Motilium Tablets for Treatment of Gastroparesis, Nausea and Vomiting

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Motilium Tablets (Domperidone) are used to treat nausea and vomiting as well as for the relief of discomfort caused by a slow moving stomach known as gastroparesis.

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Motilium Tablets for Treatment of Gastroparesis, Nausea and Vomiting

  1. 1. Motilium Tablets Motilium Tablets (Domperidone) are used to treat nausea and vomiting as well as for the relief of discomfort caused by a slow moving stomach known as gastroparesis. © The Swiss Pharmacy, Geneva Switzerland
  2. 2. Motilium Tablets Chemical Structure © The Swiss Pharmacy, Geneva Switzerland
  3. 3. Motilium Tablets Indications Motilium is used for the symptomatic treatment of the dyspeptic symptom complex which is often associated with delayed gastric emptying or gastro-oesophageal reflux and oesophagitis, epigastric sense of fullness, feeling of abdominal distension, upper abdominal pain, eructation, flatulence, heartburn. © The Swiss Pharmacy, Geneva Switzerland
  4. 4. Motilium Tablets Indications Motilium tablets are also used for the treatment of nausea and vomiting of various origins including functional, organic, infectious, dietetic origin, or induced by radiotherapy, medicine therapy. © The Swiss Pharmacy, Geneva Switzerland
  5. 5. Motilium Tablets Active Ingredient The active ingredient present in Motilium Tablets is Domperidone. Domperidone is a white to slightly beige coloured powder that is practically insoluble in water. Domperidone is a dopamine antagonist with antiemetic properties. © The Swiss Pharmacy, Geneva Switzerland
  6. 6. Motilium Tablets Recommended Adult Dosage The normal recommended dose of Motilium is one 10 mg tablet three to four times, best taken 15 to 30 minutes before meals or food, and if necessary at bedtime. Safety and efficacy of Motilium (Domperidone) use beyond six months has not been established. © The Swiss Pharmacy, Geneva Switzerland
  7. 7. Motilium Tablets Missed Dose If you miss a dose, take it as soon as you remember. However, if you remember when it is almost time for your next dose, take only your usual dose at that time. © The Swiss Pharmacy, Geneva Switzerland
  8. 8. Motilium Tablets Contraindications Motilium Tablets are contraindicated in the following cases: ➔Known hypersensitivity to Domperidone or any inactive ingredients of this medication. ➔In those patients with a prolactin-releasing pituitary tumour (prolactinoma). © The Swiss Pharmacy, Geneva Switzerland
  9. 9. Motilium Tablets Side Effects of Motilium Tablets Below are the mild side effects of Motilium headache, trouble sleeping, nervousness, dizziness, tiredness or irritability sleepiness or drowsiness, fits or seizures, agitation © The Swiss Pharmacy, Geneva Switzerland
  10. 10. Motilium Tablets Side Effects of Motilium Tablets dry mouth or thirst stomach cramps, diarrhoea, constipation, nausea, changes in appetite or heartburn rash or itchy skin itchy eyes and crusty eyelids with discharge mouth ulcers or cold sores. © The Swiss Pharmacy, Geneva Switzerland
  11. 11. Motilium Tablets Side Effects of Motilium Tablets These Side effects will reverse on stopping treatment: Uncontrollable movements Irregular or no menstrual period Unusual secretion of breast milk or Decrease in sex drive in men or women Breast tenderness or breast enlargement in men. © The Swiss Pharmacy, Geneva Switzerland
  12. 12. Motilium Tablets Side Effects of Motilium Tablets Inform your doctor immediately if you notice any of the following Serious Side Effects: Fast or irregular heart beats Swelling of hands, ankles or feet Difficulty passing urine or pain when passing urine. © The Swiss Pharmacy, Geneva Switzerland
  13. 13. Motilium Tablets Side Effects of Motilium Tablets STOP using Motilium Tablets and inform your doctor immediately if any of the following happen: You have an allergic reaction to Motilium (allergy can be recognised, for instance, by skin rash, itching, shortness of breath and/or swelling of the face, lips, mouth, tongue or throat which may cause difficulty in swallowing or breathing) © The Swiss Pharmacy, Geneva Switzerland
  14. 14. Motilium Tablets Warnings And Precautions ➔The film-coated tablets contain lactose and may be unsuitable for patients with lactose intolerance, galactosemia or glucose/galactose malabsorption. ➔Since the elimination half-life of domperidone is prolonged in severe renal impairment, on repeated administration the dosing frequency of motilium should be reduced to once or twice daily, depending on the severity of the impairment, and the dose may need to be reduced. ➔Breast feeding is not recommended for mothers who are taking Motilium. © The Swiss Pharmacy, Geneva Switzerland
  15. 15. Motilium Tablets Overdosage Symptoms Symptoms of overdosage may include disorientation, somnolence and extrapyramidal reactions. © The Swiss Pharmacy, Geneva Switzerland
  16. 16. Motilium Tablets Overdose Treatment There is no specific antidote to Domperidone, but in case overdose occurs, the administration of activated charcoal may be useful. Anticholinergics, antiparkinson drugs may be useful in controlling extrapyramidal reactions. The patient has to be observed closely and supportive measures employed. © The Swiss Pharmacy, Geneva Switzerland
  17. 17. Motilium Tablets Motilium Tablets are Manufactured by Johnson & Johnson, India For more information click here © The Swiss Pharmacy, Geneva Switzerland

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