Generic Dostinex for Treatment of Hyperprolactinemic Disorders

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Generic Dostinex (Cabgolin Tablets) are used to reduce your body’s level of a hormone known as prolactin. Dostinex is also used to prevent the production of milk in women after birth, if breast-feeding is to be prevented for medical reasons.

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Generic Dostinex for Treatment of Hyperprolactinemic Disorders

  1. 1. Generic Dostinex Tablets Generic Dostinex (Cabgolin Tablets) are used for the treatment of hyperprolactinemic disorders including amenorrhea, oligomenorrhea, anovulation and galactorrhea. Generic Dostinex is also used to treat patients with prolactin-secreting pituitary adenomas. © The Swiss Pharmacy, Geneva Switzerland
  2. 2. Generic Dostinex Tablets Active Ingredient The active ingredient in Generic Dostinex (Cabgolin Tablets) is Cabergoline, which is a dopamine receptor agonist. The 0.5 mg tablets of Cabgolin contain 0.5 mg of Cabergoline. © The Swiss Pharmacy, Geneva Switzerland
  3. 3. Generic Dostinex Tablets Chemical Structure © The Swiss Pharmacy, Geneva Switzerland
  4. 4. Generic Dostinex Tablets Indications Suppression of Lactation Generic Dostinex (Cabgolin Tablets) can also be prescribed to prevent the production of milk in women after birth, if breast-feeding is to be prevented for medical reasons. Generic Dostinex suppresses physiological lactation by inhibiting prolactin secretion. © The Swiss Pharmacy, Geneva Switzerland
  5. 5. Generic Dostinex Tablets Indications Treatment of Hyperprolactinaemic Disorders: Generic Dostinex is used for the treatment of dysfunctions associated with hyperprolactinaemia, including amenorrhoea, oligomenorrhoea, anovulation and galactorrhoea. Cabgolin is also indicated in patients with prolactin-secreting pituitary adenomas (micro- and macroprolactinomas), idiopathic hyperprolactinaemia, or empty sella syndrome with associated hyperprolactinaemia. © The Swiss Pharmacy, Geneva Switzerland
  6. 6. Generic Dostinex Tablets Recommended Adult Dosage Treatment of Hyperprolactinaemic Disorders: To treat high levels of prolactin (hyperprolactinaemia), the recommended starting dose is 0.25mg taken twice a week. The weekly dose of Generic Dostinex should be increased gradually preferably by adding 0.5mg per week at monthly intervals until the optimal therapeutic response is achieved. © The Swiss Pharmacy, Geneva Switzerland
  7. 7. Generic Dostinex Tablets Recommended Adult Dosage Inhibition of Lactation: To prevent the production of milk, the recommended dose is 1mg (two 0.5mg tablets) as a single dose taken once, on the first day after delivery. © The Swiss Pharmacy, Geneva Switzerland
  8. 8. Generic Dostinex Tablets Missed Dose If you miss a dose, take it as soon as you remember. However, if you remember when it is almost time for your next dose, take only your usual dose at that time. © The Swiss Pharmacy, Geneva Switzerland
  9. 9. Generic Dostinex Tablets Contraindications Generic Dostinex Tablets are contraindicated in the following cases: ➔Known hypersensitivity to Cabergoline or any inactive ingredients of this medication. ➔Uncontrolled hypertension. ➔Known hypersensitivity to ergot derivatives. ➔History of cardiac valvular disorders ➔History of pulmonary, pericardial, or retroperitoneal fibrotic disorders. © The Swiss Pharmacy, Geneva Switzerland
  10. 10. Generic Dostinex Tablets Side Effects of Generic Dostinex Most side effects were transient and mild to moderate in severity. The most frequently occurring side effects were dizziness/vertigo, headache, nausea and abdominal pain. Rarely occuring side effects were palpitations, epigastric pain, somnolence, epistaxis and transient hemianopsia, vomiting, syncope, asthenia, and hot flushes. © The Swiss Pharmacy, Geneva Switzerland
  11. 11. Generic Dostinex Tablets Warnings And Precautions ➔Pregnancy: Dopamine agonists in general should not be used in patients with pregnancy-induced hypertension, for example, preeclampsia, eclampsia, and post partum hypertension, unless the potential benefit is judged to outweigh the possible risk. ➔Cardiac Valvulopathy: All patients should undergo a cardiovascular evaluation, including echocardiogram to assess the potential presence of valvular disease. If valvular disease is detected, the patient should not be treated with Generic Dostinex. ➔Extracardiac Fibrotic Reactions: Postmarketing cases of pleural, pericardial, and retroperitoneal fibrosis have been reported following administration of Generic Dostinex. © The Swiss Pharmacy, Geneva Switzerland
  12. 12. Generic Dostinex Tablets Warnings And Precautions ➔General: Initial doses higher than 1.0 mg may produce orthostatic hypotension. Care should be exercised when administering Generic Dostinex with other medications known to lower blood pressure. © The Swiss Pharmacy, Geneva Switzerland
  13. 13. Generic Dostinex Tablets Overdosage Symptoms Overdosage is likely to lead to symptoms due to over-stimulation of dopamine receptors. The adverse effects may include nausea, vomiting, gastric complaints, hypotension, nasal congestion, confusion hallucinations, psychosis or thought/perception disturbances. © The Swiss Pharmacy, Geneva Switzerland
  14. 14. Generic Dostinex Tablets Overdose Treatment Administration of activated charcoal has to be considered in the event of a potentially toxic ingestion. Activated charcoal is most effective when administered within 1 hour of ingestion. In patients who are not fully conscious or have impaired gag reflex, consideration should be given to administering activated charcoal via nasogastric tube once the airway is protected. © The Swiss Pharmacy, Geneva Switzerland
  15. 15. Generic Dostinex Tablets Overdose Treatment Measures to support blood pressure should be taken if necessary. In addition, in case of pronounced central nervous system effects the administration of dopamine antagonist drugs may be advisable. © The Swiss Pharmacy, Geneva Switzerland
  16. 16. Generic Dostinex Tablets Cabgolin Tablets Manufactured by Sun Pharmaceuticals Ltd., India For more information click here © The Swiss Pharmacy, Geneva Switzerland

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