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Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
Biological solutions in a chemical world, Green Polymer Chemistry 2012
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Biological solutions in a chemical world, Green Polymer Chemistry 2012

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  • 1. BIOLOGICALSOLUTIONS IN ACHEMICALWORLDThomas SchäferSenior Director, R&DCologne, March 2012
  • 2. Safe Harbor Statement This presentation and its related comments contain forward-looking statements, including financial expectations. Forward-looking statements are by their very nature associated with risks and uncertainties that may cause actual results to differ materially from expectations. The uncertainties may include unexpected developments in the international currency exchange and securities markets, market-driven price decreases for Novozymes’ products, and the introduction of competing products in Novozymes’ core areas. 2
  • 3. Novozymes –The World Leader in Bioinnovation• Largest market share of all players in Global enzyme market Industrial Enzymes (47%) 2009 value: DKK ~ 16bn• More than 60 years legacy in the Novozymes Danisco DSM Others Captive business• 2011 sales of DKK 10,510m 47% 21% 6% 16% 10% (+8% in DKK, +10% in LCY, +7% organic) 0% 20% 40% 60% 80% 100%• 20 years sales growth CAGR of 8%• EBIT: DKK 2340m (+11 %)• ~ 14% of sales spent on R&D• + 6,300 granted and pending patents• + 5,500 employees Enzyme Business BioBusiness• Global Organisation Household Food & Feed & Micro- Biopharmaceutical Bioenergy• More than 700 products used in 130 Care Beverages other Tech. organisms ingredients countries in over 30 different industries *A+B shares April, 2011 3
  • 4. Delivering Tomorrow’s Solutions TodayDelivering solutions from Helping companies This unique approachnature: become more efficient: leads to:Enzymes energy efficiency “more with less” combined with…Active microbial products saving raw materials higher qualityProteins & peptides reducing waste lower costsPolymers replacing petro-chemicals better yields and a betterFermentation is central environment 4
  • 5. Reducing CO2 Emissions Together with Our Customers• In 2009, Novozymes helped customers save 27 million tons of CO2 – equal to half of Denmark’s annual CO2 emission• Goal: 75 Mio tons saved in 2018 Net CO2 saving using 1kg enzyme in different production processes 3800 kg 3400 kg 1300 kg Up to 600 kg CEREAL FOOD 150 kg 150 kg 200 kg BIOCATALYSIS 40 kg 100 kg 30 kg OILS & FATS PAPER FOOD BIOETHANOL DETERGENT LEATHER TEXTILES ANIMAL FEED 5
  • 6. Using Nature’s own Resources Enable SustainableSolutions and Acknowledgement Top 1% of Environmental Investment Organization carbon reporting Best in Class Storebrand SRI Member of Global100 by Innovest Member of FTSE4 Good Global and Europe Member of SB20 by SustainableBusiness.com Member of Cleantech Index Member of OMX GES Sustainability Index Dow Jones Sustainbility index Biotechnology sector leader 6
  • 7. Novozymes’ Vision • Less need for energy, water and chemicals • Better utilization of raw materials • Less CO2 emissions • Ability to convert agricultural feedstocks • Ability to produce food, feed, fibres, fuels & materials 7
  • 8. 8 NOVOZYMES PRESENTATIONBiorefinery as central element
  • 9. 9Summary: Novozymes key technologiesdeliver key enablers for the biobased society 1 2 3 Systems biology and Enzymes for key reactions in molecular biotechnology the chemical industry to create highly efficient ”superbugs” Enzyme systems for 1st and 2nd generation biomass conversion: The Sugar Platform 4 Strong partnerships
  • 10. Central Working Hypothesis: Sugar is the New Oil Fuel Chemicals Energy … 10
  • 11. Why Renewable Chemicals?• The market is of significant size• Volatile crude oil prices Commodity Chemical Market Size (2005): ~ USD 360 billion Rest of Source: World Technology Review, Japan 9% MIT, Oct 2010 Western 11% Europe 35%• Strong growth in BRIC-countries keeps demand for petro-derived products high Asia• 9 billion people in 2050, with huge middle 22% classes arising in China and India USA• Energy supply and growing environmental 23% concerns• Technology developments to enable the transition * Excluding pharmaceutical and consumer products• “Going Green”, green mission statements Source: modified from Value Creation, chapter 1 and environmental/sustainability goals Ed. Budde, Felcht, Frankemölle, 2006 defined by many companies: “from tech push to market pull” 11
