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Fluorouracil Cream 
Fluorouracil Cream (Flonida) is used by adults to 
treat skin conditions on the face and front part of...
Fluorouracil Cream 
Chemical Structure 
© The Swiss Pharmacy, Geneva Switzerland
Fluorouracil Cream 
Active Ingredient 
The active pharmaceutical ingredient 
contained in Flonida cream is 
Fluorouracil. ...
Fluorouracil Cream 
Uses of Fluorouracil Cream 
Fluorouracil Cream (Flonida) is used 
for the topical treatment of superfi...
Fluorouracil Cream 
Recommended Adult Dosage 
Generic Fluorouracil cream (Flonida cream) 
should be applied twice daily in...
Fluorouracil Cream 
Contraindications 
Generic Fluorouracil cream (Flonida cream) 
is contraindicated in patients with the...
Fluorouracil Cream 
Contraindications 
Generic Fluorouracil cream (Flonida cream) is 
contraindicated in patients with the...
Fluorouracil Cream 
Side Effects of Fluorouracil Cream 
The most common possible side effects 
of Fluorouracil cream (Flon...
Fluorouracil Cream 
Warnings And Precautions 
➔It is not known whether Fluorouracil is excreted in human 
milk. Because ma...
Fluorouracil Cream 
Warnings And Precautions 
➔Patients should discontinue therapy with Carac if symptoms of 
DPD enzyme d...
Fluorouracil Cream 
Overdose Symptoms & Treatment 
Ordinarily, topical overdosage of Fluorouracil 
cream (Flonida) will no...
Fluorouracil Cream 
Flonida -1% and 5% cream 
manufactured by Shalaks 
Pharmaceuticals Pvt. Ltd., India 
For more informat...
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Fluorouracil Cream for Treatment of Keratoses & Skin Lesions

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Fluorouracil Cream (Flonida Cream) is used by adults to treat skin conditions such as superficial pre-malignant and malignant skin lesions, keratoses, Bowen’s disease and superficial basal-cell carcinoma.

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Transcript of "Fluorouracil Cream for Treatment of Keratoses & Skin Lesions"

  1. 1. Fluorouracil Cream Fluorouracil Cream (Flonida) is used by adults to treat skin conditions on the face and front part of the scalp called solar keratosis or actinic keratosis. Flonida Cream is also used to treat Superficial pre-malignant and malignant skin lesions, Bowens disease (type of skin cancer) and Superficial Basal-Cell Carcinoma. © The Swiss Pharmacy, Geneva Switzerland
  2. 2. Fluorouracil Cream Chemical Structure © The Swiss Pharmacy, Geneva Switzerland
  3. 3. Fluorouracil Cream Active Ingredient The active pharmaceutical ingredient contained in Flonida cream is Fluorouracil. Flonida cream 1% contains 1.0% of the active ingredient Fluorouracil whereas Flonida cream 5% contains 5.0% of the active ingredient Fluorouracil. © The Swiss Pharmacy, Geneva Switzerland
  4. 4. Fluorouracil Cream Uses of Fluorouracil Cream Fluorouracil Cream (Flonida) is used for the topical treatment of superficial pre-malignant and malignant skin lesions, keratoses including senile, actinic and arsenical forms, keratoa canthoma, Bowen’s disease, superficial basal-cell carcinoma. © The Swiss Pharmacy, Geneva Switzerland
  5. 5. Fluorouracil Cream Recommended Adult Dosage Generic Fluorouracil cream (Flonida cream) should be applied twice daily in sufficient quantity to cover the entire area with a thin film. Generic Fluorouracil cream should not be applied near the eyes, nostrils or mouth. Flonida cream should be applied ten minutes after thoroughly washing, rinsing, and drying the entire area. Generic Fluorouracil cream may be applied using the fingertips. Immediately after application, the hands should be thoroughly washed. A treatment period of 2 to 6 weeks is usually required depending on the indication being treated. © The Swiss Pharmacy, Geneva Switzerland
  6. 6. Fluorouracil Cream Contraindications Generic Fluorouracil cream (Flonida cream) is contraindicated in patients with the following conditions: ➔Known hypersensitivity to Fluorouracil or any inactive ingredient of this medication. ➔Fluorouracil cream (Flonida cream) is contraindicated in women who are or may become pregnant. If Flonida cream is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. © The Swiss Pharmacy, Geneva Switzerland
  7. 7. Fluorouracil Cream Contraindications Generic Fluorouracil cream (Flonida cream) is contraindicated in patients with the following conditions: ➔Known hypersensitivity to Fluorouracil or any inactive ingredient of this medication. Fluorouracil cream should not be used in patients with dihydropyrimidine dehydrogenase (DPD) enzyme deficiency. ➔Fluorouracil cream is not recommended for use on children. © The Swiss Pharmacy, Geneva Switzerland
  8. 8. Fluorouracil Cream Side Effects of Fluorouracil Cream The most common possible side effects of Fluorouracil cream (Flonida cream) are pain, pruritus, burning, irritation, inflammation, allergic contact dermatitis and telangiectasia have been reported. Occasionally, hyperpigmentation and scarring have also been reported. © The Swiss Pharmacy, Geneva Switzerland
  9. 9. Fluorouracil Cream Warnings And Precautions ➔It is not known whether Fluorouracil is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Fluorouracil, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of this medication to the mother. ➔The potential for a delayed hypersensitivity reaction to Fluorouracil exists. Patch testing to prove hypersensitivity may be inconclusive. ➔Applications to mucous membranes should be avoided due to the possibility of local inflammation and ulceration. © The Swiss Pharmacy, Geneva Switzerland
  10. 10. Fluorouracil Cream Warnings And Precautions ➔Patients should discontinue therapy with Carac if symptoms of DPD enzyme deficiency develop. Rarely, unexpected, systemic toxicity (e.g. stomatitis, diarrhea, neutropenia, and neurotoxicity) associated with parental administration of Fluorouracil has been attributed to deficiency of dihydropyrimidine dehydrogenase “DPD” activity. ➔Occlusion of the skin with resultant hydration has been shown to increase percutaneous penetration of several topical preparations. If an occlusive dressing is used there may be an increase in the incidence of inflammatory reactions in the adjacent normal skin. ➔Flonida cream therapy is not advisable in persons who work outdoors for prolonged periods in the sun. Excessive exposure to sunlight or other forms of UV irradiation during treatment may produce a diffuse phototoxic response in the areas of application. © The Swiss Pharmacy, Geneva Switzerland
  11. 11. Fluorouracil Cream Overdose Symptoms & Treatment Ordinarily, topical overdosage of Fluorouracil cream (Flonida) will not cause acute problems. If Fluorouracil cream is accidentally ingested, induce emesis and gastric lavage. If Fluorouracil cream accidentally comes in contact is made with the eyes, flush the eyes with copious amounts of water or normal saline. Administer symptomatic and supportive care as needed. © The Swiss Pharmacy, Geneva Switzerland
  12. 12. Fluorouracil Cream Flonida -1% and 5% cream manufactured by Shalaks Pharmaceuticals Pvt. Ltd., India For more information click here © The Swiss Pharmacy, Geneva Switzerland
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