Open 2013:  Teaching Medical Technology Innovation: Lessons learned from a new master's program in translational medicine
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Open 2013: Teaching Medical Technology Innovation: Lessons learned from a new master's program in translational medicine

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  • HMGR inhibitors based on fungal metabolites

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  • 1. Teaching Medical Technology InnovationLessons learned from a new masters program in translational medicine Kyle Kurpinski, PhD Executive Director, Master of Translational Medicine Program March 21, 2013 NCIIA Open Minds 2013 conference Masters of Translational Medicine UC Berkeley/UCSF
  • 2. What “Bench to bedside” is “Translational Medicine?” Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 3. From Bench to Bedside Problem Discovery Product (at the lab bench) (at the bedside) cardiovascular disease Atorvastatin Lipitor Research Translation Synthesizing 20 structurally novel HMGR inhibitors Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 4. Early 1960s Plasma cholesterol lowered by As it looked back then inhibiting synthesis 1962 Triparanol causes cataracts in humans 1982 Compactin and lovastatin* development suspended due to pre-clinical toxicity 1985 Atorvastatin synthesized 1992 Call for a moratorium on cholesterol-lowering drugs Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program *temporarily UC Berkeley/UCSF
  • 5. How is translational medicine different? Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 6. Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 7. What do students need to know to succeed in this field? Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 8. Who are the players? Research Translation Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 9. How do I move a project forward? Research Translation Do experiments Write Publish grants results Retire Image courtesy of The Space Cowboy Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 10. Pre- Pre-clinical FDA /Clinical prototyping review Studies Needs Write grants and negotiate contracts Start finding sleeping and >5 hours concept Establish Refine a night Respond Commercial design Quality Quality again to FDA manufacturing System System Lock down Distribution & your IP Process marketing Process develop- Pre-IDE* validation Reimbursement ment meeting coding Hire staff and consultants Years of your life *Investigational Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program Device Exemption UC Berkeley/UCSF
  • 11. RockHealth 2011 survey Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 12. RockHealth 2011 survey Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 13. What do I need to unlearn? Research fundamental problem; multiple potential end goals + Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 14. Translation specific end goal; better, cheaper, and/or faster than the competition + $1,000 + $700 Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 15. How do we train leaders in this field? (Besides letting them try and fail repeatedly.) Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 16. Master of Translational Medicine (MTM) Overview MTM Mission: To provide engineers, clinicians, and life scientists with the engineering, business, and biomedical training necessary to take new medical innovations from initial idea to clinical use. Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 17. MTM Program Overview Bioengineering and Therapeutic Bioengineering Sciences College of Engineering Schools of Medicine and Pharmacy Haas School of Business Clinical and Translational Science Institute School of Public Health Entrepreneurship Center Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 18. MTM Curriculum Bioengineering Clinical/Regulatory (10 semester (6 semester units) units) Capstone Business/Leadership (8 semester units) Project Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 19. MTM Sample Program Fall Semester (UCB) Spring Semester (UCB) Categories Fall Quarter (UCSF) Winter Quarter (UCSF) Spring Quarter (UCSF) Business / Engineering Leadership I Engineering Leadership II Leadership Ethics and Social Issues in Translational Principles of Magnetic Resonance Imaging Bioengineering Medicine “Translational Translational Challenges Clinical / Challenges in Medicine: in Diagnostics, Devices, Anti-Medical School” and Therapeutics Regulatory Designing Clinical Health Care Finance and Capstone Research Economics Project Physics of Medical Clinical Trials Idea to IPO Imaging Required CAPSTONE PROJECT* CAPSTONE PROJECT* Elective *Project work continues into summer Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 20. Capstone project Needs finding Lab projects • Clinical problem • Research problem • Limited to early • Early, middle, or late-stage stage Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 21. Capstone project Connect students to projects mentored by engineers and clinicians Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 22. Project Example 1: “Gauss Surgical” Client: Dr. David Rempel Problem: Monitoring Solution: Modify existing UCB/UCSF blood loss during surgery technology to help quantify Notable achievements – Created and tested initial prototypes – Now operating as a startup company – Recently received two 510(k) clearances from FDA Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 23. Project Example 2: “NanoNerve” Client: Dr. Shyam Patel Problem: Dura mater Solution: Create a synthetic patch NanoNerve, Inc. repair that enhances dural regeneration Notable achievements – Designed and tested prototypes in a canine duraplasty model – Assisted with submission of SBIR grant proposal – Multiple publications in progress Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 24. MTM Calendar Program UCSF Fall UCSF Winter UCSF Spring Program START Quarter Quarter Quarter END Aug Sep Oct Nov Dec Jan Feb Mar Apr May Jun Jul Aug UCB Fall UCB Spring Semester Semester CAPSTONE PROJECT Full time Vetting 15-20 hours/week (40+ hr/wk) Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 25. Master of Translational Medicine vs. Master of Science MS MTM ~2 years 11 months (Aug-Jun) Focus on technology translation Focus is on basic research and product development Curriculum is predominantly Curriculum includes clinical and science / engineering business components Individual thesis project Team-based capstone project Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 26. Who are we aiming for? Early stage clinicians and engineers • New graduate engineers • Engineers with 1-4 years of industry experience • Late medical school students and medial professionals • Wild cards! Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 27. This is all easier said than done Equipment / Donors Faculty supplies Infrastructure Sponsors Staff Projects Student fees Student aid Advertising Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 28. And yet… it’s working! San Francisco VA Medical Center Children’s Hospital Oakland Kaiser Permanente Various startup companies Student population is interdisciplinary and growing 35 Medical students / MDs 30 Non-CA resident (non-medical) 25 CA resident (non-medical) 20 15 10 5 0 2010-11 2011-12 2012-13 2013-14 2014-15 2015-16 2016-17 Projected Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 29. MTM Graduates – 2012 9 in industry  Abbott Vascular  Cepheid  InSite Vision  BD Biosciences  dQ&A Market Research  Pocket Gems  C1 Consulting  Hansen Medical  Siemens Healthcare 1 in government  Singapore Economic Development Board, Biomedical Sciences 2 in medical school  UC San Diego & UCLA 1 in a PhD program  U Penn, Biomedical Imaging 3 continuing Capstone project work Masters of Translational MedicineUC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF
  • 30. The Master of Translational Medicine Program Training students how to transform cutting-edgemedical research into better patient care Visit us on the web bioeng.berkeley.edu/mtm MTM Executive Director Kyle Kurpinski, PhD kkurpins@berkeley.edu 510-664-4472 Masters of Translational Medicine UC Berkeley/UCSF