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Aldactone Tablets for Hypertension & Oedematous Disorders
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Aldactone Tablets for Hypertension & Oedematous Disorders

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Aldactone Tablets (Spironolactone) is used to treat hypertension, oedematous disorders, diagnosis and treatment of primary aldosteronism, reducing or preventing potassium loss due to thiazide …

Aldactone Tablets (Spironolactone) is used to treat hypertension, oedematous disorders, diagnosis and treatment of primary aldosteronism, reducing or preventing potassium loss due to thiazide diuretics and other conditions.

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  • 1. Aldactone Spironolactone Tablets Aldactone Tablets are used to treat hypertension, oedematous disorders, diagnosis and treatment of primary aldosteronism, reducing or preventing potassium loss due to thiazide diuretics and other conditions. © The Swiss Pharmacy, Geneva Switzerland
  • 2. Aldactone Spironolactone Tablets Chemical Structure © The Swiss Pharmacy, Geneva Switzerland
  • 3. Aldactone Spironolactone Tablets Active Ingredient The active pharmaceutical ingredient present in Aldactone Tablets is Spironolactone. © The Swiss Pharmacy, Geneva Switzerland
  • 4. Aldactone Spironolactone Tablets Indications Aldactone Tablets, is used for the treatment of: 1. Essential hypertension (high blood pressure with an unknown cause) 2. Oedematous disorders (swelling with fluid), including congestive cardiac failure 3.Diagnosis and treatment of primary aldosteronism (a hormone disorder causing fluid retention) 4.Add-on therapy in malignant hypertension 5.Reducing or preventing potassium loss due to thiazide diuretics 6.Prevention of low amounts of potassium in the blood in patients taking digitalis (a type of heart medicine) © The Swiss Pharmacy, Geneva Switzerland
  • 5. Aldactone Spironolactone Tablets Indications 7. Long-term maintenance therapy for patients with bilateral micro or macronodular adrenal hyperplasia 8. Edematous conditions for patients with Congestive heart failure: For the management of edema and sodium retention when the patient is only partially responsive to, or is intolerant of, other therapeutic measures. 9.Cirrhosis of the liver accompanied by edema and/or ascites © The Swiss Pharmacy, Geneva Switzerland
  • 6. Aldactone Spironolactone Tablets Indications 10.Nephrotic syndrome: For nephrotic patients when treatment of the underlying disease, restriction of fluid and sodium intake, and the use of other diuretics do not provide an adequate response. 11.Hypokalemia: For the treatment of patients with hypokalemia when other measures are considered inappropriate or inadequate. 12.Severe heart failure (NYHA class III – IV) To increase survival, and to reduce the need for hospitalization for heart failure when used in addition to standard therapy. © The Swiss Pharmacy, Geneva Switzerland
  • 7. Aldactone Spironolactone Tablets Indications 13.Long-term maintenance therapy for patients with discrete aldosterone-producing adrenal adenomas who are judged to be poor operative risks or who decline surgery. 14. Treatment of hirsutism © The Swiss Pharmacy, Geneva Switzerland
  • 8. Aldactone Spironolactone Tablets Recommended Adult Dosage Diagnosis of Primary Hyperaldosteronism: Long test: Aldactone is administered at a daily dosage of 400 mg for three to four weeks. Short test: Aldactone is administered at a daily dosage of 400 mg for four days. © The Swiss Pharmacy, Geneva Switzerland
  • 9. Aldactone Spironolactone Tablets Recommended Adult Dosage Edema in adults (congestive heart failure, hepatic cirrhosis, or nephrotic syndrome): An initial daily dosage of 100 mg of Aldactone administered in either single or divided doses is recommended, but may range from 25 to 200 mg daily. When given as the sole agent for diuresis, Aldactone should be continued for at least five days at the initial dosage level, after which it may be adjusted to the optimal therapeutic or maintenance level. © The Swiss Pharmacy, Geneva Switzerland
  • 10. Aldactone Spironolactone Tablets Recommended Adult Dosage Essential Hypertension. For adults, an initial daily dosage of 50 to 100 mg of Aldactone administered in either single or divided doses is recommended. Hypokalemia: Aldactone in a dosage ranging from 25 mg to 100 mg daily is useful in treating a diuretic-induced hypokalemia, when oral potassium supplements or other potassium-sparing regimens are considered inappropriate. © The Swiss Pharmacy, Geneva Switzerland