  • 12. 8/6/2012 NOVOZYMES PRESENTATIONRenewable Chemicals: from tech push to market pull ! Illustrative examples 12
  • 13. Traditional Chemicals Come from an Optimized Industry Petroleum-based chemistry Optimization: • Scale • Energy efficiency Level of optimization • Fixed cost reduction • Improved maintenance • Sourcing/supply chains • Value engineering • Plant reliability • On-stream time • … Foundation Development Expansion Diversification Maturity Time 13
  • 14. …while Renewable Chemicals are in their Infancy… Petroleum-based chemistry Level of optimization Challenge • Renewable chemicals have to compete on price and performance • No subsidies • New infrastructure • New value chains Renewable chemicals industry Time 14
  • 15. Novozymes’ Entry Technology: The Sugar Platform • Cellulosic bioethanol drives our technology development Starch Enzyme process Fermentable sugars Yeast Bio- Fermentation ethanol Waste Pre- Enzyme treatment Cellulosebiomass process process 15
  • 16. Feb 2010: Novozymes Launches Cellic® CTec2Allows production offuel ethanol frombiomass @ USD 2.00to USD 2.50 pergallon, depending onprocess 16
  • 17. Feb 2012: Next generation Cellic CTec3 ® We can secure your plant’s lowest total cost 17
  • 18. Feb 2012: Next generation Cellic CTec3 ® 18
  • 19. M&G Breaks Ground for First Commercial Plant • Novozymes’ partner M&G begins construction of the world’s first commercial-scale cellulosic ethanol plant • The plant will produce 13 million gallons of ethanol per year from biomass, and is competitive with 60- 70 USD/barrel oil • The biofuels plant will be ready in 2012, and is located in Crescentino, Northern Italy Pictures courtesy of M&G 19
  • 20. Novozymes’ Entry Technology: The Sugar Platform • Cellulosic bioethanol drives our technology development Starch Enzyme process Fermentable sugars Yeast Bio- Fermentation ethanol Waste Pre- Enzyme treatment Cellulosebiomass process process Platform Technology: enables production of a broad spectrum of products 20
  • 21. Production of Renewable Chemicals– a Good Fit to our Technology and our Vision Yeast Bio- Fermentation ethanol Fermentable sugars 21
  • 22. Production of Renewable Chemicals– a Good Fit to our Technology and our Vision Yeast Bio- Renewable Fermentation ethanol chemicals Fermentable sugars 22
  • 23. Production of Renewable Chemicals– a Good Fit to our Technology and our Vision Yeast Bio- Renewable Fermentation ethanol chemicals Fermentable sugars Heterogenous Renewable catalysis chemicals 23
  • 24. Partnering is essential for us Yeast Bio- Renewable Fermentation ethanol chemicals Fermentable sugars Chemical Renewable Catalysis chemicals Novel engineered pathway Renewable -- chemicals Novel Bioprocess/ Enzymes 24
  • 25. NOVOZYMES PRESENTATION – May 2010 EMEA Chemicals ForumThe renewable chemicals pipeline in more details 3-HP Bio-Acrylic acid Propanol Bio-PolypropyleneRenewableChemicals sugars Glycols Platform Not disclosed Not disclosed Fructose HMF/FDCA Non-exclusive New Leads 25
  • 26. HMFHMF- a new biochemical building blockBioBusiness, Novozymes
  • 27. 27 6 August 2012 Novozymes - Biochemicals PresentationHMF/FDCA have strong potentials to be futurebuilding blocks in the chemical industry Unique molecules with many new Extract from “DOE Top 12 Report” application opportunities HMF/FDCA can replace aromatic compounds that are challenging to produce from renewable feedstock Favourable production costs, no “CO2 lost” in production process HMF FDCA 5-hydroxymethyl Furan-2,5-dicarboxylic furfural acid
  • 28. 28 6 August 2012 Novozymes - Biochemicals PresentationHMF could serve multiple markets: fromspeciality chemicals to fuel Market volume Fuels Polyesters Speciality chemicals Plasticizers FDCA as partial PIA/PTA replacer in PET … etc. etc. (see Appendix B) Bisphenol A replacement in polycarbonate and epoxy resins FDCA as phthalate replacer in plasticizers … etc. etc. (see Appendix A) Time
