Healthcare Research Focus at Xerox Research Center India

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  • 1. 4th International Conference on Transforming Healthcare with IT 6th – 7th Sep. 2013 Hyderabad, India Healthcare Research Focus at Xerox Research Center India • Non-contact video-based detection of body vitals and diseases • Decision support for clinicians - diagnosis, prediction, treatment options for diseases Acknowledgements: Lalit K Mestha, Xerox Fellow; Manipal Hospital
  • 2. 4th International Conference on Transforming Healthcare with IT 6th – 7th Sep. 2013 Hyderabad, India How Deep Can We See? Mean optical path length for 500 - 650nm = ~1-2mm Mean optical path length for NIR (700 – 2400nm) = ~6-10mm Blood pool in a normal skin is at ~0.3 – 2mm deep Epidermis: 0.06– 0.5mm Dermis: 1-4mm Hypodermis: 1 – 6mm Thickness of skin layersMean Optical Path Lengths & Penetration Depth Ref: JHGM Klaessens and RM Verdaasdonk, “Non-invasive skin oxygenation imaging using a multi-spectral camera system: Effectiveness of various concentration algorithms applied on human skin”, Proc. Of SPIE Vol. 7174 717408-1, 2009
  • 3. 4th International Conference on Transforming Healthcare with IT 6th – 7th Sep. 2013 Hyderabad, India Video based Detection – in progress 1. Non-contact vitals (continuous monitoring) – Heart rate – Respiration rate – Temperature – Oxygen saturation (functional & fractional) – Pulmonary volumes with 3D – Heart rate variability – Blood pressure – Glucose 2. Disease diagnostics – Cancer screening (melanoma, breast cancer, ..) – Cardiac arrhythmias (atrial fibrillation, premature atrial contraction etc) – Strokes, diabetics etc., – Abnormalities in a comprehensive metabolic panel (CMP) etc – Sleep apnea – SIDS 3. Biometrics – Vein pattern & cardiovascular based biometrics 4. Food volume & nutrition content detection
  • 4. 4th International Conference on Transforming Healthcare with IT 6th – 7th Sep. 2013 Hyderabad, India Monitoring Respiration, Temperature Research Problems Algorithms for continuous monitoring & Data Fusion with multiple cameras Respiration signal Temperature signal
  • 5. 4th International Conference on Transforming Healthcare with IT 6th – 7th Sep. 2013 Hyderabad, India Health: Cardiac Arrhythmia (A-fib) Detection Xerox Camera Work process: 1. Patient with A-fib enrolled for the study 2. Videos were taken of the entire process of electrical cardio version 3. Holter monitor installed 4. Patient - briefed about the benefits of the study 5. Patient – undergoes electrical cardio version 6. Patient – cleared of A-fib Performed video shoot of A-fib patients interacting with Doctors, nurses and patients 461 462 463 464 465 466 467 468 -3 -2 -1 0 1 2 3 Time (in secs) NormalizedAmplitude Raw ECG v/s PPG extracted using video camera ECG lead 2 PPG (from video) Irregular beat to beat intervals
  • 6. 4th International Conference on Transforming Healthcare with IT 6th – 7th Sep. 2013 Hyderabad, India A-fib Detection – During A-fib (Patient 1) 409 410 411 412 413 414 415 416 417 -2 -1 0 1 2 3 4 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 50 time (in secs) NormalizedAmplitude ECG vs PPG ECG (lead 2) PPG (video) peaks (ECG) peaks (PPG)
  • 7. 4th International Conference on Transforming Healthcare with IT 6th – 7th Sep. 2013 Hyderabad, India A-fib Detection–Normal Sinus Rhythm (Patient 2) 843 844 845 846 847 848 849 850 851 852 853 -2 -1 0 1 2 3 900 901 902 903 904 905 906 907 908 909 910 911 912 time (in secs) NormalizedAmplitude ECG vs PPG ECG (lead 2) PPG (video) peaks (ECG) peaks (PPG)
  • 8. 4th International Conference on Transforming Healthcare with IT 6th – 7th Sep. 2013 Hyderabad, India Sample Data Collection on Cancer Patients • Patient 2: Male Patient Mammogram Images Thermal Images Right breast Left breast Left breast Confirmed malignant lesion (2.5 x 1.3 cm in the left breast) Craniocaudal and mediolateral oblique views ~45 deg right from sagittal plane Along sagittal plane
  • 9. 4th International Conference on Transforming Healthcare with IT 6th – 7th Sep. 2013 Hyderabad, India Sample Data Collection on Cancer Patients • Patient 3: Female Patient Mammogram Images Thermal Image Right breast Left breast No suspicious region foundNo cancer found. Radiology report suggested Fibroadenoma – a benign lesion ~45 deg right from sagittal plane
  • 10. 4th International Conference on Transforming Healthcare with IT 6th – 7th Sep. 2013 Hyderabad, India Sample Data Collection on Cancer Patients • Patient 4: Female Patient Mammogram Image Left breast Malignant lesion Sonomammogram Image ~10 deg right from sagittal plane Cancer is spread to lymph nodes ~45 deg right from sagittal plane
  • 11. 4th International Conference on Transforming Healthcare with IT 6th – 7th Sep. 2013 Hyderabad, India Healthcare Research Focus • Non-contact video-based detection of body vitals and diseases • Decision support for clinicians - diagnosis, prediction, treatment options for diseases
  • 12. 4th International Conference on Transforming Healthcare with IT 6th – 7th Sep. 2013 Hyderabad, India Emergency Room Decision Support: Stroke Prediction Stroke happens when blood flow to a part of the brain stops, often causing permanent damage • 4.4 million deaths each year. • ~70% of the strokes are first-ever strokes Tools for Clinical decision support, Preventive healthcare Open Innovation Project with Indian hospitals • Data collection initiated • Initial statistical model for stroke severity
  • 13. 4th International Conference on Transforming Healthcare with IT 6th – 7th Sep. 2013 Hyderabad, India Open Healthcare Analytics System Analytics Data & Process Analytics • Risk Models • Diagnostics • Treatment planning • Preventive Healthcare Data Providers, Others Clinical/patient data Process data Gene banks ML researchers Universities Crowd Experts Abstracted Data Views Analytical Models External Partners Data Integration and Privacy Management Reporting & Visualization Adapters: integrate with EHR/HIS solutions Open APIs Medical Literature Websites Social networks