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Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder
Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder
Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder
Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder
Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder
Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder
Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder
Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder
Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder
Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder
Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder
Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder
Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder
Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder
Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder
Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder
Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder
Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder
Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder
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Lamotrigine Tablets for Treatment of Epilepsy & Bipolar Disorder

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Lamotrigine Tablets (Lametec) is used as adjunctive therapy in the treatment of epilepsy, for partial seizures and generalised seizures, including tonic-clonic seizures and the seizures associated …

Lamotrigine Tablets (Lametec) is used as adjunctive therapy in the treatment of epilepsy, for partial seizures and generalised seizures, including tonic-clonic seizures and the seizures associated with Lennox-Gastaut syndrome in adults as well as children above 2 years of age. Lamotrigine is also used for the prevention of mood episodes in patients with bipolar disorder.

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  • 1. Lamotrigine Tablets Lamotrigine Tablets (Lametec) is used as adjunctive therapy in the treatment of epilepsy, for partial seizures and generalised seizures, including tonic-clonic seizures and the seizures associated with Lennox-Gastaut syndrome in adults as well as children above 2 years of age. Lamotrigine is also used for the prevention of mood episodes in patients with bipolar disorder. © The Swiss Pharmacy, Geneva Switzerland
  • 2. Lamotrigine Tablets Chemical Structure © The Swiss Pharmacy, Geneva Switzerland
  • 3. Lamotrigine Tablets Active Ingredient The active pharmaceutical ingredient present in Lametec tablets is Lamotrigine. Each Lametec 25 mg tablet contains 25 mg of the active ingredient Lamotrigine. © The Swiss Pharmacy, Geneva Switzerland
  • 4. Lamotrigine Tablets Recommended Adult Dosage ➔Dosage in Epilepsy add-on therapy for Adults (over 12 years of age): ➔In patients taking valproate with/without any other anti-epileptic medicine (AEM), the initial lamotrigine dose is 25 mg every alternate day for two weeks, followed by 25 mg once a day for two weeks. Thereafter, the dose should be increased by a maximum of 25 to 50 mg every 1 to 2 weeks until the optimal response is achieved. The usual maintenance dose to achieve optimal response is 100 to 200 mg/day given once a day or in two divided doses.The recommended adult (over 12 years) dosage for lametec (mg/day) is given below: © The Swiss Pharmacy, Geneva Switzerland
  • 5. Lamotrigine Tablets Recommended Adult Dosage ➔Usual Maintenance Dose With enzyme-inducing antiepileptic drugs(EIAEDs) & No Valproic acid (VPA): ➔Weeks 1 & 2: 50mg/day (Once a day) ➔Weeks 3 & 4: 100mg/day (Two divided doses) ➔Usual Maintenance Dose: 300mg to 500mg/day (Two divided doses). To achieve maintenence doses may be incresed by 100mg/day every 1-2 weeks. © The Swiss Pharmacy, Geneva Switzerland
  • 6. Lamotrigine Tablets Recommended Adult Dosage EIAEDs & Valproic acid (VPA): ➔Weeks 1 & 2: 25 mg every other day ➔Weeks 3 & 4: 25mg (Once a day) ➔Usual Maintenance Dose: 100mg to 400mg/day (Two divided doses). To achieve maintenence doses may be incresed by 25 mg - 50mg/day every 1-2 weeks. As there exists a risk of rash the initial dose and subsequent dose escalation should not be exceeded. © The Swiss Pharmacy, Geneva Switzerland
  • 7. Lamotrigine Tablets Recommended Dose Children (2 to 12 years of age): In patients taking valproate with/without any other AEM, the initial lamotrigine dose for treatment of in Epilepsy is 0.15 mg/kg bodyweight/day given once a day for two weeks, followed by 0.3 mg/kg/day once a day for two weeks. ➔Thereafter, the dose should be increased by a maximum of 0.3 mg/kg every 1-2 weeks until the optimal response is achieved. ➔The usual maintenance dose to achieve optimal response is 1 to 5 mg/kg/day given once a day or in two divided doses, with a maximum of 200 mg/day. The recommended dose escalation for lamotrigine (lametec) for children aged 2-12 years (total daily dose in mg/kg body weight/day) on combined drug therapy is given below. © The Swiss Pharmacy, Geneva Switzerland
  • 8. Lamotrigine Tablets Recommended Dose Children (2 to 12 years of age): With AED regimen containing VPA: ➔Weeks 1 & 2: 0.15mg/kg/day (1 or 2 divided doses) ➔Weeks 3 & 4: 0.3mg/kg/day (1 or 2 divided doses) ➔Usual Maintenance Dose: 1 mg to 5 mg/kg/day (Maximum 200mg/day in One or Two divided doses). ➔To achieve maintenence doses may be incresed by 0.5 - 1mg/kg/day every 1-2 weeks © The Swiss Pharmacy, Geneva Switzerland
