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Generic Rheumatrex Tablets for Treatment of  Cancer and  Neoplastic diseases
Generic Rheumatrex Tablets for Treatment of  Cancer and  Neoplastic diseases
Generic Rheumatrex Tablets for Treatment of  Cancer and  Neoplastic diseases
Generic Rheumatrex Tablets for Treatment of  Cancer and  Neoplastic diseases
Generic Rheumatrex Tablets for Treatment of  Cancer and  Neoplastic diseases
Generic Rheumatrex Tablets for Treatment of  Cancer and  Neoplastic diseases
Generic Rheumatrex Tablets for Treatment of  Cancer and  Neoplastic diseases
Generic Rheumatrex Tablets for Treatment of  Cancer and  Neoplastic diseases
Generic Rheumatrex Tablets for Treatment of  Cancer and  Neoplastic diseases
Generic Rheumatrex Tablets for Treatment of  Cancer and  Neoplastic diseases
Generic Rheumatrex Tablets for Treatment of  Cancer and  Neoplastic diseases
Generic Rheumatrex Tablets for Treatment of  Cancer and  Neoplastic diseases
Generic Rheumatrex Tablets for Treatment of  Cancer and  Neoplastic diseases
Generic Rheumatrex Tablets for Treatment of  Cancer and  Neoplastic diseases
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Generic Rheumatrex Tablets for Treatment of Cancer and Neoplastic diseases

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Generic Rheumatrex (Neotrexate Tablets) is an antimetabolite and antifolate drug. It is used in treatment of cancer, neoplastic diseases, severe psoriasis, autoimmune diseases, ectopic pregnancy, …

Generic Rheumatrex (Neotrexate Tablets) is an antimetabolite and antifolate drug. It is used in treatment of cancer, neoplastic diseases, severe psoriasis, autoimmune diseases, ectopic pregnancy, Eczema, Lymphoma, Trophoblastic Disease and adult rheumatoid arthritis.

