Generic Janumet Tablets for Treatment of Type 2 Diabetes

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Generic Janumet tablets (Zita-Met) are used along with diet and exercise to improve glycemic control (reduce blood sugar levels) in adults with type 2 diabetes mellitus (non-insulin dependent diabetes) when treatment with both sitagliptin and metformin is appropriate.

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Generic Janumet Tablets for Treatment of Type 2 Diabetes

  1. 1. Generic Janumet Tablets Generic Janumet Tablets (Zita-Met) are used along with diet and exercise to improve glycemic control (reduce blood sugar levels) in adults with type 2 diabetes mellitus (non-insulin dependent diabetes) when treatment with both Sitagliptin and Metformin is appropriate. © The Swiss Pharmacy, Geneva Switzerland
  2. 2. Generic Janumet Tablets Active Ingredient The active pharmaceutical ingredients contained in Generic Janumet (Zita-Met Tablets) are Sitagliptin Phosphate and Metformin Hydrochloride. Zita-Met Tablets contain 50 mg of Sitagliptin Phosphate and 500 mg of Metformin HCl . © The Swiss Pharmacy, Geneva Switzerland
  3. 3. Generic Janumet Tablets Chemical Structure (Metformin) © The Swiss Pharmacy, Geneva Switzerland
  4. 4. Generic Janumet Tablets Chemical Structure (Sitagliptin) © The Swiss Pharmacy, Geneva Switzerland
  5. 5. Generic Janumet Tablets Recommended Dosage Generic Janumet tablets should be given twice daily with meals, with gradual dose escalation, to reduce the gastrointestinal (GI) side effects due to Metformin. Starting Adult Dose : The usual starting dose of Generic Janumet tablets is 50 mg Sitagliptin/500 mg Metformin Hydrochloride twice daily . © The Swiss Pharmacy, Geneva Switzerland
  6. 6. Generic Janumet Tablets Contraindications Generic Janumet Tablets (Zita-Met) is contraindicated in patients with the following conditions: ➔Hypersensitivity to Sitagliptin Phosphate or Metformin Hydrochloride or to any inactive ingredient present in the medication. ➔Contraindicated in cases of Renal dysfunction, e.g., serum creatinine 1.5 mg/dL or more in males, 1.4 mg/dL or more in females or abnormal creatinine clearance © The Swiss Pharmacy, Geneva Switzerland
  7. 7. Generic Janumet Tablets Contraindications Generic Janumet Tablets (Zita-Met) is contraindicated in patients with the following conditions: ➔Contraindicated in cases of Metabolic acidosis, including diabetic ketoacidosis. © The Swiss Pharmacy, Geneva Switzerland
  8. 8. Generic Janumet Tablets Side Effects of Generic Janumet The most commonly observed side effects associated with the use of Generic Janumet (Zita-Met Tablets) were Diarrhoea, Headache, Nausea, Upper respiratory tract infections, Dyspepsia, Flatulence, Vomiting, Gastrointestinal adverse reactions, Hypoglycaemia on concomitant use with other anti-diabetic drugs and Allergic reactions. © The Swiss Pharmacy, Geneva Switzerland
  9. 9. Generic Janumet Tablets Warnings And Precautions ➔Lactic acidosis is a rare, but serious metabolic complication that can occur due to Metformin accumulation during treatment with Zita-Met. ➔Temporarily discontinue Generic Janumet in patients undergoing radiologic studies with intravascular administration of iodinated contrast materials or any surgical procedures necessitating restricted intake of food or fluids. ➔There have been postmarketing reports of acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis. If pancreatitis is suspected, promptly discontinue Generic Janumet. ➔Vitamin B12 deficiency: Metformin may lower Vitamin B12 levels. Measure hematologic parameters annually. © The Swiss Pharmacy, Geneva Switzerland
  10. 10. Generic Janumet Tablets Warnings And Precautions ➔There have been postmarketing reports of acute renal failure, sometimes requiring dialysis. Before initiating Generic Janumet tablets (Zita-Met) and at least annually thereafter, assess renal function and verify as normal. ➔When used with an insulin secretagogue (e.g., sulfonylurea) or with insulin, a lower dose of the insulin secretagogue or insulin may be required to reduce the risk of hypoglycemia. ➔There have been postmarketing reports of serious allergic and hypersensitivity reactions in patients treated with sitagliptin (one of the components of Generic Janumet), such as anaphylaxis, angioedema, and exfoliative skin conditions including Stevens- Johnson syndrome. In such cases, promptly stop Generic Janumet, and initiate alternative treatment for diabetes. © The Swiss Pharmacy, Geneva Switzerland
  11. 11. Generic Janumet Tablets Overdose Symptoms In case of Sitagliptin Phosphate overdose, there were no dose-related clinical adverse reactions observed with Sitagliptin with doses of up to 600 mg per day for periods of up to 10 days and 400 mg per day for periods of up to 28 days. Overdose of Metformin Hydrochloride has occurred, including ingestion of amounts greater than 50 grams. Hypoglycaemia was reported in approximately 10% of cases, but no causal association with Metformin Hydrochloride has been established. Lactic acidosis has been reported in approximately 32% of Metformin overdose cases. © The Swiss Pharmacy, Geneva Switzerland
  12. 12. Generic Janumet Tablets Overdose Treatment Sitagliptin is modestly dialysable. In clinical studies, approximately 13.5% of the dose was removed over a 3- to 4-hour haemodialysis session. Prolonged haemodialysis may be considered if clinically appropriate. Metformin is dialysable with a clearance of up to 170 mL/min under good haemodynamic conditions . Therefore, haemodialysis may be useful for removal of accumulated medicine from patients in whom Metformin overdosage is suspected. © The Swiss Pharmacy, Geneva Switzerland
  13. 13. Generic Janumet Tablets Zita-Met Tablets manufactured by Glenmark Pharmaceuticals For more information click here © The Swiss Pharmacy, Geneva Switzerland

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