Generic Bystolic Tablets 
Generic Bystolic Tablets (Nebistar) is used for the 
treatment of hypertension, to lower blood p...
Generic Bystolic Tablets 
Chemical Structure 
© The Swiss Pharmacy, Geneva Switzerland
Generic Bystolic Tablets 
Active Ingredient 
The active pharmaceutical ingredient 
contained in Generic Bystolic Tablets 
...
Generic Bystolic Tablets 
Indications 
Generic Bystolic (Nebivolol Hydrochloride) is used for the 
treatment of hypertensi...
Generic Bystolic Tablets 
Indications 
The largest and most consistent cardiovascular outcome 
benefit has been a reductio...
Generic Bystolic Tablets 
Recommended Dosage 
The dosage of Generic Bystolic (Nebivolol 
Hydrochloride) for the treatment ...
Generic Bystolic Tablets 
Recommended Dosage 
Renal Impairment: 
In patients with severe renal impairment (ClCr less 
than...
Generic Bystolic Tablets 
Contraindications 
Generic Bystolic Tablets (Nebistar) are 
contraindicated in patients with the...
Generic Bystolic Tablets 
Side Effects of Generic Bystolic 
Tablets (Nebistar) 
The most frequent side effects include 
Br...
Generic Bystolic Tablets 
Warnings And Precautions 
➔Abrupt Cessation of Therapy: Do not abruptly 
discontinue Generic Bys...
Generic Bystolic Tablets 
Warnings And Precautions 
➔Bronchospastic Diseases: In general, patients with 
bronchospastic di...
Generic Bystolic Tablets 
Warnings And Precautions 
➔Diabetes and Hypoglycemia: ß-blockers may mask 
some of the manifesta...
Generic Bystolic Tablets 
Warnings And Precautions 
➔Peripheral Vascular Disease: ß-blockers can precipitate 
or aggravate...
Generic Bystolic Tablets 
Warnings And Precautions 
➔Impaired Renal Function: Renal clearance of nebivolol 
is decreased i...
Generic Bystolic Tablets 
Overdose Symptoms 
The most common signs and symptoms of 
Generic Bystolic overdosage are 
brady...
Generic Bystolic Tablets 
Overdose Treatment 
If overdose occurs, provide general supportive and 
specific symptomatic tre...
Generic Bystolic Tablets 
Overdose Treatment 
Heart Block (second or third degree): Monitor and 
treat with isoproterenol ...
Generic Bystolic Tablets 
Nebistar Tablets manufactured 
by Lupin (Pinnacle) 
For more information click here 
© The Swiss...
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Generic Bystolic Tablets for Treatment of Hypertension

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Generic Bystolic Tablets (Nebistar) is used for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions.

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Generic Bystolic Tablets for Treatment of Hypertension

