Brufen Tablets 
Brufen Tablets (Ibuprofen) is used for relief of the 
signs and symptoms of Rheumatoid arthritis, 
Osteoar...
Brufen Tablets 
Chemical Structure 
© The Swiss Pharmacy, Geneva Switzerland
Brufen Tablets 
Active Ingredient 
The active pharmaceutical ingredient 
present in Brufen Tablets is 
Ibuprofen. Each 400...
Brufen Tablets 
Recommended Dosage 
Recommended Adult Dosage: 
The recommended initial dosage of Brufen tablets 
is 1200 m...
Brufen Tablets 
Recommended Dosage 
Primary Dysmenorrhoea: 
For the treatment of dysmenorrhea, 
beginning with the earlies...
Brufen Tablets 
Recommended Dosage 
Children: 
The daily dosage of Brufen tablets 
(Ibuprofen) is 20 mg per kg of body wei...
Brufen Tablets 
Recommended Dosage 
Maintenance Dose: 
In all indications the doses should be adjusted for 
each patient a...
Brufen Tablets 
Contraindications 
Brufen Tablets is contraindicated in 
patients with the following conditions: 
➔Hyperse...
Brufen Tablets 
Side Effects of Brufen Tablets 
The common side effects of Brufen Tablets 
(Ibuprofen) are nausea, epigast...
Brufen Tablets 
Side Effects of Brufen Tablets 
The rare side effects of Brufen Tablets (Ibuprofen) 
include Gastic or duo...
Brufen Tablets 
Side Effects of Brufen Tablets 
The rare side effects of Brufen Tablets (Ibuprofen) 
include neutropenia, ...
Brufen Tablets 
Warnings And Precautions 
➔Cardiovascular Thrombotic Events: Increased risk of 
serious cardiovascular (CV...
Brufen Tablets 
Warnings And Precautions 
➔Gastrointestinal Effects: NSAIDs, including Ibuprofen 
tablets, can cause serio...
Brufen Tablets 
Warnings And Precautions 
➔Anaphylactic/Anaphylactoid Reactions: As with other 
NSAIDs, anaphylactic/anaph...
Brufen Tablets 
Warnings And Precautions 
➔Pregnancy: In late pregnancy, as with other NSAIDs, Brufen 
tablets should be a...
Brufen Tablets 
Overdose Symptoms 
The following symptoms may be 
observed following Brufen Tablets 
(Ibuprofen) overdosag...
Brufen Tablets 
Overdose Treatment 
In cases of acute overdose of Brufen Tablets 
(Ibuprofen), the stomach should be empti...
Brufen Tablets 
Brufen Tablets Manufactured 
by Abbott, India 
For more information click here 
© The Swiss Pharmacy, Gene...
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Brufen Tablets for Treatment of Arthritis, Dysmenorrhoea, and Pyrexia

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Brufen Tablets (Ibuprofen) is used for relief of the signs and symptoms of Rheumatoid arthritis, Osteoarthritis, Juvenile rheumatoid arthritis, Primary dysmenorrhoea, and Pyrexia. Brufen is also used for the relief of acute and/or chronic pain states in which there is an inflammatory component

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Brufen Tablets for Treatment of Arthritis, Dysmenorrhoea, and Pyrexia