  • 9. Lamotrigine Tablets Recommended Dose Children (2 to 12 years of age): Added to EIAEDs and without VPA: ➔Weeks 1 & 2: 0.6mg/kg/day (2 divided doses) ➔Weeks 3 & 4: 1.2mg/kg/day (2 divided doses) ➔Usual Maintenance Dose: 5mg - 15mg/kg/day (Maximum 400mg/day in One or Two divided doses) ➔To achieve maintenence doses may be increased by 2 to 3 mg/kg/day every 1-2 weeks ➔After initial 4 weeks of therapy, the daily dosage of Lametec DT may be doubled at weekly intervals until an effective maintenance dosage of 200 mg daily is reached. The daily dosages should not exceed 200 mg daily. © The Swiss Pharmacy, Geneva Switzerland
  • 10. Lamotrigine Tablets Recommended Adult Dosage Bipolar Disorder Adults (18 years of age and over): ➔Because of the risk of rash, the initial dose and subsequent dose escalation should not be exceeded. Lamotrigine is recommended for use in bipolar patients at risk for a future depressive episode. The recommended initial adult dosage of Lametec DT is 25 mg once daily for 2 weeks, followed by 50 mg once daily for 2 weeks. ➔For Patients NOT TAKING Carbamazepine, Phenytoin, Phenobarbital, Primidone, or Valproate ➔Weeks 1 and 2 25 mg daily ➔Weeks 3 and 4 50 mg daily ➔Week 5 100 mg daily ➔Week 6 and 7 200 mg daily © The Swiss Pharmacy, Geneva Switzerland
  • 11. Lamotrigine Tablets Contraindications Generic Lamotrigine Tablets (Lametec) is contraindicated in patients with the following conditions: ➔Known hypersensitivity to Lamotrigine or any inactive ingredient of this medication. ➔Lamotrigine Tablets (Lametec) should not be used in pregnancy unless, in the opinion of the doctor, the potential benefits of treatment to the mother outweigh any possible risks to the developing foetus. © The Swiss Pharmacy, Geneva Switzerland
  • 12. Lamotrigine Tablets Side Effects of Lamotrigine Tablets The most common possible side effects of Generic Lamotrigine Tablets (Lametec) with an incidence rate of 10% or more in adult epilepsy clinical studies were dizziness, headache, diplopia, ataxia, nausea, blurred vision, somnolence, rhinitis, and rash. Additional adverse reactions (incidence rate of 10% or more) reported in children in epilepsy clinical studies included vomiting, infection, fever, accidental injury, pharyngitis, abdominal pain, and tremor. © The Swiss Pharmacy, Geneva Switzerland
  • 13. Lamotrigine Tablets Side Effects of Lamotrigine Tablets The most common possible side effects of Generic Lamotrigine Tablets (Lametec) with an incidence rate of greater than 5% in adult bipolar clinical studies were nausea, insomnia, somnolence, back pain, fatigue, rash, rhinitis, abdominal pain, and xerostomia. © The Swiss Pharmacy, Geneva Switzerland
  • 14. Lamotrigine Tablets Warnings And Precautions ➔Life-threatening serious rash and/or rash-related death may result. ➔Fatal or life-threatening hypersensitivity reaction: Multiorgan hypersensitivity reactions, also known as Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), may be fatal or life threatening. Early signs may include rash, fever, and lymphadenopathy. These reactions may be associated with other organ involvement, such as hepatitis, hepatic failure, blood dyscrasias, or acute multiorgan failure. Lamotrigine tablets (Lametec) should be discontinued if alternate etiology for this reaction is not found. © The Swiss Pharmacy, Geneva Switzerland
  • 15. Lamotrigine Tablets Warnings And Precautions ➔Blood dyscrasias (e.g., neutropenia, thrombocytopenia, pancytopenia) may occur, either with or without an associated hypersensitivity syndrome. ➔Suicidal behavior and ideation. ➔Clinical worsening, emergence of new symptoms, and suicidal ideation/behaviors may be associated with treatment of bipolar disorder. Patients should be closely monitored, particularly early in treatment or during dosage changes. ➔Aseptic meningitis reported in pediatric and adult patients. © The Swiss Pharmacy, Geneva Switzerland
  • 16. Lamotrigine Tablets Warnings And Precautions ➔Lamotrigine has been reported to pass into breast milk in highly variable concentrations, resulting in total lamotrigine levels in infants of up to approximately 50% of the mother’s. The potential benefits of breast feeding should be weighed against the potential risk of adverse effects occurring in the infant. ➔Lamotrigine is cleared primarily by metabolism in the liver. Lamotrigine (Lametec tablets) should be administered with caution in patients with hepatic impairment as clearance is reduced. ➔Medication errors involving Lamotrigine tablets (Lametec) have occurred. In particular the name Lamotrigine can be confused with names of other commonly used medications. Medication errors may also occur between the different formulations of Lamotrigine (Lametec tablets) . © The Swiss Pharmacy, Geneva Switzerland
  • 17. Lamotrigine Tablets Overdose Symptoms Acute ingestion of doses in excess of 10 to 30 times the maximum therapeutic dose of Lamotrigine, have been reported. Overdoses involving quantities up to 15 g have been reported for lamotrigine, some of which have been fatal. Overdose has resulted in symptoms including nystagmus, ataxia, blurred vision, coma, dizziness, headache, impaired consciousness, increased seizures, nystagmus, somnolence and vomiting. QRS broadening (intraventricular conduction delay) has also been observed in overdose patients. © The Swiss Pharmacy, Geneva Switzerland
  • 18. Lamotrigine Tablets Overdose Treatment No specific antidotes are available to treat overdosage of Lamotrigine (Lametec tablets). In the event of overdosage, the patient should be admitted to hospital and given appropriate supportive therapy. Measures should be taken to protect the airways, as consciousness may be impaired. © The Swiss Pharmacy, Geneva Switzerland
  • 19. Lamotrigine Tablets Lametec Tablets 25 mg, 50 mg and 100 mg manufactured by Cipla Ltd., India For more information click here © The Swiss Pharmacy, Geneva Switzerland

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