordecrease your body’s ability to process histamine.Fermented FoodsCured FoodsDyesPreservatives/AdditivesSulphitesRefrigerated Leftovers (we freeze them)AlcoholHigh Histamine FoodsHistamine Releasing FoodsHistamine Degrading Enzyme Inhibiting ChemicalsCopyright Tiffany Blackden 2013All Rights Reserved
  • 18. Some Histamine Liberating or DAO/HMT Inhibiting MedsSubstance class Some Active agents Radiological Contrast media Muscle relaxants Pancuronium, Alcuronium, D-Tubocurarin Narcotics Thiopental Analgesics Morphine, pethidine, NSAR, ASS, metamizole Local anesthetics Prilocaine Antihistamines Dyphenhydramine Antihypotensives Dobutamine Antihypertensives Verapamil, alprenolol, dihydralazine Antiarrhythmics Propafenon Diuretics Amiloride Motility agents Metoclopramide Antibiotics Cefuroxime, cefotiam, isoniazid,pentamidine,clavulanic acid, chloroquine Mucolytics Acetylcysteine, ambroxol Broncholytics Aminophylline H2 receptor antagonists Cimetidine Cytostatics Cyclophosphamide Antidepressants Amitriptylline Copyright Tiffany Blackden 2013All Rights Reserved
  • 19. Now we know how we gethistamine IN our systems…How Does Histamine*EXIT* Our Bodies?Copyright Tiffany Blackden 2013All Rights Reserved
  • 20. Deactivation AND Liver MetabolismEnzymes that BREAK DOWN Histamine:o DAO (Diamine Oxidase)o HMT/HNMT (Histamine Methyltransferase)o MAO A (Monoamine Oxidase A)Phase I & II Liver Detoxificationo Methylationo Sulfationo OxidationCopyright Tiffany Blackden 2013All Rights Reserved
  • 21. Functional Bottleneck: What other molecules use the *same exitpathways* as histamine (and other inflammatory mediators)?MedicationsPesticidesHerbicidesHormonesBacteriaAntibodiesNeurotransmittersChemical FragrancesInhaled ChemicalsChemicals in Municipal WaterPreservatives in Food and Body ProductsAdditives in Food and Body ProductsDyesMore…Copyright Tiffany Blackden 2013All Rights Reserved
  • 22. Ways to Help the Liver Flush HistamineReduce overall chemical load.Move lymph in our bodies.Exercise.Lower our stress level.Drink lots of clean water.Get adequate nutrients for detoxification.Copyright Tiffany Blackden 2013All Rights Reserved
  • 23. REDUCING OVERALL CHEMICAL LOAD-Indirect ContactYardInsect Repellants, Weed Killers, FertilizersHome Cleaning, Air freshening, Painting, Construction, Pet productsPublic Placesstores with fragrance everywhere, airborne chemicals fromproducts in stores, people with perfume/detergent/dryer sheetHobbyPaints, Compounds, Gasoline, Carbon Monoxide, Polishes,Cleaning ProductsCopyright Tiffany Blackden 2013All Rights Reserved
  • 24. REDUCING OVERALL CHEMICAL LOAD –Direct ContactBodySoaps, Shampoo/Conditioner, Lotions,Hair Sprays, Nail Products, ToothpasteDeodorantClothes with chemicals fromdetergents/dryer sheetsFoodAdditives, Preservatives, Sweeteners,Pesticides, Herbicides, Plastics,Chemicals from municipal water(Chlorine, Fluoride, Aluminum,Antibiotics, Hormones, etc)Copyright Tiffany Blackden 2013All Rights ReservedCalifornia BabyBubble BathMast CellDegranulatingPreservative
  • 25. Some doctors in Europe treat histamine intolerance as a progressingdisease process…histamine has role in chemotaxis (programmed celldeath), so could an enzyme deficiency or chronic, systemic build up ofhistamine be related to mast cell proliferation (mastocytosis)?MastocytosisMCADHypersensitivity DisorderHistaminosisHistamine IntoleranceCopyright Tiffany Blackden 2013All Rights Reserved
  • 26. Mast Cell – Histamine DiariesFoods (Sensitivities/Histamine/Glycemic Index)Beverages (Hydration Level/Dyes/Sweeteners)Exposures (Pollen/Stores/Chemicals/Smells)Reactions (Type/Duration/Medication)Sleep (Amount/Quality)Emotional State (Anxious/Depressed/Happy/Stressed)Copyright Tiffany Blackden 2013All Rights Reserved
  • 27. Our Daily High Quality NutritionDrink plenty of good quality water EVERY day. Low Histamine/Tyramine/Other Biogenic Amines, Organic Whole Foods(locally grown when possible) Rotate Foods As Much As Possible No Gluten/Dairy/Soy/Eggs/Nuts/Citrus/Dyes/AdditivesPreservatives/Polyunsaturated Fats Only grass fed beef, venison and wild caught fish Good quality fats daily(No PUFAs, we use ghee and coconut oil) Digestive Enzymes Sources of Trace Minerals (Pink Himalayan Salt, Dulse Flakes & Wakame,Superdupermineralpackedwheatgrass juice) Some High Quality Supplements (Vit D, Vit K2, Mitochondrial SupportSupps-CoQ10, l-carnitine, d-ribose and magnesium) Raw Leafy Greens (methylation support)Copyright Tiffany Blackden 2013All Rights Reserved
  • 28. Other Daily Health SupportHydration, Hydration, HydrationDense NutritionEpsom Salt Baths Almost Daily (Additional MagnesiumChloride Spray as Needed)Moderate Exercise-Play, Mini TrampolineClean AirGood Quality SleepLimit All Man-made Chemical Exposure PossibleAyurvedic-Style Meal Preparation (60%+ of calories by 1pm)12 Hour Night Fast (Liver Function Support)Low StressCopyright Tiffany Blackden 2013All Rights Reserved
  • 29. Locally grown, organic when possible:Helps us avoid GMOs, Herbicides, PesticidesThis food has more micronutrients, more live enzymes,was JUST harvested (not weeks ago, ripening on a truck)and hasn’t been sprayed with a preservative at a grocerystore(which is derived from GMO corn).Copyright Tiffany Blackden 2013All Rights Reserved
  • 30. What MCAS has taught us: WE are responsible for our family’s healthcare…it is necessary to understand as much aswe can, so we can make the lifestyle changes necessary for health. We *hire* doctors, and can choose the team that serves us best. We require that theyare open minded and willing to do some research, since this disease is such anunknown. Much of our most effective care has been out of pocket and on the peripheryof traditional western medicine. Stress has a dramatic effect on our health. This can NOT be overstated, when mast cellsand histamine levels are involved. Eating right and living in a way that has allowed a healthier life was not easy (we movedacross country, let our beloved pets go, change our diet, change all of our household andpersonal care products and homeschool to help our son), but every step we’ve taken hasbrought us to a more complete level of health and wellness. It’s a marathon, that requires daily effort. It can’t be done as a sprint…little changes,consistently added, allow for some sense of balance as you go along the path. When you have a chronically sick child, it is vitally important to take care of yourself. We must trust our intuition.Copyright Tiffany Blackden 2013All Rights Reserved
  • 31. Get in touch, get support…Please connect with me:Tiffany Blackden on Facebook, Twitter or LinkedInEmail: Tiffany@TiffanyBlackden.comJoin Facebook Group:“Mastocytosis – Holistic Approach”Our FB page for our medical journey & research:www.Facebook.com/blackdenfamilyCopyright Tiffany Blackden 2013 All Rights Reserved