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Different blood tests given for bleeding disorders or blood dyscrasia
Different blood tests given for bleeding disorders or blood dyscrasia
Different blood tests given for bleeding disorders or blood dyscrasia
Different blood tests given for bleeding disorders or blood dyscrasia
Different blood tests given for bleeding disorders or blood dyscrasia
Different blood tests given for bleeding disorders or blood dyscrasia
Different blood tests given for bleeding disorders or blood dyscrasia
Different blood tests given for bleeding disorders or blood dyscrasia
Different blood tests given for bleeding disorders or blood dyscrasia
Different blood tests given for bleeding disorders or blood dyscrasia
Different blood tests given for bleeding disorders or blood dyscrasia
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Different blood tests given for bleeding disorders or blood dyscrasia

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  • 1. Seminar on - Different Blood Tests Given For Bleeding Disorders Or Blood Dyscrasia Presented By- Tickendra Jit Das Third year BDS
  • 2. Diseases of the blood-forming organs. In most cases, this involves diseases of the bone marrow, but it might also involve the spleen and/or the liver. • The term "dyscrasia" originated in earlier medical "science" and referred to the "four humors." It has come to mean simply "disease" or "pathological condition.“ • Thus, blood dyscrasia is a pathological condition of the blood, usually involving disorders of the cellular elements of the blood. • Blood dyscrasia typically refers to a blood disorder where one part of the blood is not present in normal supply. The different constituents of blood like platelets, or white or red blood cells could be too high or too low in counts. It’s worth noting that sometimes the blood disease has to do with interference in the way blood normally works, such as in clotting diseases caused by missing •
  • 3. Generally, there are 1-3 of these symptoms: Bleeding problems due to poorly functioning platelets or decreased platelets, or loss of certain body proteins called "clotting factors" Weakness or pale skin color due to poorly functioning red blood cells or decreased numbers of red blood cells Frequent infections due to poorly functioning white blood cells or decreased numbers of white blood cells Symptoms associated with the following common blood dyscrasias (for in-depth discussions of specific diseases, see the title headings):
  • 4. Diseases of platelets: ITP (Idiopathic Thrombocytopenic Purpura) -- sudden onset of small and large bleeding points in the skin; often following a virus infection, or aspirin use. Sometimes, there are Nosebleeds or bleeding gums. TTP (Thrombotic Thrombocytopenic Purpura) -- anemia, fever, and bleeding as in ITP Diseases of clotting factors: Hemophilia -- significant bleeding during circumcision, bleeding into the joints and muscles, easy bruising, significant bleeding during surgery Von Willebrand's Disease -- frequently, a history of familial bleeding tendency; bleeding gums, Nosebleeds, easy bruising
  • 5. Diseases of red blood cells: Sickle cell anemia -- early symptoms are severe, recurrent episodes of abdominal pain; bleeding into the joints; and enlargement of the spleen. Diseases of white blood cells: Leukemia -- early signs and symptoms are anemia, bleeding tendency, bone pain, and serious infection.
  • 6. Cause There are genetic causes, which are determined by family background. There are also diseases that occur from mutation in one's genes, or infection, or from unknown causes.
  • 7. Complete blood count (CBC) Bleeding time activated partial thromboplastin time (aPTT) Platelet aggregation test Prothrombin time (PT)
  • 8. activated partial thromboplastin time (aPTT) The aPTT is functional determination of the intrinsic pathway of coagulation (factors XII, XI, IX, VIII, V, II, I, prekallikrein, high molecular weight kininogen). This pathway is intitated by the interaction of Factor XII with a negatively charged surface. A cas-cade mechanism results in fibrin production and clot formation. The aPTT is utilized to detect congenital and qcquired abnormalities of the intrinsic coagulation pathway and to monitor patients receiving heparin.
  • 9. The PT and aPTT are the fundamental assays of the coagulation system. The principal clinical uses of the aPTT include: (1) the detection of hereditary or acquired defi-ciencies or defects of the intrinsic and common pathway coagulation factors (factors XII, XI, IX, VIII, prekallikrein, high molecular weight kininogen), (2) monitoring heparin anticoagulant therapy, (3) the detection of coagulation inhibitors (i.e., lupus anticoagulant), and (4) to monitor coagulation factor replacement therapy in patients with hemophilia. The aPTT is increased above the upper limit of normal with hereditary or acquired intrinsic factor deficiencies < 40% (factor VIII:C, Factor IX, Factor XI, Factor XII, vWf), lupus anticoagulants, or specific inhibitors of the intrinsic coagulation factors. Other causes of an elevated aPTT include liver disease, disseminated intravascular coagulation (DIC), heparin or anticoagulant therapy, or improper specimen collection (i.e., traumatic phlebetomy or hemolyzed specimen).
  • 10. Blood dyscrasia typically refers to a blood disorder where one part of the blood is not present in normal supply. The different constituents of blood like platelets, or white or red blood cells could be too high or too low in counts. It’s worth noting that sometimes the blood disease has to do with interference in the way blood normally works, such as in clotting diseases caused by missing proteins, like in von Willebrand’s disease, where needed proteins to cause blood clotting are not available as normal. Thus, when abnormal function of blood or its components is present, people are thought to have a blood dyscrasia, and dyscrasia can be thought of as synonymous with disease. There are many different types of blood dyscrasia. As mentioned, von Willebrand’s disease occurs when there are poor amounts of the proteins that form blood clots. Another serious illness like this is hemophilia. Similar to blood clotting diseases affecting proteins are those that affect the platelets. Various forms thrombocytopenia or low platelet count can cause serious decrease in platelet production, which may also result in excessive bleeding. Thrombocytopenia can be induced by treatments like chemotherapy or by illness, and it can occasionally be a congenital condition. Blood dyscrasia can refer to diseases that affect white blood cells. Some of these
  • 11. Samples of blood from a healthy person and one with leukemia. Leukemia is a form of blood dyscrasia. A diagram showing different types of white blood cells. Blood dyscrasia can refer to diseases that affect white blood cells.

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