  • 11. Aldactone Spironolactone Tablets Recommended Adult Dosage Severe Heart Failure (NYHA class III – IV): Treatment should be started with Aldactone 25 mg once daily if the patient’s serum potassium is =5.0 mEq/L and the patient’s serum creatinine is = 2.5 mg/dL. Patients who tolerate 25 mg once daily may have their dosage increased to 50 mg once daily as clinically indicated. Patients who do not tolerate 25 mg once daily may have their dosage reduced to 25 mg every other day. © The Swiss Pharmacy, Geneva Switzerland
  • 12. Aldactone Spironolactone Tablets Contraindications Aldactone Tablets (Spironolactone) is contraindicated in patients with the following conditions: ➔Hypersensitivity to Spironolactone or any inactive component of this medication. ➔Contraindicated for patients with anuria, acute renal insufficiency, significant impairment of renal excretory function, or hyperkalemia. © The Swiss Pharmacy, Geneva Switzerland
  • 13. Aldactone Spironolactone Tablets Side Effects of Aldactone Tablets Tell your doctor if you notice any of the following and they worry you: Cramping or diarrhoea, nausea or vomiting, drowsiness, lethargy or generally feeling unwell, skin rash or itchiness, fever, unusual hair loss or thinning and excessive hair growth. © The Swiss Pharmacy, Geneva Switzerland
  • 14. Aldactone Spironolactone Tablets Side Effects of Aldactone Tablets Tell your doctor as soon as possible in case you notice any of the following: Frequent infection such as fever, severe chills, sore throat or mouth ulcers. A few cases of agranulocytosis (lack of white blood cells) have been reported in patients taking Aldactone Tablets. Breast enlargement. Breast enlargement may occur in men taking Aldactone Tablets. This normally goes away when Aldactone Tablets are stopped. In rare instances some breast enlargement may persist. © The Swiss Pharmacy, Geneva Switzerland
  • 15. Aldactone Spironolactone Tablets Side Effects of Aldactone Tablets Breast Lumps: Breast lumps and breast cancer have been reported in patients taking Aldactone Tablets although Aldactone has not been shown to cause breast cancer. If any of the following side effects occur, stop taking Aldactone and either inform your doctor immediately or go to Accident and Emergency at your nearest hospital: Stomach bleeding, ulcers or gastritis (inflammation of the stomach), unsteadiness when walking, leg cramps, headache, mental confusion or dizziness. © The Swiss Pharmacy, Geneva Switzerland
  • 16. Aldactone Spironolactone Tablets Side Effects of Aldactone Tablets Change in sex drive, impotence (inability to achieve or maintain an erection), breast pain, irregular periods or no periods, post-menopausal bleeding. shortness of breath and swelling of the legs from fluid build (may be due to hyperkalaemia that is very serious) These are very serious side effects. You may need urgent medical attention or hospitalisation. © The Swiss Pharmacy, Geneva Switzerland
  • 17. Aldactone Spironolactone Tablets Warnings And Precautions ➔Potassium supplementation, either in the form of medication or as a diet rich in potassium, should not ordinarily be given in association with Aldactone therapy. ➔Hyperkalemia in patients with severe heart failure. Hyperkalemia may be fatal. It is critical to monitor and manage serum potassium in patients with severe heart failure receiving Aldactone .. ➔Aldactone should be used with caution in patients with impaired hepatic function. © The Swiss Pharmacy, Geneva Switzerland
  • 18. Aldactone Spironolactone Tablets Overdose Symptoms The symptoms of acute overdosage of Aldactone are drowsiness, mental confusion, maculopapular or erythematous rash, nausea, vomiting, dizziness, or diarrhea. Rarely, instances of hyponatremia, hyperkalemia, or hepatic coma may occur in patients with severe liver disease, but these are unlikely due to acute overdosage. Hyperkalemia may occur, especially in patients with impaired renal function. © The Swiss Pharmacy, Geneva Switzerland
  • 19. Aldactone Spironolactone Tablets Overdose Treatment In the event of Aldactone overdose, Induce vomiting or evacuate the stomach by lavage. There is no specific antidote. Treatment is supportive to maintain hydration, electrolyte balance, and vital functions. © The Swiss Pharmacy, Geneva Switzerland
  • 20. Aldactone Spironolactone Tablets Aldactone Tablets manufactured by RPG Life Science Ltd., India. For more information click here © The Swiss Pharmacy, Geneva Switzerland

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