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Progynova Tablets for Treatment of  Oestrogen Deficiency
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Progynova Tablets for Treatment of Oestrogen Deficiency

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Progynova Tablets (Estradiol Valerate) is used as Hormone replacement therapy (HRT) for the treatment of signs and symptoms of oestrogen deficiency due to the menopause or after surgical removal of …

Progynova Tablets (Estradiol Valerate) is used as Hormone replacement therapy (HRT) for the treatment of signs and symptoms of oestrogen deficiency due to the menopause or after surgical removal of the ovaries.

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  • 1. Progynova Tablets Progynova Tablets is used as Hormone replacement therapy (HRT) for the treatment of signs and symptoms of oestrogen deficiency due to the menopause. © The Swiss Pharmacy, Geneva Switzerland
  • 2. Progynova Tablets Chemical Structure © The Swiss Pharmacy, Geneva Switzerland
  • 3. Progynova Tablets Active Ingredient The active pharmaceutical ingredient contained in Progynova Tablets is Estradiol Valerate (Oestradiol Valerate) . Each 1 mg Progynova tablet for oral administration contains 1 mg of Estradiol Valerate. © The Swiss Pharmacy, Geneva Switzerland
  • 4. Progynova Tablets Indications Progynova Tablets is used to treat short term treatment of climacteric complaints after the cessation of monthly bleeding, or deficiency symptoms after oophorectomy or radiological castration for non-carcinomatous diseases, such as hot flushes, outbreaks of sweat, sleep disturbances, depressive moods, irritability, headaches, dizziness. © The Swiss Pharmacy, Geneva Switzerland
  • 5. Progynova Tablets Indications Progynova also has a favourable influence on bladder irritation, signs of cutaneous and mucosal involution which normally occur with advancing age. © The Swiss Pharmacy, Geneva Switzerland
  • 6. Progynova Tablets Recommended Adult Dosage Hysterectomised patients may start at any time. If the patient is still menstruating and has an intact uterus, a combination regimen of Progynova and a progestogen should begin within the first 5 days of menstruation. Patients whose periods are very infrequent or with amenorrhoea or who are postmenopausal may start at any time, provided pregnancy has been excluded. © The Swiss Pharmacy, Geneva Switzerland
  • 7. Progynova Tablets Recommended Adult Dosage The tablet should be taken at the same time of day every day. One tablet is taken daily. The tablets are to be swallowed whole with some liquid. © The Swiss Pharmacy, Geneva Switzerland
  • 8. Progynova Tablets Missed Dose In case of a missed dose, take the tablet as soon as you remember, within the following 12 to 24 hours. If the treatment is discontinued for longer, irregular bleeding may occur. © The Swiss Pharmacy, Geneva Switzerland
  • 9. Progynova Tablets Contraindications Progynova Tablets is contraindicated in women with the following conditions: ➔Hypersensitivity to Estradiol Valerate (Oestradiol Valerate) or any inactive component of this medication. ➔Pregnancy or lactation ➔Undiagnosed vaginal bleeding ➔Acute arterial thromboembolism (myocardial infarction, stroke) or a recent history of these conditions © The Swiss Pharmacy, Geneva Switzerland
  • 10. Progynova Tablets Contraindications ➔Known or suspected cancer of the breast ➔Known or suspected premalignant conditions or malignancies, if sex steroid influenced ➔Presence or history of liver tumours (benign or malignant) ➔Severe hepatic disease ➔Active deep venous thrombosis, thromboembolic disorders, thrombophlebitis, or a documented history of these conditions © The Swiss Pharmacy, Geneva Switzerland
  • 11. Progynova Tablets Contraindications ➔Severe hypertriglyceridamia ➔Hereditary or acquired predisposition to venous thrombosis ➔A high risk of venous or arterial thrombosis © The Swiss Pharmacy, Geneva Switzerland
  • 12. Progynova Tablets Side Effects of Progynova Tablets The common side effects of Progynova Tablets are Weight increase or Weight decrease, Headache, Abdominal pain, Nausea, Rash, Pruritus, Uterine/ Vaginal bleeding including spotting. Uncommon side effects of Progynova Tablets include Hypersensitivity reaction, Depressed mood, Dizziness, Visual disturbances, Palpitations, Dyspepsia, Erythema nodosum, Urticaria, Breast pain, Breast tenderness and Oedema © The Swiss Pharmacy, Geneva Switzerland
  • 13. Progynova Tablets Side Effects of Progynova Tablets Rarely occuring side effects of Progynova Tablets are Anxiety, Libido decreased or Libido increased, Migraine, Contact lens intolerance, Bloating, Vomiting, Hirsutism, Acne, Muscle cramps, Dysmenorrhoea, Vaginal discharge, Premenstrual-like syndrome, Breast enlargement, and Fatigue © The Swiss Pharmacy, Geneva Switzerland
  • 14. Progynova Tablets Warnings And Precautions ➔Progynova Tablets cannot be used as a contraceptive. ➔Therapy with Progynova should be discontinued immediately in case a contraindication is discovered, as well as in the following situations: ➔Migrainous or frequent and unusually severe headaches that occur for the first time or other symptoms that are possible prodroma of cerebrovascular occlusion. ➔Recurrence of cholestatic jaundice or cholestatic pruritus which occurred first during pregnancy or previous use of sex steroids. ➔Symptoms of a thrombotic event or suspicion thereof. © The Swiss Pharmacy, Geneva Switzerland
  • 15. Progynova Tablets Warnings And Precautions ➔Some women are predisposed to gallbladder disease during oestrogen therapy. ➔Hormonal treatment may increase the risk of probable dementia if initiated in women aged 65 or older. ➔Suspected prolactinoma should be ruled out before starting Progynova treatment. ➔Prolonged monotherapy with oestrogens increases the risk of endometrial hyperplasia and carcinoma in postmenopausal women. ➔Chloasma may occur occasionally, especially in women with a history of chloasma gravidarum. © The Swiss Pharmacy, Geneva Switzerland
  • 16. Progynova Tablets Warnings And Precautions ➔An increased risk of ovarian cancer in menopausal women taking oestrogen only replacement therapy was observed in a large US study Clinical and observational studies have reported an increased risk of having breast cancer diagnosed in women who have used HRT for several years. ➔In rare cases benign, and even more rarely, malignant liver tumours have been observed after the use of hormonal substances such as those contained in HRT products. © The Swiss Pharmacy, Geneva Switzerland
  • 17. Progynova Tablets Storage Instructions Keep Progynova Tablets in a cool, dry place where the temperature stays below 25° C. Do not store Progynova Tablets, or any other medicine, in a bathroom or near a sink. Keep away from children and pets. © The Swiss Pharmacy, Geneva Switzerland
  • 18. Progynova Tablets Overdose Treatment Even in the case of inadvertent intake of a multiple of the recommended dose, no acute toxicity risk is to be expected. Overdose may cause nausea and vomiting and irregular bleeding may occur in some women. There are no antidotes and treatment should be symptomatic. © The Swiss Pharmacy, Geneva Switzerland
  • 19. Progynova Tablets Progynova Tablets manufactured by Schering AG Berlin. (Manufactured in India in collaboration with Zydus Healthcare) For more information click here © The Swiss Pharmacy, Geneva Switzerland