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  • 1. Generic Rheumatrex Tablets Generic Rheumatrex Tablets (Neotrexate Tablets) is an antimetabolite and antifolate drug. It is used in treatment of cancer, neoplastic diseases, severe psoriasis, autoimmune diseases, ectopic pregnancy, Eczema, Lymphoma, Trophoblastic Disease and adult rheumatoid arthritis. © The Swiss Pharmacy, Geneva Switzerland
  • 2. Generic Rheumatrex Tablets Chemical Structure © The Swiss Pharmacy, Geneva Switzerland
  • 3. Generic Rheumatrex Tablets Active Ingredient The active pharmaceutical ingredient contained in Generic Rheumatrex (Neotrexate Tablets) is Methotrexate. © The Swiss Pharmacy, Geneva Switzerland
  • 4. Generic Rheumatrex Tablets Recommended Dosage The dosage of Generic Rheumatrex (Neotrexate Tablets) is different for different diseases and treatments. The adult dosage for some indications is given below: Choriocarcinoma and Similar Trophoblastic Diseases: Methotrexate is administered orally in doses of 15 to 30 mg daily for a five-day course. Such courses are usually repeated for 3 to 5 times as required, with rest periods of one or more weeks interposed between courses, until any manifesting toxic symptoms subside. © The Swiss Pharmacy, Geneva Switzerland
  • 5. Generic Rheumatrex Tablets Recommended Dosage Adult Rheumatoid Arthritis: Recommended Starting Dosage Schedules 1. Single oral doses of 7.5 mg once weekly. 2. Divided oral dosages of 2.5 mg at 12 hour intervals for 3 doses given as a course once weekly Polyarticular-Course Juvenile Rheumatoid Arthritis: The recommended starting dose is 10 mg/m2 given once weekly © The Swiss Pharmacy, Geneva Switzerland
  • 6. Generic Rheumatrex Tablets Contraindications Generic Rheumatrex (Neotrexate Tablets) is contraindicated in patients with the following conditions: ➔Hypersensitivity to Methotrexate , or any inactive component of this medication. ➔In pregnant women with psoriasis or rheumatoid arthritis as Methotrexate can cause fetal death or teratogenic effects when administered to a pregnant woman. ➔In nursing mothers due to potential for serious adverse reactions from methotrexate in breast fed infants. © The Swiss Pharmacy, Geneva Switzerland
  • 7. Generic Rheumatrex Tablets Contraindications ➔Patients with psoriasis or rheumatoid arthritis with alcoholism, alcoholic liver disease or other chronic liver disease should not receive methotrexate (Neotrexate Tablets). ➔Patients with psoriasis or rheumatoid arthritis who have overt or laboratory evidence of immunodeficiency syndromes should not receive methotrexate. ➔Patients with psoriasis or rheumatoid arthritis who have preexisting blood dyscrasias, such as bone marrow hypoplasia, leukopenia, thrombocytopenia or significant anemia,should not receive methotrexate (Generic Rheumatrex). © The Swiss Pharmacy, Geneva Switzerland
  • 8. Generic Rheumatrex Tablets Side Effects of Generic Rheumatrex (Neotrexate Tablets) The most frequent side effects include ulcerative stomatitis, leukopenia, nausea, and abdominal distress. Other commonly reported side effects are malaise, undue fatigue, chills and fever, dizziness and decreased resistance to infection. © The Swiss Pharmacy, Geneva Switzerland
  • 9. Generic Rheumatrex Tablets Warnings And Precautions ➔The patient should be fully informed of the risks involved and should be under constant supervision of the physician. Methotrexate has the potential for serious toxicity. ➔Assessment of hematologic, hepatic, renal, and pulmonary function should be made by history, physical examination, and laboratory tests before beginning, periodically during, and before reinstituting methotrexate therapy. © The Swiss Pharmacy, Geneva Switzerland
  • 10. Generic Rheumatrex Tablets Warnings And Precautions ➔Toxic effects may be related in frequency and severity to dose or frequency of administration but have been seen at all doses ➔Most adverse reactions are reversible if detected early. When adverse reactions occur, Generic Rheumatrex (Neotrexate Tablets) should be reduced in dosage or discontinued and appropriate corrective measures should be taken © The Swiss Pharmacy, Geneva Switzerland
  • 11. Generic Rheumatrex Tablets Overdose Symptoms Symptoms commonly reported following oral overdose of Generic Rheumatrex (Neotrexate Tablets) include leukopenia, thrombocytopenia, anemia, pancytopenia, bone marrow suppression, mucositis, stomatitis, oral ulceration, nausea, vomiting, gastrointestinal ulceration, gastrointestinal bleeding. There have been reports of death following ovedose. In these cases, events such as sepsis or septic shock, renal failure, and aplastic anemia were also reported. © The Swiss Pharmacy, Geneva Switzerland
  • 12. Generic Rheumatrex Tablets Overdose Treatment Leucovorin is used to diminish the toxicity and counteract the effect of inadvertently administered overdosages of methotrexate. Leucovorin should be administered to the patient as soon as possible because as the time interval between methotrexate administration and leucovorin initiation increases, the effectiveness of leucovorin in counteracting toxicity decreases. © The Swiss Pharmacy, Geneva Switzerland
  • 13. Generic Rheumatrex Tablets Overdose Treatment In cases of massive overdosage, hydration and urinary alkalinization may be necessary to prevent the precipitation of methotrexate and/or its metabolites in the renal tubules. Effective clearance of methotrexate has been reported with acute, intermittent hemodialysis using a high-flux dialyzer. © The Swiss Pharmacy, Geneva Switzerland
  • 14. Generic Rheumatrex Tablets Neotrexate Tablets Manufactured by GlaxoSmithKline India For more information click here © The Swiss Pharmacy, Geneva Switzerland

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