  1. 1. Brufen Tablets Brufen Tablets (Ibuprofen) is used for relief of the signs and symptoms of Rheumatoid arthritis, Osteoarthritis, Juvenile rheumatoid arthritis, Primary dysmenorrhoea, and Pyrexia. Brufen is also used for the relief of acute and/or chronic pain states in which there is an inflammatory component. © The Swiss Pharmacy, Geneva Switzerland
  2. 2. Brufen Tablets Chemical Structure © The Swiss Pharmacy, Geneva Switzerland
  3. 3. Brufen Tablets Active Ingredient The active pharmaceutical ingredient present in Brufen Tablets is Ibuprofen. Each 400 mg Brufen Tablet contains 400 mg of Ibuprofen. © The Swiss Pharmacy, Geneva Switzerland
  4. 4. Brufen Tablets Recommended Dosage Recommended Adult Dosage: The recommended initial dosage of Brufen tablets is 1200 mg to 1800 mg daily in divided doses. Some patients can be maintained on 600 to 1200 mg daily. In severe or acute conditions it can be advantageous to increase the dosage until the acute phase is brought under control, providing that the total daily dosage does not exceed 2400 mg in divided doses. © The Swiss Pharmacy, Geneva Switzerland
  5. 5. Brufen Tablets Recommended Dosage Primary Dysmenorrhoea: For the treatment of dysmenorrhea, beginning with the earliest onset of such pain or menstrual bleeding, Ibuprofen tablets should be given in a dose of 400 mg every 4 to 6 hours as necessary with a maximum total daily dose of 1,600 mg. © The Swiss Pharmacy, Geneva Switzerland
  6. 6. Brufen Tablets Recommended Dosage Children: The daily dosage of Brufen tablets (Ibuprofen) is 20 mg per kg of body weight in divided doses. In juvenile rheumatoid arthritis up to 40 mg per kg of body weight in divided doses may be given. In children weighing less than 30 kg the total dose should not exceed 500 mg in a 24 hour period. © The Swiss Pharmacy, Geneva Switzerland
  7. 7. Brufen Tablets Recommended Dosage Maintenance Dose: In all indications the doses should be adjusted for each patient and the smallest dose that results in acceptable control of the symptoms employed. In general, patients with rheumatoid arthritis and osteoarthritis tend to require higher doses than patients with other conditions. Mild to Moderate Pain: The recommended adult dosage is 400 mg every 4 to 6 hours as necessary for relief of pain. © The Swiss Pharmacy, Geneva Switzerland
  8. 8. Brufen Tablets Contraindications Brufen Tablets is contraindicated in patients with the following conditions: ➔Hypersensitivity to Ibuprofen, or any inactive component of this medication. ➔Ibuprofen should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. ➔Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery © The Swiss Pharmacy, Geneva Switzerland
  9. 9. Brufen Tablets Side Effects of Brufen Tablets The common side effects of Brufen Tablets (Ibuprofen) are nausea, epigastric pain, heartburn, diarrhea, abdominal distress, nausea and vomiting, indigestion, constipation, abdominal cramps or pain, fullness of GI tract (bloating and flatulence), dizziness, headache, nervousness, rash (including maculopapular type), pruritus, tinnitus, decreased appetite, edema, and fluid retention. © The Swiss Pharmacy, Geneva Switzerland
  10. 10. Brufen Tablets Side Effects of Brufen Tablets The rare side effects of Brufen Tablets (Ibuprofen) include Gastic or duodenal ulcer with bleeding and/or perforation, gastrointestinal hemorrhage, melena, gastritis, hepatitis, jaundice, abnormal liver function tests; pancreatitis, Depression, insomina, confusion, emotional lability, somnolence, aseptic meningitis with fever and coma, vesiculobullous eruptions, urticaria, erythema multiforme, Stevens-Johnson syndrome, alopecia, hearing loss, amblyopia (blurred and/or diminished vision, scotomata and/or changes in color vision). © The Swiss Pharmacy, Geneva Switzerland
  11. 11. Brufen Tablets Side Effects of Brufen Tablets The rare side effects of Brufen Tablets (Ibuprofen) include neutropenia, agranulocytosis, aplastic anemia, hemolytic anemia (sometimes Coombs Positive), thrombocytopenia with or without purpura, eosinophilia, decreases in hemoglobin and hematocrit, congestive heart failure in patients with marginal cardiac function, elevated blood pressure, palpitations, Syndrome of abdominal pain, fever, chills, nausea and vomiting; anaphylaxis; bronchospasm, acute renal failure, decreased creatinine clearance, polyuria, azotemia, cystitis, hematuria, dry eyes and mouth, gingival ulcer and rhinitis. © The Swiss Pharmacy, Geneva Switzerland
  12. 12. Brufen Tablets Warnings And Precautions ➔Cardiovascular Thrombotic Events: Increased risk of serious cardiovascular (CV) thrombotic events, myocardial infarction, and stroke, which can be fatal. All NSAIDs, both COX-2 selective and nonselective, may have a similar risk. ➔Hypertension: NSAIDs, including Ibuprofen, can lead to onset of new hypertension or worsening of preexisting hypertension, either of which may contribute to the increased incidence of cardiovascular events. ➔Congestive Heart Failure and Edema: Fluid retention and edema have been observed in some patients taking NSAIDs. Ibuprofen should be used with caution in patients with fluid retention or heart failure. © The Swiss Pharmacy, Geneva Switzerland
  13. 13. Brufen Tablets Warnings And Precautions ➔Gastrointestinal Effects: NSAIDs, including Ibuprofen tablets, can cause serious gastrointestinal (GI) adverse events including inflammation, bleeding, ulceration, and perforation of the stomach, small intestine, or large intestine, which can be fatal. ➔Renal Effects: Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury. ➔Advanced Renal Disease: Treatment with Ibuprofen tablets is not recommended in these patients with advanced renal disease. © The Swiss Pharmacy, Geneva Switzerland
  14. 14. Brufen Tablets Warnings And Precautions ➔Anaphylactic/Anaphylactoid Reactions: As with other NSAIDs, anaphylactic/anaphylactoid reactions may occur in patients without known prior exposure to Ibuprofen. Ibuprofen should not be given to patients with the aspirin triad. This symptom complex typically occurs in asthmatic patients who experience rhinitis with or without nasal polyps, or who exhibit severe, potentially fatal bronchospasm after taking aspirin or other NSAIDs. ➔Skin Reactions: NSAIDs, including Ibuprofen, can cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. Patients should be informed about the signs and symptoms of serious skin manifestations and use of the drug should be discontinued at the first appearance of skin rash or any other sign of hypersensitivity. © The Swiss Pharmacy, Geneva Switzerland
  15. 15. Brufen Tablets Warnings And Precautions ➔Pregnancy: In late pregnancy, as with other NSAIDs, Brufen tablets should be avoided because it may cause premature closure of the ductus arteriosus. © The Swiss Pharmacy, Geneva Switzerland
  16. 16. Brufen Tablets Overdose Symptoms The following symptoms may be observed following Brufen Tablets (Ibuprofen) overdosage: Depression of the central nervous system and the respiratory system.. © The Swiss Pharmacy, Geneva Switzerland
  17. 17. Brufen Tablets Overdose Treatment In cases of acute overdose of Brufen Tablets (Ibuprofen), the stomach should be emptied by vomiting or lavage, although little of the drug will be likely to be recovered if it is more than an hour since ingestion. Because the drug is acidic and excreted in the urine, it is theoretically beneficial to administer alkali and induce diuresis. In addition to supportive measures, the use of oral activated charcoal may help reduce the absorption of Ibuprofen. © The Swiss Pharmacy, Geneva Switzerland
  18. 18. Brufen Tablets Brufen Tablets Manufactured by Abbott, India For more information click here © The Swiss Pharmacy, Geneva Switzerland

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