Sirdalud Tablets for Relief of Painful Muscle Spasms

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Sirdalud (Tizanidine) is a muscle relaxant which helps to relax certain muscles in your body. It relieves the painful muscle spasms related to the static and functional disorders of the spine or following certain surgeries such as herniated intervertebral disc or osteoarthritis of the hip. It is also used to treat spasticity due to neurological disorders such as multiple sclerosis, chronic myelopathy, degenerative spinal cord diseases, cerebrovascular accidents, and cerebral palsy.

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Sirdalud Tablets for Relief of Painful Muscle Spasms

  1. 1. Sirdalud Tablets Sirdalud (Tizanidine) is a muscle relaxant which helps to relax certain muscles in your body. Sirdalud is available in tablets containing 2 mg, 4 mg or 6 mg Tizanidine Hydrochloride. © The Swiss Pharmacy, Geneva Switzerland
  2. 2. Sirdalud Tablets Indications It relieves the painful muscle spasms related to the static and functional disorders of the spine or following certain surgeries such as herniated intervertebral disc or osteoarthritis of the hip. It is also used to treat spasticity due to neurological disorders such as multiple sclerosis, chronic myelopathy, degenerative spinal cord diseases, cerebrovascular accidents, and cerebral palsy. © The Swiss Pharmacy, Geneva Switzerland
  3. 3. Sirdalud Tablets Chemical Structure © The Swiss Pharmacy, Geneva Switzerland
  4. 4. Sirdalud Tablets Recommended Adult Dosage The Recommended dosage of Sirdalud Tablets for various indications is given below: Painful muscle spasms: 2 to 4 mg three times daily. © The Swiss Pharmacy, Geneva Switzerland
  5. 5. Sirdalud Tablets Recommended Adult Dosage Spasticity due to neurological disorders: The maximum initial recommended dosage is 6 mg/day in 3 divided doses. The dosage is then increased stepwise to achieve optimum therapeutic response (generally between 12 to 24 mg/day). The maximum daily dose is 36 mg which should not be exceeded. © The Swiss Pharmacy, Geneva Switzerland
  6. 6. Sirdalud Tablets Missed Dose If you miss a dose, take it as soon as you remember. However, if you remember when it is almost time for your next dose, take only your usual dose at that time. © The Swiss Pharmacy, Geneva Switzerland
  7. 7. Sirdalud Tablets Contraindications Sirdalud Tablets are contraindicated in the following cases: ➔Known hypersensitivity to Tizanidine Hydrochloride or any inactive ingredients of this medication. ➔Significantly impaired hepatic function. ➔Concomitant use with strong CYP1A2 inhibitors such as fluvoxamine or ciprofloxacin. © The Swiss Pharmacy, Geneva Switzerland
  8. 8. Sirdalud Tablets Side Effects of Sirdalud Tablets With low doses, such as those recommended for the relief of painful muscle spasms the reported side effects were somnolence, fatigue, asthenia, dizziness, dry mouth, nausea, gastrointestinal disorder, transaminase increase, increased spasm or tone, blood pressure decrease. © The Swiss Pharmacy, Geneva Switzerland
  9. 9. Sirdalud Tablets Side Effects of Sirdalud Tablets With the higher doses, as recommended for the treatment of spasticity, muscular weakness, insomnia, sleep disorder, hallucination, hypotension, bradycardia, hepatitis and hepatic failure have also been reported in addition to the side effects for lower doses. © The Swiss Pharmacy, Geneva Switzerland
  10. 10. Sirdalud Tablets Warnings And Precautions ➔Co-administration of Sirdalud with inhibitors of CYP1A2 such as some antiarrhythmics (amiodarone, mexiletine, propafenone), cimetidine, some fluoroquinolones (enoxacin, pefloxacin, norfloxacin), rofecoxib, oral contraceptives and ticlopidine is not recommended. ➔Hypotension may occur with potential severe symptoms such as loss of consciousness and circulatory collapse. ➔Gradual reduction in dosage is recommended to avoid withdrawal syndrome. ➔Caution is advised in patients with impaired kidney function. © The Swiss Pharmacy, Geneva Switzerland
  11. 11. Sirdalud Tablets Warnings And Precautions ➔Refrain from driving a vehicle or using machines if dizziness or hypotension occurs. ➔Use during pregnancy only if benefit clearly outweighs the risk. ➔Avoid breastfeeding. ➔Use in children not recommended and caution in elderly patients. © The Swiss Pharmacy, Geneva Switzerland
  12. 12. Sirdalud Tablets Overdosage Symptoms A decrease in sensorium was observed in the majority of cases that included lethargy, somnolence, confusion and coma. Depressed cardiac functions are also observed including most often bradycardia and hypotension. Respiratory depression is another common feature of tizanidine overdose. © The Swiss Pharmacy, Geneva Switzerland
  13. 13. Sirdalud Tablets Overdose Treatment Should overdose occur, basic steps to ensure the adequacy of an airway and the monitoring of cardiovascular and respiratory systems should be undertaken. Symptoms should usually resolve within one to three days following discontinuation of tizanidine and administration of appropriate therapy. © The Swiss Pharmacy, Geneva Switzerland
  14. 14. Sirdalud Tablets Sirdalud Tablets 2 mg Manufactured by Novartis India For more information click here © The Swiss Pharmacy, Geneva Switzerland
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