  1. 1. Generic Bystolic Tablets Generic Bystolic Tablets (Nebistar) is used for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. © The Swiss Pharmacy, Geneva Switzerland
  2. 2. Generic Bystolic Tablets Chemical Structure © The Swiss Pharmacy, Geneva Switzerland
  3. 3. Generic Bystolic Tablets Active Ingredient The active pharmaceutical ingredient contained in Generic Bystolic Tablets is Nebivolol Hydrochloride. © The Swiss Pharmacy, Geneva Switzerland
  4. 4. Generic Bystolic Tablets Indications Generic Bystolic (Nebivolol Hydrochloride) is used for the treatment of hypertension, to lower blood pressure. Generic Bystolic may be used alone or in combination with other anti-hypertensive agents. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, anti-thrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than one drug to achieve blood pressure goals. © The Swiss Pharmacy, Geneva Switzerland
  5. 5. Generic Bystolic Tablets Indications The largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke, but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly. Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mm Hg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit. © The Swiss Pharmacy, Geneva Switzerland
  6. 6. Generic Bystolic Tablets Recommended Dosage The dosage of Generic Bystolic (Nebivolol Hydrochloride) for the treatment of hypertension must be individualized to the needs of the patient. For most patients, the recommended starting dose is 5 mg once daily, with or without food, as monotherapy or in combination with other agents. For patients requiring further reduction in blood pressure, the dose can be increased at 2-week intervals up to 40 mg. © The Swiss Pharmacy, Geneva Switzerland
  7. 7. Generic Bystolic Tablets Recommended Dosage Renal Impairment: In patients with severe renal impairment (ClCr less than 30 mL/min) the recommended initial dose is 2.5 mg once daily; titrate up slowly if needed. Generic Bystolic has not been studied in patients receiving dialysis. Hepatic Impairment: In patients with moderate hepatic impairment, the recommended initial dose is 2.5 mg once daily; titrate up slowly if needed. Generic Bystolic Tablets has not been studied in patients with severe hepatic impairment and therefore it is not recommended in that population. © The Swiss Pharmacy, Geneva Switzerland
  8. 8. Generic Bystolic Tablets Contraindications Generic Bystolic Tablets (Nebistar) are contraindicated in patients with the following conditions: ➔Hypersensitivity to Nebivolol Hydrochloride, or any inactive component of this medication. ➔Severe bradycardia ➔Heart block greater than first degree ➔Patients with cardiogenic shock ➔Decompensated cardiac failure ➔Sick sinus syndrome (unless a permanent pacemaker is in place) ➔Patients with severe hepatic impairment (Child- Pugh >B) © The Swiss Pharmacy, Geneva Switzerland
  9. 9. Generic Bystolic Tablets Side Effects of Generic Bystolic Tablets (Nebistar) The most frequent side effects include Bradycardia, Diarrhea, Nausea, Fatigue, Chest pain, Peripheral edema, Headache, Dizziness, Insomnia, Dyspnea, and Rash © The Swiss Pharmacy, Geneva Switzerland
  10. 10. Generic Bystolic Tablets Warnings And Precautions ➔Abrupt Cessation of Therapy: Do not abruptly discontinue Generic Bystolic (Nebistar Tablets) therapy in patients with coronary artery disease. Severe exacerbation of angina, myocardial infarction and ventricular arrhythmias have been reported in patients with coronary artery disease following the abrupt discontinuation of therapy with ß-blockers. ➔Angina and Acute Myocardial Infarction: Generic Bystolic was not studied in patients with angina pectoris or who had a recent MI. © The Swiss Pharmacy, Geneva Switzerland
  11. 11. Generic Bystolic Tablets Warnings And Precautions ➔Bronchospastic Diseases: In general, patients with bronchospastic diseases should not receive ß-blockers. ➔Anesthesia and Major Surgery: Since beta-blocker withdrawal has been associated with an increased risk of MI and chest pain, patients already on beta-blockers should generally continue treatment throughout the perioperative period. If Generic Bystolic is to be continued perioperatively, monitor patients closely when anesthetic agents which depress myocardial function, such as ether, cyclopropane, and trichloroethylene, are used. © The Swiss Pharmacy, Geneva Switzerland
  12. 12. Generic Bystolic Tablets Warnings And Precautions ➔Diabetes and Hypoglycemia: ß-blockers may mask some of the manifestations of hypoglycemia, particularly tachycardia. Nonselective ß-blockers may potentiate insulin-induced hypoglycemia and delay recovery of serum glucose levels. ➔Thyrotoxicosis: ß-blockers may mask clinical signs of hyperthyroidism, such as tachycardia. Abrupt withdrawal of ß-blockers may be followed by an exacerbation of the symptoms of hyperthyroidism or may precipitate a thyroid storm. © The Swiss Pharmacy, Geneva Switzerland
  13. 13. Generic Bystolic Tablets Warnings And Precautions ➔Peripheral Vascular Disease: ß-blockers can precipitate or aggravate symptoms of arterial insufficiency in patients with peripheral vascular disease. ➔Non-dihydropyridine Calcium Channel Blockers: Because of significant negative inotropic and chronotropic effects in patients treated with ß-blockers and calcium channel blockers of the verapamil and diltiazem type, monitor the ECG and blood pressure in patients treated concomitantly with these agents. ➔Use with CYP2D6 Inhibitors: Nebivolol HCl exposure increases with inhibition of CYP2D6. The dose of Generic Bystolic (Nebistar Tablets) may need to be reduced. © The Swiss Pharmacy, Geneva Switzerland
  14. 14. Generic Bystolic Tablets Warnings And Precautions ➔Impaired Renal Function: Renal clearance of nebivolol is decreased in patients with severe renal impairment. Generic Bystolic (Nebistar Tablets) has not been studied in patients receiving dialysis. ➔Impaired Hepatic Function: Metabolism of nebivolol is decreased in patients with moderate hepatic impairment. Generic Bystolic has not been studied in patients with severe hepatic impairment. ➔Risk of Anaphylactic Reactions: While taking ß-blockers, patients with a history of severe anaphylactic reactions to a variety of allergens may be more reactive to repeated accidental, diagnostic, or therapeutic challenge. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reactions. © The Swiss Pharmacy, Geneva Switzerland
  15. 15. Generic Bystolic Tablets Overdose Symptoms The most common signs and symptoms of Generic Bystolic overdosage are bradycardia and hypotension. Other important adverse reactions reported with Generic Bystolic (Nebistar Tablets) overdose include cardiac failure, dizziness, hypoglycemia, fatigue and vomiting. Other adverse reactions associated with ß-blocker overdose include bronchospasm and heart block. © The Swiss Pharmacy, Geneva Switzerland
  16. 16. Generic Bystolic Tablets Overdose Treatment If overdose occurs, provide general supportive and specific symptomatic treatment. Consider the following general measures, including stopping Generic Bystolic (Nebistar Tablets), when clinically warranted: Bradycardia: Administer IV atropine. If the response is inadequate, isoproterenol or another agent with positive chronotropic properties may be given cautiously. Under some circumstances, transthoracic or transvenous pacemaker placement may be necessary. Hypotension: Administer IV fluids and vasopressors. Intravenous glucagon may be useful. © The Swiss Pharmacy, Geneva Switzerland
  17. 17. Generic Bystolic Tablets Overdose Treatment Heart Block (second or third degree): Monitor and treat with isoproterenol infusion. Under some circumstances, transthoracic or transvenous pacemaker placement may be necessary. Congestive Heart Failure: Initiate therapy with digitalis glycoside and diuretics. In certain cases, consider the use of inotropic and vasodilating agents. Bronchospasm: Administer bronchodilator therapy such as a short acting inhaled ß2-agonist and/or aminophylline. Hypoglycemia: Administer IV glucose. Repeated doses of IV glucose or possibly glucagon may be required. © The Swiss Pharmacy, Geneva Switzerland
  18. 18. Generic Bystolic Tablets Nebistar Tablets manufactured by Lupin (Pinnacle) For more information click here © The Swiss Pharmacy, Geneva Switzerland

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