  • 29. 29 6 August 2012 Novozymes - Biochemicals PresentationThe “Novozymes HMF Technology” focuses onutilising glucose as feedstock for HMF H O CH2OH H OH O HO O O OHO H GI HO H H+ O Ox O H OH H OH HO OH H OH H OH Step 1 Step 3 FDCA CH2OH CH2OH Step 2 HMF FDA Glucose Fructose 5-hydroxymethyl furfural furan-2,5-dicarboxylic acid Chemical and Chemical Saccharification enzymatic catalysis oxidation Enzymatic sacchari- Enzymatic production Chemical oxidation of fication: from starch of HMF via conversion HMF to FDCA tested in to glucose of glucose to fructose lab/pilot scale NEW: Enzymatic oxidation
  • 30. Partnering is essential for us Yeast Bio- Renewable Fermentation ethanol chemicals Fermentable sugars Chemical Renewable Catalysis chemicals Novel engineered pathway Renewable -- chemicals Novel Bioprocess/ Enzymes 30
  • 31. 31 NOVOZYMES PRESENTATIONEnzymatic modifications relevant for the chemicalindustry: > het/homogenous catalysis! Esterification and ester • Application of lipases & cutinases in aqueous or non- aqueous environment. Can be enantioselective. Also used for hydrolysis polyester synthesis. Nitrile hydrolysis • Hydrolysis to amide or carboxylic acid under mild conditions. Can be enantioselective. • Polymerization of aromatic structures by hydrogen Free-radical polymerization abstraction using oxidoreductases • Oxidation of aromatic side chains Side chain oxidation using oxidoreductases • Hydroxylation of aromatic or aliphatic carbon using Hydroxylation oxidoreductases. Can be enantioselective • Epoxidation of double bonds using lipases Epoxidation or oxidoreductases 8/6/ 201 2
  • 32. 32 8/6/2012 NOVOZYMES PRESENTATIONNovozymes’ enzymes in Biocatalysis  Proteases  Esterases/cutinases  Oxido-reductases; laccases, peroxidases, chloroperoxidase  Amylolytic enzymes  … Lipases  Commercial lipases with varying specificity  A large number of non-commercial lipases including variant lipases
  • 33. 33 8/6/2012 NOVOZYMES PRESENTATIONFrom a universe of Lipases- Three model types of lipases with different specificity CalA type of CalB type of TLL type of enzymes enzymes enzymes • Candida Antarctica • Candida Antarctica • Thermomyces lipase A lipase B lanuginosus lipase • Allows branching on • Allows larger groups • Allows larger groups C-alpha and bulky on acid part and high on both alcohol and side chains on the specificity on alcohol acid parts alcohol part part
  • 34. 34 8/6/2012 NOVOZYMES PRESENTATIONNovozymes’ discovery and development ofenzymes for Biocatalysis Resolution (Tetrahedron: Asymmetry 2002, 13, 1315-1320) NH2 Novozym 435 NHAc NH2 + EtOAc R R R rac (R) (S) Transesterification Desymmetrization R OH OAc Lipase OAc O + CH3OH R Org. solvent L M Novozym 435 L M O Ru-catalyst R R O O NH2 NHAc R + OAc R O L M Novozym 435 L M O Ru-catalyst Or polymerization and carbohydrate ester synthesis reactions
  • 35. 35 8/6/2012 NOVOZYMES PRESENTATIONPolymerization synthesis reactions Direct polycondensation of malic acid and 1,8-octane diol Li 2008 O O O Lipase * * O n CH3 CH3 Ring opening R,S-MPL polymerisation with O Lipase O O O Lipase * O O n * Poly(TMC) TMC
  • 36. 36 06/08/2012 NOVOZYMES PRESENTATION Screening and engineering tools provide the basis for new developments Specific on alcohol part and allows some branching on acid part Stereo selectivity on the acid side – also with Large and small pocket e.g. Ibuprofen. Alcohol Acid Acid Alcohol References: • Uppenberg,J.et al (1994) The sequence, Crystal structure determination and refinement of two crystal forms of lipase B from Candida antarctica. Structure 2, pp.293-308. • Henke, E. et al (2000 ) Monatshefte für chemie 131 p. 633
  • 37. 37 Novozymes - Biochemicals Presentation/TSJAExternal R&D and expertise Rich Gross ”Enzymes catalyse reactions which classical catalysis is not able to perform” Martin Hofrichter, University of Zittau, Germany Oxidreductases, lignin degradation
  • 38. Novozymes key technologies deliver key enablersfor the biobased society 1 2 3 Systems biology and Enzymes for key reactions in molecular biotechnology to the chemical industry create highly efficient ”superbugs” Enzyme systems for 1st and 2nd generation biomass conversion 4 Strong partnerships 38
  • 39. Conclusions: • The sugar platform is ready for implementation • Market pull for renewable chemicals • Untraditional partnerships - combine biology & chemistry • new growth markets for grain processors, biotech companies and consumer goods companies • In tune with the environment 39
  • 40. 40 Thank you! tsch@novozymes.com

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